Lung primary cells RNAseq for Nick
Marion Hardy
2024-04-19
Introduction
Kenneth did RNAseq on lung primary cells.
That data was aligned by the genome center, we have the preliminary reports:
qc_report_genome_center.html : quality control of the alignment of the data
initial_report_genome_center: describes each sample (used for annotations) and did a basic PCA + how many genes are differentially expressed when comparing conditions. However, they don’t give access to the underlying code and they don’t tell which thresholds of QC and differential expression and which normalization method they used.
We want to know what pathways/processes changed after different treatments. We are specifically interested in seeing why pitavastatin treatment reduced SPREADs but did not when combined with cytokine (IL6… (ask Nick))
So ultimately, what is up in cytokines vs control and down in cytokine+pitavastatin vs control?
PCA
First two PCs cover 96% of the variance in the data, yay that’s very good
Replicates don’t cluster together so it looks like possible batches are behaving ok
Cytokine_vs_Control
Pitavastatin_vs_Control
Pitava_Cyto_vs_Control
Gene expression programs changes between conditions
Cytokine vs Control
## function (...) .Primitive("c")Volcano plots
GSEA analysis (logFc)
GOBP
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 258 | 0.5158158 | 1.868329 | 0.0000014 | 0.0031036 | 0.0028865 | 1295 | FGL2/SH2D1B/SOCS1/EMILIN2/RASGRP1/CD274/SERPINB4/CD36/PTPN22/TLR4/HCK/PPARG/ARRB2/RAET1G/ZBP1/CD55/IFI35/CARD9/APPL2/UFD1/RAET1E/GBP5/SPINK5/NOD2/ARG2/SYT11/ADAM8/SEC14L1/NECTIN2/DDX60/TYRO3/KLK7/RNF125/PVR/APOE/SIRT2/FADD/PRKCA/MICA/BMP6/IL4I1/HEXIM1 |
| GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS | 457 | 0.4607031 | 1.762532 | 0.0000009 | 0.0031036 | 0.0028865 | 2373 | NOS2/CISH/SOCS1/ALOX15/SLC5A8/PNPLA3/MFSD2A/P2RY1/ELOVL5/GPER1/HAAO/GARS1/MVD/SERAC1/ADCY7/HRH1/TKT/ACSS2/NOS1/NNMT/ELOVL7/ABHD4/FDPS/HMGCS1/LCAT/ME1/INPP5J/FADS1/PLA2G4A/CKMT1A/ADSS2/G6PD/LPCAT4/ELOVL6/CKMT1B/SERINC5/PTDSS1/ACLY/SNCA/MBOAT1/SAMD8/ACOT7/ANTKMT/DGKQ/PIGH/GPAT3/ELOVL1/CWH43/ATP5F1D/DGKA/SOCS2/ELOVL4/IDH1/VPS9D1/CKB/LPIN1/PMVK/DCK/HSD17B12/P2RY6/FAR1/LIPH/IDI1/ATP5MC3/PLD2/ATP5F1B/PDHA1/ATP5MC1/PIK3C2B/SGMS1/PANK3/SLC25A1/TAFAZZIN/ACP6/ALDOA/DOLPP1/UPRT/PIP4K2A/DHDDS/NAPRT/TPK1/MVK/SLC25A16/ADGRF5/INPPL1/DGUOK/SLC26A2/PTPMT1/ACSL1/CPS1/AKR1A1/PIGS/PANK4/SLC25A13/TTC7B/DGKD/MOCS1/NMNAT1/PDHX/DOLK/PGAP4/PIP5K1A/IPPK/NADK/ATP5PO/CHP1/TMEM150A/ENO1/PLAAT3/PDXK/FLCN/LPCAT3/PDK1/ACSL3/GPAT4/GCH1/PARP9/PIGZ/DCTD/ISYNA1/ATP5PF |
| GOBP_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 13 | -0.8501069 | -2.021198 | 0.0000554 | 0.0385845 | 0.0358857 | 898 | CDT1/NUF2/CENPE/NDC80/KIF2C |
| GOBP_STEROL_BIOSYNTHETIC_PROCESS | 52 | 0.6777685 | 2.004416 | 0.0000765 | 0.0385845 | 0.0358857 | 2362 | CH25H/CYP51A1/LSS/MVD/EBP/INSIG1/DHCR7/FDPS/HMGCS1/HMGCR/MSMO1/G6PD/SREBF1/ACLY/APOE/PMVK/FDFT1/IDI1/NSDHL/SC5D/CYB5R3/MBTPS1/MVK/HSD17B7/SQLE/ABCG1/ERG28/TM7SF2/LPCAT3/CYB5R2 |
| GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS | 60 | 0.6533448 | 1.973875 | 0.0001416 | 0.0385845 | 0.0358857 | 1366 | NOS2/TAT/SLC39A8/PHGDH/GOT1/ASNS/SLC7A11/NOS1/PYCR1/ARG2/NAGS/ADHFE1/DDAH2/PRODH/GLS2 |
| GOBP_CHRONIC_INFLAMMATORY_RESPONSE | 11 | -0.8696239 | -1.966654 | 0.0000836 | 0.0385845 | 0.0358857 | 721 | ADORA2B/THBS1/TNF/VNN1/S100A9/VCAM1/S100A8 |
| GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS | 108 | 0.5932020 | 1.915776 | 0.0000310 | 0.0385845 | 0.0358857 | 1944 | CH25H/CYP51A1/LSS/MVD/EBP/PCSK9/INSIG1/NFE2L1/DHCR7/FDPS/HMGCS1/LCAT/HMGCR/CYP2C9/SCARB1/MSMO1/G6PD/NPC1/CYP27B1/SREBF1/ACLY/LDLR/ACO2/ABCA5/SULT2B1/APOE/DGKQ/GBA2/IDH1/PMVK/FDFT1/IDI1/NSDHL/CYP2R1/SC5D/CYB5R3/OSBPL1A/SREBF2/MBTPS1/CYP46A1/MVK/HSD17B7/APOL2/SQLE/ABCG1/SMPD1 |
| GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS | 105 | 0.5766859 | 1.859719 | 0.0001380 | 0.0385845 | 0.0358857 | 2567 | P2RY1/CYP51A1/GPER1/LSS/MVD/PCK2/EBP/HRH1/GOT1/INSIG1/DHCR7/FDPS/HMGCS1/HMGCR/MSMO1/G6PD/CYP27B1/SREBF1/ACLY/SNCA/PTS/APOE/DGKQ/PMVK/BMP6/P2RY6/FDFT1/IDI1/NSDHL/CYP2R1/SC5D/CYB5R3/DHDDS/MBTPS1/ACER3/MVK/HSD17B7/ABCG1/IPPK/ACER2/TM7SF2/LPCAT3/GCH1/ISYNA1/CLCN2/PCBD1 |
| GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION | 94 | -0.5108650 | -1.822729 | 0.0001098 | 0.0385845 | 0.0358857 | 2543 | TRIP13/ATM/RGCC/CCNB1/BUB1/NEK2/FBXO5/MTBP/EDN1/PLK1/EGF/KIF20B/CDCA2/BMP4/TTK/CHEK1/DLGAP5/MAD2L1/DUSP1/ANAPC4/CDT1/MKI67/CENPF/CDC25C/INSR/IGF2/BUB1B/TNF/NDC80/EPGN/IL1B/PDGFB |
| GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS | 109 | -0.4885420 | -1.792841 | 0.0001533 | 0.0385845 | 0.0358857 | 2037 | FBXO5/WNT5A/ESR1/CCDC87/PLB1/GDF9/LIF/CITED2/INHBB/HORMAD1/CDC20/NOX5/BMP4/CACNA1H/EAF2/CFAP206/TTK/UMODL1/NPR2/DUSP1/ASPM/PLA2G10/PDE5A/CDC25C/INSR/OVGP1/SHH/GJA1/OXTR/EPPIN/INHBA/ARHGDIB/DEFB1/PLAT/AR/CNTD1 |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_DEATH | 155 | 0.5185939 | 1.764463 | 0.0001127 | 0.0385845 | 0.0358857 | 1484 | NTRK1/GDNF/PLA2G3/BDNF/NTRK2/ARRB2/FZD1/SLC7A11/AARS1/CD200R1/GRIK2/BCL2/HIF1A/ADAM8/KRAS/FOXQ1/CNTF/GPNMB/ATF4/SNCA/AP2B1/SORL1/IKBKG/TYRO3/NR4A3/APOE/AXL/NRBP2/ZPR1/WFS1/GPI/UNC5B/IL27RA |
| GOBP_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES | 125 | -0.4599310 | -1.736424 | 0.0001692 | 0.0385845 | 0.0358857 | 2444 | NEXN/CELSR1/PCDHB13/PCDHGA9/ROBO3/PCDHAC2/PCDHGB2/CEACAM6/FAT2/PCDHB11/PTPRM/FAT1/PCDHGA6/PCDHGC4/PCDHGA11/PCDHB7/PCDHGB1/PCDHGC3/ITGB1/AMIGO2/CDH19/PCDHGB4/PCDHB4/MPZL2/PCDHGA8/PCDHA6/CDHR2/PCDHA11/CDH2/PCDHGA4/NECTIN1/DSC2/CDHR3/PCDHGA12/PCDHB9/PCDHB14/PCDHGA5/DSC3/L1CAM/KIRREL3/CDH23/PCDHA10/ROBO2/PCDHGB3/PTPRR/RET/PCDHGC5/CLSTN2/PCDHA5/PCDH9/DCHS2/PCDHB1/PCDHB12/PTPRT/PCDHA9/DSCAML1/PCDHA12/PCDH18 |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE | 278 | 0.4677690 | 1.708260 | 0.0000649 | 0.0385845 | 0.0358857 | 1553 | NTRK1/ANO1/SOCS1/CA2/EDNRA/KLF2/CD36/PTPN22/TLR4/PNPLA3/MAP1B/TRIB3/GJB2/PPARG/GPER1/KL/PCK2/PRKCQ/GOT1/MARS1/PTPRE/PCSK9/INSIG1/RAB15/APPL2/FBP1/GPT/CPEB2/NR4A1/NOD2/KLF11/SREBF1/FBN1/SORL1/ZBTB7B/NR4A3/GRB10/RAB31/CCND3/EEF2K/SOCS2/TBC1D4/KAT2B/SLC27A4/CYP1B1/LPIN1/CDC6/CAV2/ABCC1/DENND4C/MYO1C/EPRS1/SLC29A2/SLC9A1/PIP4K2A/ZDHHC7 |
| GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 221 | 0.4781555 | 1.702866 | 0.0001481 | 0.0385845 | 0.0358857 | 1403 | NOS2/FGL2/SH2D1B/PLA2G3/RASGRP1/SERPINB4/CD36/PTPN22/TLR4/ARRB2/RAET1G/GATA3/TNFSF13/CD55/APPL2/FZD5/RAET1E/HK1/SPINK5/GAB2/NOD2/TRPM4/ANXA1/NECTIN2/DDX60/ZBTB7B/NR4A3/KLK7/COLEC10/PVR/IL4R/CD81/FADD/IL18R1/MICA/CD47/IL20RB/IL4I1/RIPK3/AZGP1/CD40/GPI/SERPINB9 |
| GOBP_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY | 214 | 0.4781421 | 1.695589 | 0.0001654 | 0.0385845 | 0.0358857 | 2384 | CCL26/NTRK1/FZD10/RASGRP1/SFRP1/RTN4R/ARHGEF5/ASAP3/DOCK11/RGS16/RIC1/RAP1GAP/GRHL3/NEDD9/TBC1D4/SLC27A4/TBC1D10A/NGEF/TBC1D14/ARHGAP27/CCL14/ADAP2/TBC1D22A/SH3BP1/CAV2/GARNL3/CD40/EVI5L/RAPGEF4/SIPA1L2/SNX9/CHN1/GMIP/RAPGEFL1/RABGAP1/NDEL1/TBC1D16/SIPA1L1/RGP1/TBC1D9/PIP5K1A/TBC1D20/RASGRF2/BIN1/DOCK9/ARHGAP25/ABR/FLCN/RAP1A/TAX1BP3/ARHGEF10/RALGPS1/ADPRH/RAPGEF6 |
| GOBP_ANION_TRANSPORT | 330 | 0.4467745 | 1.659277 | 0.0001033 | 0.0385845 | 0.0358857 | 1695 | NOS2/ANO1/PLA2G3/CA2/SLC5A5/SLC26A4/SLC9A3/SLC24A3/CD36/SLC39A8/NTRK2/SLC16A9/SLC5A1/ACE/TTYH2/SLC26A9/SLC5A8/SLC2A6/LRRC8D/MFSD2A/SLC16A14/TCAF2/SLC6A14/SLC25A25/SLC12A2/SLC7A11/SLCO1B3/ATP8B1/TG/LRRC8B/SLC1A5/SLC36A1/RGS2/SLC26A11/PLA2G4A/CLIC3/SFXN5/ANO8/SLCO4C1/SLCO4A1/SLC7A1/ANO7/ANXA1/SLC4A9/SERINC5/SLC26A6/ATF4/LRRC8A/SNCA/SLC1A4/WNK4/SLC25A5/SLC3A2/MPC1/SLC16A7/SLC4A3/CPTP/SLC27A4/SLC25A3/SLC2A10/P2RY6/CD47/SLCO3A1/PRAF2/SLC16A4/ABCC1/CLIC4/SLC17A5/ANO10/PACC1/SLC25A1/GABRA3/SLC9A1/SLC25A22/SLC38A7/SLC6A9/SLC52A2/SLC35B4/SLC35D1/SLC66A1/SLC7A5/SLC9A9 |
| GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT | 331 | 0.4379673 | 1.625082 | 0.0001536 | 0.0385845 | 0.0358857 | 1775 | NTRK1/PTPRO/PLA2G3/SDC2/PRKD1/BDNF/NTRK2/SFRP1/PMP22/EPHA3/CRMP1/RTN4R/KLF4/MFSD2A/MAP1B/ALKAL1/DAB1/GATA3/EPHB3/FZD1/ZNF365/TNIK/CNTN1/NTNG1/SLIT1/CNR1/AMIGO1/CAMK1D/INPP5J/RGS2/PTPRD/RUFY3/TWF2/CNTF/SLIT2/SEMA6A/TENM3/MBOAT1/VEGFA/PPP2R5B/CCDC88A/FKBP1B/APOE/RELN/CHODL/EEF2K/ACAP3/SEMA3B/NGEF/SEMA4C/NRCAM/CDK5R1/KREMEN1/PTPRG/NSMF/SEMA4A/ROR1/CHN1/TRPV4/RAB11A/DBN1/BAG5/NDEL1/DGUOK/STK25/PTK6/SIPA1L1/PLXNA3/SEMA3D/KATNB1 |
| GOBP_REGULATION_OF_HORMONE_LEVELS | 329 | 0.4345424 | 1.613692 | 0.0001686 | 0.0385845 | 0.0358857 | 1492 | NOS2/ANO1/DPP4/PLA2G3/C1QTNF1/SLC5A5/TRPV6/SLC9B2/PCSK6/SFRP1/ACE/ADH1C/LRAT/CYP2S1/STC2/P2RY1/PPARG/DUOX2/GPER1/DUOXA1/GATA3/CPT1A/CYP26A1/PCK2/FOXD1/GPR27/GCNT4/FAM3B/DUOX1/TG/CNR1/DHCR7/DHRS7/CYP2C9/CYP2C18/HIF1A/TRPM4/MYRIP/VSNL1/SLCO4A1/RDH11/ATP1A1/ANXA1/EGR1/CYP27B1/SREBF1/LRRC8A/LTBP4/EIPR1/DUOXA2/CPQ/FKBP1B/DGKQ/DHRS11/DOC2B/CYP1B1/BACE2/SDR16C5/BMP6/HSD17B12/RAB11FIP1/ALDH1A3/IL4I1/RETSAT/RAPGEF4/SELENOM/HMGN3/DISP1/TRPV4/NIBAN2/RDH13 |
| GOBP_RESPONSE_TO_WOUNDING | 413 | 0.4238536 | 1.607636 | 0.0001161 | 0.0385845 | 0.0358857 | 1251 | NTRK1/CCN4/VWF/EMILIN2/ADRA2C/C1QTNF1/ALOX15/EDNRA/SELP/SERPINB2/CD36/PROCR/TLR4/SMOC2/RTN4R/CD44/KLF4/MAP1B/P2RY1/PPARG/PHLDB2/THBD/DUOX2/TNC/CLASP1/EPPK1/HBEGF/PRKCQ/PEAR1/FAP/SOX2/ENTPD2/SLC12A2/SLC7A11/CD9/DUOX1/GRHL3/F3/SPRR3/BCL2/YAP1/PLA2G4A/HIF1A/TSPAN8/SYT11/SCARB1/CNTF/MPL/ANXA1/KRT6A/RAB3A/VEGFA/TYRO3/HPSE/FKBP1B/ID3/LOX/APOE/DGKQ/DGKA/PRKCA/ZFP36/VCL/AXL/ST3GAL4/MIA3/NOTCH4/CADM4 |
| GOBP_BEHAVIOR | 376 | 0.4258180 | 1.601860 | 0.0001058 | 0.0385845 | 0.0358857 | 1086 | NTRK1/SLC18A2/CLDN5/GDNF/DPP4/LYPD1/MME/BDNF/NTRK2/SGK1/HTR1D/BRINP1/ACE/AFF2/ADM2/HOMER2/MFSD2A/EGR2/P2RY1/ARRB2/DAB1/FGF12/CPT1A/HRH1/DRD1/CNTN1/SLC7A11/GCNT4/CNR1/UCHL1/FOXO6/HMGCR/GRIK2/CIART/BCL2/HIF1A/SYT11/KRAS/MAPK8IP2/NPC1/GJB4/EGR1/LPAR5/MRAP2/ITPR3/SNCA/LDLR/NR4A3/APOE/RELN/MMP17/FADD |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS | 104 | 0.5764646 | 1.858877 | 0.0001979 | 0.0389299 | 0.0362070 | 1484 | NTRK1/GDNF/PLA2G3/BDNF/NTRK2/ARRB2/AARS1/GRIK2/BCL2/HIF1A/ADAM8/KRAS/FOXQ1/CNTF/SNCA/TYRO3/APOE/AXL/NRBP2/ZPR1/WFS1/GPI/UNC5B/IL27RA |
| GOBP_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT | 113 | 0.5577930 | 1.818429 | 0.0001999 | 0.0389299 | 0.0362070 | 1037 | NTRK1/PLA2G3/PRKD1/BDNF/NTRK2/EPHA3/ALKAL1/FZD1/CNTN1/CNR1/AMIGO1/CAMK1D/RGS2/TWF2/CNTF/TENM3/PPP2R5B/FKBP1B/APOE/RELN/EEF2K |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 120 | 0.5505350 | 1.802496 | 0.0002029 | 0.0389299 | 0.0362070 | 1295 | SH2D1B/EMILIN2/RASGRP1/CD274/TLR4/HCK/RAET1G/ZBP1/IFI35/CARD9/RAET1E/GBP5/NOD2/ADAM8/NECTIN2/DDX60/KLK7/PVR/FADD/PRKCA/BMP6/HEXIM1 |
| GOBP_REGULATION_OF_NUCLEAR_DIVISION | 109 | -0.4835062 | -1.774361 | 0.0002049 | 0.0389299 | 0.0362070 | 2543 | TRIP13/ATM/RGCC/CCNB1/BUB1/NEK2/FBXO5/WNT5A/MTBP/EDN1/PLK1/LIF/EGF/KIF20B/HORMAD1/CDC20/CDCA2/BMP4/TTK/CHEK1/DLGAP5/MAD2L1/DUSP1/ANAPC4/CDT1/MKI67/CENPF/CDC25C/INSR/IGF2/BUB1B/TNF/NDC80/EPGN/IL1B/PDGFB |
| GOBP_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS | 50 | 0.6735063 | 1.973619 | 0.0002238 | 0.0400627 | 0.0372605 | 1006 | NTRK1/DPP4/LYPD1/GJA4/BRINP1/DRD1/NOS1/GRIK2/BCL2/MAPK8IP2/LPAR5/APOE/RELN |
| GOBP_RESPONSE_TO_PEPTIDE | 370 | 0.4252330 | 1.601866 | 0.0002284 | 0.0400627 | 0.0372605 | 1815 | NTRK1/ANO1/SOCS1/CA2/EDNRA/KLF2/CD36/PTPN22/TLR4/PNPLA3/EGR2/MAP1B/TRIB3/STC2/GJB2/PPARG/GPER1/KL/PCK2/PRKCQ/GOT1/ZBED3/MARS1/PTPRE/PCSK9/INSIG1/CARD9/RAB15/APPL2/FBP1/TRIM16/GPT/CPEB2/NR4A1/NOD2/KLF11/ANXA1/EGR1/SESN2/BTG1/SREBF1/FBN1/SORL1/ZBTB7B/LTA4H/NR4A3/GRB10/RAB31/CCND3/EEF2K/SOCS2/TBC1D4/KAT2B/CYC1/SLC27A4/CYP1B1/LPIN1/CDC6/CAV2/ABCC1/DENND4C/MYO1C/EPRS1/TRPV4/SLC29A2/SLC9A1/UPRT/PIP4K2A/ZDHHC7/TIMP4/NDEL1/INPPL1/CACNB1/HADHA/OSBPL8/HSD11B2/PTPN1/CPS1/NFKBIA |
| GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION | 163 | 0.5046608 | 1.729649 | 0.0003004 | 0.0482536 | 0.0448785 | 3113 | CCL26/ALOX15/CDC42EP5/HCK/MAP1B/CLASP1/INPP5J/GSN/TWF2/TMSB10/DLG1/ARHGAP40/SLIT2/KANK3/SNCA/MET/GBA2/CDK5R1/ARPC5L/ANKRD53/FLII/SNX9/DBN1/HSPA1A/RAC1/CLIP3/TMOD2/NUMA1/RANGRF/ADD3/HIP1R/GIT1/VDAC2/TPPP/WASHC2C/ARL2/SVIL/SSH1/HSPA1B/BIN1/CAMSAP3/ARPC4/CTTN/FKBP4/RHOA/ARFGEF1/ARPC1B/DBNL/SLAIN1/CKAP5/HAX1/DMTN/KANK1/PAK1/MTOR/DCTN1/ARPC1A/EVL/AKAP9/TBCD/CAPG/EML2 |
| GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 165 | 0.4984273 | 1.717797 | 0.0003147 | 0.0482536 | 0.0448785 | 1155 | SH2D1B/SOCS1/RASGRP1/SERPINB4/PTPN22/TLR4/HCK/PPARG/ARRB2/RAET1G/ZBP1/IFI35/CARD9/APPL2/RAET1E/GBP5/NOD2/ADAM8/NECTIN2/TYRO3/PVR/APOE/FADD/MICA |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE_HORMONE_STIMULUS | 222 | 0.4604476 | 1.644657 | 0.0003101 | 0.0482536 | 0.0448785 | 2092 | SOCS1/CA2/EDNRA/PNPLA3/MAP1B/TRIB3/GJB2/PPARG/GPER1/KL/PCK2/PRKCQ/GOT1/MARS1/PTPRE/PCSK9/INSIG1/RAB15/APPL2/FBP1/GPT/CPEB2/NR4A1/SREBF1/FBN1/SORL1/ZBTB7B/NR4A3/GRB10/RAB31/CCND3/EEF2K/SOCS2/TBC1D4/KAT2B/SLC27A4/CYP1B1/LPIN1/CDC6/CAV2/DENND4C/MYO1C/EPRS1/SLC29A2/SLC9A1/PIP4K2A/ZDHHC7/NDEL1/OSBPL8/PTPN1/CPS1/SLC2A8/LPIN2/HDAC9/SELENOS/CAV1 |
| GOBP_WOUND_HEALING | 323 | 0.4273373 | 1.583786 | 0.0003175 | 0.0482536 | 0.0448785 | 1251 | CCN4/VWF/EMILIN2/ADRA2C/C1QTNF1/ALOX15/SELP/SERPINB2/CD36/PROCR/TLR4/SMOC2/CD44/P2RY1/PPARG/PHLDB2/THBD/DUOX2/CLASP1/EPPK1/HBEGF/PRKCQ/PEAR1/FAP/ENTPD2/SLC12A2/SLC7A11/CD9/DUOX1/GRHL3/F3/SPRR3/YAP1/PLA2G4A/HIF1A/TSPAN8/SYT11/SCARB1/MPL/ANXA1/KRT6A/RAB3A/VEGFA/TYRO3/HPSE/LOX/APOE/DGKQ/DGKA/PRKCA/VCL/AXL/ST3GAL4/MIA3/NOTCH4/CADM4 |
GOMF
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOMF_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 151 | 0.5308814 | 1.830024 | 0.0002392 | 0.0363147 | 0.0342398 | 1807 | SLC18A2/SLC5A5/SLC26A4/SLC9A3/SLC9B2/SLC24A3/SLC39A8/SLC16A9/SLC5A1/SLC9B1/SLC26A9/SLC5A8/MFSD2A/SLC16A14/SLC6A14/SLC45A4/SLC12A2/SLC7A11/SLCO1B3/SLC1A5/SLC36A1/SLC5A3/SLC26A11/SLCO4C1/SLCO4A1/SLC4A9/SLC26A6/SLC1A4/SLC25A5/SLC3A2/SLC16A7/SLC4A3/SLC25A3/SLC2A10/SLC35E4/SLCO3A1/SLC15A1/SLC16A4/SLC17A5/SLC25A1/SLC9A1/SLC25A22/SLC6A9/SLC45A3/SLC35D1/SLC7A5/SLC9A9/SLC25A16/SLC28A3/SLC26A2/MCU |
| GOMF_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 172 | 0.5153634 | 1.804324 | 0.0002087 | 0.0363147 | 0.0342398 | 2510 | SLC18A2/SLC5A5/SLC26A4/SLC9A3/SLC9B2/ATP12A/SLC24A3/SLC39A8/SLC5A1/SLC9B1/SLC26A9/SLC5A8/ATP6V1C2/MFSD2A/SLC45A4/SLC12A2/SLC7A11/SLCO1B3/SLC36A1/SLC5A3/SLC26A11/SLCO4C1/SLCO4A1/ATP1A1/SLC4A9/ATP7B/SLC26A6/SLC25A5/SLC3A2/SLC16A7/SLC4A3/CYC1/SLC25A3/SLC2A10/ATP1B1/SLCO3A1/SLC15A1/ABCC1/ATP5F1B/SLC17A5/SLC25A1/SLC9A1/ATP6V1E2/SLC25A22/SLC6A9/SLC45A3/SLC9A9/SLC28A3/SLC26A2/COX4I1/UQCRFS1/COX8A/COX5A/ABCC10/SLC22A18/SLC4A11/ATP6V0E2/UQCRC1/SLC38A1/COX7B/COX6B1/SLC10A3/SLC25A11/ATP6V0D1/SLC37A4/CLCN6/LETM1 |
| GOMF_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 205 | 0.4853043 | 1.732752 | 0.0001913 | 0.0363147 | 0.0342398 | 1695 | SLC18A2/ANO1/SLC5A5/SLC26A4/SLC9A3/SLC24A3/CD36/SLC39A8/TTYH2/SLC26A9/SLC5A8/SLC2A6/LRRC8D/MFSD2A/SLC6A14/SLC25A25/SLC12A2/SLC7A11/SLCO1B3/LRRC8B/SLC1A5/SLC36A1/SLC26A11/CLIC3/SFXN5/ANO8/SLCO4C1/SLCO4A1/SLC7A1/ANO7/SLC4A9/SERINC5/SLC26A6/LRRC8A/SLC1A4/SLC25A5/SLC3A2/MPC1/SLC16A7/SLC4A3/SLC27A4/SLC2A10/SLCO3A1/ABCC1/CLIC4/ANO10/PACC1/SLC25A1/GABRA3/SLC9A1/SLC25A22/SLC38A7/SLC6A9/SLC52A2/SLC35B4/SLC35D1/SLC66A1/SLC7A5/SLC9A9 |
| GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 284 | 0.4551581 | 1.681447 | 0.0001626 | 0.0363147 | 0.0342398 | 2510 | SLC18A2/SLC5A5/SLC26A4/SLC9A3/SLC9B2/ATP12A/SLC24A3/SLC39A8/SLC16A9/SLC5A1/SLC9B1/SLC26A9/SLC5A8/ATP6V1C2/MFSD2A/SLC29A4/SLC16A14/SLC6A14/SLC45A4/SLC12A2/SLC7A11/SLCO1B3/SLC1A5/SLC36A1/SLC5A3/ABCA3/SLC26A11/TAP2/SLCO4C1/SLCO4A1/ATP1A1/SLC4A9/ATP7B/SLC26A6/SLC1A4/ABCA5/SLC25A5/NDUFS7/SLC3A2/SLC16A7/SLC4A3/CYC1/SLC25A3/SLC2A10/SLC35E4/ATP1B1/SLCO3A1/SLC15A1/NDUFV1/NDUFS6/SLC16A4/ABCC1/ATP5F1B/SLC17A5/ABCA9/SLC25A1/SLC9A1/ATP6V1E2/SLC25A22/SLC6A9/SLC45A3/SLC35D1/NDUFA6/SLC7A5/SLC9A9/SLC25A16/CYB561D1/SLC28A3/SLC26A2/NDUFS8/COX4I1/MCU/ABCG1/UQCRFS1/COX8A/COX5A/ABCC10/NDUFS3/SLC22A18/NDUFA13/SLC4A11/NDUFB9/SLC16A13/ATP6V0E2/UQCRC1/SLC38A1/COX7B/COX6B1/NDUFV3/SLC10A3/ABCA7/SLC25A11/ATP6V0D1/SLC37A4/CLCN6/NDUFS4/LETM1 |
| GOMF_INORGANIC_MOLECULAR_ENTITY_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 426 | 0.4189642 | 1.618593 | 0.0000911 | 0.0363147 | 0.0342398 | 2484 | CALHM4/SLC18A2/ANO1/TRPM6/SLC5A5/TRPV6/CALHM5/KCNJ16/SLC26A4/SLC9A3/SLC9B2/ATP12A/SLC24A3/KCNS3/SLC39A8/CACNB4/SLC5A1/TTYH2/SLC9B1/KCNE3/SLC26A9/SLC5A8/ATP6V1C2/LRRC8D/MFSD2A/KCNMB4/SLC30A4/TMC1/ORAI1/SLC45A4/SLC12A2/CNR1/LRRC8B/SLC36A1/SLC5A3/GRIK2/TMC6/SLC26A11/ATP6V0A2/SCN4B/TRPM4/CLIC3/KCNK6/ANO8/ATP1A1/ANO7/SLC4A9/ATP7B/SLC26A6/NIPA1/MCUB/ITPR3/LRRC8A/TPCN2/SLC1A4/SLC25A5/FKBP1B/SLC3A2/RYR3/STIM2/SLC4A3/ATP5F1D/CYC1/SLC25A3/KCNN3/SLC2A10/NIPAL1/ATP1B1/SLC15A1/ATP5MC3/ABCC1/ATP5F1B/CLIC4/SLC17A5/ATP5MC1/ANO10/PACC1/NNT/CACNB3/HVCN1/NALF2/TRPV4/MCOLN1/GABRA3/SLC39A4/CATSPER3/PKD2/SLC9A1/ATP6V1E2/SLC25A22/SLC6A9/KCNQ5/SLC45A3/SLC39A1/TMEM63C/SLC9A9/CACNB1/SHROOM2/SLC28A3/SLC26A2/COX4I1/MCU/PKD1/UQCRFS1/COX8A/VDAC2/COX5A/ABCC10/SLC22A18/ATP5PO/PDPN/KCNG1/SLC4A11/P2RX4/CCDC51/ATP6V0E2/UQCRC1/HCN4/SLC38A1/ORAI3/KCND3/TMEM120A/CACNA2D4/MFSD5/COX7B/COX6B1/ATP5PF/SLC10A3/MMGT1/SLC25A11/ATP6V0A1/VDAC1/ATP6V0D1/SLC37A4/CLCN2/CACNG8/CLCN6 |
| GOMF_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 385 | 0.4215592 | 1.611096 | 0.0001931 | 0.0363147 | 0.0342398 | 1865 | CALHM4/SLC18A2/ANO1/TRPM6/SLC5A5/TRPV6/CALHM5/KCNJ16/SLC9A3/SLC9B2/ATP12A/SLC24A3/KCNS3/SLC39A8/CACNB4/SLC5A1/SLC9B1/KCNE3/SLC5A8/ATP6V1C2/MFSD2A/KCNMB4/SLC29A4/SLC30A4/TMC1/SLC6A14/ORAI1/SLC45A4/SLC12A2/CNR1/SLC1A5/SLC36A1/SLC5A3/GRIK2/ATP6V0A2/SCN4B/TRPM4/KCNK6/ATP1A1/SLC7A1/SLC4A9/SERINC5/ATP7B/NIPA1/ITPR3/TPCN2/SLC1A4/SLC25A5/FKBP1B/SLC3A2/RYR3/STIM2/ATP5F1D/CYC1/SLC25A3/KCNN3/SLC2A10/NIPAL1/ATP1B1/SLC15A1/ATP5MC3/ATP5F1B/SLC17A5/ATP5MC1/ANO10/NNT/CACNB3/HVCN1/NALF2/TRPV4/MCOLN1/SLC39A4/CATSPER3/PKD2/SLC9A1/ATP6V1E2/SLC25A22/SLC38A7/SLC6A9/KCNQ5/SLC45A3/SLC39A1/TMEM63C/SLC66A1/SLC7A5/SLC9A9/CACNB1/SHROOM2/SLC28A3/COX4I1/MCU/PKD1/UQCRFS1/COX8A |
Reactome
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | 62 | -0.5978841 | -1.971159 | 0.0000269 | 0.0142222 | 0.0133935 | 4503 | H2BC4/H2AC8/CENPQ/RBBP7/H2BC6/H2AX/H2BC5/H2AJ/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/RBBP4/H4C9/H4C1/CENPI/NPM1/H4C3/H4C5/CENPN/ITGB3BP/H2AC14/H2BC9/H4C6/H2AC4/CENPU/H2BC17/H4C4/KNL1/CENPP/CENPK/H4C11/CENPM/MIS18BP1/MIS18A/H4C13/H4C12/H2BC3/H2BC13/H2BC10/HJURP/CENPW |
| REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES | 61 | -0.5947811 | -1.955401 | 0.0000343 | 0.0142222 | 0.0133935 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/NCAPG2/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/SMC2/H4C5/H2AC14/SMC4/CCNB1/H2BC9/H4C6/H2AC4/H2BC17/H4C4/PLK1/H3C8/H4C11/H3C7/H4C13/CDK1/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA | 61 | -0.5932827 | -1.950475 | 0.0000375 | 0.0142222 | 0.0133935 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/RBBP7/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/EZH2/H2AC6/RBBP4/EED/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/MTF2/H2AC14/H2BC9/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_CHOLESTEROL_BIOSYNTHESIS | 24 | 0.8228980 | 2.079667 | 0.0000806 | 0.0145899 | 0.0137398 | 1757 | CYP51A1/LSS/MVD/EBP/DHCR7/FDPS/HMGCS1/HMGCR/ACAT2/MSMO1/PMVK/FDFT1/IDI1/NSDHL/SC5D/MVK/HSD17B7/SQLE |
| REACTOME_DNA_METHYLATION | 52 | -0.5996267 | -1.914176 | 0.0000890 | 0.0145899 | 0.0137398 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 | 53 | -0.5901700 | -1.903186 | 0.0000897 | 0.0145899 | 0.0137398 | 4513 | H3-3A/H2BC4/H2AC8/KDM1A/H3C6/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3/AR |
| REACTOME_RMTS_METHYLATE_HISTONE_ARGININES | 66 | -0.5600100 | -1.877083 | 0.0000615 | 0.0145899 | 0.0137398 | 4551 | RPS2/H2AC8/H3C6/RBBP7/H2AX/SMARCA2/ARID2/H2AJ/H3C11/H4C2/SMARCC1/H2AC6/ARID1B/H4C9/JAK2/H4C1/H3C1/H3C10/H4C3/ACTL6A/H4C5/H2AC15/H2AC14/SMARCE1/WDR77/H2AC16/H4C6/H2AC4/SMARCD3/H4C4/H2AC13/H2AC12/H3C8/H4C11/H2AC21/H3C7/H2AC11/H4C13/CCND1/H4C12/H3C12/H3C13/H3C2/H3C3 |
| REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION | 64 | -0.5616708 | -1.860372 | 0.0001296 | 0.0165794 | 0.0156133 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/RBBP7/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/TTF1/H2BC7/H2AC6/RBBP4/H4C9/H4C1/H3C1/H3C10/H4C3/HDAC2/H4C5/H2AC14/H2BC9/CBX3/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_MEIOTIC_RECOMBINATION | 68 | -0.5503583 | -1.853258 | 0.0001310 | 0.0165794 | 0.0156133 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/PSMC3IP/H2BC6/RPA1/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/BLM/MRE11/BRCA2/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/NBN/H4C5/H2AC14/ATM/RBBP8/RPA3/H2BC9/H4C6/H2AC4/H2BC17/H4C4/BRCA1/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_HDACS_DEACETYLATE_HISTONES | 80 | -0.5260564 | -1.829196 | 0.0001928 | 0.0219549 | 0.0206756 | 4503 | H2BC4/H2AC8/KDM1A/H3C6/RBBP7/H2BC6/ARID4A/H2BC5/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/RBBP4/H2BC18/H4C9/H4C1/H3C1/H3C10/SAP30/H4C3/HDAC8/HDAC2/H4C5/H2AC15/H2AC14/H2AC16/H2BC9/H4C6/TBL1XR1/H2AC4/H2BC17/H4C4/H2AC13/H2AC12/H3C8/H4C11/H2AC21/H3C7/H2AC11/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_SIGNALING_BY_NTRKS | 117 | 0.5677458 | 1.881234 | 0.0002208 | 0.0223787 | 0.0210747 | 3377 | NTRK1/PTPRO/PCSK6/BDNF/NTRK2/SGK1/EGR2/MAPKAPK3/DOCK3/F3/KRAS/EGR1/AP2B1/DUSP7/ID3/AP2M1/MAPK12/FOS/AP2A2/CDK5R1/DUSP3/FOSB/RAC1/PCSK5/ELK1/MAPK11/RAP1A/RHOA/NTF4/MAPKAPK2/NRAS/JUND/HRAS/CRK/MAPK3/VRK3/TRIB1/MAPK13/MAPK1/MAPK7/FYN/FURIN/SRC/RAPGEF1/PTPN11/PPP2R5D/KIDINS220 |
| REACTOME_STIMULI_SENSING_CHANNELS | 72 | 0.6027155 | 1.868450 | 0.0002358 | 0.0223787 | 0.0210747 | 1457 | ANO1/CASQ2/TRPM6/TRPV6/SLC9B2/SGK1/TTYH2/SLC9B1/STOM/TRPM4/ANO8/ANO7/TPCN2/WNK4/FKBP1B/RYR3/RIPK3/ANO10/TRPV4/MCOLN1 |
| REACTOME_ION_CHANNEL_TRANSPORT | 124 | 0.5467301 | 1.828394 | 0.0002977 | 0.0260808 | 0.0245611 | 1557 | ANO1/CASQ2/TRPM6/TRPV6/SLC9B2/ATP12A/SGK1/TTYH2/SLC9B1/ATP6V1C2/STOM/ATP8B1/ATP6V0A2/TRPM4/ANO8/ATP1A1/ANO7/ATP7B/TPCN2/WNK4/FKBP1B/RYR3/ATP1B1/ATP11A/RIPK3/ANO10/TRPV4/MCOLN1/ATP6V1E2/CAMK2D |
| REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH | 89 | -0.4945424 | -1.755491 | 0.0003460 | 0.0281469 | 0.0265068 | 4591 | POLA1/H3-3A/H2BC4/H2AC8/H3C6/CDK5/RBBP7/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/EZH2/H2AC6/RBBP4/EED/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/CAST/H2BC9/H4C6/CDC25A/H2AC4/H2BC17/H4C4/FOXO3/H3C8/H4C11/H3C7/H4C13/POLA2/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3/CDC25C/LMNB1/CAPNS2 |
| REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX | 78 | -0.5012916 | -1.733217 | 0.0003838 | 0.0291416 | 0.0274436 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/H4C6/BCL9/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/AXIN2/PYGO1/H4C12/H3C12/H2BC3/H3C13/H2BC13/TCF7/LEF1/H3C2/H2BC10/H3C3/RUNX3 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS | 71 | -0.5250209 | -1.764785 | 0.0004444 | 0.0316360 | 0.0297926 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/STAT3/H2BC5/H2AJ/CEBPB/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/CEBPA/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/DEK/RXRA/H4C6/H2AC4/H2BC17/H4C4/E2F1/TFDP2/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/LEF1/H3C2/H2BC10/H3C3/MYB |
| REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION | 56 | -0.5498277 | -1.788612 | 0.0004968 | 0.0332839 | 0.0313445 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF | 55 | 0.6344847 | 1.855576 | 0.0005359 | 0.0339115 | 0.0319355 | 2217 | CYP51A1/LSS/MVD/INSIG1/DHCR7/FDPS/HMGCS1/HMGCR/SCD/ELOVL6/SREBF1/PMVK/FDFT1/IDI1/SC5D/FASN/HELZ2/SREBF2/MBTPS1/MVK/SQLE/SEC23A/TM7SF2 |
| REACTOME_MEIOSIS | 92 | -0.4756342 | -1.696361 | 0.0006379 | 0.0382425 | 0.0360142 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/PSMC3IP/H2BC6/RPA1/H2AX/H2BC5/H2AJ/H3C11/STAG2/H4C2/H2BC8/H2BC15/H2BC12/BLM/MRE11/ATR/BRCA2/H2BC7/H2AC6/H4C9/H4C1/SYNE1/H3C1/H3C10/H4C3/NBN/HSPA2/H4C5/H2AC14/ATM/RBBP8/RPA3/H2BC9/REC8/H4C6/H2AC4/H2BC17/H4C4/BRCA1/H3C8/H4C11/H3C7/H4C13/STAG3/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3/LMNB1 |
| REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION | 56 | -0.5430690 | -1.766626 | 0.0006842 | 0.0389666 | 0.0366961 | 4513 | H3-3A/H2BC4/H2AC8/H3C6/H2BC6/H2AX/H2BC5/H2AJ/H3C11/H4C2/H2BC8/H2BC15/H2BC12/H2BC7/H2AC6/TAF1B/H4C9/H4C1/H3C1/H3C10/H4C3/H4C5/H2AC14/H2BC9/H4C6/H2AC4/H2BC17/H4C4/H3C8/H4C11/H3C7/H4C13/H4C12/H3C12/H2BC3/H3C13/H2BC13/H3C2/H2BC10/H3C3 |
| REACTOME_HYALURONAN_METABOLISM | 14 | 0.8472342 | 1.913146 | 0.0008695 | 0.0471588 | 0.0444109 | 183 | HAS2/CEMIP/HYAL1/CD44/HAS3 |
| REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP | 42 | 0.6691390 | 1.892147 | 0.0009319 | 0.0482481 | 0.0454367 | 1757 | CYP51A1/LSS/MVD/DHCR7/FDPS/HMGCS1/HMGCR/SCD/ELOVL6/SREBF1/PMVK/FDFT1/IDI1/SC5D/FASN/HELZ2/SREBF2/MVK/SQLE |
Pitavastatin vs Control
Volcano plots
GSEA analysis (logFc)
GOBP
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION | 162 | -0.6738627 | -2.608508 | 0.0000000 | 0.0000000 | 0.0000000 | 1174 | MAP10/RACGAP1/FBXO5/DSCC1/ANAPC4/MAD1L1/TRIP13/CCNB1/CDCA8/HASPIN/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/CENPF/ESPL1/KIF14/TACC3/TTK/MAD2L1/SPAG5/NDC80/PLK1/CENPE/NEK2/CDCA5/KIF4A/BUB1/DLGAP5/NUF2/KIF2C/CDC20/NCAPH/KIFC1/SGO1/BUB1B/UBE2C/CEP55/NCAPG/KIF18B |
| GOBP_SISTER_CHROMATID_SEGREGATION | 188 | -0.6545741 | -2.599064 | 0.0000000 | 0.0000000 | 0.0000000 | 1339 | RMI2/AXIN2/MAP10/RACGAP1/FBXO5/DSCC1/ANAPC4/MAD1L1/TRIP13/CCNB1/CDCA8/HASPIN/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/CENPF/ESPL1/KIF14/TACC3/TTK/MAD2L1/SPAG5/NDC80/PLK1/CENPE/NEK2/ESCO2/CDCA5/KIF4A/BUB1/DLGAP5/NUF2/KIF2C/CDC20/NCAPH/KIFC1/SGO1/BUB1B/UBE2C/TOP2A/CEP55/NCAPG/KIF18B |
| GOBP_NUCLEOSOME_ASSEMBLY | 94 | -0.6897309 | -2.491192 | 0.0000000 | 0.0000000 | 0.0000000 | 1304 | CHAF1B/H3C1/H3C13/H3C10/H2BC11/H2BC3/HMGB2/H4C13/CENPP/H2BC7/H2BC10/H4C1/OIP5/H3C7/H4C9/H1-5/ASF1B/H3C12/H2BC17/H1-1/H2BC13/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_CHROMOSOME_SEGREGATION | 308 | -0.5937955 | -2.485779 | 0.0000000 | 0.0000000 | 0.0000000 | 864 | BRIP1/ANAPC4/CCNE1/MAD1L1/TRIP13/CCNB1/MAJIN/CDCA8/HASPIN/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/CENPF/SPC24/ESPL1/KIF14/FAM83D/CCNE2/TACC3/OIP5/TTK/MAD2L1/SKA3/SPAG5/KNL1/NDC80/PLK1/CENPE/NEK2/ESCO2/CDCA5/KIF4A/BUB1/DLGAP5/NUF2/KIF2C/CDCA2/SKA1/DMC1/CDC20/NCAPH/KIFC1/SGO1/BUB1B/UBE2C/TOP2A/CEP55/NCAPG/SPC25/KIF18B/MKI67/HJURP |
| GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION | 81 | -0.6951128 | -2.472131 | 0.0000000 | 0.0000000 | 0.0000000 | 861 | HECW2/XRCC3/MAPK15/RMI2/FBXO5/ANAPC4/MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/ESPL1/TACC3/TTK/MAD2L1/NDC80/PLK1/CENPE/BUB1/DLGAP5/KIF2C/CDCA2/BUB1B/UBE2C/MKI67 |
| GOBP_STEROL_BIOSYNTHETIC_PROCESS | 53 | 0.8004700 | 2.469437 | 0.0000000 | 0.0000000 | 0.0000000 | 398 | MVD/HMGCS1/CYP51A1/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/ACLY/NSDHL/SQLE/ERG28/SC5D/MVK/DHCR24 |
| GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS | 114 | 0.7035005 | 2.459776 | 0.0000000 | 0.0000000 | 0.0000000 | 1161 | MVD/HMGCS1/CYP51A1/PCSK9/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/LIPC/ACLY/NSDHL/SQLE/SC5D/LDLR/MVK/NPC1/DISP3/LCAT/DHCR24/SCARB1/CYP46A1/PIP4P1/SCARF1/G6PD/ACADL/SREBF2/IDH1/FGF1/APOL1/APOBR/NFE2L1/PLPP6/APOL2/LIPE |
| GOBP_PROTEIN_DNA_COMPLEX_ASSEMBLY | 165 | -0.6276271 | -2.434774 | 0.0000000 | 0.0000000 | 0.0000000 | 1304 | CHAF1B/H3C1/H3C13/H3C10/H2BC11/H2BC3/HMGB2/H4C13/CENPP/H2BC7/HELLS/RAD51/CENPK/CDT1/CENPF/H2BC10/H4C1/OIP5/H3C7/H4C9/CENPE/H1-5/ASF1B/H3C12/H2BC17/H1-1/DLGAP5/H2BC13/DMC1/CDC45/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_NUCLEAR_CHROMOSOME_SEGREGATION | 250 | -0.5946602 | -2.421817 | 0.0000000 | 0.0000000 | 0.0000000 | 1339 | RMI2/AXIN2/MAP10/RACGAP1/SYCP2/FBXO5/DSCC1/BRIP1/ANAPC4/CCNE1/MAD1L1/TRIP13/CCNB1/MAJIN/CDCA8/HASPIN/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/CENPF/SPC24/ESPL1/KIF14/FAM83D/CCNE2/TACC3/TTK/MAD2L1/SPAG5/KNL1/NDC80/PLK1/CENPE/NEK2/ESCO2/CDCA5/KIF4A/BUB1/DLGAP5/NUF2/KIF2C/DMC1/CDC20/NCAPH/KIFC1/SGO1/BUB1B/UBE2C/TOP2A/CEP55/NCAPG/SPC25/KIF18B |
| GOBP_MITOTIC_NUCLEAR_DIVISION | 274 | -0.5885897 | -2.415452 | 0.0000000 | 0.0000000 | 0.0000000 | 861 | ANAPC4/KIF11/AURKA/MAD1L1/TRIP13/CCNB1/CDCA8/HASPIN/CDC25C/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/CENPF/ESPL1/KIF14/KIF20B/TACC3/FBXO43/TTK/MAD2L1/KIF15/SPAG5/ANLN/NDC80/PLK1/CENPE/NEK2/CDCA5/KIF4A/TPX2/BUB1/DLGAP5/NUF2/KIF2C/CDCA2/CDC20/NCAPH/IGF1/KIFC1/SGO1/BUB1B/UBE2C/CEP55/NCAPG/KIF18B/MKI67/MYBL2 |
| GOBP_STEROID_BIOSYNTHETIC_PROCESS | 129 | 0.6771619 | 2.398071 | 0.0000000 | 0.0000000 | 0.0000000 | 1084 | MVD/HMGCS1/CYP51A1/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/FGFR4/TM7SF2/ACLY/NSDHL/SQLE/STARD4/ERG28/SC5D/MVK/HSD17B12/DHCR24/SRD5A3/CYP46A1/HINT2/IL1A/G6PD/TNF/BMP6/PRLR/FGF1/BMP2/PLPP6 |
| GOBP_STEROL_METABOLIC_PROCESS | 116 | 0.6809713 | 2.378126 | 0.0000000 | 0.0000000 | 0.0000000 | 1161 | MVD/HMGCS1/CYP51A1/PCSK9/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/LIPC/ACLY/NSDHL/SQLE/ERG28/SC5D/LDLR/MVK/NPC1/DISP3/LCAT/DHCR24/SCARB1/CYP46A1/PIP4P1/CYP26B1/LIPA/SCARF1/G6PD/ACADL/SREBF2/FGF1/APOL1/APOBR/NFE2L1/PLPP6/APOL2/LIPE |
| GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS | 108 | 0.6730936 | 2.333432 | 0.0000000 | 0.0000000 | 0.0000000 | 1777 | MVD/HMGCS1/CYP51A1/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/ACLY/NSDHL/SC5D/MVK/FGF2/SNCA/DHCR24/SRD5A3/G6PD/BMP6/PCK2/FGF1/BMP2/PLPP6/PTAFR/GCH1/SPTSSA/PGP/ITPKC/GFI1/ACER2/NPC1L1/SPHK1/DAB2/CFTR |
| GOBP_DNA_CONFORMATION_CHANGE | 300 | -0.5574457 | -2.321438 | 0.0000000 | 0.0000000 | 0.0000000 | 1109 | DSCC1/H3C13/H3C10/EZH2/GINS1/MCMDC2/H2BC11/BRIP1/GPER1/H2BC3/HMGB2/H4C13/CENPP/BLM/H2BC7/HELLS/DNA2/RAD51/RECQL4/GINS2/CHD1L/H2BC10/H4C1/OIP5/H3C7/POLQ/H4C9/CDK1/RAD54B/PLK1/RAD54L/CDCA5/H1-5/ASF1B/H3C12/H2BC17/H1-1/ERCC6L/H2BC13/NCAPH/CDC45/TOP2A/H3C3/H2BC14/NCAPG/H3C8/H3C2/HJURP |
| GOBP_DNA_PACKAGING | 206 | -0.5727323 | -2.296497 | 0.0000000 | 0.0000000 | 0.0000000 | 995 | H3C10/EZH2/H2BC11/GPER1/H2BC3/HMGB2/H4C13/CENPP/H2BC7/HELLS/H2BC10/H4C1/OIP5/H3C7/H4C9/CDK1/PLK1/CDCA5/H1-5/ASF1B/H3C12/H2BC17/H1-1/H2BC13/NCAPH/TOP2A/H3C3/H2BC14/NCAPG/H3C8/H3C2/HJURP |
| GOBP_SPINDLE_ORGANIZATION | 184 | -0.5658778 | -2.242132 | 0.0000000 | 0.0000000 | 0.0000000 | 1641 | MAPK15/CENPJ/STARD9/WDR62/EFHC1/MAP10/RACGAP1/FBXO5/STMN1/KIF11/AURKA/CCNB1/PSRC1/KIF23/ESPL1/TACC3/GOLGA8M/TTK/KIF15/SPAG5/NDC80/PLK1/CENPE/NEK2/CCNB2/KIF4A/TPX2/DLGAP5/NUF2/GOLGA8H/CDC20/KIFC1/ASPM/SPC25/MYBL2 |
| GOBP_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION | 211 | -0.5528624 | -2.214685 | 0.0000000 | 0.0000000 | 0.0000000 | 754 | H2BC11/H2BC3/HMGB2/H4C13/CENPP/H2BC7/HELLS/RAD51/CENPK/CDT1/CENPF/H2BC10/H4C1/OIP5/H3C7/H4C9/CENPE/H1-5/ASF1B/H3C12/H2BC17/H1-1/DLGAP5/H2BC13/DMC1/CDC45/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS | 179 | 0.5891830 | 2.179669 | 0.0000000 | 0.0000000 | 0.0000000 | 1777 | MVD/HMGCS1/CYP51A1/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/FGFR4/TM7SF2/ACLY/NSDHL/SQLE/STARD4/ERG28/SC5D/MVK/FGF2/SNCA/SLC7A11/DHCR24/SRD5A3/PSAT1/CYP46A1/G6PD/TNF/BMP6/TPH2/PCK2/FGF1/BMP2/ZEB2/PLPP6/TGFB2/PTAFR/GCH1/SPTSSA/PGP/OPN3/PDXK/ITPKC/GFI1/KL/ACER2/NPC1L1/SPHK1/DAB2/CFTR |
| GOBP_DEFENSE_RESPONSE_TO_SYMBIONT | 234 | 0.5692897 | 2.168335 | 0.0000000 | 0.0000000 | 0.0000000 | 2009 | ZBP1/APOBEC3A/CXCL10/FGL2/IFIT2/MX2/ISG15/RSAD2/IFI44L/CXCL9/IFITM1/IFIT1/IFIT3/OAS3/OASL/ISG20/IFI6/MICA/OAS1/MX1/FOXP3/OAS2/IL1B/IFI27/BST2/NLRC5/IRF7/IFIH1/ZC3H12A/IL23A/PMAIP1/HERC5/BIRC3/APOBEC3B/IFITM3/MYD88/PML/PARP9/RIPK3/TICAM1/STAT1/IFIT5/GBP1/UNC13D/MICB/DTX3L/DDX60/TNFAIP3/TLR2/TRIM21/MLKL/IFNGR1/TRIM5/PLSCR1/EIF2AK2/MMP12/IFNLR1/STAT2/SHFL/IFI16/IRF9/DHX58/CD40/PTPN22/DDIT4/USP27X/ADAR/TRIM25/F2RL1 |
| GOBP_RESPONSE_TO_VIRUS | 312 | 0.5526251 | 2.165349 | 0.0000000 | 0.0000000 | 0.0000000 | 2707 | ZBP1/APOBEC3A/CXCL10/HYAL1/FGL2/IFIT2/CCL22/MX2/CCL4/ISG15/RSAD2/IFI44L/CXCL9/IFITM1/IFIT1/IFIT3/OAS3/OASL/ISG20/IFI6/MICA/OAS1/MX1/HYAL3/CCL5/BATF3/FOXP3/OAS2/IL1B/IFI27/BST2/NLRC5/IRF7/IFIH1/ZC3H12A/IL23A/PMAIP1/HERC5/BIRC3/APOBEC3B/IFITM3/MYD88/PML/PARP9/TNF/RIPK3/TICAM1/STAT1/IFIT5/MAPK11/GBP1/UNC13D/IKBKG/MICB/LGALS9/IKBKE/DTX3L/DDX60/TNFAIP3/IFI44/TLR2/NMI/TRIM21/MLKL/IFNGR1/TRIM5/PLSCR1/ITGB8/EIF2AK2/IRAK3/DUOX2/NPC2/MMP12/IFNLR1/STAT2/SHFL/IFI16/IRF9/DHX58/CD40/PTPN22/DDIT4/USP27X/ADAR/MST1R/TRIM25/F2RL1/POLR3D/ITGB6/POLR3B/IFITM2/SAP30BP/SPON2/BCL3/TRIM22/NLRP1/SRC/NPLOC4/FOSL1/AUP1/IL15/GBP3/HYAL2/MARCHF2/SLFN11/NFKB1/IRF1 |
| GOBP_ORGANELLE_FISSION | 425 | -0.5059520 | -2.164339 | 0.0000000 | 0.0000000 | 0.0000000 | 864 | BRIP1/ANAPC4/KIF11/CCNE1/AURKA/MAD1L1/TRIP13/CCNB1/MAJIN/CDCA8/HASPIN/CDC25C/RAD51/CENPK/KIF18A/PSRC1/ZWINT/PTTG1/KIF23/SGO2/CDT1/RAD51AP1/CENPF/ESPL1/KIF14/KIF20B/CCNE2/TACC3/FBXO43/TTK/MAD2L1/KIF15/SPAG5/ANLN/NDC80/RAD54B/PLK1/CENPE/NEK2/CNTD1/RAD54L/CCNB2/CDCA5/KIF4A/TPX2/BUB1/DLGAP5/NUF2/KIF2C/CDCA2/DMC1/CDC20/NCAPH/IGF1/KIFC1/SGO1/BUB1B/UBE2C/TOP2A/CEP55/ASPM/NCAPG/KIF18B/MKI67/MYBL2 |
| GOBP_STEROID_METABOLIC_PROCESS | 235 | 0.5599055 | 2.133593 | 0.0000000 | 0.0000000 | 0.0000000 | 1096 | APOC1/MVD/HMGCS1/CYP51A1/PCSK9/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/FGFR4/TM7SF2/LIPC/ACLY/NSDHL/SQLE/STARD4/ERG28/SC5D/LDLR/MVK/NPC1/HSD17B12/DISP3/LCAT/DHCR24/SRD5A3/SCARB1/CYP46A1/HINT2/PIP4P1/CYP3A5/CYP26B1/LIPA/SCARF1/IL1A/G6PD/TNF/BMP6/ACADL/SREBF2/PRLR/FGF1/APOL1/BMP2/APOBR/NFE2L1/PLPP6/APOL2 |
| GOBP_CYTOKINE_MEDIATED_SIGNALING_PATHWAY | 339 | 0.5375923 | 2.123421 | 0.0000000 | 0.0000000 | 0.0000000 | 2527 | ZBP1/CXCL10/CXCL11/CCL22/EBI3/CD70/IL36G/CCL4/ISG15/IL17REL/CXCL9/CCL20/IFITM1/CCR3/SLIT2/OAS3/OASL/CXCL2/CXCL6/CXCL3/ACSL1/CXCL8/OAS1/MX1/IL2RG/EREG/IL1R2/CCL5/CLCF1/CXCL5/OAS2/IL1RL1/IL1B/IFI27/NLRC5/IL1RAPL2/CXCL1/LRP8/IRF7/CEACAM1/BIRC3/IRAK2/CSF3/EDN1/USP18/PF4V1/IL31RA/IFITM3/MYD88/TNFSF13B/IL1RN/IL1A/CX3CL1/SOCS1/PARP9/IL1RL2/TNFRSF13C/TNF/TNFRSF1B/STAT1/NFKBIA/PRLR/IKBKE/OSMR/TNFAIP3/NMI/PDGFB/IL18R1/IFNGR1/TNIP2/ADIPOR2/PARP14/SH2B3/PTPRJ/OXSR1/IRAK3/IL34/IL36A/DUOX2/CSF1/TRAF1/ST18/CSNK2B/MMP12/GFI1/IL15RA/PALM3/IFNLR1/CCL17/STAT2/SPHK1/SP100/KRT18/IL7R/RFFL/IRAK1/USP27X/ADAR/MST1R/MAPK3/PLP2/PTPN2/F2RL1/PXDN/SYK/ADAM17/IFITM2/ILK/RIPK2/TRAF2/CCRL2/TMSB4X/SRC/STAT5A/GPS2/IL13RA1/IL4R/FAS/TYK2/IL17RD/EGR1/F3 |
| GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS | 437 | 0.5187376 | 2.083370 | 0.0000000 | 0.0000000 | 0.0000000 | 2220 | PLA2G3/APOC1/MVD/HMGCS1/CYP51A1/FADS2/ELOVL6/EBP/DHCR7/LSS/FDPS/MSMO1/FADS1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/FGFR4/TM7SF2/LIPC/ACLY/LIPG/NSDHL/SCD/MLXIPL/STARD4/SC5D/IDO1/FASN/TRIB3/MVK/ALOXE3/FGF2/SNCA/TBXAS1/HSD17B12/SLC25A1/GGT7/KYNU/NT5E/IL1B/DHCR24/KMO/SRD5A3/PSAT1/PTGS2/CEACAM1/CYP46A1/ELOVL5/GGT5/EDN1/AACS/ELOVL7/ATF3/FA2H/G6PD/TNF/BMP6/ACADL/ACACA/PCK2/PYCR1/ACSS3/FGF1/BMP2/CYP4A22/BCO1/LIPH/MTHFR/PGD/ALDH1A3/PLPP6/TPK1/PTGES/MTHFD1L/ATF4/PTAFR/ASS1/GCH1/SPTSSA/PGP/PLOD3/CBS/ELOVL1/SELENOS/HAAO/PDXK/ITPKC/NLN/UCKL1/GFI1/ACER2/NPC1L1/HSD17B8/SPHK1/DAB2/C1QTNF3/CFTR/PPARGC1A/ASL/SESN2/ACOT7/BCAT1/HRH1/HACD2/ANXA1/PTPN2/GLUD1/DHDDS/PTGES2/PNP/SYK/QDPR/GOT1/ALDH1A2/ELOVL4/ACAA2/GPT/CTH |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 302 | 0.5250369 | 2.047272 | 0.0000000 | 0.0000000 | 0.0000000 | 2699 | PLA2G3/ZBP1/S100A7/CXCL10/CCL4/LDLR/IDO1/S100A12/SLIT2/OASL/NTRK3/CXCL8/FGF2/SNCA/KDR/EREG/CCL5/LBP/IL1RL1/IL1B/NLRC5/IRF7/THBS1/IL23A/PTGS2/CNR1/SH2D1B/EDN1/FYN/IFI35/SERPINE1/ADAM8/GBP5/CXCL17/SCARF1/EMILIN2/CX3CL1/KLK7/PARP9/TNIP1/S100A8/TNF/BMP6/STX3/VEGFA/LAG3/LGALS1/NFKBIA/CD47/ARTN/LGALS9/IKBKE/LY96/OSMR/DDX60/FKBP1B/TLR2/NMI/PDGFB/RAET1E/TRIM5/TLR4/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/S100A9/OXSR1/RARRES2/CAMK2N1/MET/C2CD4A/IL34/CSF1/STX4/OPTN/LYN/NFKBIZ/CADM1/MMP12/TNFSF14/LGMN/NOD2/ETS1/IFI16/AKIRIN2/DHX58/HLA-E/SCG2/USP27X/CCN4/MAPK3/F2RL1/SERPINF2/MOSPD2/TPBG/RNF31/SYK/ADAM17/POLR3D/P2RX4/POLR3B/DAPK2/RIPK2/FLNA/TMSB4X/NLRP1/SRC/NOD1/F3/CASP6/IL15/S100A14/NECTIN2/HYAL2/NDEL1/CTSC/TRADD/SWAP70/CEBPB |
| GOBP_ALCOHOL_METABOLIC_PROCESS | 283 | 0.5304847 | 2.046629 | 0.0000000 | 0.0000000 | 0.0000000 | 1787 | MVD/HMGCS1/CYP51A1/PCSK9/EBP/ACSS2/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/LIPC/ACLY/NSDHL/SQLE/SC5D/LDLR/MVK/FGF2/RDH11/NPC1/SNCA/DISP3/LCAT/DHCR24/SRD5A3/NUDT10/SCARB1/CYP46A1/ALDH3B2/NUDT11/PIP4P1/CYP3A5/SCARF1/GALR2/G6PD/BMP6/ACADL/SDR16C5/SREBF2/PCK2/IDH1/FGF1/APOL1/BMP2/BCO1/APOBR/NFE2L1/ALDH1A3/PLPP6/TPK1/APOL2/LIPE/PTAFR/GDPD3/GCH1/RETSAT/SPTSSA/PGP/CYP1B1/NPC2/ITPKC/GFI1/GALK1/ALDH1B1/ACER2/NPC1L1/SPHK1/DAB2/DHRS7/PLPP3/CFTR/ITPK1 |
| GOBP_TAXIS | 433 | 0.4837620 | 1.942205 | 0.0000000 | 0.0000000 | 0.0000000 | 2640 | NTRK1/DEFB4A/S100A7/TNFAIP6/CXCL10/CXCL11/PAX6/CCL22/CCL4/TUBB3/CXCL9/CCL20/S100A12/CCR3/PLAUR/SLIT2/CXCL2/DPYSL2/CXCL6/NR4A1/CXCL3/NTRK3/L1CAM/CXCL8/FGF2/KDR/CCL5/LBP/DRAXIN/CXCL5/IL1B/DEFB1/SEMA3B/ITGA9/VCAM1/CXCL1/SCN1B/CCN3/RELN/CMTM3/PLAU/THBS1/IL23A/C5AR2/SEMA3D/EDN1/FYN/EPHA10/EGR2/PF4V1/TYMP/FEZ1/SERPINE1/ADAM8/CXCL17/EPHA3/SEMA7A/CX3CL1/S100A8/CXCL16/STX3/VEGFA/NRXN3/COLEC10/LAMA3/HBEGF/LAMC2/ADGRE2/FGF1/ARTN/LGALS9/SAA1/KLF7/PDGFB/PTPRO/TGFB2/PTAFR/ECE1/CCN1/PRKCQ/PTPRJ/GREM1/S100A9/PLXNA3/OXSR1/RARRES2/DUSP3/MET/IL34/FLRT2/CSF1/NRCAM/STX4/LYN/FLT1/ITGB3/TNFSF14/KIF5C/LGMN/CCL17/SLC8B1/NOD2/PIK3C2G/EFNA5/ISL1/RHOG/DUSP1/SCG2/HRH1/MAPK3/PLP2/ANXA1/PTPN2/F2RL1/PLXNA1/TRIO/MOSPD2/ITGAV/TPBG/NIBAN2/TRPM4/SYK/ADAM17/P2RX4/USP14/EPHB4/PLXNA4/RALA/BCAR1/DAPK2/TREM1/CCRL2/SLC12A2/TMSB4X/NTN1/SEMA3A/FOSL1/MAP2K1/ROBO2/F3/NRG1/VASP/CMTM7/SEMA3C/EPHA2/S100A14 |
| GOBP_CILIUM_ORGANIZATION | 375 | -0.4576607 | -1.936291 | 0.0000000 | 0.0000000 | 0.0000000 | 3908 | RSPH4A/CEP126/ATP6V1D/CFAP298/TOGARAM1/TBC1D15/STK36/UNC119B/BBS12/ARL6/ARL13B/IQCB1/SPEF1/CELSR2/TUB/CPLANE1/ARL3/TMEM216/WDR19/CLCN4/BBS4/DYNLL1/CFAP20/DNAAF5/RABL2B/DNAI3/TMEM138/CEP41/BBIP1/CEP250/DRC1/CFAP126/CCDC57/CCDC96/INTU/TBC1D19/TRAF3IP1/SPAG6/TCTN2/IFT74/DNAAF10/CFAP100/CEP135/DYNC2I1/PIBF1/ZMYND10/ODAD4/SSX2IP/LRGUK/CFAP91/WDPCP/ARMC2/TTC29/DZIP1L/TBC1D32/VDAC3/BBS9/FOXJ1/B9D1/DNAAF11/DNAAF3/TMEM237/ARMC9/KIF27/BBOF1/CFAP47/DYNLT2B/IFT43/TBC1D8/CFAP46/SPATA6/TCTN1/MKS1/HOATZ/TTLL3/CEP290/BBS2/CFAP69/DNAAF4/DNAL1/KIF24/CBY1/DYNC2LI1/CEP162/CFAP58/CCDC66/ENO4/IFT52/CCDC113/ODAD1/CEP19/IFT122/IFT140/CEP97/CCDC40/CEP164/CCDC88A/DNAJB13/CFAP52/IFT57/FUZ/NEK1/CFAP54/RSPH9/RPGRIP1L/DRC7/B9D2/IFT27/ODAD3/CATIP/WDR35/SPAG17/DZIP1/CFAP73/CFAP157/NME5/SAXO1/ODF2L/CLUAP1/PCM1/IFT88/LCA5/CPLANE2/CC2D2A/DAW1/TTC12/WDR90/CEP120/DNAI1/IFT81/RSPH1/DNAH7/TMEM67/IQCG/RFX2/RPGR/CIBAR1/UBXN10/SPEF2/CCP110/CCDC39/CEP83/SPAG16/KCTD17/IFT172/CFAP61/KIF19/IFT80/TEKT3/CDKL1/MAPK15/ROPN1B/CCDC65/HYDIN/CENPJ/CFAP206/TEKT2/LRRC49/TEKT1/RFX3/TTC21A/CDC14A/DNAI4/CFAP65/DYNC2H1/FBF1/NOTCH1/GMNC/TTC21B/DNAI2/CIBAR2/MPHOSPH9/CFAP74/CFAP44/TEKT4/MNS1/TEKT5/DNAAF8/CEP78/DNAH1/DNAH5/CFAP70/CFAP43/IQUB/CFAP221/ODAD2/LCA5L/MCIDAS/DNAAF6/RP1/DNAAF1/CFAP161/CFAP53/CCDC13/DNAH2/HYLS1/CCNO/MEIG1/CROCC/POC1A/PLK4 |
| GOBP_REGULATION_OF_DEFENSE_RESPONSE | 445 | 0.4800072 | 1.935421 | 0.0000000 | 0.0000000 | 0.0000000 | 3036 | PLA2G3/ZBP1/TNFAIP6/FGL2/ISG15/LDLR/IDO1/S100A12/IFIT1/MVK/OAS3/CXCL6/MICA/OAS1/NCF1/SNCA/EREG/CCL5/LBP/FOXP3/NT5E/IL1RL1/IL1B/NLRC5/CCN3/LRP8/IRF7/ZC3H12A/IL23A/PTGS2/CNR1/CEACAM1/SH2D1B/HERC5/BIRC3/FYN/USP18/IFI35/SERPINE1/DUOXA2/ADAM8/GBP5/MYD88/CXCL17/SEMA7A/EMILIN2/CX3CL1/SOCS1/KLK7/PARP9/TNIP1/S100A8/IL1RL2/TNF/TNFRSF1B/LAG3/STAT1/LGALS1/NFKBIA/FANCA/SOCS3/CD47/MICB/LGALS9/SAA1/IKBKE/DTX3L/OSMR/SERPINB4/TNFAIP3/SERPINB9/TLR2/NMI/TRIM21/RAET1E/PTGES/MEF2C/TRIM5/TLR4/PARP14/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/S100A9/KLF4/DUSP10/RHBDF2/CAMK2N1/IRAK3/PSMA6/SELENOS/C2CD4A/OPTN/TYRO3/LYN/NFKBIZ/CADM1/CD200/MMP12/ACE2/ARG2/IFNLR1/STAT2/NOD2/SPHK1/ETS1/FNDC4/IFI16/C1QTNF3/N4BP1/AKIRIN2/DUOXA1/DHX58/HLA-E/ISL1/PTPN22/TRAFD1/USP27X/CCN4/ADAR/SBNO2/MAPK3/ANXA1/PTPN2/F2RL1/METRNL/RNF31/SYK/POLR3D/FURIN/MAPK7/POLR3B/HLA-B/CASP5/RIPK2/TMSB4X/NLRP1/SRC/NPLOC4/GPS2/SMPDL3B/NOD1/ZFP36/CASP6/IL15/LACC1/NECTIN2/HYAL2/CTSC/IL1R1/TRADD/CEBPB/NFKB1/IRF1/MFHAS1/IL18/RHBDD3/FAM3A/C3/ZNFX1/FADD/SLC15A4/CASP8/PLCG1/GPSM3/TIRAP/HLA-A/PTPN11 |
| GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 265 | 0.5316802 | 2.044045 | 0.0000000 | 0.0000000 | 0.0000000 | 3036 | ZBP1/FGL2/ISG15/IFIT1/OAS3/OASL/CXCL6/MICA/OAS1/NCF1/EREG/CCL5/LBP/FOXP3/IL1B/NLRC5/LRP8/IRF7/ZC3H12A/IL23A/CEACAM1/SH2D1B/HERC5/BIRC3/FYN/USP18/IFI35/IL4I1/ADAM8/GBP5/EMILIN2/CX3CL1/SOCS1/KLK7/PARP9/BMP6/LAG3/STAT1/CD55/MICB/CD274/LGALS9/IKBKE/DTX3L/LY96/SERPINB4/DDX60/TNFAIP3/SERPINB9/NMI/TRIM21/RAET1E/TRIM5/TLR4/PARP14/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/DUSP10/IRAK3/OPTN/TYRO3/LYN/TRIB1/CADM1/MMP12/ARG2/IFNLR1/STAT2/NOD2/IFI16/N4BP1/AKIRIN2/DHX58/HLA-E/PTPN22/TRAFD1/USP27X/ADAR/MAPK3/PTPN2/F2RL1/RNF31/SYK/POLR3D/POLR3B/HLA-B/RIPK2/SRC/NPLOC4/NOD1/AHR/CASP6/IL15/NECTIN2/TIGAR/IRF1/FAM3A/ZNFX1/FADD/SLC15A4/CASP8/TIRAP/HLA-A/PTPN11 |
| GOBP_RESPONSE_TO_BACTERIUM | 422 | 0.4690294 | 1.878147 | 0.0000000 | 0.0000000 | 0.0000000 | 3033 | DEFB4A/S100A7/CXCL10/CXCL11/IL36G/ISG15/CXCL9/IDO1/CCL20/CMPK2/S100A12/OAS3/CXCL2/TNIP3/CXCL6/NR4A1/CXCL3/C15orf48/CXCL8/MICA/OAS1/SNCA/ALPL/PI3/CCL5/LBP/FOXP3/CXCL5/OAS2/IL1B/DEFB1/KMO/VCAM1/HP/CXCL1/HERC6/ZC3H12A/IL23A/PTGS2/CNR1/SCARB1/ADAMTS5/IRAK2/CSF3/PGLYRP4/EDN1/PF4V1/FOS/SERPINE1/ARID5A/GBP5/MYD88/GBP2/ANKRD1/EMILIN2/IL1A/ANXA3/CX3CL1/KLK7/TNIP1/S100A8/TNF/BMP6/TNFRSF1B/TICAM1/CD55/NFKBIA/NOS2/PRLR/PCK2/CD274/BMP2/LGALS9/PGLYRP3/LY96/C4BPA/TNFAIP3/IFI44/TLR2/MEF2C/FAM20A/TRIM5/TLR4/PTAFR/TNIP2/ASS1/JUND/RNF213/GCH1/S100A9/ADAMTS9/DUSP10/ADAM9/RARRES2/IRAK3/SELENOS/IL36A/OPTN/LYN/AKAP12/TRIB1/LDOC1/GFI1/LCN2/ARG2/SELP/PALM3/NOD2/H2BC21/PELI1/AKIRIN2/NOCT/BCL10/DHX58/IL7R/GBP4/HLA-E/ADGRB1/IRAK1/PTPN22/VIM/SBNO2/MAPK3/BPIFA2/F2RL1/KRT6A/WFDC3/RNF31/SYK/ADAM17/HLA-B/SMAD6/SPON2/BCL3/RIPK2/TREM1/CAPN2/NLRP1/SRC/MALT1/RNASE7/TENT5A/NOD1/PLAA/RBCK1/LRG1/ZFP36/CLDN1/CD86/AKAP8/EPHA2/S100A14/MARCHF2/CEBPB/MAP2K3/NFKB1/NFKBIB/C2/IL18/C3/ZNFX1/DAB2IP/MAPKAPK2/OCIAD2/CNP/GJB6/CASP8/LYG1/TIRAP/HLA-A |
| GOBP_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY | 193 | -0.5406367 | -2.162582 | 0.0000000 | 0.0000001 | 0.0000001 | 3197 | H2BC18/H1-2/H4C2/CENPW/H2AX/NAP1L1/H3C6/HIRIP3/H2BC6/HDAC8/H4C6/CHD3/NASP/SMYD3/L3MBTL1/PHF8/H2BC15/H2BC9/SMARCD3/H3-3A/SMARCE1/M1AP/H3C11/H4C12/MIS18A/H2BC12/H4C4/ATF7IP2/CHAF1B/H3C1/H3C13/H3C10/EZH2/H2BC11/H2BC3/HMGB2/H4C13/CENPP/H2BC7/HELLS/H2BC10/H4C1/OIP5/H3C7/H4C9/H1-5/ASF1B/H3C12/H2BC17/H1-1/H2BC13/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_MITOTIC_SPINDLE_ORGANIZATION | 122 | -0.6118388 | -2.278049 | 0.0000000 | 0.0000001 | 0.0000001 | 1470 | WDR62/EFHC1/MAP10/RACGAP1/STMN1/KIF11/AURKA/CCNB1/PSRC1/KIF23/TACC3/TTK/KIF15/NDC80/PLK1/CENPE/NEK2/KIF4A/TPX2/DLGAP5/NUF2/CDC20/KIFC1/SPC25/MYBL2 |
| GOBP_NUCLEOSOME_ORGANIZATION | 139 | -0.5828114 | -2.209606 | 0.0000000 | 0.0000001 | 0.0000001 | 1304 | CHAF1B/H3C1/H3C13/H3C10/H2BC11/H2BC3/HMGB2/H4C13/CENPP/H2BC7/H2BC10/H4C1/OIP5/H3C7/H4C9/H1-5/ASF1B/H3C12/H2BC17/H1-1/H2BC13/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_CELL_CHEMOTAXIS | 213 | 0.5468685 | 2.060977 | 0.0000000 | 0.0000001 | 0.0000001 | 2343 | DEFB4A/S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/CCR3/SLIT2/CXCL2/CXCL6/NR4A1/CXCL3/CXCL8/FGF2/KDR/CCL5/LBP/CXCL5/IL1B/ITGA9/VCAM1/CXCL1/CCN3/THBS1/IL23A/C5AR2/EDN1/PF4V1/SERPINE1/ADAM8/CXCL17/CX3CL1/S100A8/CXCL16/VEGFA/HBEGF/ADGRE2/FGF1/LGALS9/SAA1/PDGFB/PTPRO/TGFB2/PRKCQ/GREM1/S100A9/OXSR1/RARRES2/MET/IL34/CSF1/LYN/FLT1/TNFSF14/LGMN/CCL17/SLC8B1/NOD2/RHOG/DUSP1/SCG2/HRH1/MAPK3/ANXA1/F2RL1/MOSPD2/TPBG/TRPM4/SYK/ADAM17/P2RX4/BCAR1/DAPK2/TREM1/CCRL2/SLC12A2/TMSB4X |
| GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE | 357 | 0.4766531 | 1.890826 | 0.0000000 | 0.0000001 | 0.0000001 | 3034 | PLA2G3/ZBP1/THEMIS2/RSAD2/IDO1/HMSD/ITGAM/LAT2/EREG/CCL5/CLCF1/LBP/FOXP3/IL1B/NLRC5/CMTM3/IRF7/ZC3H12A/IL23A/CNR1/CEACAM1/SH2D1B/C5AR2/CD177/NR4A3/FYN/PLPP4/IFI35/ADAM8/ARID5A/GBP5/TNFSF13B/KLK7/PARP9/TNF/COLEC10/LAG3/CARD11/CD55/STXBP1/GBP1/RFTN1/IKBKG/CD47/MICB/CD274/CFB/LGALS9/IKBKE/C4BPA/UBASH3A/NMI/RAET1E/TGFB2/IL18R1/MEF2C/TRIM5/TLR4/PTAFR/CLEC7A/HLA-G/KLRD1/PLSCR1/C1S/PRKCQ/HLA-F/PVR/PTPRJ/DUSP3/CD276/STX4/CD46/LYN/NFKBIZ/CADM1/MMP12/BTN3A1/NFKBID/GAB2/NOD2/IFI16/AKIRIN2/BCL10/CD40/HLA-E/PTPN22/USP27X/ANXA1/PTPN2/F2RL1/SHLD1/RNF31/THY1/SYK/C8B/POLR3D/SHLD2/POLR3B/HLA-B/BCAR1/RIPK2/TRAF2/SRC/MALT1/PRKCH/GPS2/IL4R/LPXN/RBCK1/TFRC/CASP6/CD86/IL15/NECTIN2/IL1R1/C2/IL18/C3/ZNFX1/SHLD3/FADD/SLC15A4/PLA2G4A/PLCG1/TIRAP/HLA-A/BTN2A2 |
| GOBP_LEUKOCYTE_DIFFERENTIATION | 404 | 0.4626330 | 1.850200 | 0.0000000 | 0.0000002 | 0.0000002 | 2708 | PLA2G3/NTRK1/TNFAIP6/MT1G/FGL2/FZD9/RSAD2/DLL4/FASN/TNFSF9/LIF/EVI2B/BATF3/CLCF1/BATF2/FOXP3/KLF6/IL1B/VCAM1/HDAC9/IRF7/ZC3H12A/IL23A/CEACAM1/LRRC17/CSF3/IKZF1/IL31RA/RELB/FOS/PRXL2A/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNF/FAM20C/VEGFA/LAG3/RIPK3/CARD11/LGALS1/GPR68/VNN1/FANCA/JUN/BATF/UBD/LGALS9/FSTL3/PRDM1/TLR2/IL18R1/TLR4/DOCK10/HLA-G/RRAS/GLO1/LRRC8A/PTPRJ/IL11/ITGB8/INHBA/DUSP10/DNAJB9/TFE3/MYC/IL34/CSF1/CD46/TYRO3/LYN/NFKBIZ/TRIB1/PPARGC1B/IL15RA/NFKBID/GAB2/IFI16/SOX4/CTNNBIP1/TMEM176A/IL7R/KLF10/PTPN22/TOX/CCN4/SBNO2/SRF/ZEB1/ANXA1/PTPN2/F2RL1/PRELID1/PNP/SYK/ADAM17/ITGB6/CEBPG/MMP14/TMEM176B/HLA-B/BCL3/RIPK2/SRC/MALT1/GPS2/ST3GAL1/IL4R/EGR1/NFIL3/BAK1/TFRC/JUNB/CMTM7/CD86/IL15/EPHA2/ZBTB46/CEBPB/IRF1/WNT4 |
| GOBP_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS | 421 | 0.4560574 | 1.824662 | 0.0000000 | 0.0000004 | 0.0000003 | 1787 | MVD/HMGCS1/CYP51A1/PCSK9/EBP/ACSS2/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/FGFR4/TM7SF2/LIPC/ACLY/NSDHL/SQLE/STARD4/ERG28/SC5D/LDLR/MVK/FGF2/RDH11/NPC1/ITGAM/SNCA/SLC7A11/ALPL/DISP3/LCAT/DHCR24/SRD5A3/PSAT1/NUDT10/SCARB1/CYP46A1/ALDH3B2/NUDT11/PIP4P1/DUOXA2/CYP3A5/CYP26B1/LIPA/SCARF1/GALR2/G6PD/TNF/BMP6/ACADL/SDR16C5/SREBF2/TPH2/PCK2/IDH1/FGF1/APOL1/BMP2/BCO1/APOBR/ZEB2/NFE2L1/ALDH1A3/PLPP6/TPK1/APOL2/TGFB2/LIPE/PTAFR/GDPD3/GCH1/RETSAT/SPTSSA/PGP/PAX8/CYP1B1/DUOX2/OPN3/NPC2/PDXK/ITPKC/GFI1/KL/GALK1/ALDH1B1/ACER2/LGMN/NPC1L1/SPHK1/DAB2/DHRS7/PLPP3/CFTR/ITPK1 |
| GOBP_PHOSPHOLIPID_METABOLIC_PROCESS | 328 | 0.4795588 | 1.889764 | 0.0000000 | 0.0000005 | 0.0000004 | 1340 | PLA2G3/PNPLA3/APOC1/MVD/HMGCS1/PCSK9/FDPS/FADS1/IDI1/FDFT1/LIPC/LIPG/LPIN1/LDLR/MVK/PLA2G4C/FGF2/SNCA/LCAT/SRD5A3/GPCPD1/SCARB1/SOCS2/PLPP4/PIP4P1/ABHD4/MFSD2A/GALR2/PCYT2/SOCS1/SELENOI/TMEM86B/ENPP6/IDH1/SOCS3/LIPH/MTMR11/PLPP6/PI4K2A/PDGFB/PISD/GDPD3/PLSCR1/GPAT3/PLAAT1/PIGW/CHP1/PGP |
| GOBP_GRANULOCYTE_MIGRATION | 106 | 0.6307265 | 2.171695 | 0.0000000 | 0.0000006 | 0.0000005 | 2300 | S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/THBS1/IL23A/C5AR2/CD177/OLFM4/EDN1/PECAM1/PF4V1/ADAM8/MYD88/CXCL17/IL1A/CX3CL1/S100A8/ADGRE2/SAA1/TGFB2/S100A9/RARRES2/IL34/CSF1/CCL17/NOD2/RHOG/SCG2/HRH1/MAPK3/ANXA1/MOSPD2/SYK/XG/DAPK2/TREM1 |
| GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE | 199 | 0.5448398 | 2.031895 | 0.0000000 | 0.0000006 | 0.0000005 | 3025 | PLA2G3/ZBP1/LDLR/IDO1/S100A12/SNCA/EREG/CCL5/LBP/IL1RL1/IL1B/NLRC5/IRF7/IL23A/PTGS2/CNR1/SH2D1B/FYN/IFI35/SERPINE1/ADAM8/GBP5/EMILIN2/CX3CL1/KLK7/PARP9/TNIP1/S100A8/TNF/LAG3/LGALS1/NFKBIA/CD47/IKBKE/OSMR/TLR2/NMI/RAET1E/MEF2C/TRIM5/TLR4/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/S100A9/CAMK2N1/C2CD4A/OPTN/LYN/NFKBIZ/CADM1/MMP12/NOD2/ETS1/IFI16/AKIRIN2/HLA-E/USP27X/CCN4/MAPK3/F2RL1/RNF31/SYK/POLR3D/POLR3B/RIPK2/NLRP1/SRC/NOD1/CASP6/IL15/NECTIN2/HYAL2/CTSC/TRADD/CEBPB/IL18/C3/ZNFX1/FADD/SLC15A4/GPSM3/TIRAP |
| GOBP_LEUKOCYTE_MIGRATION | 269 | 0.4974957 | 1.915816 | 0.0000000 | 0.0000006 | 0.0000005 | 2361 | S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/SELL/CCL5/LBP/CXCL5/IL1B/ITGA9/VCAM1/CXCL1/CCN3/THBS1/IL23A/C5AR2/CD177/OLFM4/EDN1/FYN/PECAM1/PF4V1/SERPINE1/ADAM8/MYD88/CD34/CXCL17/IL1A/CX3CL1/S100A8/ASB2/TNF/CXCL16/VEGFA/RIPK3/ADGRE2/CD47/ARTN/LGALS9/SAA1/STK10/PDGFB/SPNS2/PTPRO/TGFB2/PTAFR/ICAM1/GREM1/S100A9/OXSR1/RARRES2/MSN/ADTRP/IL34/CSF1/LYN/CD200/FLT1/TNFSF14/SELP/LGMN/CCL17/SLC8B1/NOD2/RHOG/DUSP1/SCG2/ITGB7/HRH1/MAPK3/ANXA1/F2RL1/MOSPD2/TRPM4/THY1/SYK/ADAM17/CD9/XG/MMP14/P2RX4/HMOX1/DAPK2/TREM1/SLC12A2/ITGA3/SRC |
| GOBP_CHROMATIN_REMODELING | 226 | -0.4965652 | -1.997307 | 0.0000000 | 0.0000006 | 0.0000005 | 1304 | CHAF1B/H3C1/H3C13/H3C10/H2BC11/MYB/H2BC3/HMGB2/H4C13/CENPP/H2BC7/HELLS/CHD1L/H2BC10/H4C1/OIP5/H3C7/H4C9/H1-5/ASF1B/H3C12/H2BC17/H1-1/H2BC13/H3C3/H2BC14/H3C8/H3C2/HJURP |
| GOBP_POSITIVE_REGULATION_OF_LOCOMOTION | 456 | 0.4403084 | 1.779112 | 0.0000000 | 0.0000008 | 0.0000007 | 3181 | S100A7/TNFAIP6/CXCL10/HYAL1/CCL4/FGFBP1/CCL20/SLIT2/SLC8A1/NTRK3/CXCL8/FGF2/MIR200A/KDR/CCL5/LBP/IL1B/DEFB1/TMSB15B/SEMA3B/RELN/HDAC9/PLAU/THBS1/ZC3H12A/IL23A/PTGS2/SCARB1/SEMA3D/NR4A3/EDN1/FOXC2/PECAM1/SERPINE1/DUOXA2/ADAM8/CXCL17/SEMA7A/IL1A/ANXA3/CX3CL1/TNF/CEACAM6/CXCL16/STX3/RHOB/VEGFA/HBEGF/LAMC2/SOX9/JUN/CLDN4/CD47/FGF1/CD274/HDAC6/ARTN/BMP2/LGALS9/NEDD9/PDGFB/TGFB2/TLR4/PTAFR/ICAM1/CCN1/CLEC7A/RRAS/DAPK3/OXSR1/FERMT1/PODXL/ADAM9/RARRES2/ATOH8/MET/MYC/IL34/CYP1B1/EGF/DUOX2/CSF1/STX4/LYN/AKAP12/MMP7/FLT1/ITGB3/WNT7A/IRS2/TNFSF14/COL1A1/SELP/CD151/LGMN/SPHK1/DAB2/ETS1/PLPP3/MYO1C/AKT3/RIPOR1/CD40/SHTN1/SCG2/CCN4/PDGFC/MAPK3/ANXA1/F2RL1/TJP1/MOSPD2/ITGAV/TPBG/CAVIN1/THY1/ADAM17/HDAC7/XG/MMP14/P2RX4/SPAG9/ADAMTS1/HMOX1/MAP4K4/BCAR1/DAPK2/ITGA3/TMSB4X/TGFBR1/SRC/NTN1/RHOD/RHOC/SEMA3A/STAT5A/PLAA/F3/MAPRE2/CLDN1/DIAPH1/SYDE1/SEMA3C/EPHA2/S100A14/IL1R1/SUN2/MAP3K3/TRADD/SWAP70/MAP2K3/ACTG1/PIK3C2A/DOCK5/RTN4/DAB2IP/FADD/FAM83H/ITGA6/SRPX2/MYADM/NSMF/PLCG1/GPSM3/TIRAP/ITGA5/SPARC/TGFBR2/MGAT5/RRAS2/GFUS/DDRGK1/MCU/SUCNR1/TWIST1/PDPN/ACTA2/CAV1 |
| GOBP_MYELOID_LEUKOCYTE_MIGRATION | 159 | 0.5651661 | 2.048546 | 0.0000000 | 0.0000011 | 0.0000009 | 2164 | S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/CCN3/THBS1/IL23A/C5AR2/CD177/OLFM4/EDN1/PECAM1/PF4V1/SERPINE1/ADAM8/MYD88/CXCL17/IL1A/CX3CL1/S100A8/VEGFA/ADGRE2/CD47/SAA1/PDGFB/PTPRO/TGFB2/GREM1/S100A9/RARRES2/IL34/CSF1/LYN/CD200/FLT1/LGMN/CCL17/NOD2/RHOG/DUSP1/SCG2/HRH1/MAPK3/ANXA1/MOSPD2/SYK/CD9/XG/MMP14/P2RX4 |
| GOBP_MITOTIC_METAPHASE_PLATE_CONGRESSION | 52 | -0.7230919 | -2.332315 | 0.0000000 | 0.0000012 | 0.0000010 | 758 | MAD1L1/CCNB1/CDCA8/KIF18A/PSRC1/CDT1/KIF14/NDC80/CENPE/CDCA5/NUF2/KIF2C/KIFC1/CEP55 |
| GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS | 145 | -0.5598493 | -2.141243 | 0.0000000 | 0.0000013 | 0.0000010 | 1470 | WDR62/EFHC1/MAP10/RACGAP1/STMN1/KIF11/AURKA/CCNB1/PSRC1/KIF23/ESPL1/TACC3/TTK/MAD2L1/KIF15/NDC80/PLK1/CENPE/NEK2/KIF4A/TPX2/DLGAP5/NUF2/CDC20/KIFC1/SPC25/MYBL2 |
| GOBP_LEUKOCYTE_CHEMOTAXIS | 159 | 0.5632801 | 2.041710 | 0.0000000 | 0.0000013 | 0.0000010 | 2105 | S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/CCN3/THBS1/IL23A/C5AR2/EDN1/PF4V1/SERPINE1/ADAM8/CXCL17/CX3CL1/S100A8/CXCL16/VEGFA/ADGRE2/LGALS9/SAA1/PDGFB/PTPRO/TGFB2/GREM1/S100A9/OXSR1/RARRES2/IL34/CSF1/LYN/FLT1/TNFSF14/LGMN/CCL17/SLC8B1/NOD2/DUSP1/SCG2/HRH1/MAPK3/ANXA1/F2RL1/MOSPD2/TRPM4/SYK/ADAM17 |
| GOBP_GRANULOCYTE_CHEMOTAXIS | 89 | 0.6532290 | 2.187519 | 0.0000000 | 0.0000021 | 0.0000017 | 2098 | S100A7/TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/THBS1/IL23A/C5AR2/EDN1/PF4V1/CXCL17/CX3CL1/S100A8/ADGRE2/SAA1/TGFB2/S100A9/RARRES2/IL34/CSF1/CCL17/NOD2/SCG2/HRH1/MAPK3/ANXA1/MOSPD2/SYK |
| GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS | 77 | 0.6742157 | 2.202925 | 0.0000000 | 0.0000022 | 0.0000018 | 1780 | APOBEC3A/ISG15/RSAD2/IFITM1/IFIT1/OAS3/OASL/ISG20/OAS1/MX1/CCL5/OAS2/BST2/IFIH1/APOBEC3B/IFITM3/TNIP1/TNF/TRIM31/STAT1/IFIT5/TRIM21/TRIM5/PLSCR1/TRIM14/EIF2AK2/SHFL/IFI16/N4BP1 |
| GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 170 | 0.5550075 | 2.041309 | 0.0000000 | 0.0000025 | 0.0000020 | 3036 | ZBP1/ISG15/OAS3/MICA/OAS1/NCF1/EREG/CCL5/LBP/NLRC5/LRP8/IRF7/CEACAM1/SH2D1B/BIRC3/FYN/USP18/IFI35/ADAM8/GBP5/SOCS1/PARP9/LAG3/LGALS9/IKBKE/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/RAET1E/TRIM5/TLR4/PARP14/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/DUSP10/IRAK3/TYRO3/LYN/CADM1/MMP12/STAT2/NOD2/IFI16/N4BP1/AKIRIN2/DHX58/HLA-E/PTPN22/TRAFD1/USP27X/ADAR/PTPN2/SYK/POLR3D/POLR3B/HLA-B/SRC/CASP6/NECTIN2/IRF1/FAM3A/ZNFX1/FADD/SLC15A4/CASP8/TIRAP/HLA-A/PTPN11 |
| GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 235 | 0.5075557 | 1.934108 | 0.0000000 | 0.0000029 | 0.0000023 | 2669 | PLA2G3/FGL2/RSAD2/CXCL6/MICA/NCF1/ITGAM/CLCF1/LBP/FOXP3/IL1B/BST2/ZC3H12A/IL23A/CEACAM1/SH2D1B/CD177/NR4A3/CAMK4/IL4I1/ARID5A/SEMA7A/KLK7/TNF/TNFRSF1B/COLEC10/LAG3/RIPK3/TICAM1/CD55/NOS2/STXBP1/ADGRE2/UNC13D/CD47/LGALS9/C4BPA/SERPINB4/DDX60/SERPINB9/RAET1E/TGFB2/IL18R1/TLR4/PTAFR/ICAM1/CLEC7A/HLA-G/KLRD1/HLA-F/PVR/PTPRJ/DUSP10/DNAJB9/IRAK3/STX4/CD46/LYN/NFKBIZ/CADM1/NFKBID/GAB2/NOD2/BCL10/DHX58/CD40/IL7R/HLA-E/PTPN22/ANXA1/F2RL1/SHLD1/TRPM4/SYK/SHLD2/HLA-B/HMOX1/SPON2/RIPK2/TRAF2/MALT1/SLC7A5/IL4R/AHR/TFRC/CD86/LACC1/NECTIN2/IL1R1 |
| GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 344 | 0.4567902 | 1.803570 | 0.0000000 | 0.0000032 | 0.0000026 | 2707 | PLA2G3/LUM/EBI3/ISG15/RSAD2/IDO1/OAS3/OAS1/EREG/LBP/SERPINB7/FOXP3/OAS2/IL1RL1/IL1B/IRF7/IFIH1/THBS1/IL23A/PTGS2/NOX1/NR4A3/NLRP2/CAMK4/SERPINE1/ADAM8/ARID5A/GBP5/MYD88/CD83/CD34/CXCL17/SEMA7A/IL1A/CX3CL1/IL1RL2/TNF/TICAM1/STAT1/CARD11/CD55/NOS2/MAPK11/RFTN1/BATF/CD274/LGALS9/SAA1/LY96/TLR2/EIF2AK3/DDIT3/IL18R1/IFNGR1/TLR4/ATF4/PTAFR/TRIM16/CLEC7A/HLA-G/PRKCQ/HLA-F/PTPRJ/FERMT1/EIF2AK2/IRAK3/CD276/IL36A/CYP1B1/CD46/AKAP12/CADM1/CD200/MMP12/BTN3A1/PANX1/NOD2/SPHK1/IFI16/C1QTNF3/PELI1/AKIRIN2/BCL10/DHX58/CD40/HLA-E/ISL1/IRAK1/PTPN22/ANXA1/F2RL1/SERPINF2/NFATC4/PNP/SYK/PANX2/ADAM17/POLR3D/FURIN/CEBPG/POLR3B/HMOX1/SPON2/BCL3/RIPK2/TRAF2/NLRP1/SRC/MALT1/SLC7A5/NOD1/IL4R/TYK2/TMEM106A/EGR1/F3/CD86/IL15/LACC1/HYAL2/IL1R1/CEBPB/IRF1 |
| GOBP_SPINDLE_ASSEMBLY | 119 | -0.5800238 | -2.147857 | 0.0000000 | 0.0000034 | 0.0000028 | 1273 | MAP10/RACGAP1/FBXO5/KIF11/AURKA/KIF23/GOLGA8M/KIF15/SPAG5/NDC80/PLK1/NEK2/CCNB2/KIF4A/TPX2/GOLGA8H/CDC20/KIFC1/ASPM/MYBL2 |
| GOBP_MONONUCLEAR_CELL_MIGRATION | 129 | 0.5908789 | 2.092512 | 0.0000000 | 0.0000038 | 0.0000030 | 2149 | S100A7/CXCL10/CXCL11/CCL22/CCL4/CCL20/S100A12/SLIT2/CCL5/CCN3/THBS1/PECAM1/SERPINE1/ADAM8/CXCL17/CX3CL1/ASB2/TNF/CXCL16/RIPK3/CD47/ARTN/LGALS9/SAA1/STK10/PDGFB/SPNS2/PTPRO/ICAM1/GREM1/OXSR1/RARRES2/MSN/ADTRP/IL34/CSF1/LYN/CD200/FLT1/TNFSF14/LGMN/CCL17/SLC8B1/DUSP1/ITGB7/MAPK3/ANXA1/MOSPD2/TRPM4/ADAM17/XG |
| GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN | 247 | 0.5033246 | 1.923663 | 0.0000000 | 0.0000038 | 0.0000031 | 2975 | S100A7/CXCL10/CXCL11/IL36G/CXCL9/IDO1/CMPK2/CXCL2/TNIP3/CXCL6/NR4A1/CXCL3/CXCL8/SNCA/ALPL/CCL5/LBP/FOXP3/CXCL5/IL1B/KMO/VCAM1/CXCL1/ZC3H12A/PTGS2/CNR1/SCARB1/IRAK2/CSF3/EDN1/PF4V1/FOS/SERPINE1/ARID5A/MYD88/ANKRD1/IL1A/CX3CL1/TNIP1/S100A8/TNF/BMP6/TNFRSF1B/TICAM1/CD55/NFKBIA/NOS2/PCK2/CD274/LGALS9/LY96/TNFAIP3/TLR2/MEF2C/TRIM5/TLR4/PTAFR/TNIP2/ASS1/JUND/GCH1/S100A9/DUSP10/ADAM9/IRAK3/SELENOS/IL36A/LYN/AKAP12/TRIB1/LDOC1/GFI1/SELP/PALM3/NOD2/PELI1/AKIRIN2/NOCT/BCL10/IRAK1/PTPN22/VIM/SBNO2/MAPK3/ADAM17/SMAD6/SPON2/RIPK2/CAPN2/SRC/MALT1/PLAA/ZFP36/CLDN1/CD86/AKAP8/S100A14/CEBPB/MAP2K3/NFKB1/NFKBIB/C2/IL18/DAB2IP/MAPKAPK2/CNP/GJB6/CASP8 |
| GOBP_MONONUCLEAR_CELL_DIFFERENTIATION | 310 | 0.4686337 | 1.833318 | 0.0000000 | 0.0000039 | 0.0000031 | 2810 | NTRK1/MT1G/FGL2/FZD9/RSAD2/DLL4/FASN/TNFSF9/BATF3/CLCF1/BATF2/FOXP3/KLF6/IL1B/VCAM1/HDAC9/IRF7/ZC3H12A/IL23A/IKZF1/IL31RA/RELB/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/VEGFA/LAG3/RIPK3/CARD11/LGALS1/GPR68/VNN1/FANCA/JUN/BATF/UBD/LGALS9/PRDM1/IL18R1/DOCK10/HLA-G/LRRC8A/PTPRJ/IL11/ITGB8/INHBA/DUSP10/DNAJB9/MYC/IL34/CSF1/CD46/TYRO3/LYN/NFKBIZ/IL15RA/NFKBID/IFI16/SOX4/CTNNBIP1/TMEM176A/IL7R/PTPN22/TOX/SRF/ZEB1/ANXA1/PTPN2/F2RL1/PRELID1/PNP/SYK/ADAM17/ITGB6/CEBPG/MMP14/TMEM176B/HLA-B/BCL3/RIPK2/MALT1/GPS2/ST3GAL1/IL4R/EGR1/NFIL3/BAK1/CMTM7/CD86/IL15/ZBTB46/CEBPB/IRF1/WNT4/SOS2/IL18/MYH9 |
| GOBP_RESPONSE_TO_INTERLEUKIN_1 | 102 | 0.6276355 | 2.149179 | 0.0000000 | 0.0000040 | 0.0000032 | 2718 | ZBP1/HYAL1/CCL22/CCL4/CCL20/CXCL8/HYAL3/SNCA/IL1R2/CCL5/KLF2/IL1B/KMO/ZC3H12A/IRAK2/EDN1/MYD88/GBP2/ANKRD1/IL1RN/CX3CL1/IL1RL2/MAPK11/SOX9/GBP1/CD47/LGALS9/MTHFR/TNIP2/IRAK3/MYC/AKAP12/ST18/CCL17/CD40/IRAK1/MAPK3/ANXA1/RIPK2/SRC/EGR1/GBP3/HYAL2/IL1R1/CEBPB/NFKB1/RPS6KA4 |
| GOBP_CHROMOSOME_LOCALIZATION | 79 | -0.6293357 | -2.212280 | 0.0000001 | 0.0000045 | 0.0000037 | 758 | MAD1L1/CCNB1/MAJIN/CDCA8/KIF18A/PSRC1/CDT1/CENPF/KIF14/FAM83D/SPAG5/NDC80/CENPE/CDCA5/DLGAP5/NUF2/KIF2C/KIFC1/CEP55 |
| GOBP_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 | 81 | 0.6580286 | 2.177212 | 0.0000001 | 0.0000051 | 0.0000041 | 2718 | ZBP1/HYAL1/CCL22/CCL4/CCL20/CXCL8/HYAL3/IL1R2/CCL5/KLF2/IL1B/KMO/ZC3H12A/IRAK2/EDN1/MYD88/GBP2/ANKRD1/IL1RN/CX3CL1/IL1RL2/MAPK11/SOX9/GBP1/CD47/TNIP2/IRAK3/MYC/AKAP12/ST18/CCL17/CD40/IRAK1/MAPK3/EGR1/GBP3/HYAL2/IL1R1/CEBPB/NFKB1/RPS6KA4 |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS | 287 | 0.4756739 | 1.840973 | 0.0000001 | 0.0000051 | 0.0000041 | 2470 | TNFAIP6/FGL2/ISG15/LDLR/IDO1/SLIT2/OAS3/MICA/OAS1/FOXP3/IL1RL1/BST2/NLRC5/CCN3/THBS1/TSC22D3/ZC3H12A/CNR1/CEACAM1/LRRC17/C5AR2/FYN/USP18/IL31RA/IL4I1/CX3CL1/SOCS1/TNF/LAG3/CD55/GPR68/SOX9/GBP1/CD47/CD274/LGALS9/FSTL3/C4BPA/UBASH3A/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/TGFB2/TLR4/PARP14/HLA-G/KLRD1/HLA-F/PTPRJ/GREM1/INHBA/DUSP10/RHBDF2/ADTRP/IRAK3/DUSP3/SELENOS/MYC/CD46/TYRO3/LYN/TRIB1/CD200/MMP12/ARG2/HLA-DOB/STAT2/NOD2/IFI16/PELI1/TMEM176A/DHX58/IL7R/FCRLB/HLA-E/PTPN22/TRAFD1/DUSP1/ADAR/ANXA1/PTPN2/PDE5A/THY1/SYK/FURIN/TMEM176B/HLA-B/HMOX1/SRC/GPS2/IL4R/LPXN/AHR |
| GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS | 470 | 0.4214983 | 1.704118 | 0.0000001 | 0.0000052 | 0.0000042 | 1209 | PLA2G3/PNPLA3/APOC1/ACAT2/FADS2/ELOVL6/ACSS2/MSMO1/FADS1/INSIG1/ALDOB/FGFR4/ACOT1/LIPC/ACLY/LIPG/LPIN1/SLC2A6/SCD/MLXIPL/STARD4/IDO1/FASN/TRIB3/ALDOC/HKDC1/ALOXE3/ACSL1/PLA2G4C/NPC1/SNCA/TBXAS1/NUDT8/HSD17B12/ME1/KYNU/ACSL4/IL1B/KMO/ACOXL/PTGS2/CNR1/CEACAM1/CYP46A1/ELOVL5/GGT5/NR4A3/EDN1/AACS/ALDH1L2/IL4I1/MFSD2A/CYP3A5/CYP26B1/ELOVL7/FA2H/ACADL/VNN1/SOX9/ACACA/PCK2/IDH1/ECH1/CYP4A22/LIPH/PGD/PEDS1/ALDH1A3/PTGES/MTHFD1L/UGT1A10/ADIPOR2 |
| GOBP_MEIOTIC_CELL_CYCLE | 198 | -0.4943421 | -1.985473 | 0.0000001 | 0.0000056 | 0.0000045 | 2172 | PLD6/M1AP/PSMC3IP/MYBL1/SMC4/CENPC/FANCM/ERCC1/RSPH1/CKS2/HSF2BP/RNF212/TDRD9/SMC2/FMN2/MAPK15/PKMYT1/EME1/MNS1/SYCP2/FBXO5/WBP2NL/MCMDC2/BRIP1/CCNE1/AURKA/TRIP13/MAJIN/CDC25C/RAD51/CDC25A/KIF18A/XRCC2/PTTG1/SGO2/RAD51AP1/ESPL1/CCNE2/FBXO43/TTK/NDC80/RAD54B/PLK1/NEK2/CNTD1/EXO1/RAD54L/CCNB2/BUB1/NUF2/DMC1/CDC20/NCAPH/SGO1/BUB1B/TOP2A/ASPM |
| GOBP_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION | 51 | 0.7326857 | 2.225637 | 0.0000001 | 0.0000058 | 0.0000047 | 1780 | APOBEC3A/ISG15/RSAD2/IFITM1/IFIT1/OAS3/OASL/ISG20/OAS1/MX1/CCL5/OAS2/BST2/IFIH1/APOBEC3B/IFITM3/TNIP1/TNF/IFIT5/PLSCR1/EIF2AK2/SHFL/IFI16/N4BP1 |
| GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN | 154 | 0.5553555 | 2.007864 | 0.0000001 | 0.0000058 | 0.0000047 | 2733 | CXCL10/CXCL11/IL36G/CXCL9/CMPK2/CXCL2/TNIP3/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/KMO/CXCL1/ZC3H12A/SCARB1/IRAK2/CSF3/PF4V1/SERPINE1/ARID5A/MYD88/ANKRD1/IL1A/CX3CL1/TNIP1/TNF/BMP6/TNFRSF1B/TICAM1/CD55/NFKBIA/NOS2/CD274/LY96/TNFAIP3/TLR2/MEF2C/TRIM5/TLR4/PTAFR/TNIP2/ASS1/ADAM9/SELENOS/IL36A/LYN/TRIB1/LDOC1/GFI1/NOD2/BCL10/IRAK1/PTPN22/VIM/SBNO2/MAPK3/SPON2/RIPK2/CAPN2/SRC/MALT1/PLAA/ZFP36/CD86/AKAP8/CEBPB/MAP2K3/NFKB1/NFKBIB |
| GOBP_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 61 | -0.6788663 | -2.280874 | 0.0000001 | 0.0000062 | 0.0000050 | 1732 | HECW2/XRCC3/MAPK15/FBXO5/ANAPC4/MAD1L1/TRIP13/CCNB1/ZWINT/CDT1/CENPF/ESPL1/TACC3/TTK/MAD2L1/NDC80/PLK1/CENPE/BUB1/DLGAP5/BUB1B/UBE2C |
| GOBP_CHROMOSOME_SEPARATION | 88 | -0.6253701 | -2.247633 | 0.0000001 | 0.0000068 | 0.0000055 | 861 | HECW2/XRCC3/MAPK15/EME1/FBXO5/ANAPC4/MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/ESPL1/TACC3/TTK/MAD2L1/NDC80/PLK1/CENPE/BUB1/DLGAP5/NCAPH/BUB1B/UBE2C/TOP2A |
| GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 381 | -0.4017565 | -1.702334 | 0.0000001 | 0.0000070 | 0.0000056 | 1732 | HECW2/CIT/XRCC3/JADE1/BRCA1/CENPJ/MTBP/MRNIP/PKMYT1/CAMK2A/CDC7/CDC14A/GPNMB/STOX1/FBXO5/LZTS1/GJC2/EZH2/KDM8/ANAPC4/CCNF/ORC1/CCNE1/AURKA/MAD1L1/E2F1/CCNP/TRIP13/CCNB1/ATAD5/BLM/CCNO/CDC25C/CCNA2/CDC25A/CDKN2C/ZWINT/CDT1/CENPF/CDKN3/CLSPN/ESPL1/E2F7/KIF14/CCNE2/TACC3/MELK/TTK/MAD2L1/TICRR/FBXL22/ANLN/CDK1/NDC80/FOXM1/PLK1/CENPE/CCNB2/CDCA5/BUB1/DLGAP5/IQGAP3/RRM2/DTL/GTSE1/BUB1B/UBE2C |
| GOBP_REGULATION_OF_CHROMOSOME_ORGANIZATION | 201 | -0.4889944 | -1.961285 | 0.0000001 | 0.0000082 | 0.0000066 | 861 | H3-3A/SLF1/SMC4/TENT4B/ERCC1/SMC2/HECW2/XRCC3/MAPK15/ATF7IP2/RMI2/AXIN2/FBXO5/ANAPC4/MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/ESPL1/TACC3/TTK/MAD2L1/NDC80/PLK1/CENPE/NEK2/CDCA5/BUB1/DLGAP5/NCAPH/BUB1B/UBE2C/TOP2A/NCAPG |
| GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS | 476 | 0.4200914 | 1.700797 | 0.0000001 | 0.0000089 | 0.0000072 | 1983 | PNPLA3/MVD/HMGCS1/ELOVL6/ACSS2/FDPS/FADS1/IDI1/QPRT/ACLY/LPIN1/IDO1/CMPK2/MVK/ENTPD8/ACSL1/PLA2G4C/FGF2/IDO2/SNCA/HSD17B12/SLC25A1/ME1/KYNU/SLC5A8/ACSL4/PANK3/LCAT/PANK1/KMO/SRD5A3/ELOVL5/SOCS2/NAMPT/ABHD4/ADCY10/MFSD2A/PCYT2/ELOVL7/SOCS1/SELENOI/PARP9/G6PD/NOS2/ACACA/IDH1/SOCS3/LIPH/TPK1/PI4K2A/PDGFB/PISD/PTAFR/CDA/GARS1/PLSCR1/GCH1/GPAT3/PIGW/CHP1/ELOVL1/MYC/ADCY4/HAAO/ADCY5/PDXK/ITPKC/UCKL1/ANTKMT/SERINC4/LPCAT1/PIK3C2G/PPARGC1A/CTPS1/GPAT4/NADK/UPP1/ACOT7/HRH1/HACD2 |
| GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS | 158 | 0.5390324 | 1.952537 | 0.0000001 | 0.0000097 | 0.0000078 | 1147 | PLA2G3/APOC1/FADS2/ELOVL6/FADS1/INSIG1/FGFR4/LIPC/ACLY/LIPG/SCD/MLXIPL/STARD4/IDO1/FASN/TRIB3/ALOXE3/TBXAS1/HSD17B12/IL1B/KMO/PTGS2/CEACAM1/CYP46A1/ELOVL5/EDN1/ELOVL7/FA2H/ACADL/ACACA/LIPH/ALDH1A3/PTGES |
| GOBP_CELL_CYCLE_PHASE_TRANSITION | 467 | -0.3847485 | -1.667139 | 0.0000002 | 0.0000100 | 0.0000081 | 1732 | HECW2/CIT/XRCC3/JADE1/MAPK15/BRCA1/CENPJ/MTBP/MRNIP/PKMYT1/CAMK2A/CDC7/CDC14A/EME1/NEK10/GPNMB/SIX3/STOX1/FBXO5/STK33/LZTS1/GJC2/EZH2/KDM8/BRIP1/ANAPC4/CCNF/ORC1/CCNE1/AURKA/MAD1L1/E2F1/CCNP/TRIP13/CCNB1/ATAD5/NANOGP8/BLM/CCNO/CDC25C/CCNA2/DNA2/CDC25A/CDKN2C/ZWINT/CDT1/CENPF/CDKN3/CLSPN/ESPL1/E2F7/KIF14/FAM83D/CCNE2/TACC3/MELK/TTK/MAD2L1/TICRR/FBXL22/ANLN/CDK1/NDC80/FOXM1/PLK1/CENPE/CCNB2/CDCA5/BUB1/DLGAP5/IQGAP3/RRM2/CDC45/DTL/GTSE1/BUB1B/UBE2C |
| GOBP_REGULATION_OF_CELL_ACTIVATION | 434 | 0.4201055 | 1.686319 | 0.0000002 | 0.0000101 | 0.0000082 | 3181 | PLA2G3/FGL2/EBI3/CD70/THEMIS2/LDLR/IDO1/TNFSF9/MICA/ITGAM/SNCA/CCL5/CLCF1/LBP/IGF2/FOXP3/IL1RL1/IL1B/VCAM1/THBS1/ZC3H12A/IL23A/CNR1/CEACAM1/CD177/NR4A3/FYN/IL31RA/CAMK4/IL4I1/ADAM8/CYP26B1/MYD88/CD83/TNFSF13B/EMILIN2/IL1A/CX3CL1/SOCS1/IL1RL2/TNFRSF13C/TNF/TNFRSF1B/LAG3/RIPK3/TICAM1/CARD11/LGALS1/CD55/VNN1/FANCA/STXBP1/ADGRE2/UNC13D/CD47/CD274/LGALS9/PRDM1/C1QTNF1/TNFAIP3/PLPP6/PDGFB/MEF2C/TLR4/PTAFR/TNIP2/CLEC7A/SH2B3/HLA-G/JUND/PLSCR1/PRKCQ/HLA-F/CDKN1A/INHBA/DUSP10/DUSP3/CD276/STX4/CD46/TYRO3/LYN/NFKBIZ/PRKG1/CD200/IRS2/ARG2/IL15RA/BLOC1S3/HLA-DOB/TNFSF14/NFKBID/SELP/GAB2/MAPK8IP1/NOD2/SPHK1/PELI1/SOX4/BCL10/CD40/IL7R/HLA-E/MAP3K8/PTPN22/TOX/ZEB1/ANXA1/PTPN2/F2RL1/SHLD1/PRELID1/PDE5A/THY1/PNP/SYK/CD9/SHLD2/MMP14/HMOX1/RIPK2/SERPINE2/SLC7A1/SRC/MALT1/IL4R/TYK2/AHR/TFRC/CD86/IL15/NECTIN2/NCK1/CTSC/CEBPB/IRF1/SOS2/MFHAS1/IL18/RHBDD3/SHLD3/FADD/SLC15A4/ZBTB7B/PLA2G4A/TIRAP/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/HLA-DMA/PDPN/SH3KBP1/ACTA2/CAV1 |
| GOBP_REGULATION_OF_CHROMOSOME_SEPARATION | 66 | -0.6676471 | -2.264416 | 0.0000002 | 0.0000110 | 0.0000088 | 1115 | HECW2/XRCC3/MAPK15/FBXO5/ANAPC4/MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/ESPL1/TACC3/TTK/MAD2L1/NDC80/PLK1/CENPE/BUB1/DLGAP5/BUB1B/UBE2C |
| GOBP_MEIOSIS_I_CELL_CYCLE_PROCESS | 98 | -0.5856143 | -2.119285 | 0.0000002 | 0.0000110 | 0.0000088 | 2118 | M1AP/PSMC3IP/MYBL1/CENPC/FANCM/ERCC1/CKS2/HSF2BP/RNF212/TDRD9/FMN2/MAPK15/EME1/SYCP2/FBXO5/BRIP1/CCNE1/AURKA/TRIP13/MAJIN/CDC25C/RAD51/CDC25A/PTTG1/SGO2/RAD51AP1/ESPL1/CCNE2/NDC80/RAD54B/PLK1/CNTD1/RAD54L/CCNB2/DMC1/SGO1/TOP2A |
| GOBP_MICROTUBULE_BASED_MOVEMENT | 330 | -0.4226722 | -1.765346 | 0.0000002 | 0.0000110 | 0.0000088 | 3064 | TRAF3IP1/SPAG6/KIF17/SYBU/IFT74/CFAP100/DYNC2I1/ZMYND10/ODAD4/SSX2IP/CFAP91/ARMC2/TTC29/CFAP251/DNAAF11/TTLL9/KIF27/CFAP47/DYNLT5/DYNLT2B/IFT43/AQP4/CFAP46/HOATZ/SPA17/TTLL3/BBS2/CFAP69/DNAAF4/KIF24/DYNC2LI1/CFAP58/ENO4/IFT52/TMEM201/ODAD1/AGBL4/IFT122/IFT140/CCDC40/GAS2L2/CFAP52/IFT57/KIF6/CFAP54/RSPH9/DYNLT2/ZBBX/DRC7/IFT27/ODAD3/WDR35/SPAG17/DZIP1/MAPK8IP3/CFAP73/CFAP157/NME5/PCM1/IFT88/LCA5/DAW1/TTC12/DNAI1/IFT81/DNAH7/IQCG/RPGR/SPEF2/CCDC39/DPCD/FMN2/MAP1A/SPAG16/IFT172/SLC22A16/CFAP61/KIF19/TEKT3/ROPN1L/KIF1A/ROPN1B/CCDC65/HYDIN/STARD9/CFAP206/KIF22/TEKT2/TEKT1/RFX3/DNAH9/TTC21A/TCTE1/DNAI4/CFAP45/CFAP65/DYNC2H1/NEK10/TTC21B/DNAI2/DNAH3/CFAP44/TEKT4/MNS1/TEKT5/KIF21A/DNAH6/DNAH1/DNAH5/CFAP70/CFAP43/DYNLRB2/CFAP221/ODAD2/LCA5L/DNAH10/DNAAF6/DLG2/DNAAF1/CFAP53/KIF11/TTLL6/CNIH2/DNAH2/PLTP/DNAH12/CATSPERD/MEIG1/KIF18A/KIF23/KIF14/KIF20B/KIF15/DYNLT4/EPPIN/CENPE/KIF20A/KIF4A/DLGAP5/KIF2C/KIFC1/KIF18B |
| GOBP_METAPHASE_PLATE_CONGRESSION | 64 | -0.6691102 | -2.254788 | 0.0000002 | 0.0000128 | 0.0000103 | 758 | MAD1L1/CCNB1/CDCA8/KIF18A/PSRC1/CDT1/CENPF/KIF14/FAM83D/SPAG5/NDC80/CENPE/CDCA5/NUF2/KIF2C/KIFC1/CEP55 |
| GOBP_NEUTROPHIL_MIGRATION | 88 | 0.6269365 | 2.101853 | 0.0000002 | 0.0000134 | 0.0000108 | 780 | TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/IL23A/C5AR2/CD177/OLFM4/EDN1/PECAM1/PF4V1/ADAM8/MYD88/IL1A/CX3CL1/S100A8 |
| GOBP_RESPONSE_TO_TYPE_I_INTERFERON | 58 | 0.6928133 | 2.163279 | 0.0000002 | 0.0000146 | 0.0000118 | 2005 | ZBP1/ISG15/IFITM1/IFIT1/OAS3/OAS1/MX1/OAS2/IFI27/NLRC5/IRF7/USP18/IFITM3/MYD88/STAT1/IKBKE/MMP12/STAT2/SP100/SHFL/IRAK1/USP27X/ADAR/PTPN2 |
| GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS | 180 | 0.5281664 | 1.956603 | 0.0000003 | 0.0000148 | 0.0000119 | 2733 | CXCL10/CXCL11/IL36G/CXCL9/CMPK2/CXCL2/TNIP3/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/KMO/CXCL1/ZC3H12A/SCARB1/IRAK2/CSF3/PF4V1/SERPINE1/ARID5A/MYD88/ANKRD1/IL1A/CX3CL1/TNIP1/TNF/BMP6/TNFRSF1B/TICAM1/CD55/NFKBIA/NOS2/CD274/LY96/TNFAIP3/TLR2/EIF2AK3/DDIT3/MEF2C/TRIM5/TLR4/PTAFR/TNIP2/ASS1/CDA/CLEC7A/ADAM9/SELENOS/IL36A/LYN/TRIB1/LDOC1/GFI1/NOD2/BCL10/IRAK1/PTPN22/VIM/SBNO2/MAPK3/SYK/SPON2/RIPK2/CAPN2/SRC/MUS81/MALT1/PLAA/ZFP36/CD86/AKAP8/TIGAR/CEBPB/MAP2K3/NFKB1/NFKBIB |
| GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 269 | -0.4339404 | -1.775033 | 0.0000003 | 0.0000163 | 0.0000132 | 1732 | HECW2/XRCC3/JADE1/BRCA1/CENPJ/MTBP/MRNIP/CDC7/CDC14A/GPNMB/STOX1/FBXO5/GJC2/EZH2/ANAPC4/ORC1/AURKA/MAD1L1/E2F1/TRIP13/CCNB1/ATAD5/BLM/CDC25C/CDC25A/CDKN2C/ZWINT/CDT1/CENPF/CLSPN/ESPL1/E2F7/KIF14/TTK/MAD2L1/TICRR/ANLN/CDK1/NDC80/PLK1/CENPE/CDCA5/BUB1/DLGAP5/RRM2/DTL/GTSE1/BUB1B/UBE2C |
| GOBP_VIRAL_PROCESS | 357 | 0.4371036 | 1.733938 | 0.0000003 | 0.0000163 | 0.0000132 | 3596 | APOBEC3A/CCL4/ISG15/RSAD2/LDLR/IFITM1/IFIT1/OAS3/OASL/ISG20/CXCL8/OAS1/MX1/NPC1/CCL5/OAS2/IFI27/BST2/IRF7/IFIH1/ZC3H12A/SCARB1/APOBEC3B/IFITM3/LAMP3/CLDN9/PARP9/TNIP1/TNF/TRIM31/STAT1/LGALS1/CD55/IFIT5/JUN/LGALS9/TRIM21/TRIM5/ICAM1/PLSCR1/TRIM14/PVR/EIF2AK2/SLC3A2/NECTIN4/MGAT4C/CD46/TYRO3/TPCN2/CHMP7/ITGB3/TMEM41B/ACE2/GFI1/SLC52A2/SHFL/PIK3C2G/IFI16/N4BP1/CHMP6/ADAR/ITGB7/BICD1/TRIM25/ITGAV/FURIN/ITGB6/MGAT4A/IFITM2/TRIM22/STOM/VPS37B/ST3GAL1/PARP10/KPNA2/TFRC/SRPK1/ZFP36/LY6E/CLDN1/CD86/MON1B/EPHA2/NECTIN2/HYAL2/PPIA/DAG1/CAV2/ZNFX1/MGAT4B/POU2F3/P4HB/NEDD4/RNASEK/RRP1B/SMPD1/VPS18/ITGA5/ITGB5/MGAT5/HEXIM1/VCP/CAV1/CFL1/CHMP1B/TRIM27/EDEM2/PARP16/ST3GAL4/SLC1A5/CHMP4C/SLC52A1/SP1/MORC2/RAB43/PKN2/ZC3HAV1/APOBEC3F/APOBEC3G/VPS37D/SCARB2 |
| GOBP_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS | 101 | 0.6038062 | 2.061317 | 0.0000003 | 0.0000174 | 0.0000141 | 2172 | MVD/HMGCS1/ELOVL6/ACSS2/HMGCR/ACOT1/ACLY/MVK/ACSL1/SNCA/NUDT8/HSD17B12/SLC25A1/ACSL4/PANK3/PANK1/ELOVL5/ELOVL7/ACACA/ENPP1/ELOVL1/ACOT2/ACOT9/OGDH/GPAT4/ACOT7/HACD2/ACSL5/FAR2/ELOVL4 |
| GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE | 408 | -0.3938066 | -1.670572 | 0.0000003 | 0.0000178 | 0.0000144 | 1732 | HECW2/XRCC3/JADE1/BRCA1/CENPJ/MTBP/MRNIP/PKMYT1/GMNN/CDC7/CDC14A/EME1/GPNMB/STOX1/FBXO5/STK33/BTG4/GJC2/BMP7/MCIDAS/EZH2/ANAPC4/TTC28/ORC1/AURKA/MAD1L1/E2F1/TRIP13/CCNB1/ATAD5/BLM/GAS1/CDC25C/CDC25A/CDKN2C/ZWINT/CDT1/CENPF/CLSPN/ESPL1/E2F7/KIF14/KIF20B/FBXO43/TTK/MAD2L1/TICRR/ANLN/CDK1/SMOC2/NDC80/PLK1/CENPE/NEK2/CDCA5/BUB1/DLGAP5/CDCA2/IGF1/RRM2/DTL/GTSE1/BUB1B/UBE2C/MKI67 |
| GOBP_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION | 352 | -0.4074752 | -1.711448 | 0.0000006 | 0.0000326 | 0.0000263 | 1732 | HECW2/XRCC3/JADE1/MAPK15/BRCA1/CENPJ/MTBP/MRNIP/CDC7/CDC14A/EME1/NEK10/GPNMB/SIX3/STOX1/FBXO5/STK33/GJC2/EZH2/BRIP1/ANAPC4/ORC1/AURKA/MAD1L1/E2F1/TRIP13/CCNB1/ATAD5/NANOGP8/BLM/CDC25C/DNA2/CDC25A/CDKN2C/ZWINT/CDT1/CENPF/CLSPN/ESPL1/E2F7/KIF14/FAM83D/TTK/MAD2L1/TICRR/ANLN/CDK1/NDC80/PLK1/CENPE/CDCA5/BUB1/DLGAP5/RRM2/CDC45/DTL/GTSE1/BUB1B/UBE2C |
| GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION | 155 | 0.5377855 | 1.946737 | 0.0000006 | 0.0000346 | 0.0000279 | 2286 | S100A7/TNFAIP6/CXCL10/CCL4/CCL20/SLIT2/CXCL8/CCL5/LBP/CCN3/THBS1/IL23A/C5AR2/OLFM4/EDN1/SERPINE1/ADAM8/MYD88/CXCL17/IL1A/CX3CL1/TNF/VEGFA/RIPK3/CD47/LGALS9/STK10/PTAFR/ICAM1/GREM1/OXSR1/RARRES2/MSN/ADTRP/IL34/CSF1/LYN/CD200/TNFSF14/SELP/LGMN/SLC8B1/NOD2/RHOG/DUSP1/MAPK3/ANXA1/F2RL1/MOSPD2/THY1/ADAM17/CD9/XG/MMP14/P2RX4/HMOX1/DAPK2 |
| GOBP_DNA_REPLICATION_DEPENDENT_CHROMATIN_ORGANIZATION | 29 | -0.7840550 | -2.241883 | 0.0000007 | 0.0000362 | 0.0000292 | 1304 | H3C11/H4C12/H4C4/CHAF1B/H3C1/H3C10/H4C13/H4C1/H3C7/H4C9/ASF1B/H3C12/H3C3/H3C8/H3C2 |
| GOBP_IMMUNE_EFFECTOR_PROCESS | 393 | 0.4353188 | 1.735132 | 0.0000007 | 0.0000362 | 0.0000292 | 2694 | PLA2G3/FGL2/CD70/RSAD2/TCIM/CXCL6/MICA/NCF1/ITGAM/LAT2/CLCF1/LBP/FOXP3/IL1B/BST2/IRF7/ZC3H12A/IL23A/CEACAM1/SH2D1B/CD177/NR4A3/FYN/PLPP4/IFI35/RELB/CAMK4/IL4I1/ARID5A/MYD88/SEMA7A/ANXA3/KLK7/TNF/TNFRSF1B/COLEC10/LAG3/RIPK3/TICAM1/DYSF/LGALS1/CD55/NOS2/STXBP1/ADGRE2/RFTN1/BATF/UNC13D/CD47/CFB/LGALS9/C4BPA/SERPINB4/DDX60/SERPINB9/NMI/RAET1E/TGFB2/IL18R1/TLR4/PTAFR/ICAM1/DOCK10/CLEC7A/ULBP1/HLA-G/KLRD1/C1S/HLA-F/PVR/PTPRJ/DUSP10/DNAJB9/LCP1/IRAK3/STX4/CD46/LYN/ULBP3/NFKBIZ/CADM1/HLA-DOB/NFKBID/GAB2/NOD2/BCL10/DHX58/CD40/IL7R/HLA-E/PTPN22/SBNO2/ULBP2/ANXA1/F2RL1/SHLD1/TRPM4/SYK/C8B/ADAM17/SHLD2/CEBPG/RNF168/HLA-B/HMOX1/SPON2/BCL3/RIPK2/TREM1/TRAF2/SRC/MALT1/SLC7A5/ST3GAL1/IL4R/RAB27A/AHR/TUBB/TFRC/CD86/LACC1/NECTIN2/CTSC/IL1R1/SWAP70 |
| GOBP_TELOMERE_ORGANIZATION | 151 | -0.5026711 | -1.938191 | 0.0000008 | 0.0000422 | 0.0000340 | 3362 | H4C3/NAF1/POT1/PTGES3/FEN1/ATM/ATR/H4C2/MRE11/H3C6/WRN/ZBTB48/TCP1/SMC6/HDAC8/H4C6/H3-3A/WRAP53/H3C11/HSP90AA1/TENT4B/H4C12/ERCC1/H4C4/XRCC3/MAPK15/H3C1/H3C10/EZH2/CCNE1/H4C13/BLM/DNA2/RAD51/RECQL4/H4C1/CCNE2/H3C7/ZSCAN4/H4C9/NEK2/EXO1/H3C12/H3C3/H3C8/H3C2 |
| GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION | 99 | -0.5651321 | -2.057771 | 0.0000009 | 0.0000468 | 0.0000377 | 1115 | FBXO5/BMP7/ANAPC4/AURKA/MAD1L1/TRIP13/CCNB1/CDC25C/ZWINT/CDT1/CENPF/ESPL1/KIF20B/FBXO43/TTK/MAD2L1/NDC80/PLK1/NEK2/BUB1/DLGAP5/CDCA2/IGF1/BUB1B/MKI67 |
| GOBP_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION | 82 | 0.6307461 | 2.092302 | 0.0000009 | 0.0000473 | 0.0000382 | 2105 | S100A7/CXCL10/CCL4/CCL20/SLIT2/CCL5/CCN3/THBS1/SERPINE1/ADAM8/CXCL17/TNF/RIPK3/CD47/LGALS9/STK10/GREM1/OXSR1/RARRES2/MSN/ADTRP/IL34/CSF1/LYN/CD200/TNFSF14/LGMN/SLC8B1/DUSP1/MAPK3/MOSPD2/ADAM17 |
| GOBP_DNA_REPLICATION | 266 | -0.4311322 | -1.759924 | 0.0000009 | 0.0000481 | 0.0000388 | 3134 | TOP1MT/ATR/MCM4/NAP1L1/ING4/MRE11/POLH/WRN/ALYREF/RMI1/GINS4/NASP/LIG3/POLI/PRIMPOL/MMS22L/DBF4B/CCDC88A/RUVBL2/NFIX/RRM1/ENDOG/FANCM/RFC3/ZGRF1/ZRANB3/JADE1/GMNN/POLN/CDC7/EME1/RMI2/GMNC/LRWD1/CHAF1B/ORC6/WDHD1/FBXO5/DSCC1/GLI2/POLD1/MCIDAS/PCLAF/GINS1/ORC1/CCNE1/ATAD5/BLM/CCNA2/DNA2/RAD51/RECQL4/GINS2/CDT1/E2F7/CCNE2/POLQ/TICRR/CDK1/ADRA2A/ESCO2/POLE2/MCM10/RRM2/CDC45/DTL/FAM111B |
| GOBP_NEUTROPHIL_CHEMOTAXIS | 72 | 0.6501920 | 2.111644 | 0.0000010 | 0.0000498 | 0.0000402 | 1135 | TNFAIP6/CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/S100A12/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/LBP/CXCL5/IL1B/ITGA9/CXCL1/IL23A/C5AR2/EDN1/PF4V1/CX3CL1/S100A8/SAA1/TGFB2 |
| GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS | 237 | 0.4827036 | 1.842572 | 0.0000010 | 0.0000504 | 0.0000407 | 1348 | PLA2G3/APOC1/FADS2/ELOVL6/FADS1/INSIG1/FGFR4/LIPC/ACLY/LIPG/SCD/MLXIPL/STARD4/IDO1/FASN/TRIB3/ALOXE3/TBXAS1/HSD17B12/GGT7/KYNU/IL1B/KMO/PSAT1/PTGS2/CEACAM1/CYP46A1/ELOVL5/GGT5/EDN1/ELOVL7/FA2H/ACADL/ACACA/PYCR1/CYP4A22/LIPH/MTHFR/ALDH1A3/PTGES/MTHFD1L/ASS1/PLOD3/CBS/ELOVL1 |
| GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 164 | 0.5240875 | 1.917341 | 0.0000010 | 0.0000512 | 0.0000413 | 2945 | PLA2G3/RSAD2/CXCL6/MICA/ITGAM/CLCF1/FOXP3/IL1B/BST2/IL23A/CEACAM1/SH2D1B/CD177/CAMK4/IL4I1/ARID5A/TNF/TNFRSF1B/LAG3/RIPK3/TICAM1/CD55/NOS2/STXBP1/ADGRE2/UNC13D/LGALS9/C4BPA/SERPINB4/SERPINB9/RAET1E/IL18R1/TLR4/PTAFR/ICAM1/CLEC7A/HLA-G/KLRD1/HLA-F/PVR/STX4/CD46/LYN/CADM1/GAB2/NOD2/CD40/IL7R/HLA-E/F2RL1/SHLD1/TRPM4/SYK/SHLD2/HLA-B/HMOX1/TRAF2/MALT1/IL4R/AHR/TFRC/NECTIN2/IL1R1/IL18/C3/SHLD3/FADD/SLC15A4 |
| GOBP_SISTER_CHROMATID_COHESION | 54 | -0.6790918 | -2.214973 | 0.0000011 | 0.0000528 | 0.0000426 | 1521 | KIF22/AXIN2/DSCC1/HASPIN/SGO2/ESPL1/PLK1/ESCO2/CDCA5/BUB1/CDC20/SGO1/BUB1B |
| GOBP_RESPONSE_TO_CHEMOKINE | 53 | 0.6919856 | 2.134764 | 0.0000011 | 0.0000550 | 0.0000443 | 720 | CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/CCR3/SLIT2/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/CXCL1/ZC3H12A/EDN1/PF4V1/CX3CL1 |
| GOBP_VIRAL_LIFE_CYCLE | 267 | 0.4598451 | 1.770410 | 0.0000012 | 0.0000556 | 0.0000449 | 3596 | APOBEC3A/ISG15/RSAD2/LDLR/IFITM1/IFIT1/OAS3/OASL/ISG20/CXCL8/OAS1/MX1/NPC1/CCL5/OAS2/IFI27/BST2/IFIH1/ZC3H12A/SCARB1/APOBEC3B/IFITM3/LAMP3/CLDN9/TNIP1/TNF/TRIM31/LGALS1/CD55/IFIT5/LGALS9/TRIM21/TRIM5/ICAM1/PLSCR1/TRIM14/PVR/EIF2AK2/SLC3A2/NECTIN4/CD46/TYRO3/TPCN2/CHMP7/ITGB3/TMEM41B/ACE2/SLC52A2/SHFL/PIK3C2G/IFI16/N4BP1/CHMP6/ADAR/ITGB7/TRIM25/ITGAV/FURIN/ITGB6/IFITM2/TRIM22/STOM/VPS37B/PARP10/KPNA2/TFRC/SRPK1/LY6E/CLDN1/CD86/EPHA2/NECTIN2/HYAL2/PPIA/DAG1/CAV2/ZNFX1/P4HB/NEDD4/RNASEK/SMPD1/VPS18/ITGA5/ITGB5/VCP/CAV1/CHMP1B/TRIM27/SLC1A5/CHMP4C/SLC52A1/MORC2/RAB43/PKN2/ZC3HAV1/APOBEC3F/APOBEC3G/VPS37D/SCARB2 |
| GOBP_DNA_DEPENDENT_DNA_REPLICATION | 155 | -0.4997185 | -1.938897 | 0.0000013 | 0.0000599 | 0.0000483 | 2398 | FEN1/LIG1/ATR/MCM4/MRE11/WRN/ALYREF/GINS4/LIG3/PRIMPOL/MMS22L/DBF4B/RRM1/ENDOG/FANCM/RFC3/ZGRF1/ZRANB3/GMNN/POLN/CDC7/EME1/GMNC/LRWD1/ORC6/WDHD1/FBXO5/DSCC1/POLD1/MCIDAS/GINS1/ORC1/CCNE1/ATAD5/BLM/DNA2/RAD51/RECQL4/GINS2/CDT1/E2F7/CCNE2/POLQ/TICRR/POLE2/MCM10/CDC45 |
| GOBP_CELLULAR_RESPONSE_TO_LIPID | 432 | 0.4132936 | 1.658054 | 0.0000013 | 0.0000602 | 0.0000486 | 2933 | CXCL10/INSIG1/CXCL11/IL36G/CXCL9/LDLR/CMPK2/CXCL2/TNIP3/CXCL6/CXCL3/NTRK3/CXCL8/NPC1/CCL5/LBP/CXCL5/IL1B/KMO/CXCL1/NR2E3/LRP8/ZC3H12A/SCARB1/IRAK2/CSF3/NR4A3/EDN1/PF4V1/SERPINE1/ARID5A/CYP26B1/MYD88/ANKRD1/EPHA3/IL1A/CX3CL1/TNIP1/TNF/BMP6/TNFRSF1B/TICAM1/CD55/NFKBIA/NOS2/SOX9/SGK1/PCK2/CD274/HDAC6/LY96/PMEPA1/TNFAIP3/ERRFI1/TLR2/MEF2C/TRIM5/TLR4/PTAFR/TNIP2/ASS1/WBP2/INHBA/ADAM9/MSN/ADTRP/SELENOS/MYC/GJB3/IL36A/CYP1B1/LYN/ADCY5/TRIB1/PIM1/PPARGC1B/LDOC1/GFI1/COL1A1/NOD2/DAB2/CFTR/BCL10/EFNA5/ISL1/IRAK1/PTPN22/PHEX/VIM/DDIT4/SBNO2/MAPK3/ANXA1/ID3/TFPI/SYK/ALDH1A2/NDUFA13/SPON2/RIPK2/CAPN2/SRC/MGST1/MALT1/KDM4C/PLAA/AHR/MSX2/ZFP36/CLDN1/CD86/IL15/ZNF35/AKAP8/CEBPB/MAP2K3/NFKB1/NFKBIB/DAG1/IL18/DAB2IP/PID1/FAM210B/PAQR8/PGRMC2/NEDD4 |
| GOBP_FATTY_ACID_METABOLIC_PROCESS | 311 | 0.4509008 | 1.763816 | 0.0000014 | 0.0000644 | 0.0000520 | 1002 | PLA2G3/PNPLA3/APOC1/ACAT2/FADS2/ELOVL6/MSMO1/FADS1/INSIG1/ACOT1/LIPC/ACLY/LIPG/LPIN1/SCD/MLXIPL/FASN/TRIB3/ALOXE3/ACSL1/PLA2G4C/SNCA/TBXAS1/NUDT8/HSD17B12/ACSL4/IL1B/ACOXL/PTGS2/CNR1/CEACAM1/ELOVL5/GGT5/NR4A3/EDN1/AACS/ALDH1L2/MFSD2A/ELOVL7/FA2H/ACADL/SOX9/ACACA/PCK2/ECH1/CYP4A22/LIPH |
| GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS | 476 | 0.4043832 | 1.637201 | 0.0000014 | 0.0000647 | 0.0000522 | 2193 | MVD/HMGCS1/ELOVL6/ACSS2/APOBEC3A/HMGCR/QPRT/ALDOB/ACOT1/ACLY/SLC2A6/MLXIPL/GFPT2/IDO1/ALDOC/CMPK2/HKDC1/MVK/DPYSL2/ENTPD8/ACSL1/XDH/IDO2/SNCA/NUDT8/HSD17B12/SLC25A1/ME1/KYNU/SLC5A8/ACSL4/PANK3/NT5E/PANK1/KMO/PDE4C/NUDT10/ELOVL5/NAMPT/NUDT11/APOBEC3B/TYMP/ADCY10/ELOVL7/PARP9/CARD11/NOS2/ACACA/GLRX/ENTPD2/CDA/GARS1/ENPP1/NUDT17/ELOVL1/ACOT2/MYC/ADCY4/HAAO/ADCY5/UCKL1/GALT/ACOT9/ANTKMT/GALK1/ENO3/GMPR/UXS1/PPARGC1A/PMM2/PTHLH/CTPS1/OGDH/GPAT4/NADK/UPP1/ACOT7/DDIT4/HACD2/PDE5A/PNP/ACSL5/PFKFB2/FAR2/PDE9A/ENTPD5/ELOVL4/GNE/NUDT16 |
| GOBP_REGULATION_OF_VIRAL_PROCESS | 134 | 0.5464678 | 1.936180 | 0.0000015 | 0.0000684 | 0.0000552 | 2642 | APOBEC3A/ISG15/RSAD2/IFITM1/IFIT1/OAS3/OASL/ISG20/CXCL8/OAS1/MX1/CCL5/OAS2/BST2/IFIH1/APOBEC3B/IFITM3/LAMP3/TNIP1/TNF/TRIM31/STAT1/LGALS1/IFIT5/LGALS9/TRIM21/TRIM5/PLSCR1/TRIM14/EIF2AK2/TYRO3/SHFL/IFI16/N4BP1/ADAR/TRIM25/IFITM2/TRIM22/STOM/VPS37B/PARP10/KPNA2/SRPK1/ZFP36/LY6E/NECTIN2 |
| GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE | 253 | 0.4670600 | 1.790244 | 0.0000015 | 0.0000684 | 0.0000552 | 2818 | PLA2G3/ZBP1/TNFAIP6/LDLR/IDO1/S100A12/MVK/NCF1/SNCA/CCL5/LBP/FOXP3/NT5E/IL1RL1/IL1B/CCN3/IL23A/PTGS2/CNR1/BIRC3/FYN/USP18/IFI35/SERPINE1/DUOXA2/ADAM8/MYD88/CXCL17/SEMA7A/CX3CL1/TNIP1/S100A8/IL1RL2/TNF/TNFRSF1B/LGALS1/NFKBIA/FANCA/SOCS3/CD47/SAA1/OSMR/TNFAIP3/TLR2/NMI/PTGES/TLR4/S100A9/KLF4/DUSP10/RHBDF2/CAMK2N1/PSMA6/SELENOS/C2CD4A/TYRO3/LYN/NFKBIZ/CD200/ACE2/NOD2/SPHK1/ETS1/FNDC4/C1QTNF3/DUOXA1/HLA-E/ISL1/CCN4/SBNO2/ANXA1/PTPN2/METRNL/SYK/FURIN/MAPK7/CASP5/TMSB4X/NLRP1/SRC/GPS2/SMPDL3B/ZFP36/IL15/LACC1/HYAL2/CTSC/IL1R1/TRADD/CEBPB/NFKB1/MFHAS1/IL18/RHBDD3/C3 |
| GOBP_MEIOTIC_CHROMOSOME_SEGREGATION | 72 | -0.6186074 | -2.143010 | 0.0000015 | 0.0000687 | 0.0000554 | 2118 | M1AP/PSMC3IP/SMC4/CENPC/FANCM/RNF212/SMC2/FMN2/MAPK15/EME1/SYCP2/BRIP1/CCNE1/TRIP13/MAJIN/PTTG1/SGO2/ESPL1/CCNE2/TTK/PLK1/BUB1/NUF2/DMC1/NCAPH/SGO1/BUB1B/TOP2A |
| GOBP_REGULATION_OF_NUCLEAR_DIVISION | 116 | -0.5414930 | -1.994872 | 0.0000016 | 0.0000703 | 0.0000567 | 1115 | FBXO5/BMP7/ANAPC4/AURKA/MAD1L1/TRIP13/CCNB1/CDC25C/ZWINT/CDT1/RAD51AP1/CENPF/ESPL1/KIF20B/FBXO43/TTK/MAD2L1/NDC80/PLK1/NEK2/BUB1/DLGAP5/CDCA2/CDC20/IGF1/BUB1B/MKI67 |
| GOBP_RESPONSE_TO_INTERFERON_GAMMA | 104 | 0.5943803 | 2.044219 | 0.0000016 | 0.0000714 | 0.0000577 | 2005 | CCL22/CCL4/CCL20/IFITM1/SNCA/KYNU/CCL5/BST2/NLRC5/SLC26A6/EDN1/IFITM3/GBP5/GBP2/CX3CL1/SOCS1/PARP9/TNF/CXCL16/STAT1/NOS2/STXBP1/GBP1/CD47/UBD/LGALS9/TLR2/NMI/TRIM21/TLR4/ASS1/PARP14/DAPK3/GCH1/MYC/STX4/CCL17/SP100/SHFL/MYO1C/CD40/GBP4/VIM/PTPN2 |
| GOBP_DNA_REPAIR | 489 | -0.3636357 | -1.580323 | 0.0000020 | 0.0000848 | 0.0000684 | 3928 | CDC5L/BRCA2/NSMCE3/OGG1/HPF1/POLG2/FANCL/REV3L/NSD2/ERCC4/POLD3/SHPRH/PRKCG/RFC5/RPA3/BRME1/PPP4R3B/RUVBL1/ZCWPW1/RADX/TTC5/USP45/SPRTN/MSH6/FIGNL1/MSH2/UHRF1/TIMELESS/ZSWIM7/NSMCE1/NPM1/TRAIP/POT1/CRY2/ATRIP/BCCIP/FEN1/ATM/LIG1/RAD9B/PARPBP/ATR/MCM4/H2AX/UBE2T/POLR2I/C14orf39/MRE11/POLH/WRN/GTF2H5/SMC6/RAD52/HMGB1/RAD9A/RMI1/KMT5C/PDS5B/TEX264/DDB2/MC1R/NTHL1/NOP53/GINS4/MSH3/KDM4D/LIG3/POLI/PRIMPOL/MMS22L/CEP164/PMS1/RUVBL2/NEIL1/SLF1/EP400/WRAP53/MGMT/RRM1/PAXX/FANCM/TP73/ERCC1/RFC3/ABRAXAS1/HSF2BP/FMN2/ZRANB3/XRCC3/BRCA1/MRNIP/KIF22/POLN/CDC7/CETN2/EME1/RMI2/AXIN2/CHAF1B/IFFO1/NUDT1/EID3/WDHD1/EEPD1/HROB/POLD1/PCLAF/MCMDC2/BRIP1/FANCB/MUTYH/HMGB2/TRIP13/WAS/BLM/FTO/DNA2/RAD51/RECQL4/XRCC2/GINS2/PTTG1/RAD51AP1/RAD51AP2/CLSPN/CHD1L/POLQ/TICRR/CDK1/FOXM1/RAD54B/EXO1/RAD54L/ESCO2/CDCA5/NEIL3/POLE2/DMC1/CDC45/DTL |
| GOBP_MYELOID_LEUKOCYTE_ACTIVATION | 161 | 0.5149084 | 1.872394 | 0.0000020 | 0.0000860 | 0.0000694 | 1518 | PLA2G3/MT1G/LDLR/S100A12/CXCL6/CXCL8/ITGAM/SNCA/LAT2/CCL5/BATF3/LBP/BATF2/IL1RL1/THBS1/ZC3H12A/CNR1/CD177/NR4A3/IFI35/IL31RA/RELB/CAMK4/MYD88/ANXA3/CX3CL1/TNF/TICAM1/DYSF/STXBP1/ADGRE2/JUN/BATF/UNC13D/UBD/LGALS9/PLPP6/TLR2/NMI/IFNGR1/TLR4/PTAFR/TNIP2/JUND/PLSCR1/ITGB8/ADAM9/CSF1/STX4/LYN/CD200 |
| GOBP_THIOESTER_METABOLIC_PROCESS | 75 | 0.6348733 | 2.073751 | 0.0000021 | 0.0000865 | 0.0000698 | 2172 | MVD/HMGCS1/ELOVL6/ACSS2/ACOT1/ACLY/MVK/ACSL1/SNCA/NUDT8/HSD17B12/SLC25A1/ACSL4/ELOVL5/ELOVL7/ACACA/ELOVL1/ACOT2/ACOT9/OGDH/GPAT4/ACOT7/HACD2/ACSL5/FAR2/ELOVL4 |
| GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS | 117 | 0.5647145 | 1.975376 | 0.0000020 | 0.0000865 | 0.0000698 | 1002 | PLA2G3/APOC1/FADS2/ELOVL6/FADS1/INSIG1/LIPC/ACLY/LIPG/SCD/MLXIPL/FASN/TRIB3/ALOXE3/TBXAS1/HSD17B12/IL1B/PTGS2/CEACAM1/ELOVL5/EDN1/ELOVL7/FA2H/ACADL/ACACA/LIPH |
| GOBP_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 169 | 0.5074247 | 1.863321 | 0.0000025 | 0.0001037 | 0.0000836 | 2908 | PLA2G3/RSAD2/ITGAM/CLCF1/LBP/FOXP3/IL1B/IL23A/SH2D1B/CD177/NR4A3/CAMK4/ARID5A/SEMA7A/KLK7/TNF/COLEC10/LAG3/TICAM1/CD55/NOS2/STXBP1/ADGRE2/UNC13D/LGALS9/DDX60/RAET1E/IL18R1/TLR4/PTAFR/CLEC7A/HLA-G/KLRD1/HLA-F/PVR/PTPRJ/DNAJB9/STX4/CD46/LYN/NFKBIZ/CADM1/NFKBID/GAB2/NOD2/BCL10/DHX58/CD40/HLA-E/PTPN22/ANXA1/F2RL1/SHLD1/SYK/SHLD2/HLA-B/HMOX1/SPON2/RIPK2/TRAF2/MALT1/SLC7A5/IL4R/TFRC/CD86/LACC1/NECTIN2/IL1R1/IL18/C3/SHLD3/FADD |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 124 | 0.5566864 | 1.954282 | 0.0000025 | 0.0001046 | 0.0000844 | 2214 | ZBP1/OASL/EREG/CCL5/LBP/NLRC5/IRF7/SH2D1B/FYN/IFI35/ADAM8/GBP5/EMILIN2/KLK7/PARP9/BMP6/LAG3/CD274/IKBKE/LY96/DDX60/NMI/RAET1E/TRIM5/TLR4/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/LYN/CADM1/MMP12/NOD2/IFI16/AKIRIN2/DHX58/HLA-E/USP27X/F2RL1/SYK/POLR3D/POLR3B |
| GOBP_MEIOTIC_CELL_CYCLE_PROCESS | 154 | -0.5030906 | -1.951432 | 0.0000028 | 0.0001112 | 0.0000897 | 2118 | M1AP/PSMC3IP/MYBL1/SMC4/CENPC/FANCM/ERCC1/CKS2/HSF2BP/RNF212/TDRD9/SMC2/FMN2/MAPK15/EME1/SYCP2/FBXO5/BRIP1/CCNE1/AURKA/TRIP13/MAJIN/CDC25C/RAD51/CDC25A/KIF18A/PTTG1/SGO2/RAD51AP1/ESPL1/CCNE2/FBXO43/TTK/NDC80/RAD54B/PLK1/CNTD1/RAD54L/CCNB2/BUB1/NUF2/DMC1/CDC20/NCAPH/SGO1/BUB1B/TOP2A/ASPM |
| GOBP_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE | 99 | 0.5707806 | 1.937188 | 0.0000027 | 0.0001112 | 0.0000897 | 1503 | PLA2G3/ZBP1/LDLR/IDO1/S100A12/SNCA/LBP/IL1RL1/IL1B/IL23A/PTGS2/CNR1/IFI35/SERPINE1/ADAM8/CX3CL1/TNIP1/S100A8/TNF/LGALS1/NFKBIA/CD47/OSMR/TLR2/NMI/TLR4/S100A9/CAMK2N1/C2CD4A/NFKBIZ |
| GOBP_RESPONSE_TO_PEPTIDE | 380 | 0.4172853 | 1.658173 | 0.0000027 | 0.0001112 | 0.0000897 | 3482 | PNPLA3/NTRK1/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/NR4A1/CACNB1/MIR200A/EREG/KLF2/IGF2/IL1B/VCAM1/KLF11/HDAC9/PTGS2/CEACAM1/SOCS2/NAMPT/NR4A3/EDN1/FYN/FOXC2/EGR2/GDF15/STC2/MAP1B/CPEB2/RAB8B/SOCS1/AREG/TNF/STAT1/NFKBIA/PCK2/SOCS3/TNFAIP3/ERRFI1/TLR2/ADRB2/TLR4/ICAM1/TRIM16/ASS1/ENPP1/JUND/PRKCQ/GRB10/RARRES2/ANO1/SELENOS/MYC/CYP1B1/LYN/MMP12/IRS2/DDX11/LDOC1/KL/COL1A1/LGMN/STAT2/NOD2/MYO1C/MARS1/SESN2/MMP13/PTPN22/PHEX/VIM/ANXA1/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/RIPK2/BTG1/NLRP1/SRC/STAT5A/NOD1/LPIN2/CACNA1A/CCND3/YWHAG/EGR1/SLC9A1/PIP4K2C/NDEL1/NCK1/GCNT1/NFKB1/DAG1/PIK3C2A/CAV2/SLC25A33/KBTBD2/ID1/PID1/ZBTB7B/MEAK7/CDC6/PNPT1/PTPN11/RAB12/SLC39A14/ZDHHC7/CAV1/MYO5A/GJB2/RANGAP1/CACNA2D1/GRB7/GNAI2/EPM2AIP1/PIP4K2B/ARHGEF2/EPRS1/CFLAR/SP1/RELA |
| GOBP_MONOCYTE_CHEMOTAXIS | 39 | 0.7378864 | 2.134891 | 0.0000028 | 0.0001129 | 0.0000911 | 2031 | S100A7/CXCL10/CCL22/CCL4/CCL20/S100A12/SLIT2/CCL5/CCN3/SERPINE1/CXCL17/CX3CL1/PDGFB/PTPRO/GREM1/LYN/FLT1/LGMN/CCL17/DUSP1/ANXA1/MOSPD2 |
| GOBP_TISSUE_MIGRATION | 268 | 0.4510338 | 1.735382 | 0.0000029 | 0.0001134 | 0.0000915 | 3102 | HYAL1/FGFBP1/DLL4/PRSS3/SLIT2/NR4A1/FGF2/MIR200A/S100P/KDR/CCN3/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/SCARB1/EDN1/FOXC2/ANXA3/TNF/RHOB/VEGFA/STAT1/HBEGF/SOX9/JUN/FGF1/ACVRL1/HDAC6/LOXL2/DAAM2/ZEB2/PDGFB/TGFB2/MEF2C/PTP4A3/RRAS/GREM1/KLF4/ADAMTS9/FERMT1/DUSP10/ADAM9/ADTRP/ATOH8/MET/CYP1B1/EGF/CSNK2B/ITGB3/WNT7A/FSTL1/LGMN/GADD45A/BMPER/SP100/ETS1/PLPP3/AKT3/CD40/ADGRB1/SCG2/ARSB/SRF/ANXA1/GIPC1/CARD10/ADAM17/HDAC7/P2RX4/EPHB4/HMOX1/MAP4K4/BCAR1/ITGA3/TMSB4X/TGFBR1/SRC/SEMA3A/STAT5A/LPXN/TACSTD2/MAPRE2/EPHA2/MAP3K3/MAP2K3/PIK3C2A/GLUL/PLEKHG5/MYH9/DOCK5/RTN4/ID1/DAB2IP/FAP/SRPX2/JUP/PLCG1/SPARC/PTPN11/TGFBR2/GFUS |
| GOBP_MITOTIC_SPINDLE_ASSEMBLY | 68 | -0.6217962 | -2.115041 | 0.0000034 | 0.0001346 | 0.0001086 | 1273 | MAP10/RACGAP1/KIF11/KIF23/KIF15/PLK1/NEK2/KIF4A/TPX2/CDC20/KIFC1/MYBL2 |
| GOBP_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | 355 | 0.4226818 | 1.677959 | 0.0000037 | 0.0001445 | 0.0001166 | 3521 | NTRK1/S100A12/LPAR5/FOXP3/IL1B/NLRC5/RELN/LRP8/ZC3H12A/IRAK2/CSF3/EDN1/NLRP2/PPP2R5B/ADAM8/MYD88/ANXA3/CX3CL1/HES6/S100A8/TNF/TRIM31/VEGFA/RIPK3/TICAM1/CARD11/NFKBIA/FANCA/SGK1/IKBKG/FOXA2/BMP2/LGALS9/IKBKE/TNFAIP3/GLIS2/NFKBIE/TLR2/TRIM21/DDIT3/RTKN2/IL18R1/TRIM5/TLR4/CLEC7A/ENPP1/TRIM14/PRKCQ/GREM1/S100A9/KLF4/CHP1/EIF2AK2/DVL2/IRAK3/PSMA6/BHLHE40/CYP1B1/CDKN2A/TRAF1/TRIB1/CD200/PIM1/PPARGC1B/GFI1/NOD2/SPHK1/SP100/PELI1/PLPP3/CTNNBIP1/MDFI/PPARGC1A/BCL10/CD40/IRAK1/SLCO3A1/SRF/TRIM25/MAPK3/ID3/RNF31/SYK/CEBPG/CTH/HMOX1/MAP3K10/BCL3/RIPK2/TRIM22/TRAF2/FLNA/TMSB4X/MALT1/PRKCH/NOD1/FOSL1/RBCK1/PARP10/MSX2/TFRC/TRADD/RPS6KA4/NFKBIB/PPIA/IL18/ID1/DAB2IP/SAV1/JUP/TIRAP/TRAF5/DDRGK1/TWIST1/BRMS1/FLOT1/CAV1/MAP3K13/ARHGEF5/TRIM27/MAD2L2/COMMD7/ARHGEF2/CFLAR/RELA/ZC4H2/CRTC3/ADCY1 |
| GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 36 | -0.7437320 | -2.247465 | 0.0000048 | 0.0001809 | 0.0001459 | 758 | RACGAP1/MAD1L1/CCNB1/CDT1/SPC24/SPAG5/KNL1/NDC80/CENPE/NEK2/NUF2/KIF2C/SGO1/SPC25 |
| GOBP_CHRONIC_INFLAMMATORY_RESPONSE | 12 | 0.9038447 | 2.038614 | 0.0000047 | 0.0001809 | 0.0001459 | 1307 | IDO1/CCL5/FOXP3/VCAM1/THBS1/S100A8/TNF/VNN1/UNC13D/TNFAIP3/S100A9 |
| GOBP_CELL_CYCLE_CHECKPOINT_SIGNALING | 163 | -0.4804304 | -1.860500 | 0.0000048 | 0.0001809 | 0.0001459 | 864 | BRIP1/ORC1/MAD1L1/E2F1/TRIP13/CCNB1/BLM/DNA2/ZWINT/CDT1/CENPF/CLSPN/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/BUB1/CDC45/DTL/GTSE1/BUB1B |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 284 | 0.4457777 | 1.722852 | 0.0000047 | 0.0001809 | 0.0001459 | 2419 | TNFAIP6/FGL2/ISG15/LDLR/MVK/SLIT2/OAS3/RTN4R/MICA/FGF2/OAS1/FOXP3/NT5E/NLRC5/SEMA3B/CCN3/PLAU/THBS1/CEACAM1/C5AR2/SEMA3D/EDN1/FYN/USP18/SERPINE1/SERPINB2/CD34/CXCL17/SEMA7A/CX3CL1/TNF/TNFRSF1B/SOCS3/MICB/LGALS9/SAA1/SERPINB4/C1QTNF1/TNFAIP3/SERPINB9/NMI/TRIM21/PDGFB/PTPRO/PARP14/SH2B3/HLA-G/KLRD1/HLA-F/GREM1/KLF4/PLXNA3/DUSP10/RHBDF2/ADTRP/IRAK3/DUSP3/SELENOS/TYRO3/LYN/PHLDB2/TRIB1/PRKG1/CD200/MMP12/ARG2/STAT2/NOD2/FNDC4/IFI16/C1QTNF3/DHX58/HLA-E/ISL1/TRAFD1/DUSP1/ADAR/PTPN2/METRNL/SERPINF2/TFPI/SYK/CD9/FURIN/MAPK7/HLA-B/SERPINE2/SLC12A2/SRC/NPLOC4/SEMA3A/GPS2/INPP5F/SMPDL3B |
| GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS | 172 | 0.4964253 | 1.826618 | 0.0000053 | 0.0001990 | 0.0001606 | 3598 | PNPLA3/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/IGF2/IL1B/HDAC9/CEACAM1/NAMPT/FOXC2/CPEB2/RAB8B/SOCS1/STAT1/PCK2/SOCS3/ERRFI1/ENPP1/PRKCQ/GRB10/RARRES2/SELENOS/MYC/IRS2/KL/MYO1C/MARS1/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/SRC/LPIN2/CCND3/YWHAG/SLC9A1/PIP4K2C/NDEL1/NCK1/PIK3C2A/CAV2/SLC25A33/PID1/ZBTB7B/PTPN11/RAB12/SLC39A14/ZDHHC7/MYO5A/GRB7/GNAI2/PIP4K2B/EPRS1/CFLAR/SP1/IRS1/CAPN10/SHC1 |
| GOBP_VIRAL_GENOME_REPLICATION | 117 | 0.5528410 | 1.933843 | 0.0000067 | 0.0002469 | 0.0001992 | 1780 | APOBEC3A/ISG15/RSAD2/IFITM1/IFIT1/OAS3/OASL/ISG20/CXCL8/OAS1/MX1/CCL5/OAS2/IFI27/BST2/IFIH1/ZC3H12A/APOBEC3B/IFITM3/TNIP1/TNF/IFIT5/PLSCR1/EIF2AK2/TMEM41B/SHFL/PIK3C2G/IFI16/N4BP1 |
| GOBP_ADAPTIVE_IMMUNE_RESPONSE | 285 | 0.4410831 | 1.707130 | 0.0000067 | 0.0002469 | 0.0001992 | 3323 | EBI3/CD70/RSAD2/BACH2/MICA/LAT2/CLCF1/FOXP3/IL1RL1/IL1B/IRF7/ZC3H12A/IL23A/CEACAM1/SH2D1B/FYN/NFKB2/RELB/CAMK4/IL4I1/ARID5A/MYD88/TNFSF13B/TAP1/LAMP3/TNFRSF13C/TNF/TNFRSF1B/TAP2/LAG3/RIPK3/CD55/RFTN1/BATF/UNC13D/MICB/CD274/PRDM1/C4BPA/TNFAIP3/IL18R1/MEF2C/TLR4/ICAM1/CLEC7A/HLA-G/KLRD1/C1S/PRKCQ/HLA-F/PVR/DUSP10/TFE3/CD46/LYN/NFKBIZ/CADM1/BTN3A1/ARG2/HLA-C/HLA-DOB/NFKBID/NOD2/BCL10/CD40/IL7R/HLA-E/ANXA1/SHLD1/TRPM4/SYK/C8B/ADAM17/SHLD2/RAP1GAP/RNF168/HLA-B/BCL3/RIPK2/TREM1/MCOLN1/TRAF2/MALT1/IL4R/RAB27A/AHR/TFRC/CD86/RAPGEF3/NECTIN2/CTSC/IL1R1/SWAP70/IRF1/C2/IL18/C3/RAP1GAP2/SHLD3/FADD/SLC15A4/ZBTB7B/PLA2G4A/HLA-A/HLA-DMA/BTN3A3/FZD5/RNF19B/TRIM27/ADCY7/EMP2/MAD2L2/BTN3A2 |
| GOBP_LEUKOCYTE_MEDIATED_IMMUNITY | 258 | 0.4528763 | 1.741228 | 0.0000070 | 0.0002539 | 0.0002049 | 2945 | PLA2G3/CD70/RSAD2/CXCL6/MICA/ITGAM/LAT2/CLCF1/FOXP3/IL1B/BST2/IRF7/IL23A/CEACAM1/SH2D1B/CD177/NR4A3/CAMK4/IL4I1/ARID5A/MYD88/ANXA3/TNF/TNFRSF1B/LAG3/RIPK3/TICAM1/CD55/NOS2/STXBP1/ADGRE2/RFTN1/BATF/UNC13D/LGALS9/C4BPA/SERPINB4/SERPINB9/RAET1E/IL18R1/TLR4/PTAFR/ICAM1/CLEC7A/ULBP1/HLA-G/KLRD1/C1S/HLA-F/PVR/STX4/CD46/LYN/ULBP3/CADM1/HLA-DOB/GAB2/NOD2/BCL10/CD40/IL7R/HLA-E/ULBP2/F2RL1/SHLD1/TRPM4/SYK/C8B/ADAM17/SHLD2/CEBPG/RNF168/HLA-B/HMOX1/SPON2/BCL3/TREM1/TRAF2/MALT1/IL4R/RAB27A/AHR/TUBB/TFRC/NECTIN2/CTSC/IL1R1/SWAP70/C2/IL18/C3/SHLD3/FADD/SLC15A4 |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE | 286 | 0.4339842 | 1.678562 | 0.0000071 | 0.0002568 | 0.0002072 | 3604 | PNPLA3/NTRK1/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/NR4A1/CACNB1/MIR200A/KLF2/IGF2/IL1B/VCAM1/KLF11/HDAC9/CEACAM1/SOCS2/NAMPT/NR4A3/EDN1/FYN/FOXC2/GDF15/MAP1B/CPEB2/RAB8B/SOCS1/TNF/STAT1/PCK2/SOCS3/ERRFI1/ADRB2/TLR4/ICAM1/ASS1/ENPP1/PRKCQ/GRB10/RARRES2/ANO1/SELENOS/MYC/CYP1B1/LYN/IRS2/DDX11/LDOC1/KL/LGMN/NOD2/MYO1C/MARS1/PTPN22/VIM/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/RIPK2/SRC/STAT5A/NOD1/LPIN2/CACNA1A/CCND3/YWHAG/SLC9A1/PIP4K2C/NDEL1/NCK1/NFKB1/PIK3C2A/CAV2/SLC25A33/ID1/PID1/ZBTB7B/CDC6/PTPN11/RAB12/SLC39A14/ZDHHC7/CAV1/MYO5A/GJB2/RANGAP1/CACNA2D1/GRB7/GNAI2/PIP4K2B/ARHGEF2/EPRS1/CFLAR/SP1/RELA/IRS1/CAPN10/SHC1/CRK |
| GOBP_DNA_GEOMETRIC_CHANGE | 92 | -0.5488463 | -1.984623 | 0.0000079 | 0.0002843 | 0.0002294 | 1109 | DSCC1/GINS1/MCMDC2/BRIP1/HMGB2/BLM/DNA2/RAD51/RECQL4/GINS2/CHD1L/POLQ/RAD54B/RAD54L/ERCC6L/CDC45/TOP2A |
| GOBP_POSITIVE_REGULATION_OF_CELL_DEATH | 483 | 0.3884589 | 1.578424 | 0.0000081 | 0.0002882 | 0.0002325 | 3012 | ZBP1/NTRK1/PCSK9/IL19/IFIT2/FZD9/IDO1/SLIT2/NR4A1/OLFM1/PNMA2/BBC3/MIR200A/ITGAM/SNCA/ASCL1/CCL5/PHLDA2/TNFRSF10A/KMO/HP/KLF11/THBS1/ZC3H12A/PTGS2/CNR1/NOX1/OSGIN1/PMAIP1/TNFRSF12A/FYN/DKK1/FOS/PLEKHN1/ADCY10/ADAM8/ANKRD1/EMILIN2/PML/ATF3/S100A8/TNF/RHOB/TNFRSF1B/RIPK3/LGALS1/NOS2/JUN/CD274/HDAC6/SPDEF/UBD/PEA15/BMP2/LGALS9/ALDH1A3/DDIT3/TGFB2/MEF2C/TLR4/ATF4/CCN1/CLEC7A/HLA-G/DUSP6/DAPK3/CDKN1A/S100A9/INHBA/INCA1/MYC/CYP1B1/CDKN2A/STK17B/LYN/AKAP12/PHLDA1/MAP3K9/ACER2/RNF122/GADD45A/DCUN1D3/SOX4/EEF1A2/BOK/BCL10/CD40/BID/DDIT4/USP27X/ANXA1/PTPN2/ID3/NFATC4/DLC1/PRELID1/SYK/PTRH2/ALDH1A2/SLC27A4/SQSTM1/HMOX1/MAP3K10/DAPK2/RIPK2/TRAF2/BTG1/CAPN2/TGFBR1/SRC/NOD1/FOSL1/FAS/IGFBP3/RBCK1/MSX2/EGR1/E2F3/TNFRSF10C/SYCE3/SLC9A1/UBE2Z/BAK1/CASP6/HYAL2/NCK1/CTSC/TRADD/TIGAR/SLFN11/DAB2IP/TNFRSF10B/FAP/MAP3K5/FADD/SAV1/ITGA6/RRP1B/CASP8/PPP2R1B/LATS2/PLCG1/SMPD1 |
| GOBP_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY | 35 | -0.7317180 | -2.193045 | 0.0000084 | 0.0002984 | 0.0002408 | 3340 | DNAAF5/DNAI3/DRC1/DNAAF10/CFAP100/ZMYND10/ODAD4/DNAAF11/DNAAF3/DNAAF4/DNAL1/ODAD1/CCDC40/ODAD3/CFAP73/DAW1/TTC12/DNAI1/DNAH7/CCDC39/CCDC65/TEKT2/LRRC49/DNAI4/DNAI2/DNAAF8/DNAH1/DNAH5/ODAD2/DNAAF6/DNAAF1/DNAH2 |
| GOBP_LEUKOCYTE_CELL_CELL_ADHESION | 278 | 0.4418485 | 1.702533 | 0.0000085 | 0.0003000 | 0.0002420 | 3215 | FGL2/EBI3/CD70/CERCAM/IDO1/TNFSF9/SLC39A8/SELL/CCL5/IGF2/FOXP3/NT5E/IL1B/VCAM1/ZC3H12A/IL23A/CEACAM1/CD177/NR4A3/FYN/PECAM1/IL4I1/ADAM8/CD83/TNFSF13B/IL1A/SOCS1/TNIP1/S100A8/IL1RL2/TNFRSF13C/TNF/LAG3/CARD11/LGALS1/CD55/VNN1/CD47/CD274/LGALS9/STK10/PTAFR/ICAM1/ASS1/HLA-G/PRKCQ/S100A9/KLF4/DUSP10/MSN/ADTRP/DUSP3/CD276/CD46/LYN/NFKBIZ/ARG2/HLA-DOB/TNFSF14/NFKBID/SELP/NOD2/ETS1/PELI1/SOX4/OLR1/BCL10/IL7R/HLA-E/IRAK1/MAP3K8/PTPN22/ITGB7/ANXA1/PTPN2/PDE5A/THY1/PNP/SYK/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NCK1/GCNT1/CEBPB/IRF1/IL18/FADD/ZBTB7B/ITGA5/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/GFUS/HLA-DMA/CAV1/CHST2/RUNX3 |
| GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION | 35 | 0.7370437 | 2.100867 | 0.0000087 | 0.0003019 | 0.0002436 | 2141 | LUM/SERPINB7/FOXP3/THBS1/PTGS2/CD34/CX3CL1/LGALS9/TGFB2/FERMT1/ITGB8/CD46/CD200/LTBP1/CDH3/SERPINF2/ITGAV/FURIN/ITGB6 |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE | 120 | 0.5508306 | 1.924112 | 0.0000091 | 0.0003133 | 0.0002528 | 2470 | FGL2/ISG15/OAS3/MICA/OAS1/FOXP3/IL1RL1/NLRC5/ZC3H12A/CEACAM1/FYN/USP18/IL4I1/CD55/LGALS9/C4BPA/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/PARP14/HLA-G/KLRD1/HLA-F/DUSP10/RHBDF2/IRAK3/SELENOS/CD46/TYRO3/LYN/MMP12/ARG2/STAT2/NOD2/IFI16/DHX58/IL7R/FCRLB/HLA-E/TRAFD1/ADAR/ANXA1/PTPN2/SYK/FURIN/HLA-B/HMOX1/SRC/IL4R/AHR |
| GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 54 | 0.6703952 | 2.078033 | 0.0000096 | 0.0003290 | 0.0002655 | 2005 | ISG15/OAS3/MICA/OAS1/NLRC5/CEACAM1/USP18/LGALS9/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/PARP14/HLA-G/KLRD1/HLA-F/DUSP10/IRAK3/TYRO3/MMP12/STAT2/IFI16/DHX58/HLA-E/TRAFD1/ADAR/PTPN2 |
| GOBP_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS | 17 | -0.8507884 | -2.171924 | 0.0000099 | 0.0003358 | 0.0002709 | 945 | ECRG4/ANAPC4/CDC20B/PLK1/CDC20/UBE2C |
| GOBP_ENDOTHELIAL_CELL_MIGRATION | 196 | 0.4770946 | 1.774880 | 0.0000101 | 0.0003431 | 0.0002768 | 3031 | FGFBP1/DLL4/PRSS3/SLIT2/NR4A1/FGF2/MIR200A/S100P/KDR/CCN3/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/SCARB1/EDN1/FOXC2/ANXA3/TNF/RHOB/VEGFA/STAT1/FGF1/ACVRL1/LOXL2/PDGFB/MEF2C/PTP4A3/RRAS/GREM1/KLF4/ADAMTS9/ADTRP/ATOH8/MET/CYP1B1/EGF/CSNK2B/ITGB3/WNT7A/FSTL1/LGMN/GADD45A/BMPER/SP100/ETS1/PLPP3/AKT3/CD40/ADGRB1/SCG2/SRF/ANXA1/GIPC1/CARD10/ADAM17/HDAC7/P2RX4/EPHB4/HMOX1/BCAR1/TMSB4X/TGFBR1/STAT5A/LPXN/EPHA2/MAP3K3/MAP2K3/PIK3C2A/GLUL/PLEKHG5/MYH9/ID1/DAB2IP/FAP/SRPX2/JUP/PLCG1/SPARC |
| GOBP_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION | 19 | 0.8294400 | 2.071200 | 0.0000108 | 0.0003642 | 0.0002939 | 2138 | LUM/SERPINB7/FOXP3/THBS1/PTGS2/CD34/CX3CL1/LGALS9/FERMT1/CD46/CD200/SERPINF2/FURIN |
| GOBP_DNA_REPLICATION_INITIATION | 37 | -0.7109489 | -2.167754 | 0.0000110 | 0.0003683 | 0.0002972 | 1540 | GMNN/GMNC/LRWD1/ORC6/MCIDAS/ORC1/CCNE1/CDT1/CCNE2/TICRR/MCM10/CDC45 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION | 99 | -0.5320265 | -1.937226 | 0.0000113 | 0.0003744 | 0.0003021 | 1641 | MAPK15/CENPJ/MTBP/CDC7/STOX1/FBXO5/EZH2/ANAPC4/CCNB1/ATAD5/NANOGP8/CDC25C/CDC25A/CDT1/ESPL1/FAM83D/CDK1/CDCA5/DLGAP5/RRM2/DTL/UBE2C |
| GOBP_REGULATION_OF_CELL_CELL_ADHESION | 345 | 0.4152753 | 1.639386 | 0.0000119 | 0.0003905 | 0.0003151 | 3215 | MUC21/FGL2/EBI3/CD70/IDO1/PLAUR/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/ZC3H12A/IL23A/CEACAM1/NR4A3/FYN/IL4I1/ADAM8/CD83/TNFSF13B/EMILIN2/IL1RN/IL1A/CX3CL1/SOCS1/IL1RL2/TNFRSF13C/TNF/CEACAM6/BMP6/VEGFA/LAG3/CARD11/LGALS1/CD55/VNN1/CD47/CD274/FOXA2/BMP2/LGALS9/PIEZO1/FSTL3/C1QTNF1/FXYD5/FUT3/PTAFR/ASS1/SH2B3/HLA-G/PRKCQ/KLF4/TENM3/PODXL/DUSP10/ADTRP/DUSP3/CD276/CD46/LYN/NFKBIZ/PRKG1/ARG2/HLA-DOB/TNFSF14/NFKBID/SELP/NOD2/ETS1/PELI1/SOX4/PLPP3/BCL10/EFNA5/IL7R/HLA-E/IRAK1/MAP3K8/PTPN22/ANXA1/PTPN2/SERPINF2/TJP1/PDE5A/ABCA12/THY1/PNP/SYK/CD9/MAPK7/RIPK2/SERPINE2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NCK1/SWAP70/CEBPB/IRF1/WNT4/IL18/EPCAM/CDH1/FADD/ZBTB7B/MYADM/HLA-A/BTN2A2/PTPN11/TGFBR2/JAK1/SIRPA/HLA-DMA/PDPN/FLOT1/CAV1/CHST2/RUNX3 |
| GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS | 330 | 0.4233081 | 1.669969 | 0.0000124 | 0.0004036 | 0.0003256 | 3319 | MVD/HMGCS1/ELOVL6/ACSS2/HMGCR/ALDOB/ACOT1/ACLY/SLC2A6/MLXIPL/ALDOC/HKDC1/MVK/ACSL1/XDH/SNCA/NUDT8/HSD17B12/SLC25A1/ACSL4/PANK3/NT5E/PANK1/PDE4C/NUDT10/ELOVL5/NUDT11/ADCY10/ELOVL7/G6PD/CARD11/ACACA/CDA/ENPP1/ELOVL1/ACOT2/MYC/ADCY4/ADCY5/UCKL1/ACOT9/ANTKMT/GALK1/ENO3/PPARGC1A/PTHLH/CTPS1/OGDH/GPAT4/UPP1/ACOT7/DDIT4/HACD2/PDE5A/PNP/ACSL5/PFKFB2/FAR2/PDE9A/ENTPD5/ELOVL4/NUDT16/BPGM/GUCY1A2/PMVK/TMSB4X/PDE8A/DGAT1/EPHA2/TJP2/DIP2A/TIGAR/FOXK2/NT5C2/GDA/SULT1B1/PRXL2C/PID1/PDHB/ADPGK/HK2/FLCN/PFKP/GUK1/HACD1/VCP/DLAT/FITM2/FAR1/ALDOA/DHODH/ADCY7/PPT1 |
| GOBP_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION | 81 | -0.5671035 | -2.016873 | 0.0000125 | 0.0004057 | 0.0003274 | 758 | MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/ESPL1/TTK/MAD2L1/NDC80/PLK1/BUB1/BUB1B/TOP2A |
| GOBP_CILIUM_MOVEMENT | 137 | -0.4931120 | -1.860512 | 0.0000133 | 0.0004280 | 0.0003454 | 3461 | KIF9/BBS4/CFAP20/DNAAF5/DNAI3/ADCY3/DRC1/CATSPER2/SLC26A8/SPAG6/CFAP100/ZMYND10/ODAD4/CFAP91/ARMC2/TTC29/CFAP251/DNAAF11/TTLL9/KIF27/CFAP47/AQP4/CFAP46/HOATZ/SPA17/TTLL3/BBS2/CFAP69/DNAAF4/CFAP58/ENO4/ODAD1/CCDC40/GAS2L2/CFAP52/CFAP54/RSPH9/ZBBX/DRC7/ODAD3/SPAG17/DZIP1/CFAP73/CFAP157/NME5/DAW1/TTC12/DNAI1/DNAH7/IQCG/SPEF2/CCDC39/DPCD/SPAG16/SLC22A16/CFAP61/TEKT3/ROPN1L/ROPN1B/CCDC65/HYDIN/CFAP206/TEKT2/TEKT1/RFX3/DNAH9/TTC21A/TCTE1/DNAI4/CFAP45/CFAP65/NEK10/DNAI2/CFAP44/TEKT4/MNS1/TEKT5/DNAH1/DNAH5/CFAP70/CFAP43/CFAP221/ODAD2/DNAAF6/DNAAF1/CFAP53/TTLL6/PLTP/CATSPERD/MEIG1/EPPIN |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 90 | 0.5850602 | 1.960550 | 0.0000137 | 0.0004395 | 0.0003546 | 2005 | FGL2/ISG15/OAS3/MICA/OAS1/FOXP3/NLRC5/CEACAM1/USP18/IL4I1/MICB/LGALS9/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/PARP14/HLA-G/KLRD1/HLA-F/DUSP10/IRAK3/TYRO3/TRIB1/MMP12/ARG2/STAT2/IFI16/DHX58/HLA-E/TRAFD1/ADAR/PTPN2 |
| GOBP_BLOOD_VESSEL_MORPHOGENESIS | 487 | 0.3869370 | 1.574846 | 0.0000146 | 0.0004622 | 0.0003730 | 3125 | S100A7/CXCL10/HYAL1/THSD7A/FGFBP1/DLL4/LDLR/CCR3/SLIT2/NR4A1/CXCL8/FGF2/XDH/KDR/EREG/KLF2/IL1B/ADM2/CCN3/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/YJEFN3/NOX1/STRA6/EDN1/TNFRSF12A/FOXC2/CLIC4/TYMP/ANGPTL4/SERPINE1/ADAM8/CD34/CXCL17/EMILIN2/IL1A/ANXA3/CX3CL1/PML/TNF/RHOB/FMNL3/VEGFA/WARS1/STAT1/MMP19/JUN/FGF1/ACVRL1/LOXL2/VASH2/TNFAIP2/PRDM1/TNFAIP3/ENG/EIF2AK3/TGFB2/CCN1/ADIPOR2/HLA-G/RRAS/RNF213/GREM1/KLF4/ADAMTS9/MFGE8/ITGB8/ADTRP/CYP1B1/EGF/NRCAM/ESM1/PLCD3/FLT1/ITGB3/WNT7A/COL22A1/GADD45A/BMPER/CEMIP2/SPHK1/SP100/ETS1/SOX4/AKT3/CD40/ADGRB1/ISL1/HSPG2/SCG2/COL8A2/SRF/ANXA1/SERPINF2/TJP1/ITGAV/CARD10/NFATC4/NIBAN2/MYDGF/THY1/SYK/NTRK2/HDAC7/TGFBI/MMP14/MAPK7/EPHB4/ADAMTS1/HMOX1/BTG1/SLC12A2/FLNA/TGFBR1/CALD1/TGFA/LRG1/F3/BAK1/JUNB/RAPGEF3/EPHA2/MAP3K3/WNT4/ACTG1/DAG1/PIK3C2A/GLUL/ECM1/IL18/MYH9/C3/ID1/DAB2IP/FAP/HK2/SARS1/CASP8/SRPX2/JUP/PLCG1/PKNOX1/ITGA5/SHB/SPARC/TGFBR2/JAK1/C1GALT1/ADGRG1/TWIST1 |
| GOBP_ISOPRENOID_BIOSYNTHETIC_PROCESS | 26 | 0.7744146 | 2.066951 | 0.0000154 | 0.0004853 | 0.0003916 | 1075 | MVD/HMGCS1/LSS/FDPS/HMGCR/IDI1/MVK/SRD5A3/BCO1/ALDH1A3 |
| GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION | 364 | 0.4024128 | 1.598766 | 0.0000155 | 0.0004853 | 0.0003916 | 3761 | HYAL1/FGFBP1/DLL4/PRSS3/SLIT2/SLC8A1/NR4A1/FGF2/MIR200A/S100P/KDR/SEMA3B/CCN3/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/SCARB1/SEMA3D/EDN1/FOXC2/ALX1/SEMA7A/ANXA3/PML/TNF/RHOB/VEGFA/STAT1/HBEGF/SOX9/JUN/FGF1/ACVRL1/HDAC6/LOXL2/DAAM2/ZEB2/ENG/PDGFB/TGFB2/MEF2C/PTP4A3/RRAS/GREM1/KLF4/ADAMTS9/FERMT1/DUSP10/ADAM9/ADTRP/ATOH8/MET/CYP1B1/EGF/AKAP12/CSNK2B/ITGB3/WNT7A/GNA12/FSTL1/LGMN/GADD45A/BMPER/SP100/ETS1/PLPP3/AKT3/CD40/RFFL/ADGRB1/ISL1/SCG2/ARSB/ITGB7/SRF/ANXA1/GIPC1/CARD10/TPBG/ADAM17/HDAC7/P2RX4/EPHB4/ILK/HMOX1/MAP4K4/BCAR1/ITGA3/TMSB4X/TGFBR1/CAP1/SRC/SEMA3A/STAT5A/LPXN/TACSTD2/MAPRE2/SYDE1/SEMA3C/EPHA2/HYAL2/MAP3K3/MAP2K3/PIK3C2A/GLUL/PLEKHG5/MYH9/DOCK5/RTN4/ID1/DAB2IP/FAP/ITGB4/SRPX2/JUP/PLCG1/SPARC/PTPN11/TGFBR2/GFUS/TWIST1/ACTA2/TESK1/PLK2/EMP2/RAB25/HAS2/IQGAP1/SP1/PKN2/PLEC/PFN1/KRT16/MACF1/SGPL1/AMOTL2/BMP4/RIC8A/RHOA/BMPR2/RAC1/TIMP1/SDC4 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS | 197 | -0.4453124 | -1.785554 | 0.0000172 | 0.0005343 | 0.0004311 | 2173 | SLF1/SOX15/SMPD3/RRM1/PRKCE/CEP120/SASS6/CIT/XRCC3/MAPK15/CENPJ/MTBP/DRD2/CDC7/CDC14A/MAP10/STOX1/RACGAP1/FBXO5/EZH2/ANAPC4/AURKA/MAD1L1/CCNB1/ATAD5/NANOGP8/CDC25C/CDC25A/KIF23/CDT1/RAD51AP1/ESPL1/E2F7/KIF14/KIF20B/FAM83D/MAD2L1/SPAG5/CDK1/NDC80/PLK4/CDCA5/DLGAP5/IGF1/RRM2/DTL/UBE2C |
| GOBP_RESPONSE_TO_INSULIN | 210 | 0.4632356 | 1.746000 | 0.0000173 | 0.0005343 | 0.0004311 | 3598 | PNPLA3/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/IGF2/IL1B/HDAC9/CEACAM1/NAMPT/FOXC2/EGR2/CPEB2/RAB8B/SOCS1/STAT1/PCK2/SOCS3/ERRFI1/TLR2/ENPP1/PRKCQ/GRB10/RARRES2/SELENOS/MYC/LYN/IRS2/KL/MYO1C/MARS1/SESN2/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/SRC/LPIN2/CCND3/YWHAG/EGR1/SLC9A1/PIP4K2C/NDEL1/NCK1/GCNT1/PIK3C2A/CAV2/SLC25A33/KBTBD2/PID1/ZBTB7B/MEAK7/PTPN11/RAB12/SLC39A14/ZDHHC7/MYO5A/GRB7/GNAI2/EPM2AIP1/PIP4K2B/EPRS1/CFLAR/SP1/IRS1/CAPN10/SHC1 |
| GOBP_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION | 141 | -0.4778623 | -1.815462 | 0.0000176 | 0.0005401 | 0.0004358 | 3640 | ALMS1/PARD6G/MAP9/BBS4/GCC2/NPM1/PARD6A/CHORDC1/CEP250/HAUS4/CCDC57/CEP44/CEP76/KIAA1614/RBM14/CEP135/HAUS1/SSX2IP/CEP295/FOXJ1/CHD3/STIL/BCAS3/DEUP1/HAUS5/MPDZ/CCDC61/DZIP1/PCM1/CEP120/TMEM67/CETN3/SASS6/CCP110/XRCC3/BRCA1/CENPJ/WDR62/CEP152/CETN2/CEP68/MDM1/MCIDAS/PCLAF/CCNF/CCDC78/KIF11/AURKA/CROCC/XRCC2/CDK1/NDC80/HEPACAM2/PLK1/NEK2/PLK4/SGO1 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS | 258 | -0.4061857 | -1.652553 | 0.0000198 | 0.0006029 | 0.0004865 | 1693 | XRCC3/JADE1/BRCA1/MTBP/MRNIP/EME1/GPNMB/MDM1/FBXO5/STK33/GJC2/BMP7/EZH2/BRIP1/CCNF/ORC1/GPER1/MAD1L1/E2F1/TRIP13/CCNB1/BLM/DNA2/ZWINT/PTTG1/CDT1/CENPF/CLSPN/ESPL1/E2F7/FBXO43/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/NEK2/BUB1/CDC45/DTL/GTSE1/BUB1B |
| GOBP_REGULATION_OF_VIRAL_GENOME_REPLICATION | 78 | 0.5964776 | 1.958688 | 0.0000201 | 0.0006101 | 0.0004923 | 866 | APOBEC3A/ISG15/RSAD2/IFITM1/IFIT1/OAS3/OASL/ISG20/CXCL8/OAS1/MX1/CCL5/OAS2/BST2/IFIH1/APOBEC3B/IFITM3/TNIP1/TNF/IFIT5 |
| GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS | 93 | 0.5619551 | 1.895567 | 0.0000205 | 0.0006182 | 0.0004988 | 1290 | PNPLA3/APOC1/PCSK9/INSIG1/LIPC/LIPG/LPIN1/LDLR/ACSL1/SNCA/SCARB1/MFSD2A/DGKI/PCK2/LIPH/APOBR/LIPE/GPAT3 |
| GOBP_LYMPHOCYTE_CHEMOTAXIS | 35 | 0.7246645 | 2.065581 | 0.0000207 | 0.0006188 | 0.0004993 | 1714 | S100A7/CXCL10/CXCL11/CCL22/CCL4/CCL20/CCL5/ADAM8/CX3CL1/CXCL16/SAA1/OXSR1/TNFSF14/CCL17/SLC8B1 |
| GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS | 230 | 0.4493609 | 1.709796 | 0.0000211 | 0.0006285 | 0.0005071 | 3396 | PNPLA3/MVD/HMGCS1/FDPS/FADS1/IDI1/LPIN1/MVK/PLA2G4C/FGF2/LCAT/SRD5A3/SOCS2/ABHD4/MFSD2A/PCYT2/SOCS1/SELENOI/IDH1/SOCS3/LIPH/PI4K2A/PDGFB/PISD/PLSCR1/GPAT3/PIGW/CHP1/ITPKC/SERINC4/LPCAT1/PIK3C2G/GPAT4/DHDDS/PIP4K2A/PIK3C2B/PMVK/CAPN2/HEXB/INPP5F/PIP4K2C/LPCAT4/MBOAT7/PIK3C2A/PGAP4/PIGA/CISH/TTC7A/PLA2G4A/SYNJ2/SGMS1/PIGZ/FITM2/PITPNM2/FAR1/PIGS/ABHD5/PIP4K2B/INPP1/PTDSS1 |
| GOBP_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 101 | 0.5544740 | 1.892903 | 0.0000213 | 0.0006304 | 0.0005087 | 3025 | ZBP1/EREG/CCL5/LBP/NLRC5/IRF7/SH2D1B/FYN/IFI35/ADAM8/GBP5/PARP9/LAG3/IKBKE/NMI/RAET1E/TRIM5/TLR4/CLEC7A/HLA-G/KLRD1/PLSCR1/HLA-F/PVR/LYN/CADM1/MMP12/NOD2/IFI16/AKIRIN2/HLA-E/USP27X/SYK/POLR3D/POLR3B/SRC/CASP6/NECTIN2/ZNFX1/FADD/SLC15A4/TIRAP |
| GOBP_ALPHA_BETA_T_CELL_PROLIFERATION | 31 | 0.7440556 | 2.065858 | 0.0000222 | 0.0006519 | 0.0005260 | 3060 | EBI3/IL23A/CD55/CD274/LGALS9/ARG2/MAPK8IP1/HLA-E/PTPN22/ELF4/SYK/RIPK2/TYK2/IL15/IRF1/IL18/ZBTB7B/HLA-A/TGFBR2 |
| GOBP_WOUND_HEALING | 337 | 0.4059146 | 1.601884 | 0.0000229 | 0.0006679 | 0.0005390 | 3947 | SPRR3/PLAUR/SERPINC1/FGF2/KDR/SLC7A11/EREG/PLAU/THBS1/CEACAM1/SCARB1/TFPI2/PROCR/PEAR1/EDN1/TNFRSF12A/FOXC2/PF4V1/SERPINE1/VWF/SERPINB2/CD34/DGKI/EMILIN2/IL1A/CX3CL1/OCLN/S100A8/TNF/VEGFA/DYSF/HBEGF/STXBP1/CLDN4/FGF1/ACVRL1/FOXA2/ENTPD2/RAP2B/SAA1/C1QTNF1/TNFAIP3/PDGFB/TGFB2/TLR4/CCN1/ADIPOR2/VCL/MYL9/CLEC7A/SH2B3/PLSCR1/PRKCQ/CDKN1A/FERMT1/LCP1/ADTRP/VKORC1/DUOX2/TYRO3/LYN/PHLDB2/PRKG1/CHMP7/ITGB3/WNT7A/MMP12/GNA12/BLOC1S3/COL1A1/SELP/CD151/PLPP3/ITPK1/CSRP1/CD40/ANXA8/CHMP6/MYL12A/CCN4/CDH3/SRF/ANXA1/F2RL1/KRT6A/SERPINF2/TFPI/SYK/ADAM17/CD9/TPM1/ITGB6/ILK/HMOX1/DCBLD2/SERPINE2/SLC12A2/FLNA/TGFBR1/SRC/PAFAH2/RHOC/TGFA/RAB27A/MSX2/F3/NRG1/CNN2/CLDN1/ACTB/C6orf89/WNT4/ACTG1/PPIA/DAG1/MYH9/FAP/MAP3K5/PLA2G4A/SMPD1/ITGA5/TGFBR2/GRHL3/PDPN/ACTA2/CAV1/CHMP1B/ST3GAL4/CHMP4C/EXT1/F12/CFLAR/ABAT/PLEC/PDGFRA/MACF1/CRK/HRAS/ALOX5/RHOA/PPL/TIMP1/SDC4/B4GALT1/SMAD3/SERPINA1/EVPL/HIF1A/PPARD/ACTN1/MRTFA/MYOF/CHMP2B/TEC/DST/SYT7/TSKU |
| GOBP_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | 207 | 0.4669593 | 1.756843 | 0.0000236 | 0.0006858 | 0.0005534 | 3060 | PLA2G3/TNFAIP6/FGL2/TNFSF9/LIF/EVI2B/FOXP3/IRF7/ZC3H12A/IL23A/CEACAM1/LRRC17/FOS/PRXL2A/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/SOCS1/IL1RL2/TNF/LAG3/CARD11/LGALS1/GPR68/VNN1/FANCA/LGALS9/FSTL3/PRDM1/TLR4/HLA-G/INHBA/DUSP10/TFE3/MYC/IL34/CSF1/CD46/LYN/NFKBIZ/TRIB1/PPARGC1B/IL15RA/NFKBID/SOX4/CTNNBIP1/TMEM176A/IL7R/KLF10/TOX/ZEB1/ANXA1/PTPN2/PRELID1/PNP/SYK/MMP14/TMEM176B/HLA-B/RIPK2/MALT1/IL4R/CD86/IL15/ZBTB46/CEBPB/IRF1/SOS2/IL18/FADD/ZBTB7B/CASP8/BTN2A2/TGFBR2 |
| GOBP_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA | 85 | 0.5815217 | 1.943007 | 0.0000271 | 0.0007799 | 0.0006293 | 2005 | CCL22/CCL4/CCL20/CCL5/NLRC5/SLC26A6/EDN1/GBP5/GBP2/CX3CL1/SOCS1/PARP9/TNF/STAT1/NOS2/STXBP1/GBP1/CD47/LGALS9/TLR2/NMI/TLR4/ASS1/PARP14/DAPK3/MYC/STX4/CCL17/SP100/MYO1C/GBP4/VIM/PTPN2 |
| GOBP_LYMPHOCYTE_MIGRATION | 72 | 0.6032070 | 1.959050 | 0.0000287 | 0.0008214 | 0.0006628 | 2149 | S100A7/CXCL10/CXCL11/CCL22/CCL4/CCL20/CCL5/ADAM8/CX3CL1/CXCL16/RIPK3/ARTN/SAA1/STK10/SPNS2/ICAM1/OXSR1/MSN/ADTRP/CD200/TNFSF14/CCL17/SLC8B1/ITGB7/ADAM17/XG |
| GOBP_RESPONSE_TO_PEPTIDE_HORMONE | 304 | 0.4243352 | 1.654817 | 0.0000299 | 0.0008510 | 0.0006866 | 3604 | PNPLA3/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/NR4A1/EREG/IGF2/IL1B/HDAC9/PTGS2/CEACAM1/SOCS2/NAMPT/NR4A3/EDN1/FOXC2/EGR2/GDF15/STC2/MAP1B/CPEB2/RAB8B/SOCS1/AREG/STAT1/PCK2/SOCS3/ERRFI1/TLR2/TRIM16/ASS1/ENPP1/JUND/PRKCQ/GRB10/RARRES2/SELENOS/MYC/CYP1B1/LYN/IRS2/KL/COL1A1/STAT2/MYO1C/MARS1/SESN2/PHEX/ANXA1/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/BTG1/SRC/STAT5A/LPIN2/CCND3/YWHAG/EGR1/SLC9A1/PIP4K2C/NDEL1/NCK1/GCNT1/NFKB1/DAG1/PIK3C2A/CAV2/SLC25A33/KBTBD2/PID1/ZBTB7B/MEAK7/CDC6/PNPT1/PTPN11/RAB12/SLC39A14/ZDHHC7/CAV1/MYO5A/GJB2/RANGAP1/GRB7/GNAI2/EPM2AIP1/PIP4K2B/EPRS1/CFLAR/SP1/RELA/IRS1/CAPN10/SHC1/CRK |
| GOBP_MICROTUBULE_BUNDLE_FORMATION | 106 | -0.5156886 | -1.884766 | 0.0000305 | 0.0008628 | 0.0006962 | 3340 | DNAAF5/DNAI3/DRC1/NCKAP5L/TPPP3/SPAG6/DNAAF10/CFAP100/ZMYND10/ODAD4/LRGUK/CFAP91/ARMC2/FOXJ1/DNAAF11/DNAAF3/CFAP47/CFAP46/HOATZ/TTLL3/BBS2/CFAP69/DNAAF4/DNAL1/CFAP58/CCDC66/ODAD1/CCDC40/GAS2L2/DNAJB13/RSPH9/DRC7/ODAD3/SPAG17/CFAP73/CFAP157/CC2D2A/DAW1/TTC12/DNAI1/RSPH1/DNAH7/IQCG/SPEF2/CCDC39/SPAG16/CCDC65/HYDIN/CFAP206/TEKT2/LRRC49/DNAI4/CFAP65/DNAI2/CFAP74/CFAP44/MNS1/DNAAF8/DNAH1/DNAH5/CFAP43/ODAD2/DNAAF6/RP1/DNAAF1/TTLL6/DNAH2/NCKAP5/MEIG1/PSRC1/CAPN6/PLK1/KIF20A |
| GOBP_REGULATION_OF_LYMPHOCYTE_ACTIVATION | 335 | 0.4088649 | 1.612035 | 0.0000311 | 0.0008742 | 0.0007054 | 3215 | FGL2/EBI3/CD70/THEMIS2/IDO1/TNFSF9/MICA/CCL5/CLCF1/IGF2/FOXP3/IL1B/VCAM1/ZC3H12A/IL23A/CEACAM1/FYN/CAMK4/IL4I1/ADAM8/CYP26B1/MYD88/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNFRSF13C/TNFRSF1B/LAG3/RIPK3/TICAM1/CARD11/LGALS1/CD55/VNN1/FANCA/CD47/CD274/LGALS9/PRDM1/TNFAIP3/MEF2C/TLR4/TNIP2/CLEC7A/HLA-G/PRKCQ/HLA-F/CDKN1A/INHBA/DUSP10/DUSP3/CD276/CD46/TYRO3/LYN/NFKBIZ/IRS2/ARG2/IL15RA/BLOC1S3/HLA-DOB/TNFSF14/NFKBID/MAPK8IP1/NOD2/PELI1/SOX4/BCL10/CD40/IL7R/HLA-E/MAP3K8/PTPN22/TOX/ZEB1/ANXA1/PTPN2/SHLD1/PRELID1/PDE5A/THY1/PNP/SYK/SHLD2/MMP14/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/AHR/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/SOS2/IL18/RHBDD3/SHLD3/FADD/SLC15A4/ZBTB7B/TIRAP/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/HLA-DMA/SH3KBP1/CAV1/RUNX3 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 205 | 0.4603584 | 1.726160 | 0.0000329 | 0.0009198 | 0.0007422 | 3102 | HYAL1/FGFBP1/DLL4/SLIT2/FGF2/MIR200A/KDR/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/SCARB1/EDN1/FOXC2/ANXA3/TNF/RHOB/VEGFA/HBEGF/SOX9/JUN/FGF1/ACVRL1/HDAC6/PDGFB/TGFB2/MEF2C/RRAS/KLF4/ADAMTS9/DUSP10/ADAM9/ATOH8/MET/EGF/CSNK2B/ITGB3/WNT7A/LGMN/GADD45A/BMPER/SP100/ETS1/PLPP3/AKT3/CD40/ADGRB1/ARSB/ANXA1/CARD10/ADAM17/HDAC7/P2RX4/HMOX1/MAP4K4/BCAR1/ITGA3/TMSB4X/SRC/SEMA3A/STAT5A/TACSTD2/MAPRE2/EPHA2/MAP3K3/MAP2K3/PIK3C2A/GLUL/DOCK5/RTN4/DAB2IP/SRPX2/JUP/PLCG1/SPARC/TGFBR2/GFUS |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION | 102 | 0.5494612 | 1.881490 | 0.0000353 | 0.0009807 | 0.0007913 | 2286 | S100A7/CXCL10/CCL4/CCL20/CXCL8/CCL5/LBP/THBS1/IL23A/EDN1/SERPINE1/ADAM8/CXCL17/IL1A/CX3CL1/TNF/VEGFA/CD47/LGALS9/PTAFR/ICAM1/OXSR1/RARRES2/IL34/CSF1/TNFSF14/SELP/LGMN/MAPK3/F2RL1/MOSPD2/THY1/ADAM17/XG/MMP14/P2RX4/DAPK2 |
| GOBP_MITOTIC_CELL_CYCLE_CHECKPOINT_SIGNALING | 124 | -0.4910530 | -1.830207 | 0.0000375 | 0.0010332 | 0.0008337 | 828 | XRCC3/BRCA1/MRNIP/EME1/STK33/ORC1/MAD1L1/TRIP13/CCNB1/BLM/ZWINT/CDT1/CENPF/CLSPN/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/BUB1/DTL/GTSE1/BUB1B |
| GOBP_POSITIVE_REGULATION_OF_CELL_ACTIVATION | 270 | 0.4288050 | 1.650773 | 0.0000376 | 0.0010332 | 0.0008337 | 3215 | PLA2G3/EBI3/CD70/TNFSF9/ITGAM/CCL5/CLCF1/LBP/IGF2/FOXP3/IL1RL1/IL1B/VCAM1/THBS1/IL23A/CD177/NR4A3/FYN/IL4I1/ADAM8/MYD88/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNFRSF13C/TNF/TICAM1/CARD11/LGALS1/CD55/VNN1/STXBP1/CD47/CD274/LGALS9/PLPP6/MEF2C/TLR4/PTAFR/TNIP2/CLEC7A/HLA-G/JUND/PRKCQ/HLA-F/CDKN1A/DUSP10/CD276/STX4/CD46/LYN/NFKBIZ/IRS2/IL15RA/BLOC1S3/HLA-DOB/TNFSF14/NFKBID/SELP/GAB2/NOD2/PELI1/SOX4/BCL10/CD40/IL7R/HLA-E/MAP3K8/PTPN22/TOX/ANXA1/F2RL1/SHLD1/THY1/PNP/SYK/SHLD2/MMP14/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NECTIN2/NCK1/CTSC/IL18/SHLD3/FADD/ZBTB7B/PLA2G4A/TIRAP/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/HLA-DMA/SH3KBP1/ACTA2/CAV1/RUNX3 |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION | 23 | -0.7538232 | -2.077560 | 0.0000385 | 0.0010507 | 0.0008478 | 537 | MTBP/HASPIN/CDT1/TTK/KNL1/CDK1/NDC80 |
| GOBP_CHROMOSOME_CONDENSATION | 40 | -0.6714381 | -2.074125 | 0.0000395 | 0.0010730 | 0.0008658 | 193 | GPER1/CDK1/PLK1/CDCA5/H1-5/H1-1/NCAPH/TOP2A/NCAPG |
| GOBP_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS | 55 | 0.6291240 | 1.951512 | 0.0000405 | 0.0010895 | 0.0008791 | 906 | ELOVL6/ACSS2/ACLY/ACSL1/SNCA/HSD17B12/SLC25A1/ACSL4/PANK3/PANK1/ELOVL5/ELOVL7/ACACA |
| GOBP_T_CELL_ACTIVATION | 362 | 0.4057908 | 1.606282 | 0.0000406 | 0.0010895 | 0.0008791 | 3215 | FGL2/EBI3/CD70/RSAD2/DLL4/IDO1/TNFSF9/MICA/CCL5/IGF2/FOXP3/IL1B/HSH2D/VCAM1/ZC3H12A/IL23A/CEACAM1/FYN/RELB/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNFRSF13C/TNFRSF1B/LAG3/RIPK3/CARD11/LGALS1/CD55/VNN1/FANCA/BATF/CD47/MICB/CD274/LGALS9/PRDM1/FKBP1B/IL18R1/ICAM1/CLEC7A/HLA-G/PRKCQ/DUSP10/LCP1/MSN/DUSP3/CD276/CD46/LYN/NFKBIZ/CADM1/BTN3A1/ARG2/HLA-DOB/TNFSF14/NFKBID/CD151/MAPK8IP1/NOD2/PELI1/SOX4/BCL10/CTPS1/IL7R/HLA-E/MAP3K8/PTPN22/TOX/SRF/ZEB1/ANXA1/PTPN2/F2RL1/ELF4/PRELID1/PDE5A/THY1/PNP/SYK/ADAM17/BCL3/RIPK2/SLC7A1/SRC/MALT1/IL4R/RAB27A/TYK2/CCND3/EGR1/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/WNT4/SOS2/IL18/MYH9/FADD/ZBTB7B/CASP8/RUNX2/PKNOX1/HLA-A/BTN2A2/PTPN11/KIF13B/TGFBR2/SIRPA/HLA-DMA/CAV1/FZD5/RUNX3 |
| GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR | 192 | 0.4651349 | 1.728842 | 0.0000409 | 0.0010910 | 0.0008803 | 3661 | HYAL1/CCL22/CD70/CCL4/SLC2A4/CCL20/CXCL8/HYAL3/CCL5/KLF2/VCAM1/THBS1/ZC3H12A/PTGS2/BIRC3/EDN1/TNFSF13B/GBP2/ANKRD1/CX3CL1/TNFRSF13C/TNF/CXCL16/TNFRSF1B/STAT1/NFKBIA/GBP1/PCK2/UBD/TNFAIP3/ASS1/GCH1/ADAM9/CYP1B1/TRAF1/AKAP12/ST18/COL1A1/CCL17/SPHK1/KRT18/CD40/RFFL/MAPK3/PTPN2/F2RL1/SYK/ADAM17/ILK/TRAF2/TMSB4X/GPS2/FAS/ZFP36/CLDN1/GBP3/HYAL2/TRADD/NFKB1/DAB2IP/PID1/MAP3K5/NKIRAS2/CASP8/SMPD1/TRAF5/NUB1/GSDME/TNFRSF1A/COMMD7/EXT1/HAS2/ARHGEF2/RELA/SHARPIN/TNFRSF25/AIM2/IL18BP/TRAF3IP2 |
| GOBP_TRIGLYCERIDE_METABOLIC_PROCESS | 69 | 0.6051059 | 1.966560 | 0.0000436 | 0.0011400 | 0.0009198 | 1290 | PNPLA3/APOC1/PCSK9/INSIG1/LIPC/LIPG/LPIN1/LDLR/ACSL1/SCARB1/MFSD2A/PCK2/LIPH/APOBR/LIPE/GPAT3 |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME | 88 | -0.5426552 | -1.950349 | 0.0000431 | 0.0011400 | 0.0009198 | 2301 | RUVBL2/FAM47E/SLF1/WRAP53/MTBP/MRNIP/LRWD1/IFFO1/EZH2/HASPIN/CDT1/TTK/KNL1/CDK1/NDC80/PLK1/ESCO2/CDCA5/H1-5 |
| GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS | 130 | 0.5070176 | 1.795190 | 0.0000437 | 0.0011400 | 0.0009198 | 1727 | PLA2G3/APOC1/DHCR7/INSIG1/FGFR4/LPIN1/MLXIPL/STARD4/LDLR/TRIB3/IL1B/PTGS2/CEACAM1/SCARB1/ELOVL5/MFSD2A/IL1A/TNF/BMP6/ACADL/IDH1/FGF1/BMP2/PDGFB/CCN1/CHP1/GFI1/LPCAT1/SPHK1/DAB2 |
| GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS | 274 | 0.4171700 | 1.605968 | 0.0000434 | 0.0011400 | 0.0009198 | 1359 | MVD/HMGCS1/ELOVL6/ACSS2/HYAL1/ACOT1/ACLY/CLIC3/MVK/ACSL1/GSTT2B/XDH/SNCA/NUDT8/HSD17B12/SLC7A11/SLC25A1/GGT7/ACSL4/CHAC1/CLIC2/ELOVL5/GGT5/ELOVL7/G6PD/OPLAH/MICAL2/ACACA/CHST1/IDH1/MTHFR/TPK1/SQOR/ENPP1/GLO1/CHPF/CBS/PAX8/ELOVL1/ACOT2 |
| GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY | 299 | 0.4231353 | 1.645987 | 0.0000456 | 0.0011819 | 0.0009537 | 3181 | THEMIS2/RSAD2/OAS3/OASL/TNIP3/OAS1/LAT2/LBP/FOXP3/CMTM3/IRF7/IFIH1/ZC3H12A/CEACAM1/C5AR2/BIRC3/IRAK2/NR4A3/FYN/PLPP4/IFI35/MYD88/TNIP1/TNF/TICAM1/CARD11/NFKBIA/GBP1/RFTN1/IKBKG/CD47/SLC15A3/MICB/LGALS9/LY96/UBASH3A/DDX60/TNFAIP3/TLR2/NMI/MEF2C/TLR4/TNIP2/CLEC7A/HLA-G/KLRD1/PLSCR1/PRKCQ/PTPRJ/IRAK3/DUSP3/CD276/TYRO3/LYN/NFKBIZ/BTN3A1/GFI1/NFKBID/NOD2/PELI1/BCL10/DHX58/CD40/IRAK1/PTPN22/TRIM25/PTPN2/F2RL1/RNF31/THY1/SYK/BCAR1/RIPK2/SRC/MALT1/NPLOC4/PRKCH/GPS2/SMPDL3B/NOD1/LPXN/RBCK1/LACC1/S100A14/NECTIN2/IRF1/MFHAS1/RTN4/DAB2IP/MAPKAPK2/SLC15A4/PLCG1/TIRAP/HLA-A/BTN2A2/BTN3A3/MAPKAPK3/FLOT1/RPS6KA3/CAV1 |
| GOBP_RESPONSE_TO_WOUNDING | 433 | 0.3814135 | 1.531297 | 0.0000471 | 0.0012146 | 0.0009801 | 2736 | NTRK1/PAX6/SPRR3/NREP/PLAUR/RTN4R/NTRK3/SERPINC1/FGF2/KDR/SLC7A11/EREG/PLAU/THBS1/CEACAM1/SCARB1/TFPI2/PROCR/PEAR1/EDN1/TNFRSF12A/FOXC2/PF4V1/SERPINE1/VWF/SERPINB2/CD34/DGKI/SCARF1/EMILIN2/MAP1B/IL1A/CX3CL1/OCLN/S100A8/TNF/VEGFA/DYSF/HBEGF/STXBP1/JUN/CLDN4/FGF1/ACVRL1/FOXA2/ENTPD2/RAP2B/SAA1/C1QTNF1/TNFAIP3/FKBP1B/PDGFB/TGFB2/TLR4/CCN1/ADIPOR2/VCL/MYL9/CLEC7A/SH2B3/PLSCR1/PRKCQ/CDKN1A/KLF4/FERMT1/INHBA/LCP1/ADTRP/MYC/VKORC1/DUOX2/TYRO3/LYN/PHLDB2/PRKG1/CHMP7/ITGB3/WNT7A/MMP12/GNA12/BLOC1S3/COL1A1/SELP/CD151/PLPP3/ITPK1/CSRP1/RIPOR1/CD40/ANXA8/ISL1/CHMP6/MYL12A/CCN4/CDH3/SRF/ANXA1/F2RL1/KRT6A/SERPINF2/ID3/TFPI/SYK/ADAM17/CD9/TPM1/ITGB6/P2RX4/ILK/HMOX1/DCBLD2/SERPINE2/SLC12A2/FLNA/TGFBR1/SRC/PAFAH2/RHOC/INPP5F/TGFA/RAB27A/MSX2/MAP2K1/F3/NRG1/CNN2/ZFP36/CLDN1/ACTB/NDEL1/C6orf89/WNT4/ACTG1/PPIA/DAG1 |
| GOBP_NON_MEMBRANE_BOUNDED_ORGANELLE_ASSEMBLY | 341 | -0.3678643 | -1.548310 | 0.0000489 | 0.0012555 | 0.0010131 | 3166 | HAUS4/RPS28/CCDC57/CDS1/CEP44/CENPW/CEP76/MAPRE3/RBM14/RPL3/CEP135/GOLGA8B/HAUS1/PIBF1/CNOT6L/RPS23/CEP295/RPL11/NOP53/HSPA1A/RPSA/GOLGA8A/STIL/RPL6/DEUP1/HAUS5/CEP97/RPS14/PUM2/TOGARAM2/CCDC61/RPL5/CENPC/C9orf72/CENPH/ABRAXAS1/CEP120/SASS6/CCP110/CAPN3/MAPK15/BRCA1/CENPJ/STARD9/WDR62/CEP152/CETN2/MAP10/MDM1/KLHL41/RACGAP1/ADPRHL1/FBXO5/MYLK3/NEB/MCIDAS/CCDC78/KIF11/AURKA/CSRP2/HCK/FLNC/CENPK/TNNT3/KIF23/CENPF/GOLGA8M/CSF2/KIF15/SPAG5/ANLN/NDC80/PLK1/CENPE/NEK2/CCNB2/PLK4/KIF4A/TPX2/DLGAP5/GOLGA8H/CDC20/KIFC1/ASPM/MYBL2 |
| GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION | 163 | 0.4816594 | 1.760941 | 0.0000494 | 0.0012603 | 0.0010169 | 2009 | PLA2G3/TNFAIP6/MT1G/FASN/LIF/EVI2B/BATF3/BATF2/IRF7/IL23A/CEACAM1/LRRC17/CSF3/IL31RA/RELB/FOS/PRXL2A/CAMK4/TNF/FAM20C/VEGFA/GPR68/JUN/BATF/UBD/LGALS9/FSTL3/TLR2/TLR4/GLO1/ITGB8/INHBA/TFE3/MYC/IL34/CSF1/LYN/TRIB1/PPARGC1B/GAB2/IFI16/CTNNBIP1/KLF10/CCN4/SBNO2/PTPN2/F2RL1 |
| GOBP_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS | 98 | 0.5484206 | 1.864628 | 0.0000560 | 0.0014209 | 0.0011465 | 980 | PLA2G3/APOC1/INSIG1/FGFR4/MLXIPL/STARD4/TRIB3/SNCA/SLC7A11/IL1B/PTGS2/CNR1/CEACAM1/ELOVL5/NR4A3/MFSD2A/BMP6/ACADL/SOX9/BMP2 |
| GOBP_AXONEME_ASSEMBLY | 78 | -0.5585574 | -1.960956 | 0.0000578 | 0.0014599 | 0.0011780 | 3340 | DNAAF5/DNAI3/DRC1/SPAG6/DNAAF10/CFAP100/ZMYND10/ODAD4/LRGUK/CFAP91/ARMC2/FOXJ1/DNAAF11/DNAAF3/CFAP47/CFAP46/HOATZ/TTLL3/BBS2/CFAP69/DNAAF4/DNAL1/CFAP58/ODAD1/CCDC40/DNAJB13/RSPH9/DRC7/ODAD3/SPAG17/CFAP73/CFAP157/CC2D2A/DAW1/TTC12/DNAI1/RSPH1/DNAH7/IQCG/SPEF2/CCDC39/SPAG16/CCDC65/HYDIN/CFAP206/TEKT2/LRRC49/DNAI4/CFAP65/DNAI2/CFAP74/CFAP44/MNS1/DNAAF8/DNAH1/DNAH5/CFAP43/ODAD2/DNAAF6/RP1/DNAAF1/DNAH2/MEIG1 |
| GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS | 209 | 0.4440940 | 1.671355 | 0.0000595 | 0.0014941 | 0.0012056 | 3323 | EBI3/CD70/RSAD2/BACH2/MICA/CLCF1/FOXP3/IL1RL1/IL1B/IRF7/ZC3H12A/IL23A/CEACAM1/NFKB2/RELB/IL4I1/ARID5A/MYD88/TNFSF13B/TNF/TNFRSF1B/RIPK3/CD55/RFTN1/BATF/UNC13D/CD274/C4BPA/TNFAIP3/IL18R1/MEF2C/TLR4/ICAM1/CLEC7A/HLA-G/KLRD1/C1S/PRKCQ/HLA-F/PVR/CD46/NFKBIZ/CADM1/HLA-DOB/NFKBID/NOD2/BCL10/CD40/IL7R/HLA-E/ANXA1/SHLD1/TRPM4/C8B/ADAM17/SHLD2/RNF168/HLA-B/BCL3/RIPK2/TRAF2/MALT1/IL4R/RAB27A/AHR/TFRC/NECTIN2/CTSC/IL1R1/SWAP70/C2/IL18/C3/SHLD3/FADD/SLC15A4/ZBTB7B/PLA2G4A/HLA-A/HLA-DMA/BTN3A3/FZD5/EMP2/MAD2L2/BTN3A2 |
| GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS | 63 | 0.5962516 | 1.909282 | 0.0000603 | 0.0015046 | 0.0012141 | 2425 | IDO1/SLC7A11/CCL5/HSH2D/IRF7/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/MEF2C/PRKCQ/SELENOS/CDKN2A/LYN/IRS2/ARG2/NOD2/BCL10/IL7R/ANXA1/PRELID1/ADAM17/PIP/ST3GAL1 |
| GOBP_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION | 42 | -0.6599689 | -2.068812 | 0.0000624 | 0.0015504 | 0.0012510 | 1115 | FBXO5/MAD1L1/TRIP13/CCNB1/ZWINT/PTTG1/CDT1/CENPF/TTK/MAD2L1/NDC80/PLK1/BUB1/BUB1B |
| GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS | 340 | 0.3959589 | 1.562439 | 0.0000691 | 0.0017071 | 0.0013774 | 3249 | MVD/HMGCS1/ELOVL6/ACSS2/HMGCR/ALDOB/ACOT1/ACLY/SLC2A6/MLXIPL/ALDOC/HKDC1/MVK/ACSL1/XDH/SNCA/NUDT8/HSD17B12/SLC25A1/ACSL4/PANK3/NT5E/PANK1/PDE4C/NUDT10/ELOVL5/NUDT11/ADCY10/ELOVL7/CARD11/NOS2/ACACA/ENPP1/ELOVL1/ACOT2/MYC/ADCY4/ADCY5/ACOT9/ANTKMT/GALK1/ENO3/GMPR/PPARGC1A/PTHLH/OGDH/GPAT4/ACOT7/DDIT4/HACD2/PDE5A/PNP/ACSL5/PFKFB2/FAR2/PDE9A/ENTPD5/ELOVL4/NUDT16/BPGM/GUCY1A2/PMVK/TMSB4X/PDE8A/DGAT1/LACC1/EPHA2/TJP2/DIP2A/TIGAR/FOXK2/NT5C2/GDA/SULT1B1/PRXL2C/PID1/PDHB/ADPGK/HK2/FLCN/PFKP/GUK1/HACD1/VCP/DLAT/FITM2/FAR1/ALDOA |
| GOBP_GLYCEROLIPID_METABOLIC_PROCESS | 322 | 0.4000542 | 1.572344 | 0.0000697 | 0.0017132 | 0.0013824 | 1340 | PLA2G3/PNPLA3/APOC1/PCSK9/INSIG1/LIPC/LIPG/LPIN1/LDLR/ACSL1/PLA2G4C/FGF2/LCAT/GPCPD1/SCARB1/SOCS2/PIP4P1/ABHD4/MFSD2A/DGKI/GALR2/PCYT2/SOCS1/SELENOI/TMEM86B/ENPP6/PCK2/SOCS3/LIPH/APOBR/MTMR11/PI4K2A/PDGFB/PISD/LIPE/GDPD3/PLSCR1/GPAT3/PLAAT1/PIGW/PGP |
| GOBP_REGULATION_OF_CHEMOTAXIS | 161 | 0.4726228 | 1.718628 | 0.0000728 | 0.0017807 | 0.0014368 | 2694 | S100A7/TNFAIP6/CXCL10/CCL4/SLIT2/NTRK3/CXCL8/FGF2/KDR/CCL5/LBP/SEMA3B/CCN3/THBS1/IL23A/C5AR2/SEMA3D/EDN1/SERPINE1/CXCL17/SEMA7A/STX3/VEGFA/FGF1/ARTN/LGALS9/PDGFB/PTPRO/GREM1/PLXNA3/OXSR1/RARRES2/DUSP3/MET/IL34/CSF1/STX4/LYN/TNFSF14/LGMN/SLC8B1/NOD2/DUSP1/SCG2/MAPK3/PTPN2/F2RL1/MOSPD2/TPBG/ADAM17/P2RX4/USP14/PLXNA4/DAPK2/TMSB4X/SEMA3A/ROBO2/F3/SEMA3C/S100A14/SWAP70 |
| GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE | 169 | 0.4691835 | 1.722894 | 0.0000738 | 0.0017943 | 0.0014478 | 2419 | TNFAIP6/FGL2/ISG15/LDLR/MVK/OAS3/MICA/OAS1/FOXP3/NT5E/NLRC5/CCN3/CEACAM1/FYN/USP18/CXCL17/CX3CL1/TNFRSF1B/SOCS3/MICB/LGALS9/SAA1/SERPINB4/TNFAIP3/SERPINB9/NMI/TRIM21/PARP14/HLA-G/KLRD1/HLA-F/KLF4/DUSP10/RHBDF2/IRAK3/SELENOS/TYRO3/LYN/CD200/MMP12/ARG2/STAT2/NOD2/FNDC4/IFI16/C1QTNF3/DHX58/HLA-E/ISL1/TRAFD1/ADAR/PTPN2/METRNL/SYK/FURIN/MAPK7/HLA-B/SRC/NPLOC4/GPS2/SMPDL3B |
| GOBP_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS | 87 | 0.5539909 | 1.853841 | 0.0000754 | 0.0018252 | 0.0014727 | 2105 | S100A7/TNFAIP6/CXCL10/CCL4/SLIT2/CXCL8/CCL5/LBP/CCN3/THBS1/IL23A/C5AR2/EDN1/SERPINE1/CXCL17/VEGFA/LGALS9/GREM1/OXSR1/RARRES2/IL34/CSF1/LYN/TNFSF14/LGMN/SLC8B1/NOD2/DUSP1/MAPK3/F2RL1/MOSPD2/ADAM17 |
| GOBP_KERATINOCYTE_DIFFERENTIATION | 101 | 0.5330497 | 1.819764 | 0.0000787 | 0.0018948 | 0.0015289 | 1457 | SPRR2E/SPRR2F/SPRR2A/S100A7/SPRR1A/PAX6/SPRR3/SPRR2D/EREG/IVL/CLIC4/CYP26B1/SFN/IL1A/SCEL/ERRFI1/ZBED2/KRT17/TRIM16/SPRR1B/ADAM9/OPN3 |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE_HORMONE_STIMULUS | 226 | 0.4464594 | 1.696410 | 0.0000824 | 0.0019723 | 0.0015914 | 3604 | PNPLA3/PCSK9/INSIG1/GRB14/LPIN1/SLC29A2/SLC2A4/TRIB3/NR4A1/IGF2/IL1B/HDAC9/CEACAM1/SOCS2/NAMPT/NR4A3/EDN1/FOXC2/GDF15/MAP1B/CPEB2/RAB8B/SOCS1/STAT1/PCK2/SOCS3/ERRFI1/ASS1/ENPP1/PRKCQ/GRB10/RARRES2/SELENOS/MYC/CYP1B1/LYN/IRS2/KL/MYO1C/MARS1/PTPN2/TBC1D4/BCAR3/GOT1/SLC27A4/PIP4K2A/GPT/BCAR1/SRC/STAT5A/LPIN2/CCND3/YWHAG/SLC9A1/PIP4K2C/NDEL1/NCK1/NFKB1/PIK3C2A/CAV2/SLC25A33/PID1/ZBTB7B/CDC6/PTPN11/RAB12/SLC39A14/ZDHHC7/CAV1/MYO5A/GJB2/RANGAP1/GRB7/GNAI2/PIP4K2B/EPRS1/CFLAR/SP1/RELA/IRS1/CAPN10/SHC1/CRK |
| GOBP_RESPONSE_TO_INTERFERON_ALPHA | 19 | 0.7943011 | 1.983454 | 0.0000860 | 0.0020487 | 0.0016531 | 2232 | IFIT2/MX2/IFITM1/IFIT3/BST2/IFITM3/LAMP3/EIF2AK2/ADAR/IFITM2 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION | 223 | 0.4439309 | 1.683512 | 0.0000913 | 0.0021628 | 0.0017452 | 3036 | MUC21/FGL2/IDO1/FOXP3/RND1/THBS1/ZC3H12A/CEACAM1/IL4I1/SERPINE1/IL1RN/CX3CL1/SOCS1/SPRY4/BMP6/VEGFA/LAG3/GBP1/ACVRL1/CD274/BMP2/LGALS9/C1QTNF1/FXYD5/PTPRO/MELTF/ASS1/SH2B3/HLA-G/KLF4/PLXNA3/PODXL/ADTRP/DUSP3/CYP1B1/CDKN2A/PHLDB2/PRKG1/MMP12/ARG2/COL1A1/ACER2/PELI1/EFNA5/PTPN22/DUSP1/ANXA1/PTPN2/PLXNA1/DLC1/PDE5A/ABCA12/CD9/SPOCK1/TGFBI/MMP14/MAPK7/PLXNA4/MAP4K4/SERPINE2/SRC/IL4R/LPXN/TACSTD2/CD86/ARHGDIA/SWAP70/CEBPB/IRF1/MUC1/EPCAM/CDH1/ZBTB7B/MYADM/BTN2A2/PTPN11 |
| GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION | 354 | 0.3945957 | 1.564132 | 0.0000965 | 0.0022763 | 0.0018368 | 3244 | HYAL1/EBI3/CD70/PLAUR/TNFSF9/LIF/KDR/HSD17B12/CCL5/IGF2/FOXP3/IL1B/VCAM1/IL23A/OLFM4/NR4A3/FYN/FOXC2/IL4I1/ADAM8/CD83/TNFSF13B/EMILIN2/IL1A/CX3CL1/SOCS1/IL1RL2/TNFRSF13C/TNF/CEACAM6/STX3/VEGFA/CARD11/LGALS1/CD55/VNN1/UNC13D/CD47/CD274/FOXA2/LGALS9/SAA1/PIEZO1/NEDD9/FSTL3/FUT3/CYTH3/PDGFB/TGFB2/PTAFR/CCN1/HLA-G/RRAS/PRKCQ/PTPRJ/TRIOBP/FERMT1/PODXL/DUSP10/VIT/ADAM9/TFE3/CD276/CSF1/RAC3/STX4/CD46/LYN/FRMD5/NFKBIZ/HLA-DOB/TNFSF14/NFKBID/SELP/NOD2/DAB2/ETS1/SOX4/PLPP3/BCL10/IL7R/HLA-E/IRAK1/MAP3K8/PTPN22/S100A10/ANXA1/SERPINF2/TJP1/ITGAV/THY1/PNP/SYK/TPM1/ILK/COL16A1/MAP4K4/RIPK2/SLC7A1/FLNA/ITGA3/SRC/MALT1/RHOD/IL4R/TYK2/ARPC2/TFRC/RSU1/CD86/IL15/NCK1/WNT4/DAG1/IL18/DOCK5/P4HB/FADD/ZBTB7B/MYADM/JUP/ITGA5/HLA-A/BTN2A2/PTPN11/TGFBR2/JAK1/SIRPA/FLCN/GFUS/ADGRG1/HLA-DMA/PDPN/FLOT1/CAV1/CHST2/RUNX3/TESK1 |
| GOBP_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS | 139 | 0.4919110 | 1.755936 | 0.0000975 | 0.0022883 | 0.0018464 | 2408 | ZBP1/ISG15/SLIT2/OAS3/OAS1/IL1R2/CCL5/NLRC5/IRF7/IFIH1/IRAK2/EDN1/USP18/IL1RN/SOCS1/PARP9/IKBKE/TNFAIP3/TLR2/TLR4/PARP14/SH2B3/KLF4/IRAK3/CSF1/MMP12/GFI1/PALM3/STAT2/SPHK1/RFFL/IRAK1/USP27X/ADAR/PTPN2/F2RL1/PXDN/SYK/ADAM17/MAPK7/RIPK2/TRAF2/GPS2 |
| GOBP_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING | 175 | 0.4628158 | 1.703306 | 0.0000999 | 0.0023319 | 0.0018816 | 3681 | S100A12/IL1B/BST2/BIRC3/FYN/MYD88/IL1A/CX3CL1/CASP10/TNF/TICAM1/CARD11/LGALS1/IFIT5/SLC20A1/IKBKG/UBD/LGALS9/IKBKE/TRIM21/TRIM5/TLR4/TNIP2/CLEC7A/TRIM14/SHISA5/SECTM1/NOD2/PELI1/BCL10/CD40/IRAK1/LURAP1L/TRIM25/F2RL1/RNF31/TAB3/CTH/HMOX1/RIPK2/TRIM22/TRAF2/GOLT1B/FLNA/MALT1/RHOC/NOD1/RBCK1/TMEM106A/TFRC/MAP3K3/TRADD/PLEKHG5/ECM1/TNFRSF10B/FADD/CASP8/TIRAP/TRAF5/MUL1/TRIM27/PLK2/TNFRSF1A/CFLAR/RELA/SHARPIN/S100A4/SLC44A2/TRAF3IP2/LITAF/RHOA |
| GOBP_DNA_REPLICATION_INDEPENDENT_CHROMATIN_ORGANIZATION | 32 | -0.6950848 | -2.048955 | 0.0001041 | 0.0024065 | 0.0019418 | 3093 | H4C2/CENPW/H4C6/NASP/H3-3A/H4C12/MIS18A/H4C4/H4C13/CENPP/H4C1/OIP5/H4C9/ASF1B/HJURP |
| GOBP_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING | 255 | 0.4300472 | 1.651154 | 0.0001041 | 0.0024065 | 0.0019418 | 3681 | S100A12/TNIP3/IL1B/BST2/ZC3H12A/BIRC3/IRAK2/EDN1/FYN/RELB/MYD88/IL1A/CX3CL1/CASP10/TNIP1/TNF/RIPK3/TICAM1/STAT1/CARD11/LGALS1/NFKBIA/IFIT5/SLC20A1/IKBKG/UBD/LGALS9/IKBKE/TNFAIP3/TLR2/TRIM21/TRIM5/TLR4/TNIP2/CLEC7A/TRIM14/TLE1/TRAF1/OPTN/SHISA5/SECTM1/NOD2/PELI1/BCL10/CD40/IRAK1/LURAP1L/TRIM25/F2RL1/RNF31/TAB3/SQSTM1/CTH/HMOX1/BCL3/RIPK2/TRIM22/TRAF2/GOLT1B/FLNA/MALT1/RHOC/NOD1/RBCK1/TMEM106A/TFRC/MAP3K3/TRADD/NFKBIB/PLEKHG5/ECM1/DAB2IP/TNFRSF10B/FADD/CARD19/NKIRAS2/CASP8/TIRAP/TRAF5/SIRPA/DDRGK1/MUL1/TRIM27/PLK2/TNFRSF1A/CFLAR/RELA/SHARPIN/S100A4/SLC44A2/TRAF3IP2/LITAF/RHOA |
| GOBP_PYRIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS | 33 | 0.7061658 | 1.981321 | 0.0001107 | 0.0025458 | 0.0020542 | 2094 | QPRT/IDO1/IDO2/ALPL/KYNU/SLC5A8/KMO/PSAT1/NAMPT/PARP9/NUDT17/HAAO/PDXK/NADK/PNP |
| GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS | 28 | 0.7379423 | 2.012460 | 0.0001147 | 0.0026255 | 0.0021185 | 2327 | APOC1/LPIN1/LDLR/SCARB1/MFSD2A/IDH1/PDGFB/CHP1/LPCAT1/ABCA3/CAPN2 |
| GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE | 52 | -0.5980795 | -1.929091 | 0.0001169 | 0.0026497 | 0.0021380 | 2420 | ANKRD31/C14orf39/MRE11/NCAPD3/NDC1/MSH5/PSMC3IP/SMC4/RNF212/SMC2/SYCP2/BRIP1/CCNE1/TRIP13/MAJIN/RAD51/SGO2/CCNE2/BUB1/DMC1/NCAPH/SGO1/BUB1B |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE | 267 | -0.3805732 | -1.554988 | 0.0001169 | 0.0026497 | 0.0021380 | 2196 | CITED2/SLF1/SOX15/SMPD3/RRM1/MEIS2/PRKCE/CEP120/CKS2/SASS6/CIT/XRCC3/MAPK15/CENPJ/MTBP/DRD2/CDC7/CDC14A/TGM1/MAP10/STOX1/RACGAP1/FBXO5/EZH2/MIR590/ANAPC4/AURKA/MAD1L1/CCNB1/ATAD5/NANOGP8/CDC25C/CDC25A/PSRC1/KIF23/CDT1/RAD51AP1/ESPL1/E2F7/KIF14/KIF20B/FAM83D/MAD2L1/SPAG5/CDK1/SMOC2/NDC80/PLK4/CDCA5/DLGAP5/IGF1/RRM2/DTL/UBE2C |
| GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION | 219 | -0.4031903 | -1.617718 | 0.0001188 | 0.0026785 | 0.0021613 | 1693 | XRCC3/JADE1/BRCA1/MRNIP/EME1/GPNMB/FBXO5/STK33/GJC2/EZH2/BRIP1/ORC1/MAD1L1/E2F1/TRIP13/CCNB1/BLM/DNA2/ZWINT/CDT1/CENPF/CLSPN/E2F7/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/BUB1/CDC45/DTL/GTSE1/BUB1B |
| GOBP_SERTOLI_CELL_DIFFERENTIATION | 13 | 0.8543487 | 1.967525 | 0.0001263 | 0.0028303 | 0.0022837 | 884 | NTRK1/SCX/IL1A/SOX9 |
| GOBP_POSITIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | 222 | 0.4464077 | 1.693379 | 0.0001267 | 0.0028303 | 0.0022837 | 3521 | NTRK1/S100A12/LPAR5/IL1B/RELN/LRP8/IRAK2/CSF3/EDN1/PPP2R5B/ADAM8/MYD88/ANXA3/CX3CL1/S100A8/TNF/TRIM31/VEGFA/RIPK3/TICAM1/CARD11/IKBKG/BMP2/LGALS9/IKBKE/TLR2/TRIM21/DDIT3/RTKN2/IL18R1/TRIM5/TLR4/CLEC7A/TRIM14/PRKCQ/GREM1/S100A9/EIF2AK2/DVL2/IRAK3/PSMA6/TRAF1/CD200/PPARGC1B/NOD2/SPHK1/PLPP3/PPARGC1A/BCL10/CD40/IRAK1/SLCO3A1/SRF/TRIM25/RNF31/CEBPG/CTH/RIPK2/TRIM22/TRAF2/MALT1/PRKCH/NOD1/FOSL1/RBCK1/TFRC/TRADD/RPS6KA4/PPIA/IL18/SAV1/JUP/TIRAP/TRAF5/DDRGK1/FLOT1/CAV1/MAP3K13/ARHGEF5/TRIM27/ARHGEF2/CFLAR/RELA/ZC4H2/CRTC3/ADCY1 |
| GOBP_REGULATION_OF_HEMOPOIESIS | 281 | 0.4097894 | 1.579660 | 0.0001288 | 0.0028633 | 0.0023103 | 2975 | PLA2G3/TNFAIP6/FGL2/ISG15/TCIM/TNFSF9/LIF/EVI2B/FOXP3/IRF7/ZC3H12A/IL23A/CEACAM1/LRRC17/CSF3/FOS/PRXL2A/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/SOCS1/IL1RL2/TNF/LAG3/STAT1/CARD11/LGALS1/NFKBIA/GPR68/MAPK11/VNN1/FANCA/LGALS9/FSTL3/PRDM1/MEF2C/TLR4/HLA-G/INHBA/DUSP10/TFE3/MYC/IL34/CSF1/CD46/LYN/NFKBIZ/TRIB1/PPARGC1B/IL15RA/NFKBID/ETS1/SOX4/CTNNBIP1/TMEM176A/IL7R/KLF10/TOX/ZEB1/ANXA1/PTPN2/PRELID1/PNP/SYK/MMP14/TMEM176B/HLA-B/RIPK2/MALT1/IL4R/ZFP36/CD86/IL15/ZBTB46/CEBPB/IRF1/SOS2/IL18/FAM210B/FADD/KLF13/ZBTB7B/CASP8 |
| GOBP_POSITIVE_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION | 44 | 0.6513918 | 1.928796 | 0.0001312 | 0.0029039 | 0.0023431 | 2105 | S100A7/CXCL10/CCL4/CCL20/CCL5/SERPINE1/ADAM8/CXCL17/TNF/CD47/LGALS9/OXSR1/TNFSF14/LGMN/MOSPD2/ADAM17 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE | 328 | -0.3607713 | -1.505696 | 0.0001382 | 0.0030436 | 0.0024559 | 1693 | XRCC3/JADE1/BRCA1/MTBP/MRNIP/GMNN/MYOCD/EME1/GMNC/GPNMB/MDM1/FBXO5/STK33/NUDT6/HEXIM2/BTG4/GJC2/BMP7/MCIDAS/EZH2/BRIP1/CCNF/ORC1/GPER1/MAD1L1/E2F1/TRIP13/CCNB1/BLM/GAS1/DNA2/CDKN2C/ZWINT/PTTG1/CDT1/CENPF/CLSPN/ESPL1/E2F7/FBXO43/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/NEK2/BUB1/CDC45/DTL/GTSE1/BUB1B |
| GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION | 104 | 0.5358419 | 1.842891 | 0.0001430 | 0.0031345 | 0.0025292 | 3006 | FGFBP1/DLL4/SLIT2/NR4A1/FGF2/MIR200A/KDR/HDAC9/THBS1/PTGS2/SCARB1/FOXC2/TNF/VEGFA/ACVRL1/PDGFB/MEF2C/GREM1/KLF4/ADTRP/CSNK2B/GADD45A/ETS1/AKT3/CD40/SRF/ANXA1/CARD10/ADAM17/HDAC7/P2RX4/EPHB4/HMOX1/TMSB4X/STAT5A/EPHA2/MAP3K3/MAP2K3/PIK3C2A/MYH9/ID1/SRPX2/JUP/PLCG1 |
| GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE | 359 | 0.3874059 | 1.536393 | 0.0001456 | 0.0031772 | 0.0025636 | 2541 | NTRK1/S100A7/ADRA1A/FGFR4/CCL22/CCL4/DOK6/CCL20/S100A12/NTRK3/FGF2/NCF1/XDH/LIF/KDR/MAPK8IP2/CCL5/IGF2/IL1B/KLB/THBS1/ZC3H12A/CAVIN3/NOX1/C5AR2/EDN1/DKK1/GDF15/ADAM8/MYD88/CXCL17/SEMA7A/IL1A/CX3CL1/TNF/VEGFA/JUN/GRM1/FGF1/BMP2/LGALS9/FGD2/C1QTNF1/PDGFB/TGFB2/ADRB2/TRIM5/TLR4/ICAM1/CLEC7A/PTPRJ/IL11/ADAM9/EIF2AK2/DVL2/IL34/ABCA7/EGF/TRAF1/AKAP12/FLT1/WNT7A/KL/DOK4/SHC2/GADD45A/MAPK8IP1/BMPER/CCL17/NOD2/SPHK1/CD40/IRAK1/PTPN22/MST1R/PDGFC/GPR37L1/MAPK3/F2RL1/SERPINF2/TPBG/MYDGF/PDE5A/SYK/NTRK2/BCAR3/SPAG9/ERP29/MAP3K10/GAREM1/RIPK2/TRAF2/TGFBR1/SRC/SEMA3A/NOD1/TGFA/TMEM106A/MAP2K1/PDE8A/NRG1 |
| GOBP_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY | 464 | 0.3689653 | 1.490456 | 0.0001484 | 0.0032238 | 0.0026012 | 3851 | NTRK1/ADRA1A/RGS7/CCL22/CCL4/CCL20/RGS16/RTN4R/NTRK3/FGF2/BBC3/XDH/SNCA/ADPRH/CCL5/PMAIP1/FYN/NLRP2/CX3CL1/CASP10/PML/RASGRP3/S100A8/TNF/VEGFA/RIPK3/TBC1D3D/PSME4/CLDN4/ARHGAP11B/BMP2/LGALS9/NEDD9/EIF2AK3/MEF2C/PTAFR/SNX9/DOCK10/ADAP2/CCN1/CLEC7A/S100A9/TIAM2/DVL2/GNA15/MYC/LYN/ASAP3/ST18/CD200/FLT1/GNA12/PPARGC1B/DDX11/NGEF/LPAR2/PCOLCE2/ACER2/LGMN/CCL17/IFI16/AKIRIN2/BOK/BCL10/PRSS22/CD40/GMIP/BID/RHOG/RGS10/S100A10/F2RL1/ARHGAP27/DLC1/PRELID1/THY1/SYK/TBC1D4/BCAR3/NDUFA13/RAP1GAP/SLC27A4/DOCK6/TNFSF15/MAP4K4/CASP5/RIPK2/NLRP1/MALT1/RHOC/NOD1/FAS/PLAA/ARF4/ADAP1/SYDE2/F3/MAPRE2/BAK1/RSU1/CD86/RAPGEF3/SYDE1/EPHA2/NDEL1/TBC1D25/TBC1D10A/C6orf89/ASAP2/WNT4/SOS2/CAV2/RPS27L/RAP1GAP2/MAP3K5/FADD/ITGA6/CASP8/PSME2/FLCN/DDRGK1/GRHL3/MUL1/VCP/CAV1/RANGAP1/ARHGEF5/TBC1D22B/ABL2/ABHD5/TBC1D10B/ARHGAP29/TBC1D17/CFLAR/BCL2L13/TBC1D1/BIN1/PDGFRA/TGM2/PICALM/CRK/HRAS/PPP1R15B/AIM2/RGP1/MAPK12/APH1A/RHOA/RGS14/SGSM3/ARHGEF10/RAPGEF1/TMEM106B/CHN1/GSK3B/PIP5K1A/SMAD3/MMUT/CORO1C |
| GOBP_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 153 | -0.4414726 | -1.710430 | 0.0001503 | 0.0032482 | 0.0026210 | 1693 | XRCC3/JADE1/BRCA1/MRNIP/GPNMB/FBXO5/GJC2/EZH2/ORC1/MAD1L1/TRIP13/CCNB1/BLM/ZWINT/CDT1/CENPF/CLSPN/E2F7/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/BUB1/DTL/GTSE1/BUB1B |
| GOBP_ACUTE_INFLAMMATORY_RESPONSE | 68 | 0.5748697 | 1.865659 | 0.0001560 | 0.0033561 | 0.0027080 | 2818 | LBP/IL1B/SERPINA3/VCAM1/HP/PTGS2/CNR1/IL31RA/ADAM8/IL1A/S100A8/TNF/VNN1/SAA1/OSMR/APOL2/PTGES/ASS1/PLSCR1/SAA2/SELENOS/C2CD4A/KL/CTNNBIP1/HLA-E/SERPINF2/TREM1/F3/TFRC/CEBPB/RHBDD3/C3 |
| GOBP_COENZYME_A_METABOLIC_PROCESS | 18 | 0.7885310 | 1.952658 | 0.0001571 | 0.0033650 | 0.0027152 | 410 | HMGCR/ACLY/NUDT8/PANK3/PANK1 |
| GOBP_THIOESTER_BIOSYNTHETIC_PROCESS | 40 | 0.6609781 | 1.922589 | 0.0001583 | 0.0033747 | 0.0027230 | 906 | ELOVL6/ACSS2/ACLY/ACSL1/SNCA/HSD17B12/SLC25A1/ACSL4/ELOVL5/ELOVL7/ACACA |
| GOBP_REGULATION_OF_SECRETION | 429 | 0.3802824 | 1.524832 | 0.0001603 | 0.0034013 | 0.0027445 | 2252 | PLA2G3/ACHE/CYP51A1/HMGCR/ADRA1A/RSAD2/SYT2/TTN/HYAL3/LIF/SYT1/ITGAM/SNCA/CCL5/ACSL4/OAS2/IL1B/KMO/CCN3/CHRNB4/SYT17/CNR1/CEACAM1/CD177/EDN1/AACS/ADAM8/ANKRD1/IL1A/RAB8B/S100A8/TNF/BMP6/TNFRSF1B/NOS2/GPR68/STXBP1/ADGRE2/SGK1/PCK2/UNC13D/FOXA2/BMP2/LGALS9/SAA1/C1QTNF1/FKBP1B/TLR2/KLF7/TGFB2/PTGES/MEF2C/TLR4/PTAFR/CBARP/LRRC8A/HLA-F/IL11/INHBA/PAX8/RHBDF2/ADAM9/GPR27/ADTRP/ANO1/EGF/STX4/ATP13A2/LYN/ADCY5/RAB11FIP1/TPCN2/CD200/WNT7A/LLGL2/IRS2/GAB2/SLC8B1/DAB2/C1QTNF3/SOX4/CFTR/MICAL1/EFNA5/ZBED6/ISL1/RAB27B/CHMP6/FAM3D/ENSA/GABBR1/ANXA1/F2RL1/GLUD1/DNAJC1/GIPC1/TRPM4/HAP1/TRPV6/ABCA12/SYK/PFKFB2/STX1A/RAB11FIP5/P2RX4/RALA/ERP29/DOC2B/HMOX1 |
| GOBP_ACETYL_COA_METABOLIC_PROCESS | 29 | 0.7123267 | 1.962284 | 0.0001671 | 0.0035145 | 0.0028358 | 288 | MVD/HMGCS1/ACSS2/ACLY/MVK/NUDT8 |
| GOBP_ACUTE_PHASE_RESPONSE | 29 | 0.7122948 | 1.962196 | 0.0001671 | 0.0035145 | 0.0028358 | 1334 | LBP/IL1B/SERPINA3/HP/PTGS2/CNR1/IL1A/TNF/SAA1/APOL2/PTGES/ASS1/PLSCR1/SAA2 |
| GOBP_CELLULAR_KETONE_METABOLIC_PROCESS | 160 | 0.4705810 | 1.709587 | 0.0001689 | 0.0035372 | 0.0028541 | 980 | PLA2G3/APOC1/INSIG1/FGFR4/MLXIPL/STARD4/IDO1/TRIB3/IDO2/SNCA/SLC7A11/KYNU/IL1B/KMO/PTGS2/CNR1/CEACAM1/CYP46A1/ELOVL5/NR4A3/MFSD2A/BMP6/ACADL/SOX9/BMP2 |
| GOBP_T_CELL_PROLIFERATION | 153 | 0.4688922 | 1.692180 | 0.0001730 | 0.0036052 | 0.0029090 | 3060 | EBI3/CD70/IDO1/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/IL23A/FYN/IL4I1/TNFSF13B/IL1A/TNFRSF13C/TNFRSF1B/RIPK3/CARD11/CD55/CD274/LGALS9/FKBP1B/HLA-G/PRKCQ/MSN/CD276/CD46/CADM1/BTN3A1/ARG2/TNFSF14/CD151/MAPK8IP1/PELI1/CTPS1/HLA-E/PTPN22/ANXA1/ELF4/PDE5A/PNP/SYK/RIPK2/SLC7A1/MALT1/TYK2/CCND3/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/WNT4/SOS2/IL18/FADD/ZBTB7B/HLA-A/BTN2A2/TGFBR2 |
| GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS | 32 | 0.7033259 | 1.957194 | 0.0001758 | 0.0036482 | 0.0029437 | 1854 | PLA2G3/PNPLA3/LPIN1/ABHD4/LIPH/GPAT3/LPCAT1/GPAT4 |
| GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT | 123 | 0.4991942 | 1.750668 | 0.0001870 | 0.0038635 | 0.0031174 | 3125 | HYAL1/CCR3/CXCL8/FGF2/KDR/IL1B/ADM2/THBS1/ZC3H12A/FOXC2/ANGPTL4/SERPINE1/CD34/EMILIN2/IL1A/ANXA3/RHOB/VEGFA/FGF1/ACVRL1/VASH2/ENG/RRAS/GREM1/KLF4/ITGB8/CYP1B1/FLT1/BMPER/SPHK1/ETS1/AKT3/CD40/ISL1/TJP1/MYDGF/HMOX1/BTG1/LRG1/F3/RAPGEF3/ECM1/C3/HK2/JUP/PLCG1/ITGA5/TGFBR2/JAK1/TWIST1 |
| GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS | 31 | 0.7064890 | 1.961555 | 0.0001902 | 0.0039119 | 0.0031565 | 826 | PLA2G3/APOC1/INSIG1/MLXIPL/TRIB3/IL1B/PTGS2/CEACAM1/ELOVL5/ACADL |
| GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE | 191 | 0.4554215 | 1.691456 | 0.0001912 | 0.0039149 | 0.0031589 | 2462 | PLA2G3/FGL2/TCIM/ITGAM/LAT2/CLCF1/LBP/FOXP3/ZC3H12A/IL23A/CEACAM1/SH2D1B/CD177/NR4A3/IFI35/RELB/MYD88/ANXA3/TICAM1/DYSF/LGALS1/STXBP1/ADGRE2/BATF/UNC13D/LGALS9/NMI/IL18R1/TLR4/PTAFR/ICAM1/DOCK10/CLEC7A/HLA-F/LCP1/STX4/CD46/LYN/NFKBIZ/NFKBID/GAB2/CD40/SBNO2/ANXA1/F2RL1/SHLD1/SYK/SHLD2/RNF168/HMOX1/BCL3/RIPK2/MALT1/ST3GAL1/IL4R/RAB27A |
| GOBP_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY | 38 | 0.6744023 | 1.945690 | 0.0001926 | 0.0039272 | 0.0031688 | 2005 | ZBP1/ISG15/OAS3/OAS1/NLRC5/IRF7/USP18/IKBKE/MMP12/STAT2/USP27X/ADAR/PTPN2 |
| GOBP_ERK1_AND_ERK2_CASCADE | 237 | 0.4279093 | 1.633412 | 0.0001954 | 0.0039658 | 0.0031999 | 2119 | NTRK1/S100A7/ADRA1A/FGFR4/CCL22/CCL4/CCL20/DUSP5/NTRK3/FGF2/LIF/KDR/CCL5/ROS1/IL1B/CAVIN3/CEACAM1/C5AR2/EDN1/CXCL17/SEMA7A/IL1A/CX3CL1/ATF3/TNIP1/SPRY4/TNF/CHRNA10/SOX9/GBP1/JUN/FGF1/BMP2/LGALS9/ERRFI1/PDGFB/TLR4/ICAM1/CCN1/RRAS/DUSP6/SPRY1/DUSP10/GRB10/DUSP3/MYC/ABCA7/EGF/LYN/AKAP12/ACE2/BMPER/CCL17/NOD2/DAB2/PTPN22/PDGFC/MAPK3/PTPN2/F2RL1/SERPINF2/ITGAV/TPBG/SYK/NTRK2 |
| GOBP_INTRACILIARY_TRANSPORT | 36 | -0.6814082 | -2.059130 | 0.0001979 | 0.0039992 | 0.0032269 | 3781 | BBS12/TUB/ARL3/WDR19/RABL2B/TRAF3IP1/IFT74/DYNC2I1/SSX2IP/DYNLT2B/IFT43/DYNC2LI1/IFT52/IFT122/IFT140/IFT57/IFT27/WDR35/PCM1/IFT88/LCA5/IFT81/RPGR/IFT172/TTC21A/DYNC2H1/TTC21B/LCA5L |
| GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS | 450 | 0.3721207 | 1.501424 | 0.0002021 | 0.0040665 | 0.0032812 | 3295 | PNPLA3/PCSK9/INSIG1/GRB14/LPIN1/EBI3/SLC29A2/SLC2A4/TRIB3/SLIT2/NR4A1/ACSL1/NPC1/IGF2/FOSB/IL1B/NR2E3/HDAC9/CEACAM1/GNG2/SOCS2/NAMPT/NR4A3/EDN1/FOXC2/FOS/GDF15/ARID5A/MAP1B/CPEB2/RAB8B/SOCS1/STAT1/UCN2/PRLR/SGK1/ACACA/PCK2/SOCS3/HDAC6/PMEPA1/ERRFI1/SERPINB9/MEF2C/ASS1/ADIPOR2/ENPP1/PRKCQ/WBP2/INHBA/PAX8/GRB10/RARRES2/ADTRP/SELENOS/MYC/CYP1B1/LYN/CSNK2B/SFR1/IRS2/PPARGC1B/KL/DAB2/MYO1C/MARS1/EFNA5/ISL1/PHEX/DDIT4/ANXA1/PTPN2/TFPI/TBC1D4/BCAR3/GOT1/SLC5A5/SLC27A4/PIP4K2A/GPT/BCAR1/SRC/KDM4C/STAT5A/LPIN2/CCND3/YWHAG/ROBO2/IGFBP7/SLC9A1/ZFP36/AKAP8/PIP4K2C/NDEL1/NCK1/NFKB1/PIK3C2A/CAV2/SLC25A33/PID1/PAQR8/PGRMC2/NEDD4/ZBTB7B/LATS2/NSMF/VPS18/CDC6/PTPN11/RAB12/CACNA1H/DDRGK1/SLC39A14/ZDHHC7/CAV1/MYO5A/GJB2/RANGAP1/GNB1/GRB7/GNAI2 |
| GOBP_CENTROMERIC_SISTER_CHROMATID_COHESION | 11 | -0.8705264 | -2.003857 | 0.0002074 | 0.0041566 | 0.0033539 | 363 | AXIN2/SGO2/BUB1/SGO1/BUB1B |
| GOBP_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 14 | -0.8248562 | -2.001125 | 0.0002170 | 0.0043289 | 0.0034930 | 758 | MAD1L1/CDT1/NDC80/CENPE/NUF2/KIF2C |
| GOBP_REGULATION_OF_T_CELL_ACTIVATION | 248 | 0.4106785 | 1.570633 | 0.0002187 | 0.0043449 | 0.0035059 | 3215 | FGL2/EBI3/CD70/IDO1/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/ZC3H12A/IL23A/CEACAM1/FYN/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNFRSF13C/TNFRSF1B/LAG3/RIPK3/CARD11/LGALS1/CD55/VNN1/FANCA/CD47/CD274/LGALS9/PRDM1/HLA-G/PRKCQ/DUSP10/DUSP3/CD276/CD46/LYN/NFKBIZ/ARG2/HLA-DOB/TNFSF14/NFKBID/MAPK8IP1/NOD2/PELI1/SOX4/BCL10/IL7R/HLA-E/MAP3K8/PTPN22/TOX/ZEB1/ANXA1/PTPN2/PRELID1/PDE5A/THY1/PNP/SYK/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/SOS2/IL18/FADD/ZBTB7B/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/HLA-DMA/CAV1/RUNX3 |
| GOBP_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 12 | -0.8473021 | -1.972223 | 0.0002261 | 0.0044354 | 0.0035789 | 1174 | RACGAP1/CCNB1/SPAG5/NEK2 |
| GOBP_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS | 50 | 0.6346280 | 1.920333 | 0.0002249 | 0.0044354 | 0.0035789 | 2252 | FGFBP1/DLL4/SLIT2/NR4A1/FGF2/KDR/HDAC9/THBS1/PTGS2/FOXC2/VEGFA/GREM1/KLF4/ADTRP/AKT3/SRF/ANXA1/CARD10/HDAC7/EPHB4/HMOX1 |
| GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS | 67 | 0.5771196 | 1.866109 | 0.0002254 | 0.0044354 | 0.0035789 | 884 | PLA2G3/APOC1/INSIG1/MLXIPL/TRIB3/SNCA/IL1B/PTGS2/CNR1/CEACAM1/ELOVL5/NR4A3/MFSD2A/ACADL/SOX9 |
| GOBP_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY | 27 | 0.7181646 | 1.941007 | 0.0002310 | 0.0045122 | 0.0036408 | 2718 | ZBP1/IL1R2/IL1B/IRAK2/MYD88/IL1RN/IL1RL2/TNIP2/IRAK3/ST18/IRAK1/MAPK3/EGR1/IL1R1/RPS6KA4 |
| GOBP_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY | 40 | 0.6501961 | 1.891227 | 0.0002330 | 0.0045335 | 0.0036580 | 2437 | PLA2G3/CXCL6/ITGAM/CD177/CAMK4/TICAM1/STXBP1/ADGRE2/UNC13D/LGALS9/PTAFR/STX4/LYN/GAB2/HLA-E/F2RL1/SYK/HMOX1/IL4R |
| GOBP_PROTEIN_LOCALIZATION_TO_CONDENSED_CHROMOSOME | 18 | -0.7833819 | -2.016042 | 0.0002423 | 0.0046948 | 0.0037882 | 537 | MTBP/HASPIN/CDT1/TTK/KNL1/CDK1/NDC80 |
| GOBP_KERATINIZATION | 28 | 0.7236879 | 1.973587 | 0.0002707 | 0.0052220 | 0.0042136 | 1326 | SPRR2E/SPRR2F/SPRR2A/SPRR1A/SPRR3/SPRR2D/IVL/CYP26B1/SFN/IL1A/KRT17/SPRR1B |
| GOBP_KINETOCHORE_ORGANIZATION | 22 | -0.7494002 | -2.056496 | 0.0002776 | 0.0052894 | 0.0042679 | 2062 | SMC4/CENPC/CENPH/SMC2/CENPK/CDT1/CENPF/NDC80/CENPE/DLGAP5/NUF2 |
| GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE | 138 | 0.4727582 | 1.688980 | 0.0002774 | 0.0052894 | 0.0042679 | 3379 | RSAD2/CLCF1/FOXP3/IL1RL1/IL1B/IRF7/ZC3H12A/IL23A/CEACAM1/IL4I1/ARID5A/TNFSF13B/TNF/TNFRSF1B/RIPK3/CD55/CD274/C4BPA/TNFAIP3/IL18R1/MEF2C/CLEC7A/HLA-G/KLRD1/PRKCQ/HLA-F/PVR/DUSP10/CD46/NFKBIZ/NFKBID/NOD2/CD40/IL7R/HLA-E/ANXA1/SHLD1/TRPM4/SHLD2/HLA-B/RIPK2/TRAF2/MALT1/IL4R/AHR/TFRC/NECTIN2/IL1R1/IRF1/IL18/C3/SHLD3/FADD/SLC15A4/ZBTB7B/PLA2G4A/HLA-A/FZD5/TRIM27/ADCY7/MAD2L2/MR1 |
| GOBP_EPIDERMAL_CELL_DIFFERENTIATION | 151 | 0.4603292 | 1.657375 | 0.0002756 | 0.0052894 | 0.0042679 | 1457 | SPRR2E/SPRR2F/SPRR2A/S100A7/SPRR1A/PAX6/SPRR3/SPRR2D/EREG/MAFF/IVL/CLIC4/CYP26B1/SFN/IL1A/FA2H/OVOL1/SCEL/ERRFI1/ZBED2/KLF7/KRT17/TRIM16/KLF4/SPRR1B/TRIOBP/ADAM9/OPN3 |
| GOBP_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 80 | -0.5224518 | -1.840351 | 0.0002789 | 0.0052927 | 0.0042707 | 1590 | CENPJ/MTBP/CDC7/STOX1/FBXO5/ANAPC4/CCNB1/CDC25C/CDC25A/CDT1/ESPL1/CDK1/CDCA5/DLGAP5/RRM2/DTL/UBE2C |
| GOBP_INDOLALKYLAMINE_METABOLIC_PROCESS | 10 | 0.8726233 | 1.863066 | 0.0002858 | 0.0054020 | 0.0043588 | 1470 | IDO1/IDO2/KYNU/KMO/IL4I1/HAAO |
| GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 136 | 0.4720814 | 1.677113 | 0.0002991 | 0.0056310 | 0.0045436 | 3102 | HYAL1/FGFBP1/FGF2/MIR200A/KDR/HDAC9/THBS1/ZC3H12A/PTGS2/SCARB1/EDN1/FOXC2/ANXA3/RHOB/VEGFA/HBEGF/SOX9/JUN/FGF1/HDAC6/PDGFB/TGFB2/RRAS/ADAM9/ATOH8/MET/EGF/ITGB3/WNT7A/LGMN/ETS1/PLPP3/AKT3/CD40/ANXA1/ADAM17/HDAC7/P2RX4/HMOX1/MAP4K4/BCAR1/ITGA3/TMSB4X/SRC/STAT5A/MAPRE2/MAP3K3/MAP2K3/PIK3C2A/DOCK5/RTN4/SRPX2/PLCG1/SPARC/TGFBR2/GFUS |
| GOBP_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS | 26 | 0.7220012 | 1.927057 | 0.0003033 | 0.0056867 | 0.0045885 | 1885 | QPRT/IDO1/IDO2/KYNU/SLC5A8/KMO/PSAT1/NAMPT/PARP9/HAAO/PDXK/NADK |
| GOBP_HORMONE_TRANSPORT | 203 | 0.4338852 | 1.621545 | 0.0003058 | 0.0057109 | 0.0046080 | 2148 | PLA2G3/LIF/CCL5/ACSL4/IL1B/SLCO4A1/CCN3/CNR1/EDN1/AACS/CLTRN/SLCO1B1/IL1RN/RAB8B/TNF/BMP6/NOS2/GPR68/PCK2/FOXA2/C1QTNF1/FKBP1B/KLF7/LRRC8A/IL11/INHBA/PAX8/GPR27/ANO1/STX4/LYN/ADCY5/RAB11FIP1/IRS2/SLC8B1/DAB2/C1QTNF3/SOX4/CFTR/EFNA5/ZBED6/ISL1/CRYM/FAM3D/ENSA/GABBR1/ANXA1/GLUD1/NIBAN2/TRPM4/TRPV6/ABCA12/PFKFB2/STX1A/RAB11FIP5 |
| GOBP_REGULATION_OF_LYMPHOCYTE_MIGRATION | 44 | 0.6367903 | 1.885560 | 0.0003210 | 0.0059712 | 0.0048181 | 1714 | S100A7/CXCL10/CCL4/CCL20/CCL5/ADAM8/RIPK3/STK10/OXSR1/MSN/ADTRP/CD200/TNFSF14/SLC8B1 |
| GOBP_T_CELL_CYTOKINE_PRODUCTION | 26 | 0.7195550 | 1.920528 | 0.0003314 | 0.0061400 | 0.0049543 | 3192 | RSAD2/FOXP3/IL1B/ARID5A/TNFRSF1B/CD55/IL18R1/HLA-F/TRPM4/TRAF2/MALT1/IL1R1/IL18/HLA-A/FZD5 |
| GOBP_RESPONSE_TO_EXTRACELLULAR_STIMULUS | 367 | 0.3775645 | 1.500357 | 0.0003436 | 0.0063407 | 0.0051163 | 1996 | NTRK1/PCSK9/SGIP1/CXCL10/FADS1/LIPG/LDLR/SLC8A1/ACSL1/ALPL/ASCL1/KYNU/VCAM1/KIF26A/ZC3H12A/PTGS2/CNR1/PMAIP1/CDKN2B/FOS/GDF15/STC2/MFSD2A/CYP26B1/MAP1LC3B2/MAP1B/IL1A/DSC2/ATF3/G6PD/TNF/STAT1/SREBF2/UCN2/TPH2/PCK2/FOXA2/MTHFR/FKBP1B/EIF2AK3/DDIT3/ADRB2/ATF4/ASS1/GABARAPL1/CDKN1A/SLC25A25/CBS/EIF2AK2/CYP1B1/LYN/PIM1/KL/WIPI1/COL1A1/NOD2/IFI16/PPARGC1A/MARS1/NOCT/BCL10/RIPOR1/KLF10/SESN2/HTR4/PHEX/UPP1/ENSA/ARSB/SRF/TRIM25/ZEB1/MAPK3 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION | 224 | 0.4244581 | 1.613140 | 0.0003469 | 0.0063771 | 0.0051456 | 3215 | EBI3/CD70/PLAUR/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/IL23A/NR4A3/FYN/IL4I1/ADAM8/CD83/TNFSF13B/EMILIN2/IL1A/CX3CL1/SOCS1/IL1RL2/TNFRSF13C/TNF/CEACAM6/CARD11/LGALS1/CD55/VNN1/CD47/CD274/FOXA2/LGALS9/PIEZO1/FSTL3/FUT3/PTAFR/HLA-G/PRKCQ/PODXL/DUSP10/CD276/CD46/LYN/NFKBIZ/HLA-DOB/TNFSF14/NFKBID/SELP/NOD2/ETS1/SOX4/PLPP3/BCL10/IL7R/HLA-E/IRAK1/MAP3K8/PTPN22/ANXA1/SERPINF2/TJP1/THY1/PNP/SYK/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NCK1/IL18/FADD/ZBTB7B/HLA-A/BTN2A2/PTPN11/TGFBR2/JAK1/SIRPA/HLA-DMA/PDPN/FLOT1/CAV1/CHST2/RUNX3 |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 69 | 0.5673061 | 1.843712 | 0.0003499 | 0.0064066 | 0.0051695 | 2470 | FGL2/MICA/FOXP3/BST2/ZC3H12A/CEACAM1/IL4I1/TNF/CD55/CD47/LGALS9/C4BPA/SERPINB4/SERPINB9/TGFB2/HLA-G/KLRD1/HLA-F/DUSP10/IRAK3/CD46/NOD2/IL7R/HLA-E/ANXA1/HLA-B/HMOX1/IL4R/AHR |
| GOBP_MYELOID_CELL_DIFFERENTIATION | 318 | 0.3859634 | 1.511602 | 0.0003661 | 0.0066776 | 0.0053881 | 3060 | PLA2G3/TNFAIP6/MT1G/ISG15/FASN/LIF/EVI2B/KLF2/BATF3/BATF2/IRF7/IL23A/CEACAM1/LRRC17/CSF3/IKZF1/CDKN2B/IL31RA/RELB/FOS/PRXL2A/CAMK4/CDKN1C/FLVCR1/PML/G6PD/TNF/FAM20C/VEGFA/STAT1/NFKBIA/GPR68/MAPK11/JUN/BATF/UBD/LGALS9/FSTL3/TLR2/MEF2C/TLR4/SH2B3/GLO1/IL11/ITGB8/INHBA/TFE3/MYC/IL34/CSF1/LYN/TRIB1/FLI1/PPARGC1B/GAB2/ETS1/IFI16/CTNNBIP1/KLF10/SLC11A2/CCN4/ADAR/SBNO2/SRF/PTPN2/F2RL1/ITGB6/CEBPG/PIP4K2A/BPGM/SRC/TFRC/JUNB/ZFP36/IL15/EPHA2/ZBTB46/CEBPB/MFHAS1/MYH9/TMOD3/FAM210B/FADD/KLF13/ERCC2/CASP8/PKNOX1/TIRAP/PTPN11/TGFBR2 |
| GOBP_CENTROMERE_COMPLEX_ASSEMBLY | 30 | -0.6848709 | -1.996767 | 0.0003783 | 0.0067426 | 0.0054405 | 648 | H3-3A/CENPC/MIS18A/CENPH/CENPP/HELLS/CENPK/CENPF/OIP5/CENPE/DLGAP5/HJURP |
| GOBP_MITOTIC_SISTER_CHROMATID_COHESION | 26 | -0.7009907 | -1.955982 | 0.0003765 | 0.0067426 | 0.0054405 | 1109 | DSCC1/HASPIN/CDCA5/CDC20/SGO1 |
| GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION | 24 | 0.7315028 | 1.916119 | 0.0003776 | 0.0067426 | 0.0054405 | 1633 | S100A7/CXCL10/CCL4/CCL20/CCL5/ADAM8/OXSR1/TNFSF14 |
| GOBP_FATTY_ACYL_COA_METABOLIC_PROCESS | 32 | 0.6869693 | 1.911677 | 0.0003776 | 0.0067426 | 0.0054405 | 3319 | ELOVL6/ACSL1/NUDT8/HSD17B12/SLC25A1/ACSL4/ELOVL5/ELOVL7/ACACA/ELOVL1/ACOT7/HACD2/ACSL5/FAR2/ELOVL4/DGAT1/HACD1/FITM2/FAR1/PPT1 |
| GOBP_B_CELL_ACTIVATION | 184 | 0.4422579 | 1.637372 | 0.0003784 | 0.0067426 | 0.0054405 | 2605 | NTRK1/CD70/THEMIS2/FZD9/LAT2/CLCF1/FOXP3/KLF6/BST2/VCAM1/HDAC9/IL4I1/TNFSF13B/TNFRSF13C/TICAM1/CARD11/LGALS1/BATF/TNFAIP3/MEF2C/TLR4/TNIP2/DOCK10/LRRC8A/CDKN1A/PTPRJ/IL11/INHBA/DNAJB9/LYN/IRS2/NOD2/PELI1/CTPS1/CD40/IL7R/PTPN2/SHLD1/SYK/ADAM17/SHLD2/CEBPG/MMP14/RNF168/BCL3/MALT1/GPS2/ST3GAL1/AHR/BAK1/TFRC/CMTM7/CD86 |
| GOBP_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS | 396 | 0.3708885 | 1.481330 | 0.0003742 | 0.0067426 | 0.0054405 | 2666 | ACHE/ELOVL6/CDHR1/SGIP1/LPIN1/SCD/MLXIPL/ALOXE3/ACSL1/PCDH15/SCX/OAS1/SLC39A8/KDR/ALPL/CNGB1/IL1B/SERPINA3/PTGS2/CNR1/ADAMTS5/NR4A3/FOXC2/PECAM1/ADAM8/MFSD2A/CYP26B1/LIPA/CD34/SFN/ESAM/IL1A/FA2H/OCLN/TNF/ZG16B/BMP6/VEGFA/ACADL/SOX9/PRLR/ACACA/CLDN4/TMPRSS11F/TP53INP2/TNFAIP3/DDIT3/IL18R1/PTGES/ADRB2/TLR4/ATF4/ADIPOR2/VCL/MFAP2/ELOVL1/GRB10/TFE3/MET/CSF1/RAC3/PLCL1/ITGB3/PPARGC1B/LCN2/MYO5B/LPCAT1/PIWIL4/NOD2/CFTR/PPARGC1A/AKT3/SLC11A2/PDGFC/CDH3/SRF/METRNL/TJP1/ABCA12/SYK/ADAM17/CLDN12/ITGB6/P2RX4/LSR/SQSTM1/LAMC1/ABCA3/SLC12A2/KRAS/PIP/SRC/APBB2/IL4R/EGR1/GRHL1/ACADVL/TFRC/CLDN1/ACTB/IL15/HYAL2/NOVA1/TJP2 |
| GOBP_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 15 | -0.8139781 | -2.002999 | 0.0003809 | 0.0067618 | 0.0054560 | 1641 | MAPK15/ANAPC4/CDT1/ESPL1/DLGAP5 |
| GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE | 64 | 0.5613376 | 1.803637 | 0.0003853 | 0.0068140 | 0.0054981 | 758 | DEFB4A/S100A7/CXCL10/CXCL11/CXCL9/PRSS3/S100A12/CXCL2/CXCL6/CXCL3/CXCL8/PI3/CXCL5/DEFB1/CXCL1/PGLYRP4/PF4V1/KLK7 |
| GOBP_ANTIMICROBIAL_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_ANTIMICROBIAL_PEPTIDE | 43 | 0.6418616 | 1.889615 | 0.0003898 | 0.0068682 | 0.0055419 | 1012 | DEFB4A/S100A7/CXCL10/CXCL11/CXCL9/S100A12/CXCL2/CXCL6/CXCL3/CXCL8/CXCL5/DEFB1/CXCL1/PGLYRP4/PF4V1/KLK7/PGLYRP3 |
| GOBP_NEGATIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 39 | -0.6428854 | -1.980237 | 0.0003926 | 0.0068741 | 0.0055467 | 1115 | FBXO5/MAD1L1/TRIP13/CCNB1/ZWINT/CDT1/CENPF/TTK/MAD2L1/NDC80/PLK1/BUB1/BUB1B |
| GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE | 76 | 0.5492611 | 1.797363 | 0.0003931 | 0.0068741 | 0.0055467 | 2798 | RSAD2/FOXP3/IL1B/BST2/NR4A3/CAMK4/ARID5A/SEMA7A/TNF/TNFRSF1B/TICAM1/CD55/TGFB2/IL18R1/TLR4/CLEC7A/HLA-G/HLA-F/IRAK3/NOD2/BCL10/HLA-E/F2RL1/TRPM4/HMOX1/SPON2/TREM1/TRAF2/MALT1/SLC7A5/LACC1/IL1R1/IL18 |
| GOBP_REGULATION_OF_CELL_MORPHOGENESIS | 262 | 0.4106489 | 1.582147 | 0.0003977 | 0.0069284 | 0.0055904 | 3791 | ARC/SYT2/SYT1/KDR/NTNG1/UNC13A/RND1/RELN/LRP8/SYT17/STRIP2/RNF157/OLFM4/FYN/MFSD2A/CDC42EP1/SPRY4/RHOB/FMNL3/VEGFA/GBP1/CLDN4/UNC13D/RND3/FGD2/NEDD9/PLEKHO1/MELTF/RHOF/DAPK3/PLXNA3/TRIOBP/MSN/DVL2/RAC3/GNA12/EPB41/DBN1/DAB2/PRAG1/EFNA5/RHOG/S100A10/NTNG2/CDC42EP3/ANXA1/PLXNA1/PARP6/DLC1/TPM1/SPAG9/PLXNA4/ILK/FLNA/FBLIM1/SRC/ATP10A/HEXB/RHOD/RHOC/PLAA/TACSTD2/ITSN2/ARPC2/DIAPH1/RHOBTB3/DAG1/RASAL1/FGD6/MYH9/DOCK5/CDC42EP5/P4HB/MYADM/SPARC/MYH14/MUL1/PDPN/SH3KBP1/CFL1/MAP3K13/FITM2/TESK1/ALDOA/CDC42SE1/HAS2/GRIP1/WASHC2C/MACF1/CRK/SMURF1/WDR1/RHOA/FGD4/RAC1/RAC2/STRIP1/PALM2AKAP2 |
| GOBP_REGULATION_OF_RECEPTOR_RECYCLING | 20 | 0.7665114 | 1.942323 | 0.0004042 | 0.0070165 | 0.0056615 | 1468 | ACHE/PCSK9/LDLR/SNCA/ECE1/OPTN |
| GOBP_ENDOTHELIUM_DEVELOPMENT | 108 | 0.5015915 | 1.738881 | 0.0004343 | 0.0075094 | 0.0060593 | 2022 | CXCL10/DLL4/FASN/XDH/KDR/FOXP3/IL1B/CEACAM1/FOXC2/PECAM1/CLIC4/MYD88/CD34/TNF/BMP6/RHOB/VEGFA/FGF1/ACVRL1/RAP2B/HOXB5/ICAM1/VCL/PLOD3/MSN/ATOH8/MET/CSNK2B/FSTL1/COL22A1/ZEB1/F2RL1/TJP1 |
| GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION | 142 | -0.4317744 | -1.645693 | 0.0004372 | 0.0075318 | 0.0060774 | 1724 | CIT/BRCA1/MRNIP/PKMYT1/CDC7/NEK10/STOX1/FBXO5/KDM8/ORC1/AURKA/CCNB1/ATAD5/BLM/CDC25C/CCNA2/CDC25A/CENPF/CLSPN/KIF14/MELK/TICRR/FBXL22/CDK1/NDC80/FOXM1/PLK1/CCNB2/DTL |
| GOBP_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY | 142 | 0.4588213 | 1.643391 | 0.0004483 | 0.0076946 | 0.0062087 | 3181 | RSAD2/OAS3/OASL/TNIP3/OAS1/LBP/IRF7/IFIH1/BIRC3/IRAK2/IFI35/MYD88/TNIP1/TNF/TICAM1/NFKBIA/RFTN1/SLC15A3/LGALS9/LY96/DDX60/TNFAIP3/TLR2/NMI/TLR4/TNIP2/CLEC7A/IRAK3/TYRO3/LYN/GFI1/NOD2/PELI1/BCL10/DHX58/CD40/IRAK1/PTPN22/TRIM25/F2RL1/RIPK2/NPLOC4/GPS2/SMPDL3B/NOD1/LACC1/S100A14/IRF1/MFHAS1/RTN4/DAB2IP/MAPKAPK2/SLC15A4/TIRAP/MAPKAPK3/FLOT1/RPS6KA3/CAV1 |
| GOBP_POSITIVE_REGULATION_OF_HEMOPOIESIS | 120 | 0.4921583 | 1.719163 | 0.0004710 | 0.0080550 | 0.0064995 | 3060 | PLA2G3/TNFSF9/LIF/EVI2B/FOXP3/IL23A/FOS/IL4I1/ADAM8/CD83/SOCS1/IL1RL2/TNF/LGALS1/GPR68/VNN1/LGALS9/HLA-G/DUSP10/IL34/CSF1/CD46/NFKBIZ/TRIB1/PPARGC1B/IL15RA/NFKBID/SOX4/CTNNBIP1/IL7R/KLF10/TOX/ANXA1/PNP/SYK/MMP14/RIPK2/MALT1/IL4R/CD86/IL15/ZBTB46/IL18/FADD/ZBTB7B/CASP8/BTN2A2/TGFBR2 |
| GOBP_INTERLEUKIN_2_PRODUCTION | 47 | 0.6192443 | 1.852877 | 0.0004852 | 0.0082675 | 0.0066710 | 2605 | FOXP3/IL1B/CD83/CD34/IL1A/LAG3/CARD11/GBP1/HOMER3/TNFAIP3/CLEC7A/PRKCQ/NOD2/ANXA1/PNP/HDAC7/RIPK2/TRAF2/MALT1/ZFP36/CD86 |
| GOBP_HUMORAL_IMMUNE_RESPONSE | 130 | 0.4701054 | 1.664495 | 0.0005032 | 0.0085127 | 0.0068688 | 1474 | DEFB4A/S100A7/CXCL10/CXCL11/EBI3/CXCL9/PRSS3/S100A12/CXCL2/CXCL6/CXCL3/CXCL8/PI3/CXCL5/IL1B/DEFB1/CXCL1/PGLYRP4/PF4V1/CD83/KLK7/TNF/COLEC10/CD55/CFB/PGLYRP3/C4BPA/SPNS2/MEF2C/C1S/S100A9/RARRES2/TFE3/CD46 |
| GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION | 153 | 0.4558189 | 1.645000 | 0.0005032 | 0.0085127 | 0.0068688 | 3102 | FGFBP1/DLL4/SLIT2/FGF2/MIR200A/KDR/HDAC9/THBS1/ZC3H12A/PTGS2/CEACAM1/SCARB1/EDN1/FOXC2/ANXA3/TNF/RHOB/VEGFA/FGF1/ACVRL1/PDGFB/MEF2C/RRAS/KLF4/ADAMTS9/ATOH8/MET/EGF/CSNK2B/ITGB3/WNT7A/LGMN/GADD45A/BMPER/SP100/ETS1/PLPP3/AKT3/CD40/ADGRB1/ANXA1/CARD10/ADAM17/HDAC7/P2RX4/HMOX1/BCAR1/TMSB4X/STAT5A/EPHA2/MAP3K3/MAP2K3/PIK3C2A/GLUL/DAB2IP/SRPX2/JUP/PLCG1/SPARC/GFUS |
| GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY | 35 | 0.6641021 | 1.892955 | 0.0005055 | 0.0085199 | 0.0068746 | 2470 | MICA/FOXP3/CEACAM1/IL4I1/CD55/LGALS9/C4BPA/SERPINB4/SERPINB9/HLA-G/KLRD1/HLA-F/CD46/NOD2/IL7R/HLA-E/HLA-B/AHR |
| GOBP_POSITIVE_REGULATION_OF_ION_TRANSPORT | 181 | 0.4451013 | 1.647003 | 0.0005096 | 0.0085484 | 0.0068976 | 1177 | PLA2G3/ARC/CXCL10/CXCL11/RGS7/CCL4/CXCL9/SCN3B/SYT1/SNCA/CCL5/LRRC55/IL1B/KMO/SCN1B/RELN/PRSS8/EDN1/CLTRN/GALR2/ANK2/IL1A/CX3CL1/G6PD/STXBP1/GLRX/TRPV3/PDGFB/PTGES/ADRB2/ATF4/PTAFR |
| GOBP_DOUBLE_STRAND_BREAK_REPAIR | 258 | -0.3725545 | -1.515726 | 0.0005108 | 0.0085484 | 0.0068976 | 4164 | SFPQ/SETD2/CIB1/RAD51B/TRRAP/MCM6/PNKP/KDM1A/MBTD1/BRCA2/OGG1/HPF1/REV3L/NSD2/ERCC4/RPA3/BRME1/PPP4R3B/RUVBL1/ZCWPW1/RADX/FIGNL1/MSH2/TIMELESS/ZSWIM7/NSMCE1/POT1/FEN1/ATM/PARPBP/MCM4/H2AX/C14orf39/MRE11/WRN/SMC6/RAD52/HMGB1/RMI1/KMT5C/GINS4/KDM4D/LIG3/MMS22L/RUVBL2/SLF1/EP400/WRAP53/MGMT/PAXX/FANCM/ERCC1/ABRAXAS1/HSF2BP/FMN2/XRCC3/BRCA1/MRNIP/POLN/CDC7/EME1/RMI2/IFFO1/MCMDC2/BRIP1/FANCB/HMGB2/TRIP13/WAS/BLM/DNA2/RAD51/RECQL4/XRCC2/GINS2/RAD51AP1/RAD51AP2/POLQ/FOXM1/RAD54B/RAD54L/ESCO2/CDCA5/DMC1/CDC45 |
| GOBP_ACTIVATION_OF_IMMUNE_RESPONSE | 214 | 0.4147664 | 1.563217 | 0.0005282 | 0.0088079 | 0.0071070 | 2469 | ZBP1/THEMIS2/HMSD/LAT2/FOXP3/IL1B/CMTM3/ZC3H12A/CEACAM1/C5AR2/NR4A3/FYN/PLPP4/COLEC10/CARD11/CD55/GBP1/RFTN1/IKBKG/CD47/MICB/CFB/C4BPA/UBASH3A/MEF2C/TRIM5/TLR4/CLEC7A/KLRD1/PLSCR1/C1S/PTPRJ/DUSP3/CD276/CD46/LYN/NFKBIZ/BTN3A1/NFKBID/NOD2/IFI16/BCL10/PTPN22/PTPN2/RNF31/THY1/SYK/C8B/BCAR1/RIPK2/SRC/MALT1/PRKCH/GPS2/LPXN/RBCK1 |
| GOBP_REGULATION_OF_MONOCYTE_CHEMOTAXIS | 19 | 0.7615164 | 1.901587 | 0.0005330 | 0.0088562 | 0.0071460 | 2031 | S100A7/CXCL10/SLIT2/CCL5/CCN3/SERPINE1/CXCL17/GREM1/LYN/LGMN/DUSP1/MOSPD2 |
| GOBP_RESPONSE_TO_MECHANICAL_STIMULUS | 158 | 0.4500563 | 1.630239 | 0.0005390 | 0.0089233 | 0.0072002 | 3060 | NTRK1/CXCL10/PHF24/SLC8A1/TTN/SCX/HABP4/TNFRSF10A/FOSB/IL1B/ATP8A2/THBS1/CLCN6/PTGS2/STRA6/EDN1/FYN/FOS/MYD88/ANKRD1/MAP1B/TNF/BMP6/CHRNA10/STAT1/NFKBIA/SCEL/SOX9/JUN/PIEZO1/ENG/TLR4/JUND/CNTNAP2/TNFSF14/COL1A1/GADD45A/TMEM120A/BCL10/CD40/MAPK3/MMP14/CASP5/SERPINE2/SRC/FOSL1/FAS/SLC9A1/BAK1/CNN2/NFKB1/IRF1/ACTG1/DAG1/TNFRSF10B/FADD/TMC1/CASP8/JUP/ETV1/TGFBR2 |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_DEATH | 165 | 0.4420679 | 1.620255 | 0.0005458 | 0.0089738 | 0.0072409 | 2346 | PLA2G3/NTRK1/NES/FZD9/SNCA/SLC7A11/CLCF1/DRAXIN/NCOA7/CSF3/NR4A3/ADAM8/CD34/CX3CL1/TNFRSF1B/STXBP1/JUN/IKBKG/EN2/MEF2C/ATF4/HLA-F/AGAP2/CSF1/ATP13A2/TYRO3/FOXB1/CD200/LGMN/PPARGC1A/BOK/ISL1/NFATC4/AP2B1/NTRK2/PCDHGC3/HMOX1/TRAF2/KRAS |
| GOBP_DNA_RECOMBINATION | 281 | -0.3593186 | -1.486766 | 0.0005440 | 0.0089738 | 0.0072409 | 3626 | RPA3/BRME1/RUVBL1/ZCWPW1/RADX/MSH6/FIGNL1/MSH2/H1-3/TIMELESS/ZSWIM7/NSMCE1/FEN1/ATM/LIG1/H1-2/PARPBP/MCM4/ANKRD31/H2AX/C14orf39/MRE11/WRN/SMC6/RAD52/HMGB1/ALYREF/RMI1/KMT5C/HSPD1/GINS4/MSH3/KDM4D/LIG3/MMS22L/MSH5/RUVBL2/EP400/WRAP53/PSMC3IP/ENDOG/FANCM/ERCC1/HSF2BP/RNF212/ZRANB3/XRCC3/BRCA1/MRNIP/POLN/CDC7/TCF7/EME1/RMI2/HROB/LEF1/MCMDC2/BRIP1/FANCB/HMGB2/TRIP13/ATAD5/WAS/BLM/BCL11B/RAD51/RECQL4/XRCC2/GINS2/RAD51AP1/RAD51AP2/ZSCAN4/POLQ/RAD54B/CNTD1/EXO1/RAD54L/H1-5/H1-1/DMC1/CDC45/TOP2A |
| GOBP_SERTOLI_CELL_DEVELOPMENT | 10 | 0.8571657 | 1.830064 | 0.0005492 | 0.0089977 | 0.0072601 | 884 | NTRK1/IL1A/SOX9 |
| GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION | 51 | -0.5763372 | -1.863719 | 0.0005702 | 0.0093085 | 0.0075109 | 1115 | XRCC3/MTBP/FBXO5/BMP7/MAD1L1/TRIP13/CCNB1/ZWINT/CDT1/CENPF/FBXO43/TTK/MAD2L1/NDC80/PLK1/BUB1/BUB1B |
| GOBP_SKIN_DEVELOPMENT | 207 | 0.4259012 | 1.602370 | 0.0005806 | 0.0094128 | 0.0075951 | 2684 | SPRR2E/SPRR2F/SPRR2A/S100A7/SPRR1A/PAX6/SPRR3/NSDHL/SPRR2D/ALOXE3/EREG/ATP8A2/DHCR24/FST/IVL/DKK1/CLIC4/CYP26B1/SFN/IL1A/FA2H/TNF/OVOL1/SCEL/SOX9/CLDN4/ERRFI1/ZBED2/KRT17/TGFB2/TRIM16/SPRR1B/FERMT1/INHBA/ELOVL1/ADAM9/MET/GJB3/OPN3/COL5A3/HOXC13/COL1A1/CDH3/SRF/ANXA1/ABCB6/ABCA12/ITGB6/SLC27A4/LSR/ITGA3/ST14/PRKCH/MSX2/MAP2K1/GRHL1/ZFP36/CLDN1/EPHA2/TRADD |
| GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS | 264 | 0.3997466 | 1.536936 | 0.0005787 | 0.0094128 | 0.0075951 | 1340 | PLA2G3/PNPLA3/APOC1/LIPC/LPIN1/LDLR/PLA2G4C/FGF2/LCAT/GPCPD1/SCARB1/SOCS2/PIP4P1/ABHD4/MFSD2A/GALR2/PCYT2/SOCS1/SELENOI/TMEM86B/ENPP6/SOCS3/LIPH/MTMR11/PI4K2A/PDGFB/PISD/GDPD3/PLSCR1/GPAT3/PLAAT1/PIGW/PGP |
| GOBP_RECEPTOR_RECYCLING | 31 | 0.6807703 | 1.890148 | 0.0005833 | 0.0094138 | 0.0075959 | 1468 | ACHE/PCSK9/LDLR/SNCA/PHETA2/ECE1/OPTN |
| GOBP_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE | 62 | 0.5729497 | 1.822921 | 0.0005847 | 0.0094138 | 0.0075959 | 2252 | PLA2G3/ITGAM/LAT2/LBP/CD177/NR4A3/IFI35/MYD88/ANXA3/TICAM1/DYSF/STXBP1/ADGRE2/UNC13D/LGALS9/NMI/PTAFR/STX4/LYN/GAB2/SBNO2/F2RL1/SYK/HMOX1 |
| GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY | 48 | 0.6168958 | 1.855775 | 0.0005877 | 0.0094167 | 0.0075983 | 3751 | MICA/CEACAM1/SH2D1B/LAG3/UNC13D/LGALS9/SERPINB4/SERPINB9/RAET1E/ULBP1/HLA-G/KLRD1/HLA-F/PVR/ULBP3/CADM1/HLA-E/ULBP2/CEBPG/HLA-B/RAB27A/TUBB/NECTIN2/IL18/HLA-A/RNF19B/RAET1G/PLEKHM2/CRK/IL12A |
| GOBP_REGULATION_OF_HORMONE_SECRETION | 159 | 0.4496869 | 1.629971 | 0.0005889 | 0.0094167 | 0.0075983 | 2245 | PLA2G3/LIF/CCL5/ACSL4/IL1B/CCN3/CNR1/EDN1/AACS/RAB8B/TNF/BMP6/NOS2/GPR68/PCK2/FOXA2/C1QTNF1/FKBP1B/KLF7/LRRC8A/IL11/INHBA/PAX8/GPR27/ANO1/STX4/ADCY5/RAB11FIP1/IRS2/SLC8B1/DAB2/C1QTNF3/SOX4/CFTR/EFNA5/ZBED6/ISL1/FAM3D/ENSA/GABBR1/ANXA1/GLUD1/TRPM4/ABCA12/PFKFB2/STX1A/RAB11FIP5/DOC2B |
| GOBP_CELL_GROWTH | 400 | 0.3648108 | 1.456704 | 0.0005988 | 0.0095422 | 0.0076995 | 2656 | TMEM97/HYAL1/ADRA1A/SLIT2/DPYSL2/RTN4R/OLFM1/SYT2/L1CAM/SYT1/MEG3/MAP2/ISLR2/ROS1/DRAXIN/UNC13A/BST2/SEMA3B/CCN3/KIF26A/SYT17/CEACAM1/OSGIN1/RNF157/SOCS2/SEMA3D/EDN1/MFSD2A/SFN/SEMA7A/MAP1B/PML/FGF13/S100A8/G6PD/CXCL16/VEGFA/HBEGF/SOX9/SGK1/ACVRL1/HDAC6/KRT17/MELTF/TGFB2/WASF1/VCL/CDA/ENPP1/PRKCQ/CDKN1A/PTPRJ/GREM1/S100A9/PLXNA3/INHBA/NRCAM/CDKN2A/DBN1/SPHK1/DAB2/DCUN1D3/SLC9A6/EFNA5/SESN2/CLSTN3/SHTN1/SRF/PLXNA1/ADAM17/SPOCK1/MMP14/NDUFA13/SPAG9/PLXNA4/COBL/DCBLD2/BCAR1/SERPINE2/BTG1/TGFBR1/NTN1/SEMA3A/PLAA/ITSN2/IGFBP7/SLC9A1/PDLIM5/TFRC/SEMA3C/HYAL2/NDEL1 |
| GOBP_T_CELL_MIGRATION | 45 | 0.6164673 | 1.836174 | 0.0006068 | 0.0096372 | 0.0077762 | 2331 | S100A7/CXCL10/CXCL11/CCL20/CCL5/ADAM8/CXCL16/RIPK3/ICAM1/OXSR1/MSN/CD200/TNFSF14/ITGB7/ADAM17/XG/SLC12A2 |
| GOBP_REGULATION_OF_CELL_KILLING | 59 | 0.5794385 | 1.811753 | 0.0006127 | 0.0096969 | 0.0078244 | 2242 | CXCL6/MICA/ITGAM/IL23A/CEACAM1/LAG3/RIPK3/CD55/NOS2/LGALS9/SERPINB4/SERPINB9/RAET1E/TGFB2/ICAM1/CLEC7A/HLA-G/KLRD1/HLA-F/PVR/IL11/CADM1/IL7R/HLA-E/F2RL1/SYK/HLA-B |
| GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS | 373 | 0.3748911 | 1.491130 | 0.0006223 | 0.0098162 | 0.0079206 | 3295 | APOC1/HMGCR/PAX6/LPIN1/MLXIPL/TRIB3/SLIT2/SLC8A1/NTRK3/PTPRH/XDH/SNCA/IL1B/ZC3H12A/CEACAM1/CDKN2B/DKK1/UCHL1/CDKN1C/SFN/SOCS1/SPRY4/OCLN/TNF/WARS1/MASTL/JUN/PIK3IP1/SOCS3/FOXA2/BMP2/PMEPA1/TNFAIP3/ERRFI1/FKBP1B/ENG/GPRC5A/PDGFB/PTPRO/TGFB2/PARP14/CDA/SH2B3/ENPP1/DUSP6/CDKN1A/PTPRJ/SPRY1/GREM1/RUBCN/CHP1/INHBA/DUSP10/GRB10/NIBAN1/ANKLE2/INCA1/CAMK2N1/IRAK3/DUSP3/CDKN2A/LYN/DBNDD1/TRIB1/IRS2/TRIB2/GADD45A/MAPK8IP1/LPCAT1/PLPP3/MICAL1/CHMP6/PTPN22/DUSP1/ENSA/DDIT4/ADAR/PTPN2/TMEM225B/THY1/DUSP16/SPAG9/PIP4K2A/SMAD6/PRKRIP1/INPP5F/IGFBP3/YWHAG/BAK1/PIP4K2C/HYAL2/NCK1/TIGAR/SWAP70/PPIA/MFHAS1/DAB2IP/PID1/STK38/LATS2/MYADM/SPRED2/SMPD1/ARPP19/SIRPA/MGAT5/FLCN/SH3BP5/TWIST1/HEXIM1/CAV1/EIF4G1/TESK1/TRIM27/GNAI2 |
| GOBP_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE | 197 | -0.4047889 | -1.623068 | 0.0006273 | 0.0098611 | 0.0079568 | 1693 | XRCC3/JADE1/BRCA1/MTBP/MRNIP/EME1/GPNMB/FBXO5/STK33/BTG4/GJC2/BMP7/EZH2/ORC1/MAD1L1/TRIP13/CCNB1/BLM/GAS1/ZWINT/CDT1/CENPF/CLSPN/E2F7/TTK/MAD2L1/TICRR/CDK1/NDC80/PLK1/BUB1/DTL/GTSE1/BUB1B |
| GOBP_REGULATION_OF_LEUKOCYTE_DEGRANULATION | 33 | 0.6720917 | 1.885718 | 0.0006440 | 0.0100904 | 0.0081419 | 2437 | PLA2G3/ITGAM/CEACAM1/CD177/STXBP1/ADGRE2/UNC13D/LGALS9/PTAFR/HLA-F/STX4/LYN/GAB2/F2RL1/SYK/HMOX1/IL4R |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | 118 | 0.4747687 | 1.654019 | 0.0006543 | 0.0102173 | 0.0082443 | 1400 | PAX6/FGF2/XDH/LIF/ASCL1/MAFF/IL1B/CEACAM1/CDKN2B/SERPINE1/CDKN1C/SFN/IL1A/TNF/BMP6/VEGFA/STAT1/SOX9/PRLR/ACVRL1/ERRFI1/ZBED2/KLF7/TRIM16/VCL/SPRY1/PAX8/ATOH8 |
| GOBP_MEIOTIC_SPINDLE_ORGANIZATION | 13 | -0.8239656 | -1.962020 | 0.0006950 | 0.0108171 | 0.0087282 | 1115 | FBXO5/AURKA/ESPL1/NDC80/CCNB2/ASPM |
| GOBP_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY | 29 | 0.6829164 | 1.881266 | 0.0006990 | 0.0108426 | 0.0087488 | 3751 | MICA/CEACAM1/SH2D1B/LAG3/LGALS9/SERPINB4/SERPINB9/RAET1E/HLA-G/KLRD1/HLA-F/PVR/CADM1/HLA-E/HLA-B/NECTIN2/HLA-A/RAET1G/CRK/IL12A |
| GOBP_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS | 16 | 0.7745517 | 1.873806 | 0.0007264 | 0.0112308 | 0.0090620 | 2105 | S100A7/CXCL10/CCL4/CCL5/OXSR1/TNFSF14/SLC8B1/ADAM17 |
| GOBP_T_CELL_MEDIATED_IMMUNITY | 77 | 0.5383706 | 1.759066 | 0.0007300 | 0.0112487 | 0.0090764 | 3379 | CD70/RSAD2/MICA/FOXP3/IL1B/IL23A/CEACAM1/IL4I1/ARID5A/TNFRSF1B/RIPK3/CD55/RFTN1/IL18R1/ICAM1/HLA-G/KLRD1/HLA-F/PVR/CD46/CADM1/NOD2/IL7R/HLA-E/TRPM4/HLA-B/TRAF2/MALT1/RAB27A/AHR/NECTIN2/CTSC/IL1R1/IL18/FADD/HLA-A/BTN3A3/FZD5/EMP2/BTN3A2/MR1 |
| GOBP_PYRIDINE_NUCLEOTIDE_METABOLIC_PROCESS | 27 | 0.6907847 | 1.867006 | 0.0007468 | 0.0113981 | 0.0091970 | 1885 | QPRT/IDO1/IDO2/KYNU/SLC5A8/KMO/NAMPT/PARP9/NUDT17/HAAO/NADK |
| GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY | 70 | 0.5502025 | 1.792986 | 0.0007447 | 0.0113981 | 0.0091970 | 2437 | PLA2G3/CXCL6/ITGAM/LAT2/CD177/NR4A3/CAMK4/MYD88/ANXA3/TICAM1/STXBP1/ADGRE2/UNC13D/LGALS9/SERPINB9/PTAFR/STX4/LYN/GAB2/HLA-E/F2RL1/SYK/ADAM17/HMOX1/SPON2/TREM1/IL4R |
| GOBP_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY | 135 | 0.4667094 | 1.659587 | 0.0007495 | 0.0113981 | 0.0091970 | 3482 | NTRK1/S100A12/IL1B/IRAK2/ADAM8/MYD88/CX3CL1/S100A8/TNF/RIPK3/TICAM1/CARD11/IKBKG/LGALS9/TLR2/TRIM21/RTKN2/IL18R1/TRIM5/TLR4/CLEC7A/TRIM14/PRKCQ/GREM1/S100A9/EIF2AK2/IRAK3/PSMA6/TRAF1/NOD2/SPHK1/BCL10/CD40/IRAK1/SLCO3A1/TRIM25/RNF31/CTH/RIPK2/TRIM22/TRAF2/MALT1/PRKCH/NOD1/RBCK1/TFRC/TRADD/RPS6KA4/PPIA/IL18/TIRAP/TRAF5/DDRGK1/FLOT1/CAV1/MAP3K13/TRIM27/ARHGEF2/CFLAR/RELA |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 99 | 0.4889111 | 1.659328 | 0.0007475 | 0.0113981 | 0.0091970 | 2908 | RSAD2/ITGAM/CLCF1/FOXP3/IL1B/IL23A/SH2D1B/CD177/CAMK4/ARID5A/TNF/LAG3/TICAM1/CD55/NOS2/RAET1E/IL18R1/PTAFR/CLEC7A/HLA-G/KLRD1/HLA-F/PVR/STX4/CADM1/NOD2/CD40/HLA-E/F2RL1/SHLD1/SHLD2/HLA-B/TRAF2/MALT1/TFRC/NECTIN2/IL1R1/IL18/C3/SHLD3/FADD |
| GOBP_EXTRACELLULAR_TRANSPORT | 42 | -0.6036004 | -1.892113 | 0.0007653 | 0.0115816 | 0.0093451 | 3061 | GAS8/NPHP3/KATNIP/TTLL1/STK36/DNAH11/SPAG6/ODAD4/DNAAF11/KIF27/AQP4/SPA17/DNAAF4/CCDC40/CFAP54/SPAG17/NME5/DAW1/DNAI1/SPEF2/CCDC39/DPCD/SPAG16/ROPN1L/RFX3/DNAH9/CFAP45/NEK10/DNAH1/DNAH5/CFAP43/CFAP221/DNAAF1/CFAP53 |
| GOBP_RECOMBINATIONAL_REPAIR | 155 | -0.4193094 | -1.626912 | 0.0007665 | 0.0115816 | 0.0093451 | 4164 | SFPQ/SETD2/RAD51B/TRRAP/MCM6/KDM1A/MBTD1/BRCA2/REV3L/ERCC4/RPA3/RUVBL1/RADX/FIGNL1/TIMELESS/ZSWIM7/NSMCE1/FEN1/ATM/PARPBP/MCM4/H2AX/MRE11/WRN/SMC6/RAD52/RMI1/GINS4/KDM4D/LIG3/MMS22L/RUVBL2/EP400/WRAP53/FANCM/XRCC3/BRCA1/MRNIP/POLN/CDC7/RMI2/HROB/MCMDC2/FANCB/WAS/BLM/RAD51/RECQL4/XRCC2/GINS2/RAD51AP1/RAD51AP2/POLQ/RAD54B/RAD54L/DMC1/CDC45 |
| GOBP_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION | 11 | 0.8448268 | 1.842752 | 0.0007869 | 0.0118136 | 0.0095323 | 720 | LUM/SERPINB7/FOXP3/THBS1/CX3CL1 |
| GOBP_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION | 11 | 0.8448268 | 1.842752 | 0.0007869 | 0.0118136 | 0.0095323 | 720 | LUM/SERPINB7/FOXP3/THBS1/CX3CL1 |
| GOBP_NECROTIC_CELL_DEATH | 52 | 0.5856043 | 1.798427 | 0.0008166 | 0.0122196 | 0.0098599 | 5214 | ZBP1/FZD9/BIRC3/OLFM4/TNF/RIPK3/MLKL/PELI1/ITPK1/BOK/TRAF2/FAS/RBCK1/CASP6/MAP3K5/FADD/CASP8/CAV1/GSDME/NINJ1/ARHGEF2/CFLAR/HEBP2/TP53/RIPK1/CYLD/ATG9A/PGAM5/TSPO/BAX/TLR3/ALKBH7/PPIF/NUPR1/ADPRS/NOL3/PYGL |
| GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY | 104 | -0.4684251 | -1.706692 | 0.0008246 | 0.0122634 | 0.0098952 | 3461 | KIF9/BBS4/CFAP20/DNAI3/ADCY3/DRC1/CATSPER2/SLC26A8/SPAG6/ARMC2/CFAP251/DNAAF11/TTLL9/CFAP47/CFAP46/HOATZ/TTLL3/BBS2/CFAP69/CFAP58/ENO4/CCDC40/GAS2L2/CFAP52/CFAP54/RSPH9/EFHC2/DRC7/DZIP1/CFAP157/TTC12/DNAI1/DNAH7/IQCG/SPEF2/CCDC39/DPCD/SPAG16/SLC22A16/TEKT3/ROPN1L/ROPN1B/CCDC65/CFAP206/TEKT2/TEKT1/RFX3/TTC21A/TCTE1/EFHC1/CFAP45/CFAP65/DNAH3/CFAP44/TEKT4/MNS1/TEKT5/DNAH6/DNAH1/DNAH5/CFAP43/DNAAF6/TTLL6/DNAH2/PLTP/CATSPERD/MEIG1/EPPIN |
| GOBP_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY | 497 | 0.3480488 | 1.419701 | 0.0008247 | 0.0122634 | 0.0098952 | 3037 | NTRK1/FGFR4/GRB14/DOK6/FGFBP1/SLC2A4/PLAUR/NTRK3/IFI6/FGF2/NCF1/XDH/SNCA/KDR/EREG/HHIP/ROS1/IGF2/IL1B/KLB/THBS1/CEACAM1/SOCS2/NAMPT/NR4A3/FYN/FOXC2/EPHA10/IL31RA/PPP2R5B/GDF15/EPHA3/SOCS1/AREG/SPRY4/FAM20C/VEGFA/HBEGF/SOX9/PRLR/SOCS3/FGF1/BMP2/NEDD9/SH3TC2/ERRFI1/GPRC5A/EIF2AK3/PDGFB/CSRNP1/FGFBP3/ANKS1B/WASF1/ADRB2/PTP4A3/SH2B3/ENPP1/PRKCQ/PTPRJ/SPRY1/GREM1/RHBDF2/GRB10/RARRES2/DUSP3/MET/SVEP1/FLRT2/EGF/CSF1/ESM1/TYRO3/LYN/FLT1/ITGB3/IRS2/KL/DOK4/NGEF/SHC2/COL1A1/GAB2/LGMN/PTPN12/MPZL1/MYO1C/EFNA5/CHMP6/DDIT4/LRIT3/MST1R/PDGFC/CDH3/PTPN2/NFATC4/NIBAN2/HAP1/SYK/ADAM17/NTRK2/BCAR3/SLC27A4/EPHB4/PIP4K2A/GAREM1/BCAR1/SRC/STAT5A/PTPN18/TGFA/IGFBP3/CCND3/F3/NRG1/PIP4K2C/EPHA2/NDEL1/NCK1/TRADD/WNT4/PIK3C2A/CAV2/RTN4/DAB2IP/PID1/MAPKAPK2/NEDD4/ZBTB7B/RUNX2/PLCG1/ITGA5/PTPN11/RHBDF1 |
| GOBP_DNA_UNWINDING_INVOLVED_IN_DNA_REPLICATION | 22 | -0.7273444 | -1.995971 | 0.0008343 | 0.0123661 | 0.0099781 | 932 | MCM4/WRN/GINS4/GINS1/BLM/RAD51/RECQL4/GINS2/CDC45 |
| GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS | 218 | 0.4159581 | 1.576635 | 0.0008517 | 0.0125844 | 0.0101542 | 2172 | ELOVL6/ACSS2/QPRT/ACLY/IDO1/CMPK2/ENTPD8/ACSL1/IDO2/SNCA/HSD17B12/SLC25A1/ME1/KYNU/SLC5A8/ACSL4/PANK3/PANK1/KMO/ELOVL5/NAMPT/ADCY10/ELOVL7/PARP9/NOS2/ACACA/CDA/GARS1/ELOVL1/MYC/ADCY4/HAAO/ADCY5/UCKL1/ANTKMT/PPARGC1A/CTPS1/NADK/UPP1/ACOT7/HACD2/PNP/ACSL5/ELOVL4 |
| GOBP_POSITIVE_REGULATION_OF_CHEMOTAXIS | 101 | 0.4913546 | 1.677422 | 0.0008590 | 0.0126524 | 0.0102091 | 2343 | S100A7/CXCL10/CCL4/SLIT2/NTRK3/CXCL8/FGF2/KDR/CCL5/LBP/THBS1/IL23A/EDN1/SERPINE1/CXCL17/STX3/VEGFA/ARTN/LGALS9/PDGFB/OXSR1/RARRES2/MET/IL34/CSF1/STX4/TNFSF14/LGMN/SCG2/MAPK3/F2RL1/MOSPD2/TPBG/ADAM17/P2RX4/DAPK2/TMSB4X |
| GOBP_DEFENSE_RESPONSE_TO_BACTERIUM | 154 | 0.4447197 | 1.607865 | 0.0008907 | 0.0130781 | 0.0105526 | 2699 | DEFB4A/S100A7/ISG15/CCL20/S100A12/OAS3/CXCL6/MICA/OAS1/PI3/LBP/OAS2/DEFB1/HP/IL23A/ADAMTS5/PGLYRP4/SERPINE1/MYD88/GBP2/EMILIN2/ANXA3/KLK7/S100A8/TNF/NOS2/PGLYRP3/TLR2/TLR4/RNF213/S100A9/RARRES2/OPTN/LCN2/ARG2/SELP/NOD2/H2BC21/IL7R/GBP4/HLA-E/ADGRB1/BPIFA2/F2RL1/KRT6A/WFDC3/RNF31/SYK/ADAM17/SPON2/BCL3/RIPK2/TREM1/NLRP1/RNASE7/NOD1/RBCK1/EPHA2/S100A14/MARCHF2/CEBPB |
| GOBP_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY | 118 | 0.4685812 | 1.632463 | 0.0008943 | 0.0130888 | 0.0105612 | 3033 | RSAD2/MICA/CLCF1/FOXP3/IL1B/IL23A/CEACAM1/SH2D1B/IL4I1/ARID5A/TNF/TNFRSF1B/LAG3/RIPK3/CD55/LGALS9/C4BPA/SERPINB4/SERPINB9/RAET1E/IL18R1/HLA-G/KLRD1/HLA-F/PVR/CD46/CADM1/NOD2/CD40/IL7R/HLA-E/SHLD1/TRPM4/SHLD2/HLA-B/TRAF2/MALT1/AHR/TFRC/NECTIN2/IL1R1/IL18/C3/SHLD3/FADD/SLC15A4/HLA-A |
| GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY | 11 | -0.8454535 | -1.946142 | 0.0008974 | 0.0130939 | 0.0105654 | 155 | CDC20B/PLK1/CDC20/UBE2C |
| GOBP_RESPONSE_TO_FUNGUS | 27 | 0.6868591 | 1.856396 | 0.0009006 | 0.0130991 | 0.0105695 | 2811 | ZBP1/S100A12/MYD88/S100A8/TLR4/CLEC7A/S100A9/RARRES2/BCL10/SYK/SPON2/MALT1/RNASE7/COTL1/BAK1/FAM3A |
| GOBP_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY | 17 | 0.7689283 | 1.882653 | 0.0009152 | 0.0132698 | 0.0107073 | 2005 | ISG15/OAS3/OAS1/NLRC5/USP18/MMP12/STAT2/ADAR/PTPN2 |
| GOBP_LONG_CHAIN_FATTY_ACYL_COA_METABOLIC_PROCESS | 20 | 0.7462146 | 1.890892 | 0.0009201 | 0.0133005 | 0.0107320 | 2545 | ELOVL6/ACSL1/HSD17B12/ACSL4/ELOVL5/ELOVL7/ELOVL1/ACOT7/HACD2/ACSL5/FAR2/ELOVL4/DGAT1 |
| GOBP_CELLULAR_RESPONSE_TO_HEAT | 60 | 0.5722227 | 1.795924 | 0.0009421 | 0.0135767 | 0.0109549 | 2252 | CXCL10/TCIM/THBS1/PTGS2/CD34/IL1A/HSPA6/FGF1/IER5/ANO1/LYN/SLC52A3/IRAK1/STAC/HMOX1 |
| GOBP_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS | 23 | 0.7114300 | 1.856931 | 0.0009620 | 0.0137776 | 0.0111170 | 768 | QPRT/IDO1/IDO2/KYNU/SLC5A8/KMO/NAMPT/PARP9 |
| GOBP_DNA_INTEGRITY_CHECKPOINT_SIGNALING | 118 | -0.4393844 | -1.627748 | 0.0009600 | 0.0137776 | 0.0111170 | 1635 | BRCA1/MRNIP/EME1/STK33/BRIP1/ORC1/E2F1/BLM/DNA2/CDT1/CLSPN/TICRR/CDK1/PLK1/CDC45/DTL/GTSE1 |
| GOBP_INNER_DYNEIN_ARM_ASSEMBLY | 16 | -0.7686835 | -1.918978 | 0.0009900 | 0.0140931 | 0.0113716 | 3340 | DNAAF5/DNAI3/CFAP100/ZMYND10/DNAAF11/DNAAF4/CCDC40/CFAP73/DNAH7/CCDC39/TEKT2/DNAH1/DNAAF6/DNAAF1/DNAH2 |
| GOBP_LEUKOCYTE_APOPTOTIC_PROCESS | 84 | 0.5223690 | 1.737741 | 0.0009884 | 0.0140931 | 0.0113716 | 2563 | IDO1/SLC7A11/CCL5/HSH2D/IRF7/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/MEF2C/PRKCQ/SELENOS/CDKN2A/LYN/IRS2/ARG2/NOD2/BCL10/IL7R/ANXA1/PRELID1/ADAM17/PIP/ST3GAL1/FAS/BAK1 |
| GOBP_CELL_ADHESION_MEDIATED_BY_INTEGRIN | 67 | 0.5434258 | 1.757161 | 0.0010040 | 0.0142479 | 0.0114965 | 3082 | LIF/ITGAM/CCL5/ITGA9/CCN3/PLAU/FOXC2/SERPINE1/ITGA10/PIEZO1/TGFB2/ICAM1/FERMT1/ITGB8/PODXL/ADAM9/CYP1B1/RAC3/LYN/ITGB3/ACER2/PLPP3/ITGB7/ITGAV/SYK/ADAM17/ITGB6/COL16A1/ITGA3/LPXN/EPHA2/SWAP70/MUC1/ITGB4/ITGA6/ITGA5/PTPN11/ITGB5 |
| GOBP_ENTRY_INTO_HOST | 121 | 0.4633653 | 1.621410 | 0.0010146 | 0.0143545 | 0.0115825 | 3406 | LDLR/IFITM1/CXCL8/NPC1/SCARB1/IFITM3/LAMP3/CLDN9/TRIM31/LGALS1/CD55/LGALS9/TRIM21/TRIM5/ICAM1/PLSCR1/TRIM14/PVR/SLC3A2/NECTIN4/CD46/TYRO3/TPCN2/ITGB3/ACE2/SLC52A2/ITGB7/TRIM25/KRT6A/ITGAV/ITGB6/IFITM2/TRIM22/SRC/TFRC/LY6E/CLDN1/CD86/EPHA2/NECTIN2/HYAL2/DAG1/CAV2/P4HB/RNASEK/SMPD1/VPS18/ITGA5/ITGB5/CAV1/TRIM27/EXOC2/SLC1A5/SLC52A1 |
| GOBP_REGULATION_OF_ION_TRANSPORT | 445 | 0.3479130 | 1.402809 | 0.0010179 | 0.0143589 | 0.0115861 | 1603 | PLA2G3/ARC/PCSK9/CXCL10/CXCL11/GEM/RGS7/CLIC3/CCL4/CXCL9/SCN3B/KCNH8/SLC8A1/CACNB1/SYT2/SYT1/SNCA/MAPK8IP2/CCL5/LRRC55/IL1B/KMO/SCN1B/RELN/CLIC2/SYT17/PRSS8/PTGS2/CNR1/NOX1/CATSPER3/EDN1/FYN/PLPP4/CLTRN/CLIC4/STC2/FXYD6/GALR2/HVCN1/ANK2/IL1A/CX3CL1/PML/FGF13/G6PD/TNF/STXBP1/GLRX/KCNK15/CACNA2D4/HOMER3/JPH3/FKBP1B/FXYD5/TRPV3/PDGFB/ANO9/PTGES/MEF2C/ADRB2/ATF4/PTAFR/CBARP/CACNG8/REM1/CHP1/OXSR1/EGF/LYN/TPCN2/ITGB3/KCND3/ACE2/EPB41/KCNS3/ANTKMT |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION | 19 | 0.7458595 | 1.862490 | 0.0010381 | 0.0145190 | 0.0117153 | 2437 | PLA2G3/ITGAM/CD177/STXBP1/PTAFR/HLA-F/STX4/GAB2/F2RL1/SYK/IL4R |
| GOBP_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR | 82 | 0.5267599 | 1.747361 | 0.0010386 | 0.0145190 | 0.0117153 | 1653 | HYAL1/FGFR4/FGFBP1/DLL4/NR4A1/CXCL8/FGF2/CCL5/HHIP/KLB/THBS1/SPRY4/FAM20C/FGF1/FGFBP3/IER2/SPRY1/MYC/FLRT2/KL/COL1A1 |
| GOBP_ANION_TRANSPORT | 360 | 0.3656735 | 1.451474 | 0.0010326 | 0.0145190 | 0.0117153 | 2427 | PLA2G3/GABRA4/SLC26A9/SLC2A6/CLIC3/ANO4/SNCA/SLC39A8/SLC7A11/SLC25A1/SLC5A1/SLCO4C1/SLC26A4/SLC5A8/SLC7A9/SLC16A13/IL1B/KMO/SLCO4A1/SLC6A11/CLIC2/SLC2A3/CLCN6/CEACAM1/SLC26A6/EDN1/CLTRN/CLIC4/SLCO1B1/MFSD2A/SLC16A4/SLC9A4/IL1A/SLC6A14/TNF/SLC13A5/NOS2/STXBP1/SLC20A1/GRM1/CLDN4/CD47/ANO2/APOL1/SLC9A2/SLC16A3/SLC10A6/SLC9A3/SLC25A23/ANO9/PTGES/ATF4/PTAFR/ENPP1/LRRC8A/PACC1/SLC25A25/ANO10/SLC4A3/MPC1/SLC3A2/ANO1/PRAF2/MYC/ACE2/SLC12A4/SLC52A2/SLC52A3/SLC7A7/SLC9A6/CFTR/SLC25A21/SLCO3A1/ANO7/SLC1A4/GABBR1/ANXA1/GIPC1/SLC10A3/SYK/GLRA2/NTRK2/P2RX4/SLC5A5/SLC27A4/SLC5A12/TG/SLC7A1/SLC12A2/MGST1/LRRC8C/SLC7A5/SLC5A6/SLC9A7/CYB5R1/SLC27A5 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS | 63 | 0.5438866 | 1.741602 | 0.0010453 | 0.0145693 | 0.0117558 | 2160 | ISG15/SLIT2/OAS3/OAS1/IL1R2/CCL5/NLRC5/USP18/IL1RN/PARP14/SH2B3/KLF4/IRAK3/MMP12/PALM3/STAT2/RFFL/ADAR/PTPN2/F2RL1/PXDN/MAPK7 |
| GOBP_PROGRAMMED_NECROTIC_CELL_DEATH | 40 | 0.6131173 | 1.783376 | 0.0010560 | 0.0146735 | 0.0118399 | 5214 | ZBP1/FZD9/BIRC3/TNF/RIPK3/MLKL/PELI1/ITPK1/BOK/TRAF2/FAS/RBCK1/CASP6/MAP3K5/FADD/CASP8/CAV1/ARHGEF2/CFLAR/TP53/RIPK1/CYLD/PGAM5/BAX/TLR3/ALKBH7/PPIF/NUPR1/ADPRS/PYGL |
| GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 41 | 0.6139391 | 1.788920 | 0.0010732 | 0.0148689 | 0.0119976 | 2470 | MICA/FOXP3/BST2/CEACAM1/IL4I1/CD55/LGALS9/C4BPA/SERPINB4/SERPINB9/HLA-G/KLRD1/HLA-F/CD46/NOD2/IL7R/HLA-E/HLA-B/HMOX1/AHR |
| GOBP_NEGATIVE_REGULATION_OF_CELL_KILLING | 17 | 0.7647784 | 1.872493 | 0.0010800 | 0.0149194 | 0.0120383 | 2242 | MICA/CEACAM1/LGALS9/SERPINB4/SERPINB9/HLA-G/KLRD1/HLA-F/IL7R/HLA-E/HLA-B |
| GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS | 25 | 0.7014195 | 1.850522 | 0.0010887 | 0.0149634 | 0.0120738 | 884 | APOC1/INSIG1/TRIB3/CNR1/CEACAM1/MFSD2A/ACADL/SOX9 |
| GOBP_CELL_KILLING | 103 | 0.4864908 | 1.668480 | 0.0010896 | 0.0149634 | 0.0120738 | 2908 | DEFB4A/S100A12/CXCL6/MICA/ITGAM/IL23A/CEACAM1/PGLYRP4/MYD88/LAG3/RIPK3/CD55/NOS2/UNC13D/LGALS9/PGLYRP3/SERPINB4/SERPINB9/RAET1E/TGFB2/ICAM1/CLEC7A/ULBP1/HLA-G/KLRD1/HLA-F/PVR/IL11/ULBP3/CADM1/IL7R/HLA-E/ULBP2/F2RL1/SYK/CEBPG/HLA-B/TREM1/RAB27A/TUBB/NECTIN2/CTSC/IL18/C3/FADD |
| GOBP_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY | 221 | 0.4075309 | 1.543630 | 0.0011216 | 0.0153573 | 0.0123917 | 3880 | NTRK1/RGS7/CCL22/CCL4/CCL20/RGS16/RTN4R/NTRK3/ADPRH/CCL5/CX3CL1/RASGRP3/TBC1D3D/ARHGAP11B/NEDD9/SNX9/DOCK10/ADAP2/TIAM2/DVL2/ASAP3/NGEF/CCL17/CD40/GMIP/RHOG/RGS10/S100A10/F2RL1/ARHGAP27/THY1/TBC1D4/BCAR3/RAP1GAP/SLC27A4/DOCK6/MAP4K4/ADAP1/SYDE2/MAPRE2/RSU1/RAPGEF3/SYDE1/EPHA2/NDEL1/TBC1D25/TBC1D10A/ASAP2/WNT4/SOS2/CAV2/RAP1GAP2/ITGA6/FLCN/GRHL3/RANGAP1/ARHGEF5/TBC1D22B/TBC1D10B/ARHGAP29/TBC1D17/TBC1D1/BIN1/TGM2/PICALM/CRK/HRAS/RGP1/RGS14/SGSM3/ARHGEF10/RAPGEF1/CHN1/GSK3B/PIP5K1A/MMUT/CORO1C/TBC1D20 |
| GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS | 13 | 0.8140413 | 1.874699 | 0.0011399 | 0.0155172 | 0.0125206 | 826 | APOC1/INSIG1/TRIB3/CEACAM1/ACADL |
| GOBP_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY | 52 | 0.5765706 | 1.770684 | 0.0011399 | 0.0155172 | 0.0125206 | 2384 | CCL5/LBP/IL1B/SCARB1/IRAK2/MYD88/CX3CL1/TNF/BMP6/TICAM1/CD55/NFKBIA/LY96/TNFAIP3/TLR2/TRIM5/TLR4/PTAFR/LYN/TRIB1/BCL10/IRAK1/PTPN22/MAPK3/RIPK2/MALT1 |
| GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY | 195 | 0.4167784 | 1.549743 | 0.0011837 | 0.0160655 | 0.0129631 | 3461 | CD70/RSAD2/MICA/CLCF1/FOXP3/IL1B/IRF7/IL23A/CEACAM1/SH2D1B/IL4I1/ARID5A/MYD88/TNF/TNFRSF1B/LAG3/RIPK3/CD55/RFTN1/BATF/UNC13D/LGALS9/C4BPA/SERPINB4/SERPINB9/RAET1E/IL18R1/ICAM1/ULBP1/HLA-G/KLRD1/C1S/HLA-F/PVR/CD46/ULBP3/CADM1/HLA-DOB/NOD2/BCL10/CD40/IL7R/HLA-E/ULBP2/SHLD1/TRPM4/C8B/SHLD2/CEBPG/RNF168/HLA-B/BCL3/TRAF2/MALT1/IL4R/RAB27A/AHR/TUBB/TFRC/NECTIN2/CTSC/IL1R1/SWAP70/C2/IL18/C3/SHLD3/FADD/SLC15A4/HLA-A/HLA-DMA/BTN3A3/FZD5/RNF19B/EMP2/MAD2L2/BTN3A2/MR1/RAET1G/PLEKHM2 |
| GOBP_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS | 21 | 0.7312148 | 1.864036 | 0.0012479 | 0.0168879 | 0.0136266 | 2172 | ELOVL6/ACSL1/HSD17B12/SLC25A1/ACSL4/ELOVL5/ELOVL7/ACACA/ELOVL1/HACD2/ACSL5/ELOVL4 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION | 139 | 0.4434036 | 1.582783 | 0.0013004 | 0.0175476 | 0.0141589 | 3034 | MUC21/FGL2/IDO1/FOXP3/ZC3H12A/CEACAM1/IL4I1/IL1RN/SOCS1/BMP6/VEGFA/LAG3/CD274/BMP2/LGALS9/C1QTNF1/FXYD5/ASS1/SH2B3/HLA-G/KLF4/PODXL/ADTRP/DUSP3/PRKG1/ARG2/PELI1/PTPN22/ANXA1/PTPN2/PDE5A/ABCA12/CD9/MAPK7/SERPINE2/IL4R/CD86/SWAP70/CEBPB/IRF1/EPCAM/CDH1/ZBTB7B/MYADM/BTN2A2 |
| GOBP_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS | 12 | 0.8170587 | 1.842869 | 0.0013133 | 0.0175691 | 0.0141763 | 2109 | IDO1/IDO2/KYNU/KMO/IL4I1/HAAO/QDPR |
| GOBP_HOMOTYPIC_CELL_CELL_ADHESION | 74 | 0.5305467 | 1.730276 | 0.0013086 | 0.0175691 | 0.0141763 | 3146 | PLAUR/SLC7A11/CCL5/CEACAM1/PEAR1/CEACAM5/EMILIN2/DSC2/STXBP1/RAP2B/C1QTNF1/VCL/MYL9/SH2B3/PRKCQ/TYRO3/LYN/PRKG1/DSG2/ITGB3/PLPP3/CSRP1/MYL12A/SYK/CD9/XG/ILK/SERPINE2/FLNA/ACTB/TJP2/ACTG1/PPIA/MYH9/JUP/JAK1/PDPN |
| GOBP_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC | 128 | -0.4341052 | -1.626075 | 0.0013115 | 0.0175691 | 0.0141763 | 513 | H3C10/EZH2/HELLS/XIST/H3C7/DIRAS3/H3C12/LHX2/H3C3/H3C8/H3C2 |
| GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS | 57 | 0.5726279 | 1.785098 | 0.0013223 | 0.0176396 | 0.0142332 | 1887 | PLA2G3/APOC1/LIPC/LDLR/PLA2G4C/LCAT/SCARB1/ABHD4/MFSD2A/TMEM86B/GDPD3/PLAAT1/LPCAT1/GPAT4/PLA2G15 |
| GOBP_RESPONSE_TO_INTERFERON_BETA | 24 | 0.6990071 | 1.830999 | 0.0013274 | 0.0176569 | 0.0142471 | 3624 | IFITM1/OAS1/XAF1/BST2/IFITM3/STAT1/IKBKE/PLSCR1/SHFL/IFI16/NDUFA13/IFITM2/CAPN2/IRF1/PNPT1/CDC34/AIM2 |
| GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS | 52 | 0.5727748 | 1.759027 | 0.0013663 | 0.0181230 | 0.0146233 | 2664 | ELOVL6/ACSL1/NUDT8/HSD17B12/SLC25A1/GGT7/ACSL4/ELOVL5/GGT5/AACS/ELOVL7/ACACA/ACSS3/ELOVL1/ACOT7/HACD2/ACSL5/FAR2/ELOVL4/SLC27A5/DGAT1/PAM |
| GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION | 236 | 0.3987374 | 1.521086 | 0.0013814 | 0.0182711 | 0.0147427 | 2974 | LUM/FGFR4/NOXO1/SCX/SLC39A8/HSD17B12/MMP25/MMP16/MMP10/NTNG1/SMOC1/MMP17/COL13A1/ADAMTS14/NOX1/ADAMTS5/FOXC2/NFKB2/ADAM8/KLK7/TNF/TNFRSF1B/MMP19/SOX9/ERO1A/LAMB3/LOXL2/BMP2/CAPG/ENG/MELTF/TGFB2/MMP15/COLGALT2/CCN1/COL9A2/GREM1/ADAMTS9/FERMT1/PLOD3/VIT/LCP1/ADTRP/FOXF2/CYP1B1/FLRT2/MMP7/PHLDB2/COLGALT1/MMP12/COL5A3/FMOD/COL1A1/COL22A1/MMP13/MIA/NTNG2/COL8A2/CTSV/SERPINF2/PXDN/COL12A1/MMP24/FURIN/SERPINH1/TGFBI/MMP14/ADAMTS1/PBXIP1/COL16A1/LAMC1/BCL3/COL17A1/TGFBR1/COL24A1/SPINT1/SH3PXD2B/THSD4/VIPAS39/TLL1/DAG1/MMP11/CAV2/FAP/OLFML2A/NTN4/ERCC2/NID2 |
| GOBP_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE | 90 | 0.5072647 | 1.699856 | 0.0014015 | 0.0184851 | 0.0149155 | 3033 | RSAD2/CLCF1/IL1B/NR4A3/CAMK4/ARID5A/SEMA7A/KLK7/TICAM1/CD55/IL18R1/TLR4/CLEC7A/HLA-G/HLA-F/DNAJB9/STX4/NOD2/BCL10/CD40/HLA-E/PTPN22/F2RL1/SHLD1/SHLD2/SPON2/TRAF2/MALT1/SLC7A5/IL4R/TFRC/CD86/LACC1/IL1R1/IL18/SHLD3/HLA-A |
| GOBP_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION | 50 | -0.5627564 | -1.803521 | 0.0014208 | 0.0186870 | 0.0150784 | 2665 | GINS4/LIG3/DBF4B/ENDOG/RFC3/ZRANB3/GMNN/CDC7/FBXO5/DSCC1/MCIDAS/GINS1/BLM/GINS2/CDT1/E2F7/TICRR |
| GOBP_LEUKOCYTE_DEGRANULATION | 50 | 0.5885403 | 1.780876 | 0.0014652 | 0.0192169 | 0.0155060 | 2462 | PLA2G3/ITGAM/LAT2/CEACAM1/CD177/NR4A3/ANXA3/STXBP1/ADGRE2/UNC13D/LGALS9/PTAFR/HLA-F/STX4/LYN/GAB2/F2RL1/SYK/HMOX1/IL4R/RAB27A |
| GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE | 140 | 0.4546879 | 1.630152 | 0.0014921 | 0.0195144 | 0.0157460 | 2541 | NTRK1/S100A7/ADRA1A/FGFR4/CCL22/CCL4/CCL20/NTRK3/FGF2/KDR/CCL5/CAVIN3/C5AR2/CXCL17/SEMA7A/IL1A/CX3CL1/TNF/JUN/FGF1/BMP2/LGALS9/PDGFB/TLR4/ICAM1/ABCA7/AKAP12/BMPER/CCL17/NOD2/PTPN22/PDGFC/MAPK3/F2RL1/SERPINF2/TPBG/NTRK2/GAREM1/RIPK2/SRC/NOD1/MAP2K1/PDE8A/NRG1 |
| GOBP_RESPONSE_TO_ACID_CHEMICAL | 105 | 0.4781684 | 1.644900 | 0.0015180 | 0.0197980 | 0.0159748 | 2472 | PNPLA3/NTRK1/KLF2/EDN1/FYN/SOCS1/TNF/VEGFA/MTHFR/COL6A1/ASS1/MYC/CASTOR1/LYN/COL1A1/SESN2/PDGFC/ZEB1/GLRA2/NTRK2/COL16A1/CAPN2/RRAGC |
| GOBP_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS | 29 | 0.6636183 | 1.828104 | 0.0015334 | 0.0199421 | 0.0160911 | 1290 | PNPLA3/LPIN1/LDLR/ACSL1/SCARB1/MFSD2A/PCK2/GPAT3 |
| GOBP_REGULATION_OF_T_CELL_PROLIFERATION | 125 | 0.4617792 | 1.619840 | 0.0015578 | 0.0202040 | 0.0163024 | 3060 | EBI3/CD70/IDO1/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/IL23A/IL4I1/TNFSF13B/IL1A/TNFRSF13C/TNFRSF1B/RIPK3/CARD11/CD55/CD274/LGALS9/HLA-G/PRKCQ/CD276/CD46/ARG2/MAPK8IP1/PELI1/HLA-E/PTPN22/ANXA1/PDE5A/PNP/SYK/RIPK2/SLC7A1/TYK2/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/SOS2/IL18/FADD/ZBTB7B/HLA-A/BTN2A2/TGFBR2 |
| GOBP_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE | 120 | 0.4682442 | 1.635628 | 0.0016030 | 0.0207321 | 0.0167285 | 3033 | RSAD2/CLCF1/FOXP3/IL1B/BST2/NR4A3/CAMK4/ARID5A/SEMA7A/KLK7/TNF/TNFRSF1B/TICAM1/CD55/TGFB2/IL18R1/TLR4/CLEC7A/HLA-G/HLA-F/DNAJB9/IRAK3/STX4/NOD2/BCL10/CD40/HLA-E/PTPN22/F2RL1/SHLD1/TRPM4/SHLD2/HMOX1/SPON2/TRAF2/MALT1/SLC7A5/IL4R/TFRC/CD86/LACC1/IL1R1/IL18/SHLD3/SLC15A4/HLA-A |
| GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION | 43 | -0.5842008 | -1.842492 | 0.0016137 | 0.0208126 | 0.0167935 | 2420 | NDC1/MSH5/PSMC3IP/CENPC/RNF212/FMN2/SYCP2/BRIP1/CCNE1/TRIP13/MAJIN/PTTG1/SGO2/ESPL1/CCNE2/PLK1/DMC1/SGO1 |
| GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA | 203 | 0.4085066 | 1.526698 | 0.0016217 | 0.0208583 | 0.0168303 | 3215 | NREP/SCX/THBS1/PEG10/CDKN2B/EDN1/FYN/FOS/GDF15/CDKN1C/ANKRD1/LTBP2/PML/SOX9/JUN/ACVRL1/BMP2/ZEB2/SMAD9/PMEPA1/ENG/TGFB2/MEF2C/TGFB1I1/SPRY1/FERMT1/ITGB8/ADAM9/WNT7A/PTPRK/FMOD/COL1A1/DAB2/FNDC4/LTBP1/VEPH1/ZEB1/GIPC1/ADAM17/FURIN/ITGB6/MAPK7/SMAD6/ITGA3/TGFBR1/SRC/LPXN/IL17RD/LRG1/CLDN1/VASN/HYAL2/WNT4/CAV2/ID1/LATS2/SPRED2/ZMIZ2/TGFBR2/ITGB5/FLCN/CAV1/WNT10A/RUNX3 |
| GOBP_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION | 15 | 0.7867733 | 1.867785 | 0.0016325 | 0.0209406 | 0.0168967 | 3060 | EBI3/IL23A/CD55/LGALS9/HLA-E/PTPN22/SYK/RIPK2/TYK2/IL18/HLA-A/TGFBR2 |
| GOBP_HEAT_GENERATION | 14 | 0.7948442 | 1.849892 | 0.0016707 | 0.0213706 | 0.0172437 | 1164 | IL1B/PTGS2/CNR1/IL1A/TNF/PTGES/ADRB2 |
| GOBP_NEURON_DEATH | 288 | 0.3805995 | 1.472442 | 0.0017543 | 0.0223788 | 0.0180573 | 2543 | PLA2G3/NTRK1/PCSK9/NES/FZD9/MIR200A/ITGAM/SNCA/SLC7A11/ASCL1/CCL5/CLCF1/DRAXIN/DHCR24/NCOA7/KMO/CSF3/NR4A3/FYN/DKK1/FOS/ADAM8/CD34/CX3CL1/G6PD/TNF/TNFRSF1B/STXBP1/JUN/IKBKG/EN2/DDIT3/TGFB2/MEF2C/TLR4/ATF4/HLA-F/CHP1/AGAP2/CSF1/ATP13A2/TYRO3/FOXB1/SIGMAR1/CD200/LGMN/PPARGC1A/BOK/ISL1/BID/DDIT4/NFATC4/AP2B1/NTRK2/PCDHGC3/HMOX1/TRAF2/CAPN2/NLRP1/KRAS/FAS/HYOU1/CASP7/EGR1/SLC9A1 |
| GOBP_LONG_CHAIN_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS | 15 | 0.7850939 | 1.863798 | 0.0017619 | 0.0223977 | 0.0180725 | 2172 | ELOVL6/ACSL1/HSD17B12/ACSL4/ELOVL5/ELOVL7/ELOVL1/HACD2/ACSL5/ELOVL4 |
| GOBP_PEPTIDE_CROSS_LINKING | 23 | 0.6945966 | 1.812993 | 0.0017653 | 0.0223977 | 0.0180725 | 1424 | SPRR2E/SPRR1A/SPRR3/PI3/THBS1/IVL/TGM4/SPRR1B/ABCA7 |
| GOBP_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS | 26 | 0.6784571 | 1.810836 | 0.0017774 | 0.0224295 | 0.0180981 | 3998 | IDO1/CCL5/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/PRKCQ/ARG2/IL7R/PRELID1/PIP/ST3GAL1/FADD/BMP4/HIF1A/RAG1/TP53 |
| GOBP_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION | 98 | -0.4595980 | -1.663244 | 0.0017770 | 0.0224295 | 0.0180981 | 1635 | BRCA1/MRNIP/CDC7/NEK10/STOX1/FBXO5/ORC1/AURKA/CCNB1/ATAD5/BLM/CDC25C/CDC25A/CENPF/CLSPN/KIF14/TICRR/CDK1/PLK1/DTL |
| GOBP_CELL_CYCLE_DNA_REPLICATION | 41 | -0.5776279 | -1.810220 | 0.0017990 | 0.0226408 | 0.0182686 | 1540 | GMNN/CDC7/FBXO5/GINS1/ATAD5/BLM/DNA2/RAD51/CDT1/E2F7/CDC45 |
| GOBP_POSITIVE_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY | 38 | 0.6220897 | 1.794766 | 0.0018127 | 0.0227518 | 0.0183582 | 1440 | ARC/NCF1/EREG/RELN/EDN1/AREG/HBEGF/HDAC6/ADRB2/GREM1/EGF |
| GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST | 157 | 0.4383808 | 1.589312 | 0.0018311 | 0.0229211 | 0.0184948 | 3406 | LDLR/IFITM1/IFIT1/CXCL8/NPC1/SCARB1/IFITM3/LAMP3/CLDN9/TRIM31/LGALS1/CD55/LGALS9/TRIM21/TRIM5/ICAM1/PLSCR1/TRIM14/PVR/SLC3A2/NECTIN4/CD46/TYRO3/TPCN2/CHMP7/ITGB3/ACE2/THOC6/SLC52A2/CHMP6/ITGB7/TRIM25/KRT6A/ITGAV/ITGB6/IFITM2/TRIM22/SRC/VPS37B/TFRC/LY6E/CLDN1/CD86/EPHA2/NECTIN2/HYAL2/PPIA/DAG1/CAV2/P4HB/RNASEK/SMPD1/VPS18/ITGA5/ITGB5/CAV1/CHMP1B/TRIM27/EXOC2/SLC1A5/CHMP4C/SLC52A1 |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS | 66 | 0.5513975 | 1.775465 | 0.0018364 | 0.0229254 | 0.0184983 | 2105 | S100A7/CXCL10/CCL4/CXCL8/CCL5/LBP/THBS1/IL23A/EDN1/SERPINE1/CXCL17/VEGFA/LGALS9/OXSR1/RARRES2/IL34/CSF1/TNFSF14/LGMN/MAPK3/F2RL1/MOSPD2/ADAM17 |
| GOBP_DNA_REPLICATION_CHECKPOINT_SIGNALING | 16 | -0.7544040 | -1.883330 | 0.0018440 | 0.0229593 | 0.0185256 | 828 | ORC1/DNA2/CDT1/CLSPN/TICRR/CDC45 |
| GOBP_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS | 42 | 0.6075937 | 1.781879 | 0.0018527 | 0.0230058 | 0.0185632 | 2425 | IDO1/CCL5/HSH2D/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/PRKCQ/LYN/IRS2/ARG2/BCL10/IL7R/PRELID1/PIP/ST3GAL1 |
| GOBP_ANTIVIRAL_INNATE_IMMUNE_RESPONSE | 15 | 0.7830219 | 1.858879 | 0.0018588 | 0.0230210 | 0.0185754 | 255 | CXCL10/IFIT1/OAS1/MX1 |
| GOBP_PROTEIN_LOCALIZATION_TO_CILIUM | 66 | -0.5150113 | -1.746731 | 0.0018667 | 0.0230577 | 0.0186050 | 4445 | INPP5E/CDK20/GAS8/TMEM107/ATP6V1D/ARL6/ARL13B/DNAH11/TUB/ROM1/ARL3/WDR19/BBS4/BBIP1/TCTN2/ZMYND10/ODAD4/DZIP1L/TBC1D32/BBS9/DNAAF11/SPATA7/TCTN1/CFAP58/CCDC66/EFCAB7/IFT122/IFT140/CCDC88A/LZTFL1/WDR35/DZIP1/CC2D2A/CCDC39/IFT80/MAPK15/ROPN1B/TTC21A/DYNC2H1/TTC21B/CROCC |
| GOBP_REGULATION_OF_LEUKOCYTE_PROLIFERATION | 175 | 0.4195424 | 1.544046 | 0.0019135 | 0.0235734 | 0.0190211 | 3060 | EBI3/CD70/IDO1/TNFSF9/CCL5/CLCF1/IGF2/FOXP3/IL1B/BST2/VCAM1/IL23A/IL4I1/MYD88/TNFSF13B/IL1A/TNFRSF13C/TNFRSF1B/RIPK3/TICAM1/CARD11/CD55/CD274/LGALS9/TNFAIP3/MEF2C/TLR4/HLA-G/PRKCQ/CDKN1A/GREM1/CD276/IL34/CSF1/CD46/LYN/IRS2/ARG2/MAPK8IP1/PELI1/CD40/HLA-E/PTPN22/MAPK3/ANXA1/PDE5A/PNP/SYK/RIPK2/SLC7A1/TYK2/AHR/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/SOS2/IL18/FADD/ZBTB7B/TIRAP/HLA-A/BTN2A2/TGFBR2 |
| GOBP_CYTOPLASMIC_TRANSLATION | 142 | -0.4074974 | -1.553162 | 0.0019413 | 0.0238527 | 0.0192465 | 4600 | MIF4GD/RPL10/RWDD1/RPS11/RPS26/DPH5/RPL18/RPS16/RPL18A/RPS24/RPL23A/RPL24/EIF4A2/RPS5/NEMF/RPS27/RPS12/RPL27/EIF3D/RPL9/RPS8/RPL7A/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/ZNF385A/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/PABPC1/RPS29/RPL3/RPS2/RPS20/RPS13/RPL29/RPS23/RPL11/CPEB3/RPS25/DPH6/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/EIF2D/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/RPL22/EIF4B/RPS14/RPL7/RPL5/RPL10A/RBM4/RPS3A/RPS10/RBM24 |
| GOBP_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS | 38 | 0.6177682 | 1.782298 | 0.0019790 | 0.0242523 | 0.0195690 | 2031 | S100A7/TNFAIP6/SLIT2/CXCL8/CCL5/LBP/THBS1/IL23A/C5AR2/EDN1/CXCL17/RARRES2/IL34/CSF1/NOD2/MAPK3/MOSPD2 |
| GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS | 259 | 0.3890120 | 1.495425 | 0.0019969 | 0.0244072 | 0.0196939 | 1807 | PLA2G3/APOC1/DHCR7/INSIG1/FGFR4/LPIN1/MLXIPL/STARD4/LDLR/TRIB3/FGF2/SNCA/DISP3/IL1B/SERPINA3/PTGS2/CNR1/CEACAM1/SCARB1/ELOVL5/NR4A3/MFSD2A/IL1A/TNF/BMP6/ACADL/LACTB/SOX9/PIK3IP1/IDH1/FGF1/BMP2/PDGFB/CCN1/RNF213/RUBCN/CHP1/AGAP2/RARRES2/ABCA7/LYN/NPC2/FLT1/IRS2/GFI1/LPCAT1/NOD2/SPHK1/DAB2/EEF1A2/PPARGC1A |
| GOBP_POSITIVE_REGULATION_OF_T_CELL_MIGRATION | 22 | 0.7119548 | 1.835751 | 0.0020986 | 0.0254502 | 0.0205355 | 2105 | S100A7/CXCL10/CCL20/CCL5/ADAM8/OXSR1/TNFSF14/ADAM17 |
| GOBP_PROTEIN_KINASE_B_SIGNALING | 152 | 0.4358229 | 1.568777 | 0.0020979 | 0.0254502 | 0.0205355 | 2830 | NTRK1/NTRK3/FGF2/XDH/KDR/CCL5/IGF2/IL1B/THBS1/CAVIN3/CSF3/PEAR1/PLK3/GDF15/ADAM8/CX3CL1/TNF/MEIS3/HBEGF/SOX9/C1QTNF1/ENG/DDIT3/SH2B3/HLA-G/RRAS/PTPRJ/ADTRP/MET/EGF/TYRO3/CD40/SESN2/MST1R/TPBG/MYDGF/NTRK2/P2RX4/ILK/RASD2/TGFBR1/SRC/INPP5F/F3/NRG1/EPHA2/HYAL2/DAG1/MFHAS1/IL18/RTN4 |
| GOBP_REGULATION_OF_PROTEIN_SECRETION | 191 | 0.4194406 | 1.557821 | 0.0020933 | 0.0254502 | 0.0205355 | 2429 | ACHE/CYP51A1/HMGCR/RSAD2/TTN/CCL5/ACSL4/IL1B/CCN3/CNR1/AACS/ADAM8/ANKRD1/IL1A/TNF/BMP6/NOS2/GPR68/PCK2/FOXA2/SAA1/FKBP1B/TLR2/KLF7/TGFB2/TLR4/LRRC8A/RHBDF2/ADAM9/GPR27/ADTRP/ANO1/STX4/ATP13A2/ADCY5/RAB11FIP1/CD200/LLGL2/IRS2/SLC8B1/C1QTNF3/SOX4/CFTR/EFNA5/ZBED6/ISL1/FAM3D/ENSA/F2RL1/GLUD1/DNAJC1/TRPM4/ABCA12/PFKFB2/STX1A/RAB11FIP5/ERP29/DOC2B/SLC12A2/FRMD4A/SERGEF |
| GOBP_INTERLEUKIN_6_PRODUCTION | 110 | 0.4701540 | 1.632479 | 0.0021250 | 0.0256511 | 0.0206976 | 3125 | EREG/KLF2/LBP/FOXP3/IL1B/IFIH1/ZC3H12A/C5AR2/ARID5A/MYD88/IL1A/CX3CL1/IL1RL2/TNF/TICAM1/NOS2/CD47/LGALS9/TNFAIP3/TLR2/TLR4/PTAFR/CLEC7A/IRAK3/SELENOS/IL36A/CD200/NOD2/C1QTNF3/AKIRIN2/BCL10/ISL1/PTPN22/F2RL1/SYK/HLA-B/SPON2/RIPK2/CAPN2/NOD1/TMEM106A/HYAL2/CEBPB/MAPKAPK2/TIRAP/PTPN11/SIRPA/TWIST1 |
| GOBP_OSSIFICATION | 322 | 0.3550264 | 1.395370 | 0.0021261 | 0.0256511 | 0.0206976 | 2264 | ACHE/EBP/TNFAIP6/ISG15/FZD9/FASN/IFITM1/SLC8A1/SCX/FGF2/ALPL/MMP16/IGF2/SMOC1/COL13A1/BMP8B/PTGS2/LRRC17/DKK1/FOXC2/EGR2/SEMA7A/AREG/TNF/FAM20C/BMP6/MAPK11/SOX9/BMP2/COL6A1/FSTL3/TP53INP2/EIF2AK3/TGFB2/MEF2C/ADRB2/ATF4/CCN1/ENPP1/JUND/GREM1/PDLIM7/CSF1/TPM4/TUFT1/PPARGC1B/KL/COL1A1/ID4/CTNNBIP1/RRBP1/NOCT/PTHLH/KLF10/MMP13/BCAP29/PHEX/CCN4/ADAR/GABBR1/SBNO2/MAPK3/ID3/TRPM4/IARS1/HDAC7/MMP14/CTHRC1/ILK/SMAD6 |
| GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS | 34 | 0.6384570 | 1.812473 | 0.0021514 | 0.0258891 | 0.0208897 | 2172 | ELOVL6/ACSL1/HSD17B12/SLC25A1/GGT7/ACSL4/ELOVL5/GGT5/AACS/ELOVL7/ACACA/ACSS3/ELOVL1/HACD2/ACSL5/FAR2/ELOVL4 |
| GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS | 111 | 0.4631159 | 1.611132 | 0.0021670 | 0.0260092 | 0.0209866 | 1807 | PLA2G3/APOC1/MLXIPL/STARD4/LDLR/FGF2/DISP3/IL1B/PTGS2/SCARB1/ELOVL5/NR4A3/MFSD2A/IL1A/TNF/BMP6/FGF1/PDGFB/CCN1/CHP1/AGAP2/LYN/FLT1/IRS2/NOD2/DAB2/EEF1A2/PPARGC1A |
| GOBP_SKELETAL_SYSTEM_DEVELOPMENT | 372 | 0.3609576 | 1.433915 | 0.0021811 | 0.0261111 | 0.0210688 | 2677 | EBP/INSIG1/HYAL1/DLX2/SCX/SNORC/FGF2/HYAL3/HOXB1/KDR/ALPL/HOXA10/MMP16/HHIP/MATN3/COL13A1/BMP8B/CCN3/LRRC17/FST/EDN1/FOXC2/ARID5A/CYP26B1/ALX1/CDKN1C/FLVCR1/FAM20C/BMP6/GPR68/MAPK11/SOX9/ACVRL1/LOXL2/BMP2/HOXB5/ENG/EIF2AK3/SPNS2/CSRNP1/TGFB2/MEF2C/MTHFD1L/HAPLN3/CCN1/SH2B3/COL9A2/GREM1/ITGB8/VKORC1/TTC9/WNT7A/FLI1/PPARGC1B/COL1A1/HOXB6/CTC1/SOX4/MDFI/PTHLH/MAF/MMP13/PHEX/CCN4/PDGFC/SRF/ZEB1/MAPK3/SLC39A1/ITGB6/SERPINH1/TGFBI/MMP14/PIP4K2A/PBXIP1/PLS3/PKDCC/TGFBR1/SRC/HEXB/SH3PXD2B/MSX2/BMP3/HSD17B1/TLL1/EPHA2/HYAL2/ZNF219 |
| GOBP_B_CELL_DIFFERENTIATION | 93 | 0.4804024 | 1.620476 | 0.0021907 | 0.0261594 | 0.0211077 | 2594 | NTRK1/FZD9/CLCF1/KLF6/VCAM1/HDAC9/IL4I1/TNFSF13B/CARD11/LGALS1/DOCK10/LRRC8A/PTPRJ/IL11/INHBA/DNAJB9/PTPN2/SYK/ADAM17/CEBPG/MMP14/BCL3/MALT1/GPS2/ST3GAL1/BAK1/CMTM7 |
| GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS | 262 | 0.3884004 | 1.496428 | 0.0022381 | 0.0266574 | 0.0215096 | 2218 | PLA2G3/APOC1/DHCR7/INSIG1/FGFR4/SLC2A6/MLXIPL/STARD4/LDLR/TRIB3/PPP1R3G/SNCA/SLC7A11/PHLDA2/IGF2/IL1B/PTGS2/CNR1/CEACAM1/PMAIP1/ELOVL5/NR4A3/MFSD2A/TNF/BMP6/ACADL/NOS2/SOX9/FGF1/FOXA2/BMP2/C1QTNF1/PTAFR/CDA/ENPP1/PGP/SELENOS/MYC/IRS2/NLN/GFI1/ANTKMT/SLC7A7/DAB2/C1QTNF3/PPARGC1A/SESN2/DDIT4/HRH1/ANXA1/PTPN2/PFKFB2/ENTPD5/SLC27A4/GPT |
| GOBP_LIPID_HOMEOSTASIS | 122 | 0.4618754 | 1.617223 | 0.0022627 | 0.0268813 | 0.0216902 | 906 | PNPLA3/TMEM97/PCSK9/INSIG1/FGFR4/LIPC/LIPG/MLXIPL/LDLR/NPC1/DISP3/LCAT/HDAC9/ACOXL/SCARB1/ABHD4/ANGPTL4/TLCD1/SREBF2/EHD1/ACACA |
| GOBP_MEIOSIS_II_CELL_CYCLE_PROCESS | 10 | -0.8125776 | -1.812781 | 0.0022732 | 0.0269376 | 0.0217357 | 363 | SGO2/BUB1/SGO1/BUB1B |
| GOBP_HORMONE_BIOSYNTHETIC_PROCESS | 45 | 0.5864124 | 1.746654 | 0.0023198 | 0.0274064 | 0.0221139 | 2708 | DHCR7/HSD17B7/HSD17B12/SRD5A3/STC2/BMP6/BMP2/DUOX2/GFI1/HSD17B8/DAB2/TG/EGR1/HSD17B1/NFKB1/WNT4 |
| GOBP_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 98 | 0.4855197 | 1.650765 | 0.0023303 | 0.0274064 | 0.0221139 | 3181 | RSAD2/TNIP3/OAS1/LBP/IRF7/BIRC3/IRAK2/IFI35/MYD88/TNIP1/TNF/TICAM1/NFKBIA/RFTN1/LGALS9/LY96/TNFAIP3/TLR2/NMI/TLR4/TNIP2/IRAK3/TYRO3/LYN/GFI1/NOD2/PELI1/BCL10/CD40/IRAK1/PTPN22/F2RL1/RIPK2/GPS2/SMPDL3B/S100A14/IRF1/MFHAS1/RTN4/DAB2IP/MAPKAPK2/SLC15A4/TIRAP/MAPKAPK3/FLOT1/RPS6KA3/CAV1 |
| GOBP_ENDOCYTOSIS | 459 | 0.3433469 | 1.388456 | 0.0023263 | 0.0274064 | 0.0221139 | 3636 | ARC/APOC1/ACHE/PCSK9/SGIP1/SLC2A4/LDLR/DPYSL2/SYT2/CXCL8/SYT1/NPC1/ITGAM/SNCA/NOSTRIN/LBP/LRP8/THBS1/CEACAM1/SCARB1/CD177/PEAR1/DKK1/SERPINE1/SCARF1/EPHA3/ANK2/TMPRSS5/AMN/CXCL16/VEGFA/COLEC10/EHD1/ELMO1/LOXL2/APOBR/C4BPA/MARCHF3/RAB5B/WASF1/ADRB2/SNX9/CLEC7A/ENPP1/LDLRAD3/PACSIN1/GREM1/RUBCN/CACNG8/MFGE8/XKR9/ABCA7/PDLIM7/EGF/TPCN2/ITGB3/HOOK2/EHD4/CD151/SPHK1/DAB2/RAB4B/MICALL1/TMPRSS13/OLR1/CSNK1G2/ADGRB1/HSPG2/RAB27B/RHOG/BICD1/MAPK3/F2RL1/XKR8/ITGAV/ARHGAP27/AP2B1/GULP1/SYK/CD9/STX1A/SPON2/SNX12/CAP1/SRC/ITSN1/SURF4/INPP5F/RINL/ITSN2/ARHGAP12/NECAP1/TFRC/ACTB/MARCHF2/ACTG1/PIK3C2A/CAV2/MYH9/C3/MAPKAPK2/OCIAD2/NEDD4/RNASEK/CLTB/SMPD1/SYNJ2/TGFBR2/MAPKAPK3/FLOT1/DNER/LGALS3BP/SH3KBP1/CAV1/ARFGAP1/DNAJC13/ABL2/ANKFY1/PPT1/SH3GL1/RIN3/WASL/RAB34/CTTN/NECAP2/BIN1/TNK2/CD63/PICALM/PACSIN2/SCARB2/CLCN5/HRAS/CYTH2/LRP10 |
| GOBP_MACROAUTOPHAGY | 291 | 0.3734198 | 1.444303 | 0.0023727 | 0.0278345 | 0.0224594 | 4649 | NPC1/HSPB8/KDR/ADPRH/UCHL1/FEZ1/MAP1LC3B2/IKBKG/HDAC6/TP53INP2/ADRB2/GABARAPL1/RNF213/RUBCN/OPTN/ATP13A2/CHMP7/TMEM41B/WIPI1/NOD2/STBD1/SESN2/CHMP6/EPM2A/MAPK3/RNF31/VPS33B/VMP1/PIP4K2A/SQSTM1/GPSM1/HMOX1/RIPK2/MCOLN1/SRC/VPS37B/NOD1/PLAA/AUP1/ATG2A/VIPAS39/PIP4K2C/TBC1D25/TIGAR/RHEB/ERN1/GABARAP/NEDD4/MAP1LC3B/ATP6V1E2/DDRGK1/FEZ2/SH3GLB1/VCP/UBQLN4/CHMP1B/ATG13/PIP4K2B/CHMP4C/WDR45/RETREG3/TAFAZZIN/RAB43/PACS2/VPS37D/EI24/PHF23/SMURF1/ZFYVE1/ATP6V1B2/ULK3/ILRUN/RAB33B/HIF1A/VPS4A/CHMP2B/ATG14/VPS37A/USP36/ATP6V0B/EXOC8/TP53/UFM1/STX12/PIKFYVE/ATP6V0A1/SPTLC2/RAB7A/MVB12A/AKT1/ARL8B/RAB19/WDR81/PSEN1/SNF8/UBQLN1/MTMR14/SNX6/ATG101/CALCOCO2/QSOX1/ATP6V1H/ATG9A/HTT/GNAI3/RALB/CHMP1A/ATG7/RAB5A/CHMP3/NRBP2/AP4M1/PGAM5/PIK3CA |
| GOBP_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION | 20 | 0.7212036 | 1.827514 | 0.0023825 | 0.0278739 | 0.0224912 | 3192 | RSAD2/IL1B/ARID5A/CD55/IL18R1/TRAF2/MALT1/IL1R1/IL18/HLA-A/FZD5 |
| GOBP_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE | 107 | -0.4537849 | -1.653937 | 0.0023880 | 0.0278739 | 0.0224912 | 1590 | RRM1/MEIS2/SASS6/CENPJ/MTBP/CDC7/STOX1/FBXO5/ANAPC4/CCNB1/CDC25C/CDC25A/CDT1/ESPL1/CDK1/SMOC2/CDCA5/DLGAP5/RRM2/DTL/UBE2C |
| GOBP_REGULATED_EXOCYTOSIS | 172 | 0.4095559 | 1.506978 | 0.0024016 | 0.0279632 | 0.0225632 | 2252 | PLA2G3/ADRA1A/SYT2/HYAL3/SYT1/ITGAM/SYNGR3/SNCA/LAT2/UNC13A/SYT17/CNR1/CEACAM1/CD177/NR4A3/CLTRN/ANXA3/STX3/STXBP1/ADGRE2/STX11/UNC13D/LGALS9/PPFIA3/PTAFR/CBARP/HLA-F/STX4/LYN/RAB11FIP1/WNT7A/GAB2/MICAL1/F2RL1/GIPC1/TRPV6/ABCA12/SYK/ARHGAP17/STX1A/RAB11FIP5/DOC2B/HMOX1 |
| GOBP_LIPID_LOCALIZATION | 338 | 0.3555691 | 1.403628 | 0.0024168 | 0.0280700 | 0.0226494 | 2427 | PLA2G3/APOC1/PCSK9/LIPC/LIPG/SQLE/STARD4/LDLR/ANO4/ACSL1/PLA2G4C/NPC1/SLC5A8/DISP3/LBP/LCAT/IL1B/ATP8A2/THBS1/ZC3H12A/CEACAM1/SCARB1/YJEFN3/STRA6/EDN1/SLCO1B1/MFSD2A/IL1A/TNF/BMP6/NFKBIA/NOS2/SREBF2/EHD1/APOL1/IKBKE/STOML1/APOBR/SLC10A6/C1QTNF1/APOL2/SPNS2/ANO9/PTGES/ENPP1/RNF213/PLSCR1/APOL6/INHBA/XKR9/ABCA7/EGF/SIGMAR1/NPC2/TPCN2/ITGB3/TMEM41B/IRS2/NPC1L1/DAB2/ESYT1/CFTR/SLCO3A1/ANO7/ANXA1/PTPN2/XKR8/ITGAV/PRELID1/GULP1/ABCA12/SLC10A3/PITPNB/SYK/ACSL5/ATP11A/FURIN/P2RX4/VMP1/SLC27A4/PIP4K2A/ABCA3/ATP10A/HEXB/GPS2/SURF4/SLC27A5 |
| GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS | 38 | 0.6120432 | 1.765781 | 0.0024447 | 0.0282531 | 0.0227971 | 2425 | IDO1/CCL5/HSH2D/IRF7/TSC22D3/PRKCQ/SELENOS/IRS2/ARG2/NOD2/BCL10/IL7R/PIP/ST3GAL1 |
| GOBP_INTERFERON_GAMMA_PRODUCTION | 77 | 0.5107054 | 1.668673 | 0.0024388 | 0.0282531 | 0.0227971 | 3323 | EBI3/ISG15/FOXP3/IL1RL1/IL1B/ZC3H12A/IL23A/ARID5A/TNF/RIPK3/CD47/CD274/LGALS9/DDIT3/IL18R1/TLR4/CLEC7A/INHBA/CD276/BTN3A1/NOD2/ISL1/PTPN22/F2RL1/CEBPG/BCL3/RIPK2/SLC7A5/TYK2/IL1R1/IL18/FADD/HLA-A/SIRPA/FZD5/TRIM27/BTN3A2 |
| GOBP_MONOCYTE_DIFFERENTIATION | 29 | 0.6527612 | 1.798196 | 0.0024687 | 0.0283902 | 0.0229078 | 1778 | MT1G/FASN/IRF7/IL31RA/VEGFA/GPR68/JUN/MYC/IL34/CSF1/IFI16/CTNNBIP1 |
| GOBP_REGULATION_OF_HORMONE_LEVELS | 352 | 0.3547027 | 1.404237 | 0.0024667 | 0.0283902 | 0.0229078 | 3119 | PLA2G3/DHCR7/HSD17B7/LIF/RDH11/HSD17B12/CCL5/ACSL4/IL1B/SLCO4A1/CCN3/SRD5A3/CNR1/CYP46A1/EDN1/AACS/CLTRN/SLCO1B1/IL4I1/DUOXA2/STC2/CYP3A5/CYP26B1/IL1RN/RAB8B/TNF/BMP6/SDR16C5/NOS2/GPR68/PCK2/ERO1A/FOXA2/BMP2/BCO1/C1QTNF1/ALDH1A3/FKBP1B/KLF7/LIPE/ECE1/LRRC8A/RETSAT/IL11/INHBA/PAX8/GPR27/ANO1/CYP1B1/DUOX2/STX4/LYN/ADCY5/RAB11FIP1/IRS2/ACE2/GFI1/HSD17B8/SLC8B1/DAB2/C1QTNF3/DHRS7/SOX4/CFTR/DUOXA1/EFNA5/ZBED6/ISL1/CRYM/FAM3D/ENSA/GABBR1/ANXA1/GLUD1/NIBAN2/TRPM4/TRPV6/ABCA12/PFKFB2/FURIN/STX1A/RAB11FIP5/ALDH1A2/SLC5A5/GCNT4/DOC2B/TG/SLC7A5/EGR1/CYP2S1/DGAT1/RDH13/HSD17B1/CYP2C18/PLB1/NFKB1/WNT4/GLUL/SULT1B1/PNPLA2/CYP2C9/RDH10/PIM3/BRSK2/PTPN11/ICA1/CACNA1H/MCU/SLC39A14/CPT1A |
| GOBP_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY | 170 | 0.4180710 | 1.537659 | 0.0024767 | 0.0284120 | 0.0229253 | 2469 | THEMIS2/LAT2/FOXP3/CMTM3/ZC3H12A/CEACAM1/C5AR2/NR4A3/FYN/PLPP4/CARD11/GBP1/RFTN1/IKBKG/CD47/MICB/UBASH3A/MEF2C/CLEC7A/HLA-G/KLRD1/PLSCR1/PRKCQ/PTPRJ/DUSP3/CD276/LYN/NFKBIZ/BTN3A1/NFKBID/BCL10/CD40/PTPN22/PTPN2/RNF31/THY1/SYK/BCAR1/RIPK2/SRC/MALT1/PRKCH/GPS2/LPXN/RBCK1 |
| GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION | 222 | 0.3999774 | 1.517253 | 0.0024837 | 0.0284226 | 0.0229339 | 3406 | CCL4/LDLR/IFITM1/IFIT1/CXCL6/CXCL8/NPC1/CCL5/IFI27/ZC3H12A/SCARB1/IFITM3/MYD88/LAMP3/CLDN9/TRIM31/LGALS1/CD55/JUN/APOL1/LGALS9/TRIM21/TRIM5/ICAM1/PLSCR1/TRIM14/PVR/SLC3A2/NECTIN4/CD46/TYRO3/TPCN2/CHMP7/ITGB3/TMEM41B/ACE2/THOC6/SLC52A2/CHMP6/ITGB7/TRIM25/F2RL1/KRT6A/ITGAV/ITGB6/IFITM2/SAP30BP/TREM1/TRIM22/SRC/STOM/VPS37B/TFRC/LY6E/CLDN1/CD86/EPHA2/NECTIN2/HYAL2/RAB9A/PPIA/DAG1/CAV2/POU2F3/P4HB/RNASEK/RRP1B/SMPD1/VPS18/ITGA5/ITGB5/CAV1/CFL1/CHMP1B/TRIM27/EXOC2/SLC1A5/CHMP4C/SLC52A1 |
| GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT | 218 | 0.3999367 | 1.515908 | 0.0024912 | 0.0284387 | 0.0229469 | 3061 | CXCL10/HYAL1/CCR3/CXCL8/FGF2/KDR/KLF2/IL1B/ADM2/THBS1/ZC3H12A/CEACAM1/YJEFN3/FOXC2/ANGPTL4/SERPINE1/CD34/EMILIN2/IL1A/ANXA3/PML/TNF/RHOB/VEGFA/WARS1/STAT1/FGF1/ACVRL1/VASH2/TNFAIP3/ENG/TGFB2/HLA-G/RRAS/GREM1/KLF4/ADAMTS9/ITGB8/CYP1B1/FLT1/GADD45A/BMPER/CEMIP2/SPHK1/SP100/ETS1/AKT3/CD40/ADGRB1/ISL1/HSPG2/TJP1/NIBAN2/MYDGF/MAPK7/ADAMTS1/HMOX1/BTG1/SLC12A2/LRG1/F3/RAPGEF3/EPHA2/WNT4/GLUL/ECM1/C3/ID1/DAB2IP/HK2/SARS1/JUP/PLCG1/ITGA5/SPARC/TGFBR2/JAK1 |
| GOBP_SPROUTING_ANGIOGENESIS | 107 | 0.4749596 | 1.641439 | 0.0025411 | 0.0289374 | 0.0233493 | 2252 | FGFBP1/DLL4/SLIT2/NR4A1/FGF2/KDR/KLF2/HDAC9/THBS1/PTGS2/CEACAM1/YJEFN3/FOXC2/VEGFA/FGF1/ACVRL1/LOXL2/ENG/RNF213/GREM1/KLF4/ADAMTS9/ADTRP/ESM1/BMPER/CEMIP2/AKT3/SRF/ANXA1/TJP1/CARD10/HDAC7/EPHB4/HMOX1 |
| GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE | 10 | -0.8093837 | -1.805656 | 0.0025548 | 0.0290227 | 0.0234181 | 297 | CES1/NR1H3/TREM2/ABCA1/ABCG1 |
| GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE | 56 | 0.5592054 | 1.741046 | 0.0025655 | 0.0290739 | 0.0234594 | 3192 | RSAD2/IL1B/NR4A3/CAMK4/ARID5A/SEMA7A/TICAM1/CD55/IL18R1/TLR4/CLEC7A/HLA-G/HLA-F/NOD2/BCL10/HLA-E/F2RL1/SPON2/TRAF2/MALT1/SLC7A5/LACC1/IL1R1/IL18/HLA-A/FZD5 |
| GOBP_MEMBRANE_RAFT_ORGANIZATION | 19 | 0.7196942 | 1.797153 | 0.0025871 | 0.0292470 | 0.0235991 | 3584 | NPC1/YJEFN3/FA2H/RFTN1/ABCA7/S100A10/CAV2/MYADM/FLOT1/CAV1/EMP2/PPT1/PACSIN2 |
| GOBP_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY | 14 | 0.7779271 | 1.810520 | 0.0027293 | 0.0307799 | 0.0248360 | 2470 | FOXP3/CEACAM1/IL4I1/HLA-G/KLRD1/HLA-F/NOD2/IL7R/AHR |
| GOBP_LEUKOCYTE_PROLIFERATION | 224 | 0.3962407 | 1.505900 | 0.0027612 | 0.0310653 | 0.0250662 | 3060 | EBI3/CD70/IDO1/TNFSF9/CCL5/CLCF1/IGF2/FOXP3/IL1B/BST2/VCAM1/IL23A/FYN/IL4I1/MYD88/TNFSF13B/IL1A/CX3CL1/TNFRSF13C/TNFRSF1B/RIPK3/TICAM1/CARD11/CD55/CD274/LGALS9/TNFAIP3/FKBP1B/MEF2C/TLR4/HLA-G/PRKCQ/CDKN1A/GREM1/MSN/CD276/IL34/CSF1/CD46/LYN/CADM1/IRS2/BTN3A1/ARG2/TNFSF14/CD151/MAPK8IP1/PELI1/CTPS1/CD40/IL7R/HLA-E/PTPN22/MAPK3/ANXA1/F2RL1/ELF4/PDE5A/PNP/SYK/RIPK2/SLC7A1/MALT1/TYK2/AHR/CCND3/TFRC/CD86/IL15/NCK1/CEBPB/IRF1/WNT4/SOS2/IL18/FADD/ZBTB7B/TIRAP/HLA-A/BTN2A2/TGFBR2 |
| GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION | 30 | 0.6478465 | 1.785041 | 0.0027755 | 0.0311508 | 0.0251353 | 1908 | KLF2/FOXP3/ZC3H12A/C5AR2/CX3CL1/TNF/TNFAIP3/TLR4/IRAK3/SELENOS/CD200/C1QTNF3/PTPN22 |
| GOBP_ISOPRENOID_METABOLIC_PROCESS | 91 | 0.4869516 | 1.638078 | 0.0028169 | 0.0315398 | 0.0254492 | 1492 | MVD/HMGCS1/LSS/FDPS/HMGCR/IDI1/FDFT1/MVK/RDH11/LRP8/SRD5A3/CYP3A5/CYP26B1/SDR16C5/BCO1/ALDH1A3/PLPP6/LIPE/RETSAT/RARRES2/CYP1B1/NPC2 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION | 29 | -0.6209820 | -1.775601 | 0.0028431 | 0.0316811 | 0.0255632 | 3621 | PBX1/CDK4/NPM1/MECP2/DYRK3/DBF4B/RRM1/CDC7/STOX1/FBXO5/CCNB1/ATAD5/CDC25C/CDC25A/CDK1/DTL |
| GOBP_SIGNAL_RELEASE | 321 | 0.3668131 | 1.439774 | 0.0028385 | 0.0316811 | 0.0255632 | 2164 | PLA2G3/ADRA1A/NR4A1/SYT2/LIF/SYT1/SNCA/CCL5/ACSL4/UNC13A/IL1B/KMO/CCN3/CHRNB4/SYT17/CNR1/EDN1/AACS/CLTRN/IL1RN/IL1A/RAB8B/TNF/BMP6/STX3/NOS2/GPR68/STXBP1/PCK2/STX11/FOXA2/C1QTNF1/FKBP1B/KLF7/PPFIA3/PTGES/MEF2C/LRRC8A/IL11/INHBA/PAX8/GPR27/ANO1/STX4/LYN/ADCY5/RAB11FIP1/WNT7A/IRS2/PORCN/SLC8B1/DAB2/C1QTNF3/SOX4/CFTR/EFNA5/ZBED6/ISL1/FAM3D/ENSA/GABBR1/ANXA1/F2RL1/GLUD1/GIPC1/NIBAN2/TRPM4/TRPV6/ABCA12/SYK/PFKFB2/STX1A/RAB11FIP5/P2RX4 |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMATIN | 31 | -0.6143845 | -1.798488 | 0.0028593 | 0.0317860 | 0.0256478 | 2301 | RUVBL2/FAM47E/MRNIP/LRWD1/EZH2/PLK1/ESCO2/CDCA5/H1-5 |
| GOBP_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH | 24 | 0.6764509 | 1.771915 | 0.0028999 | 0.0320841 | 0.0258883 | 3437 | ZBP1/FZD9/BIRC3/RIPK3/PELI1/BOK/RBCK1/CASP6/FADD/CASP8/CAV1/ARHGEF2/CFLAR |
| GOBP_REGULATION_OF_RESPONSE_TO_WOUNDING | 124 | 0.4501608 | 1.580317 | 0.0028994 | 0.0320841 | 0.0258883 | 2734 | RTN4R/SERPINC1/FGF2/PLAU/THBS1/CEACAM1/EDN1/TNFRSF12A/FOXC2/SERPINE1/SERPINB2/CD34/SCARF1/OCLN/TNF/HBEGF/CLDN4/FOXA2/C1QTNF1/TNFAIP3/FKBP1B/PDGFB/CLEC7A/SH2B3/KLF4/FERMT1/ADTRP/VKORC1/DUOX2/PHLDB2/PRKG1/PLPP3/CCN4/ANXA1/F2RL1/SERPINF2/TFPI/CD9/SERPINE2/SLC12A2/FLNA/INPP5F/MAP2K1/F3/CLDN1/NDEL1/WNT4/ACTG1 |
| GOBP_REGULATION_OF_GTPASE_ACTIVITY | 304 | 0.3686144 | 1.437517 | 0.0029224 | 0.0322571 | 0.0260279 | 3880 | NTRK1/RGS7/CCL22/CCL4/CCL20/RGS16/RTN4R/NTRK3/ADPRH/CCL5/TRAPPC6A/EPHA3/CX3CL1/CPEB2/RASGRP3/TBC1D3D/ARHGAP11B/FGD2/NEDD9/SNX9/DOCK10/ADAP2/RASA4B/SPRY1/PLXNA3/TIAM2/DVL2/MET/ASAP3/PRKG1/NGEF/CCL17/CD40/EFNA5/GMIP/RHOG/RGS10/S100A10/F2RL1/PLXNA1/ARHGAP27/THY1/TBC1D4/NTRK2/BCAR3/RAP1GAP/SLC27A4/PLXNA4/DOCK6/PBXIP1/GPSM1/MAP4K4/ADAP1/SYDE2/ARHGAP12/MAPRE2/RSU1/RAPGEF3/CCPG1/SYDE1/EPHA2/NDEL1/TBC1D25/TBC1D10A/ASAP2/WNT4/SOS2/CAV2/RASAL1/FGD6/RAP1GAP2/DAB2IP/ITGA6/RRP1B/STMN3/FLCN/GRHL3/RANGAP1/ARHGEF5/TBC1D22B/TBC1D10B/ARHGAP29/TBC1D17/IQGAP1/TBC1D1/BIN1/TGM2/ARL2/PICALM/CRK/HRAS/RGP1/FGD4/RASA2/RGS14/SGSM3/ARHGEF10/RAPGEF1/CHN1/GSK3B/PIP5K1A/MMUT/CORO1C/TBC1D20 |
| GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS | 17 | 0.7405220 | 1.813103 | 0.0029993 | 0.0328725 | 0.0265245 | 1470 | IDO1/IDO2/KYNU/KMO/IL4I1/TPH2/HAAO |
| GOBP_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION | 84 | 0.5008464 | 1.666143 | 0.0029877 | 0.0328725 | 0.0265245 | 2005 | PLA2G3/TNFAIP6/LIF/EVI2B/IRF7/IL23A/CEACAM1/LRRC17/FOS/PRXL2A/CAMK4/TNF/GPR68/FSTL3/TLR4/INHBA/TFE3/MYC/IL34/CSF1/LYN/TRIB1/PPARGC1B/CTNNBIP1/KLF10/PTPN2 |
| GOBP_AXON_DEVELOPMENT | 382 | 0.3423554 | 1.361973 | 0.0029979 | 0.0328725 | 0.0265245 | 2656 | NTRK1/PAX6/NREP/TUBB3/SLIT2/DPYSL2/RTN4R/OLFM1/L1CAM/MAP2/ISLR2/DRAXIN/NTNG1/ATP8A2/SEMA3B/SCN1B/RELN/CHODL/CNR1/ACTBL2/SEMA3D/EDN1/FYN/EPHA10/EGR2/UCHL1/FEZ1/SCARF1/EPHA3/SEMA7A/MAP1B/FGF13/VEGFA/NRXN3/LAMA3/LAMC2/STXBP1/JUN/SLITRK5/HDAC6/VASH2/ARTN/FKBP1B/KLF7/PTPRO/ECE1/VCL/PRKCQ/KLF4/PLXNA3/TIAM2/FLRT2/NRCAM/FOXB1/WNT7A/NCAM2/KIF5C/DBN1/SLC9A6/EFNA5/ADGRB1/ISL1/SHTN1/RHOG/NTNG2/S100A6/SRF/PLXNA1/TRIO/NIBAN2/THY1/NTRK2/B4GALT5/EPHB4/PLXNA4/COBL/FLNA/CCK/NTN1/SEMA3A/INPP5F/MAP2K1/ROBO2/VASP/ACTB/SEMA3C/EPHA2/NDEL1 |
| GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS | 263 | 0.3839703 | 1.478389 | 0.0030126 | 0.0329409 | 0.0265797 | 3087 | PCSK9/FADS1/SCX/HABP4/TNFRSF10A/IL1B/VCAM1/KIF26A/ZC3H12A/PTGS2/PMAIP1/CDKN2B/FOS/MFSD2A/MAP1LC3B2/MYD88/ANKRD1/DSC2/ATF3/BMP6/SREBF2/UCN2/SOX9/FOXA2/PIEZO1/ENG/EIF2AK3/TLR4/ATF4/CDA/GABARAPL1/CDKN1A/CBS/EIF2AK2/LYN/PIM1/TNFSF14/WIPI1/COL1A1/GADD45A/IFI16/MARS1/BCL10/RIPOR1/CD40/KLF10/SESN2/PHEX/UPP1/SRF/MAPK3/HMOX1/CASP5/FOSL1/FAS/RRAGC/SLC9A1/BAK1/CNN2/SLC39A4/IL15/NFKB1/IRF1/WNT4/DAG1/GLUL/FOXA3/GABARAP/TNFRSF10B/NDOR1/MAP3K5/FADD/MAP1LC3B/CASP8/BRSK2/DEPDC5/FLCN |
| GOBP_RESPONSE_TO_NUTRIENT | 112 | 0.4605837 | 1.604550 | 0.0030664 | 0.0334515 | 0.0269917 | 2252 | CXCL10/LIPG/SLC8A1/ACSL1/ALPL/ASCL1/KYNU/VCAM1/PTGS2/CNR1/CDKN2B/STC2/CYP26B1/MAP1B/IL1A/STAT1/FOXA2/MTHFR/FKBP1B/ASS1/CYP1B1/PIM1/KL/COL1A1/NOD2/PHEX/ENSA/ARSB/SRF/TRIM25/ALDH1A2/SLC27A4/HMOX1 |
| GOBP_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS | 36 | 0.6155064 | 1.761968 | 0.0030766 | 0.0334844 | 0.0270183 | 2981 | FGFBP1/DLL4/FGF2/KDR/HDAC9/THBS1/PTGS2/FOXC2/VEGFA/KLF4/AKT3/ANXA1/CARD10/HDAC7/HMOX1/MAP3K3/PIK3C2A/SRPX2 |
| GOBP_GLYCEROLIPID_CATABOLIC_PROCESS | 49 | 0.5740603 | 1.734775 | 0.0031206 | 0.0338056 | 0.0272774 | 1186 | PNPLA3/APOC1/LIPC/LIPG/LDLR/PLA2G4C/GPCPD1/SCARB1/ENPP6/LIPH/LIPE/GDPD3 |
| GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY | 258 | 0.3775577 | 1.451642 | 0.0031185 | 0.0338056 | 0.0272774 | 2298 | APOC1/LPIN1/PLAUR/NR4A1/IFI6/SERPINC1/HMSD/SNCA/A2ML1/SERPINB12/PI3/SERPINB7/DHCR24/BST2/SERPINA3/HDAC9/THBS1/PTGS2/TFPI2/BIRC3/COL6A3/ANGPTL4/SERPINE1/SERPINB2/SFN/SERPINB8/CPEB2/CST1/LAMP3/TIMP2/TNF/VEGFA/MASTL/SERPINB4/SERPINB9/FKBP1B/TGFB2/SPRY1/KLF4/CHP1/CSTB/CPAMD8/TNFSF14/IFI16/MICAL1/ANXA8/RFFL/GMIP/BICD1/ANXA1/SERPINF2/WFDC3/TMEM225B/TFPI/SPOCK1/FURIN/SERPINH1/MAPK7/USP14/SLC27A4/RARRES1/GPSM1/SERPINE2 |
| GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS | 40 | 0.5819566 | 1.692739 | 0.0031424 | 0.0339625 | 0.0274040 | 715 | PLA2G3/FADS2/ELOVL6/FADS1/SCD/TBXAS1/IL1B/PTGS2/ELOVL5/EDN1/ELOVL7 |
| GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS | 136 | 0.4336511 | 1.540586 | 0.0032243 | 0.0346078 | 0.0279247 | 3210 | APOC1/LIPC/LIPG/LDLR/ENTPD8/PLA2G4C/XDH/NUDT8/NT5E/PDE4C/GPCPD1/NUDT10/SCARB1/NUDT11/TYMP/ENPP6/IDH1/ENTPD2/PLPP6/GDPD3/ENPP1/NUDT17/PLA2G15/UPP1/ACOT7/PDE5A/PNP/PDE9A/ENTPD5/NUDT16/INPP5F/ENTPD6/SMPDL3B/PDE8A/PLB1/NT5C2/GDA/CNP/PLA2G4A/PLCG1/SMPD1/SYNJ2/VCP/PLBD2/FITM2 |
| GOBP_TEMPERATURE_HOMEOSTASIS | 136 | 0.4326608 | 1.537068 | 0.0032243 | 0.0346078 | 0.0279247 | 2841 | ACHE/ELOVL6/LPIN1/SCD/ACSL1/ALPL/IL1B/PTGS2/CNR1/ADAMTS5/FOXC2/IL1A/TNF/VEGFA/ACADL/PRLR/DDIT3/IL18R1/PTGES/ADRB2/TLR4/ATF4/ADIPOR2/MFAP2/GRB10/TFE3/PLCL1/PPARGC1B/LCN2/PPARGC1A/PDGFC/SYK/ADAM17/SQSTM1/IL4R/EGR1/ACADVL/IL15/NOVA1/CEBPB/IL18/RHEB/ID1 |
| GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION | 440 | 0.3428628 | 1.377389 | 0.0032147 | 0.0346078 | 0.0279247 | 4023 | ACHE/CYP51A1/HMGCR/INSIG1/RSAD2/TTN/BBC3/ITGAM/SLC7A11/CCL5/ACSL4/IL1B/IFI27/CCN3/DERL3/ZC3H12A/PTGS2/CNR1/PLK3/FYN/AACS/ADAM8/SFN/ANKRD1/IL1A/TNF/BMP6/NOS2/GPR68/SREBF2/PCK2/HDAC6/FOXA2/SAA1/SH3TC2/FKBP1B/TLR2/KLF7/TGFB2/TLR4/PTP4A3/LRRC8A/CHP1/FERMT1/RHBDF2/ADAM9/GPR27/LCP1/ADTRP/ANO1/STX4/MTCL1/ATP13A2/ADCY5/RAB11FIP1/ABLIM3/CD200/LLGL2/IRS2/SLC8B1/SP100/C1QTNF3/SOX4/CFTR/MYO1C/RIPOR1/EFNA5/ZBED6/ISL1/FAM3D/ENSA/EDEM1/B3GAT3/F2RL1/GLUD1/DNAJC1/RNF31/TRPM4/MICALL2/ABCA12/PFKFB2/STX1A/RAB11FIP5/ERP29/DOC2B/PKDCC/SLC12A2/FLNA/SNX12/SRC/STOM/FRMD4A/SERGEF/MIEF2/RAPGEF3/HYAL2/NDEL1/PAM/PPIA/GLUL/RHBDD3/CDH1/PIM3/JUP/BRSK2/PTPN11/RHBDF1/ICA1/SIRT7/MCU/CPT1A/SH3GLB1/FZD5/ZPR1/RANGAP1/ARHGEF5/ATG13/STXBP5/EDEM2/P3H1/MIEF1/NUP58/OS9/TMEM30A/ABAT/IRS1/CAPN10/HRAS/ALOX5/UBE2J1/BMP4/NMT1/PRNP/KCNN4/MIDN/SEC24A/IL12A/RAC2/GSK3B/SMAD3/LLGL1/HIF1A/PPARD/PTPN1/LEPROT/SYT7/USP36/VEGFC/DISP1/UFM1/DERL2/RAB8A |
| GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | 492 | 0.3300427 | 1.343228 | 0.0032984 | 0.0353214 | 0.0285005 | 2494 | TNFAIP6/CXCL10/INSIG1/PAX6/FGL2/PRTG/LDLR/TRIB3/DLX2/RTN4R/NTRK3/HOPX/XDH/MAP2/ASCL1/EREG/DISP3/IGF2/DRAXIN/FOXP3/IL1B/SEMA3B/CCN3/ZC3H12A/CEACAM1/LRRC17/FST/CDKN2B/SEMA3D/DKK1/CEACAM5/SEMA7A/IL1A/SOCS1/FGF13/AREG/SPRY4/G6PD/TNF/VEGFA/LAG3/STAT1/NFKBIA/GPR68/SOX9/GBP1/ACVRL1/SPDEF/FOXA2/DAAM2/BMP2/FSTL3/DDIT3/PDGFB/MELTF/TGFB2/TLR4/TGFB1I1/ENPP1/HLA-G/SPRY1/GREM1/PLXNA3/INHBA/DUSP10/MYC/LYN/TRIB1/ITGB3/WNT7A/TRIB2/CCL17/PRDM6/ID4/TMEM176A/NOCT/PTHLH/MARK1/JDP2/EFNA5/ZBED6/ISL1/CCN4/GPR37L1/ZEB1/ANXA1/PTPN2/TRIO/ID3/ITGAV/NFATC4/TRPM4/THY1/HDAC7/RAP1GAP/SPAG9/TMEM176B/SMAD6/KRAS/TGFBR1/NTN1/SEMA3A/GPS2/IL4R/TACSTD2/MSX2/IL17RD |
| GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 205 | 0.3959600 | 1.484692 | 0.0033332 | 0.0356125 | 0.0287353 | 2718 | IDO1/OAS3/OAS1/IL1R2/KLF2/LBP/FOXP3/IL1RL1/BST2/HDAC9/THBS1/ZC3H12A/IL23A/CEACAM1/C5AR2/RELB/CD83/CD34/CX3CL1/PML/TNF/LAG3/GBP1/CD274/LGALS9/HOMER3/TNFAIP3/ERRFI1/NMI/DDIT3/TGFB2/TLR4/HLA-F/KLF4/INHBA/IRAK3/SELENOS/CD200/TRIB2/ARG2/NOD2/C1QTNF3/N4BP1/DHX58/PTPN22/CDH3/ANXA1/F2RL1/HDAC7/FURIN/HMOX1/BCL3/TMSB4X/NPLOC4/ZFP36/AKAP8/EPHA2/NFKB1/RPS6KA4 |
| GOBP_REGULATORY_T_CELL_DIFFERENTIATION | 24 | 0.6722603 | 1.760938 | 0.0033638 | 0.0357768 | 0.0288680 | 1920 | FOXP3/IL4I1/SOCS1/LAG3/FANCA/LGALS9/HLA-G/DUSP10/CD46/TOX |
| GOBP_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION | 52 | 0.5528158 | 1.697731 | 0.0033639 | 0.0357768 | 0.0288680 | 3006 | FGFBP1/FGF2/MIR200A/KDR/HDAC9/THBS1/PTGS2/FOXC2/VEGFA/PDGFB/ETS1/AKT3/CD40/ANXA1/ADAM17/HDAC7/P2RX4/HMOX1/TMSB4X/STAT5A/MAP3K3/MAP2K3/PIK3C2A/SRPX2/PLCG1 |
| GOBP_RESPONSE_TO_NICOTINE | 34 | 0.6289518 | 1.785489 | 0.0033999 | 0.0359160 | 0.0289803 | 790 | NTRK1/SLC7A11/VCAM1/CHRNB4/CNR1/EDN1/TNF |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION | 187 | 0.4135987 | 1.533941 | 0.0033954 | 0.0359160 | 0.0289803 | 3215 | EBI3/CD70/TNFSF9/CCL5/IGF2/FOXP3/IL1B/VCAM1/IL23A/NR4A3/FYN/IL4I1/ADAM8/CD83/TNFSF13B/IL1A/SOCS1/IL1RL2/TNFRSF13C/TNF/CARD11/LGALS1/CD55/VNN1/CD47/CD274/LGALS9/PTAFR/HLA-G/PRKCQ/DUSP10/CD276/CD46/LYN/NFKBIZ/HLA-DOB/TNFSF14/NFKBID/SELP/NOD2/ETS1/SOX4/BCL10/IL7R/HLA-E/IRAK1/MAP3K8/PTPN22/ANXA1/THY1/PNP/SYK/RIPK2/SLC7A1/SRC/MALT1/IL4R/TYK2/TFRC/CD86/IL15/NCK1/IL18/FADD/ZBTB7B/HLA-A/BTN2A2/PTPN11/TGFBR2/SIRPA/HLA-DMA/CAV1/CHST2/RUNX3 |
| GOBP_ORGANIC_ANION_TRANSPORT | 248 | 0.3740808 | 1.430666 | 0.0034001 | 0.0359160 | 0.0289803 | 2427 | PLA2G3/SLC26A9/SLC2A6/SNCA/SLC39A8/SLC7A11/SLC25A1/SLCO4C1/SLC26A4/SLC5A8/SLC7A9/SLC16A13/IL1B/KMO/SLCO4A1/SLC6A11/SLC2A3/CEACAM1/SLC26A6/EDN1/CLTRN/SLCO1B1/MFSD2A/SLC16A4/IL1A/SLC6A14/TNF/SLC13A5/NOS2/STXBP1/GRM1/CD47/SLC16A3/SLC10A6/SLC25A23/PTGES/LRRC8A/SLC25A25/SLC4A3/MPC1/SLC3A2/PRAF2/MYC/ACE2/SLC52A2/SLC52A3/SLC7A7/CFTR/SLC25A21/SLCO3A1/SLC1A4/GABBR1/ANXA1/GIPC1/SLC10A3/SYK/NTRK2/P2RX4/SLC27A4/SLC5A12/SLC7A1/SLC12A2/MGST1/LRRC8C/SLC7A5/SLC5A6/CYB5R1/SLC27A5 |
| GOBP_CELLULAR_RESPONSE_TO_VIRUS | 66 | 0.5352818 | 1.723574 | 0.0034386 | 0.0361591 | 0.0291764 | 1988 | CXCL10/OAS3/OASL/IFI6/OAS1/CCL5/IRF7/IFIH1/ZC3H12A/BIRC3/MAPK11/LGALS9/IKBKE/DDX60/MMP12/DHX58/ADAR/TRIM25 |
| GOBP_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY | 114 | 0.4596136 | 1.607030 | 0.0034347 | 0.0361591 | 0.0291764 | 1592 | ARC/PCSK9/NCF1/MAPK8IP2/EREG/PHLDA2/RELN/PLAU/EDN1/DKK1/PPP2R5B/SERPINE1/AREG/TNF/HBEGF/LYNX1/HDAC6/ERRFI1/GPRC5A/MEF2C/ADRB2/GREM1/CACNG8/EGF/ACE2/LDOC1 |
| GOBP_LYMPHOCYTE_APOPTOTIC_PROCESS | 57 | 0.5455006 | 1.700532 | 0.0034640 | 0.0363446 | 0.0293261 | 4124 | IDO1/CCL5/HSH2D/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/PRKCQ/LYN/IRS2/ARG2/BCL10/IL7R/PRELID1/PIP/ST3GAL1/FAS/BAK1/FADD/FNIP1/BMP4/TRAF3IP2/HIF1A/RAG1/TP53/RIPK1/AKT1 |
| GOBP_TOLERANCE_INDUCTION | 18 | 0.7150158 | 1.770611 | 0.0034908 | 0.0365436 | 0.0294867 | 2242 | IDO1/FOXP3/CD274/LGALS9/TNFAIP3/HLA-G/IRAK3/LYN/HLA-E/XKR8/HLA-B |
| GOBP_REGULATION_OF_MAP_KINASE_ACTIVITY | 157 | 0.4273157 | 1.549197 | 0.0035065 | 0.0366258 | 0.0295530 | 2445 | HMGCR/TRIB3/S100A12/NTRK3/FGF2/IL1B/THBS1/EDN1/DKK1/UCHL1/ADAM8/SPRY4/TNF/VEGFA/FGF1/BMP2/FGD2/PDGFB/TLR4/SH2B3/PTPRJ/SPRY1/DUSP10/ADAM9/DVL2/IRAK3/IL34/EGF/LYN/TRIB1/FLT1/TRIB2/MAPK8IP1/NOD2/CD40/IRAK1/PTPN22/DUSP1/MST1R/PDGFC/PDE5A/SYK/DUSP16/ERP29/MAP3K10/TRAF2/SRC/TGFA |
| GOBP_FEMALE_MEIOTIC_NUCLEAR_DIVISION | 27 | -0.6445368 | -1.800840 | 0.0035209 | 0.0366617 | 0.0295820 | 1152 | HSF2BP/FMN2/SYCP2/FBXO5/AURKA/TRIP13/TTK/NDC80/PLK1/CCNB2/NCAPH/TOP2A |
| GOBP_REGULATION_OF_T_CELL_MIGRATION | 32 | 0.6292288 | 1.750999 | 0.0035256 | 0.0366617 | 0.0295820 | 1633 | S100A7/CXCL10/CCL20/CCL5/ADAM8/RIPK3/OXSR1/CD200/TNFSF14 |
| GOBP_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 99 | 0.4579285 | 1.554176 | 0.0035791 | 0.0371347 | 0.0299636 | 3674 | THEMIS2/FOXP3/ZC3H12A/CEACAM1/FYN/CARD11/GBP1/RFTN1/IKBKG/UBASH3A/PTPRJ/DUSP3/CD276/NFKBIZ/BTN3A1/NFKBID/BCL10/PTPN22/PTPN2/RNF31/THY1/BCAR1/RIPK2/MALT1/RBCK1/NECTIN2/PLCG1/HLA-A/BTN2A2/BTN3A3/BTN3A2/RELA/HRAS/PRNP/KCNN4 |
| GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION | 270 | 0.3696986 | 1.423231 | 0.0035921 | 0.0371879 | 0.0300065 | 2245 | ACHE/CYP51A1/HMGCR/RSAD2/TTN/CCL5/ACSL4/IL1B/CCN3/CNR1/AACS/CLTRN/ADAM8/ANKRD1/LTBP2/IL1RN/IL1A/RAB8B/TNF/BMP6/NOS2/GPR68/PCK2/CTAGE4/FOXA2/SAA1/FKBP1B/TLR2/KLF7/TGFB2/TLR4/LRRC8A/RHBDF2/ADAM9/GPR27/ADTRP/ANO1/STX4/ATP13A2/ADCY5/RAB11FIP1/CD200/LLGL2/IRS2/BLOC1S3/PORCN/SLC8B1/C1QTNF3/SOX4/CFTR/LTBP1/EFNA5/ZBED6/ISL1/FAM3D/ENSA/SCG2/ANXA1/F2RL1/GLUD1/DNAJC1/CAVIN1/TRPM4/ABCA12/PFKFB2/STX1A/RAB11FIP5/ERP29/DOC2B |
| GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS | 196 | 0.3990776 | 1.484643 | 0.0036281 | 0.0374767 | 0.0302395 | 2106 | ARC/APOC1/ACHE/PCSK9/SGIP1/LDLR/CXCL8/ITGAM/SNCA/CEACAM1/DKK1/SERPINE1/SCARF1/AMN/CXCL16/VEGFA/WASF1/ADRB2/SNX9/LDLRAD3/GREM1/CACNG8/PDLIM7/EGF/TPCN2/ITGB3/DAB2/MICALL1/HSPG2/BICD1/ITGAV/ARHGAP27/AP2B1/SYK/CD9 |
| GOBP_RESPONSE_TO_LECTIN | 15 | 0.7606176 | 1.805692 | 0.0037360 | 0.0384218 | 0.0310022 | 2361 | FYN/CLEC7A/KLRD1/MYC/LYN/SYK/SRC |
| GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION | 53 | 0.5506392 | 1.698713 | 0.0037295 | 0.0384218 | 0.0310022 | 2297 | ISG15/OAS3/OAS1/OAS2/IRF7/IFIH1/MYD88/TICAM1/STAT1/TLR2/TLR4/MMP12/DHX58/IRAK1/PTPN22/SYK/POLR3D/POLR3B/RIPK2 |
| GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY | 443 | 0.3357231 | 1.351969 | 0.0038140 | 0.0391375 | 0.0315796 | 2024 | DEFB4A/CXCL10/CXCL11/ADRA1A/RGS7/RASD1/CCL22/CCL4/FZD9/CXCL9/PHF24/CCL20/CCR3/RGS16/CXCL8/OXER1/SNCA/EREG/CCL5/LPAR5/CNGB1/DEFB1/OR2I1P/CGB7/CXCL1/ADM2/GRK5/CNR1/MRGPRX3/C5AR2/GNG2/RNF157/EDN1/DGKI/GALR2/ADGRG2/CX3CL1/TAS2R3/AREG/RGS9/RGS20/GPR68/ADGRD1/UCN2/ADGRE2/GRM1/CELSR3/OR5P3/GNAZ/ENTPD2/HOMER3/GPRC5A/SPNS2/ADRB2/PTAFR/ECE1/PAX8/GPR27/ADGRF4/ANO1/MET/GNA15/ADCY4/OPN3/TYRO3/AKAP12/SIGMAR1/ADCY5/GNA12/NLN/TPRA1/LPAR2/GPR85/ITPR3/CCL17/SPHK1/GPR157/HCAR3/PTHLH/ADGRB1/HTR4/TMOD2/RGS10/GABBR1/HRH1/GPR37L1/BICD1/ANXA1/GPR63/F2RL1/GIPC1 |
| GOBP_NEGATIVE_REGULATION_OF_PROTEIN_BINDING | 80 | 0.4946292 | 1.636662 | 0.0038539 | 0.0394605 | 0.0318403 | 2049 | PCSK9/TEX14/IFIT2/NES/IFIT1/MAP2/DKK1/PDGFB/ADRB2/CDKN1A/DDX11/DAB2/CTNNBIP1/MAPK3/NFATC4 |
| GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS | 45 | 0.5712801 | 1.701582 | 0.0038689 | 0.0395269 | 0.0318938 | 1724 | APOC1/INSIG1/LPIN1/TRIB3/CEACAM1/ACADL/BMP2/PDGFB/GFI1/LPCAT1/SPHK1 |
| GOBP_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC | 48 | 0.5709614 | 1.717593 | 0.0039037 | 0.0397959 | 0.0321109 | 1313 | NTRK1/SYT1/MAPK8IP2/UNC13A/KMO/RELN/PTGS2/CNR1/DKK1/DGKI/TNF/STXBP1/GRM1/MEF2C/CACNG8 |
| GOBP_MICROTUBULE_ORGANIZING_CENTER_LOCALIZATION | 31 | -0.6060729 | -1.774158 | 0.0039183 | 0.0398573 | 0.0321605 | 2141 | AKAP9/FHOD1/CEP83/AURKA/MAD2L1/DLGAP5/ASPM |
| GOBP_MUSCLE_STRUCTURE_DEVELOPMENT | 471 | 0.3309346 | 1.340435 | 0.0039472 | 0.0400645 | 0.0323277 | 2810 | CXCL10/ADRA1A/CXCL9/DLL4/SLC8A1/NR4A1/SMTN/TTN/SCX/HOPX/LIF/EREG/MAFF/PDLIM3/IGF2/CCN3/HDAC9/CHODL/GPCPD1/ADAMTS5/STRA6/RCAN1/TMOD4/EDN1/DKK1/FOXC2/CEACAM5/EGR2/COL6A3/FOS/GDF15/UCHL1/CYP26B1/ANKRD1/ANK2/ATF3/POPDC3/G6PD/ASB2/TNF/VEGFA/CFL2/DYSF/IGSF8/LGALS1/HBEGF/SVIL/MAPK11/SOX9/EHD1/BMP2/PIEZO1/PLEKHO1/ENG/DDIT3/PDGFB/ITGB1BP2/TGFB2/MEF2C/ASS1/MYL9/LRRC8A/PAX7/GREM1/IFRD1/LMNA/PDLIM7/FLII/SGCE/NLN/TNFSF14/PDLIM2/CCL17/PRDM6/CSRP1/TAGLN/ZBED6/ADGRB1/ISL1/TMOD2/VAMP5/SRF/ZEB1/ID3/XKR8/NFATC4/POPDC2/NIBAN2/CD9/TPM1/ATP11A/MMP14/SPAG9/CTH/BTG1/CAPN2/KRAS/TGFBR1/MAMSTR/IL4R/IGFBP3/EGR1/NRG1/SLC9A1/PDLIM5/LY6E/FOXN2/WNT4/ACTG1/DAG1/MYL6/CAV2/IL18/MYH9 |
| GOBP_HEMOSTASIS | 172 | 0.4040895 | 1.486864 | 0.0039802 | 0.0403110 | 0.0325265 | 2735 | PLAUR/SERPINC1/SLC7A11/NFE2/PLAU/THBS1/CEACAM1/TFPI2/PROCR/PEAR1/EDN1/PF4V1/SERPINE1/VWF/SERPINB2/CD34/DGKI/EMILIN2/STXBP1/FOXA2/ENTPD2/RAP2B/SAA1/C1QTNF1/PDGFB/TLR4/VCL/MYL9/SH2B3/PLSCR1/PRKCQ/ADTRP/VKORC1/TYRO3/LYN/PRKG1/ITGB3/FLI1/GNA12/BLOC1S3/SELP/ITPK1/CSRP1/CD40/ANXA8/MYL12A/SRF/F2RL1/SERPINF2/TFPI/SYK/CD9/ILK/SERPINE2/FLNA/SRC/PAFAH2/RAB27A/F3/ACTB/ACTG1/PPIA |
| GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS | 59 | 0.5383297 | 1.683217 | 0.0040116 | 0.0404542 | 0.0326421 | 3409 | TRIB3/BBC3/CHAC1/PMAIP1/PML/ERO1A/EIF2AK3/DDIT3/ATF4/SELENOS/BOK/PTPN2/ERP29/TRAF2/HYOU1/BAK1/NCK1/CEBPB/ERN1/DAB2IP/TNFRSF10B/MAP3K5/BRSK2/SYVN1/HERPUD1 |
| GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION | 82 | 0.4940855 | 1.638974 | 0.0040064 | 0.0404542 | 0.0326421 | 2245 | PLA2G3/ACSL4/EDN1/AACS/RAB8B/BMP6/GPR68/PCK2/C1QTNF1/LRRC8A/INHBA/GPR27/ANO1/STX4/IRS2/DAB2/C1QTNF3/SOX4/CFTR/ISL1/GABBR1/GLUD1/TRPM4/PFKFB2/DOC2B |
| GOBP_ENDOTHELIAL_CELL_PROLIFERATION | 125 | 0.4427950 | 1.553247 | 0.0040256 | 0.0405073 | 0.0326850 | 2814 | FGFBP1/DLL4/CCR3/NR4A1/FGF2/XDH/KDR/IGF2/THBS1/SCARB1/CD34/TNF/BMP6/VEGFA/STAT1/JUN/ACVRL1/LOXL2/VASH2/BMP2/PDGFB/MEF2C/ATOH8/EGF/FLT1/ITGB3/BMPER/AKT3/FUT2/SCG2/MYDGF/ADAM17/MMP14/ALDH1A2/HMOX1/TGFBR1/STAT5A/NRAS/LRG1/F3/EPHA2/CAV2/ECM1/ERN1 |
| GOBP_ALPHA_BETA_T_CELL_ACTIVATION | 108 | 0.4511977 | 1.564179 | 0.0040591 | 0.0407565 | 0.0328860 | 3060 | EBI3/RSAD2/FOXP3/ZC3H12A/IL23A/RELB/CD83/SOCS1/CD55/BATF/CD274/LGALS9/PRDM1/IL18R1/PRKCQ/NFKBIZ/ARG2/NFKBID/MAPK8IP1/HLA-E/PTPN22/TOX/ANXA1/ELF4/PNP/SYK/BCL3/RIPK2/MALT1/IL4R/TYK2/CD86/IL15/IRF1/IL18/ZBTB7B/HLA-A/TGFBR2 |
| GOBP_CONNECTIVE_TISSUE_DEVELOPMENT | 196 | 0.3969216 | 1.476622 | 0.0042085 | 0.0421668 | 0.0340239 | 3953 | HYAL1/DLX2/SCX/SNORC/FGF2/HYAL3/SERPINB7/MATN3/BMP8B/CCN3/NAMPT/EDN1/FOXC2/ARID5A/CD34/BMP6/SOX9/ACVRL1/LOXL2/BMP2/KLF7/EIF2AK3/PDGFB/MEF2C/CCN1/SLC25A25/GREM1/ITGB8/CSF1/WNT7A/COL1A1/ID4/PPARGC1A/PTHLH/MAF/MMP13/CCN4/SRF/ZEB1/MAPK3/TRPM4/SERPINH1/TGFBI/PBXIP1/PKDCC/TGFBR1/SH3PXD2B/MSX2/EGR1/BMP3/SLC39A13/HYAL2/ZNF219/ECM1/PGRMC2/RUNX2/PTPN11/TGFBR2/DDRGK1/SLC39A14/ACTA2/FOXD1/RUNX3/EXT1/CFLAR/BMP4/HMGA2/BMPR2/MEX3C/BMP1/TIMP1/CSGALNACT1/SMAD3/HIF1A/PPARD/ARRDC3/TSKU/MEF2D |
| GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION | 73 | 0.5017162 | 1.630775 | 0.0042244 | 0.0422353 | 0.0340793 | 3215 | RSAD2/FOXP3/ZC3H12A/IL23A/RELB/CD83/SOCS1/CD55/BATF/CD274/LGALS9/IL18R1/PRKCQ/NFKBIZ/ARG2/NFKBID/TOX/ANXA1/BCL3/RIPK2/MALT1/IL4R/CD86/IL18/ZBTB7B/TGFBR2/RUNX3 |
| GOBP_CELL_SUBSTRATE_ADHESION | 302 | 0.3609446 | 1.407428 | 0.0043426 | 0.0433241 | 0.0349578 | 3890 | L1CAM/ITGAM/KDR/HSD17B12/NTNG1/COL13A1/ITGA9/VCAM1/PLAU/THBS1/OLFM4/SERPINE1/VWF/ITGA10/CD34/EPHA3/CX3CL1/SPRY4/CEACAM6/VEGFA/TIMM10B/GBP1/UNC13D/ACVRL1/LAMB3/NEDD9/PDGFB/PTPRO/MELTF/CCN1/VCL/RRAS/DAPK3/PTPRJ/GREM1/ADAMTS9/TRIOBP/FERMT1/ITGB8/VIT/ADAM9/DUSP3/CSF1/RAC3/CDKN2A/TYRO3/PHLDB2/ITGB3/MMP12/COL5A3/SGCE/PTPRK/COL1A1/ACER2/DAB2/EFNA5/S100A10/ITGB7/NTNG2/SRF/ITGAV/DLC1/MICALL2/THY1/SPOCK1/ITGB6/MMP14/ILK/COL16A1/LAMC1/SMAD6/MAP4K4/COL17A1/FLNA/ITGA3/SRC/RHOD/LPXN/ATRNL1/TACSTD2/SLC9A1/ARPC2/RSU1/WNT4/ACTG1/DAG1/EPDR1/DOCK5/ID1/P4HB/ITGB4/NTN4/ITGA6/NID2/MYADM/JUP/ITGA5/ITGB5/GFUS/PDPN/TESK1/EMP2/HAS2/PLEKHA2/CTTN/AGR2/ARL2/WASHC2C/CD63/MACF1/CRK/ITGAL/RHOA/RELL2/RAC1/SDC4/RAC2/GSK3B/PIP5K1A/SMAD3/CORO1C/PPARD/ACTN1 |
| GOBP_EPITHELIAL_CELL_PROLIFERATION | 329 | 0.3529265 | 1.391437 | 0.0043555 | 0.0433601 | 0.0349868 | 2876 | HYAL1/PAX6/FGFBP1/DLL4/CCR3/NR4A1/FGF2/XDH/KDR/EREG/IGF2/CCN3/THBS1/CEACAM1/SCARB1/C5AR2/FST/CDKN2B/NR4A3/CDKN1C/CD34/SFN/AREG/TNF/BMP6/VEGFA/SDR16C5/STAT1/SOX9/JUN/FGF1/ACVRL1/LOXL2/VASH2/BMP2/TNFAIP3/ERRFI1/PDGFB/TGFB2/MEF2C/FERMT1/DUSP10/ATOH8/MYC/EGF/FLT1/ITGB3/WNT7A/MMP12/PTPRK/BMPER/NOD2/DAB2/AKT3/FUT2/ISL1/SCG2/SGPP2/COL8A2/CDH3/MYDGF/ADAM17/MMP14/ALDH1A2/RAP1GAP/HMOX1/TINF2/LAMC1/TGFBR1/STAT5A/TGFA/NRAS/TACSTD2/MAP2K1/LRG1/F3/ZFP36/CLDN1/EPHA2/C6orf89/CEBPB/GLUL/CAV2/ECM1/ERN1/RTN4/ID1/DAB2IP/EAF2/FAP |
| GOBP_TYPE_I_INTERFERON_PRODUCTION | 82 | 0.4904537 | 1.626926 | 0.0044480 | 0.0441868 | 0.0356539 | 3160 | ISG15/OAS3/OAS1/OAS2/IRF7/IFIH1/RELB/MYD88/TICAM1/STAT1/TLR2/NMI/TRIM21/TLR4/MMP12/DHX58/IRAK1/PTPN22/SYK/POLR3D/POLR3B/RIPK2/NPLOC4/IRF1/TIRAP/PTPN11/SIRPA/FLOT1 |
| GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS | 28 | 0.6494222 | 1.771055 | 0.0045476 | 0.0450055 | 0.0363145 | 2425 | IDO1/CCL5/HSH2D/TSC22D3/PRKCQ/IRS2/ARG2/BCL10/IL7R/PIP/ST3GAL1 |
| GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY | 157 | 0.4214115 | 1.527792 | 0.0045497 | 0.0450055 | 0.0363145 | 3181 | NREP/THBS1/PEG10/CDKN2B/FOS/GDF15/CDKN1C/LTBP2/PML/JUN/ACVRL1/BMP2/ZEB2/SMAD9/PMEPA1/ENG/TGFB2/TGFB1I1/SPRY1/FERMT1/ITGB8/ADAM9/PTPRK/FMOD/DAB2/LTBP1/VEPH1/ZEB1/GIPC1/ADAM17/FURIN/ITGB6/SMAD6/ITGA3/TGFBR1/SRC/LPXN/IL17RD/LRG1/VASN/CAV2/ID1/LATS2/SPRED2/ZMIZ2/TGFBR2/ITGB5/FLCN/CAV1 |
| GOBP_OUTER_DYNEIN_ARM_ASSEMBLY | 19 | -0.6935882 | -1.804013 | 0.0045677 | 0.0450880 | 0.0363810 | 3340 | DNAAF5/ZMYND10/ODAD4/DNAAF11/DNAAF4/DNAL1/ODAD1/ODAD3/DAW1/DNAI1/LRRC49/DNAI2/DNAAF8/DNAH5/ODAD2/DNAAF6/DNAAF1 |
| GOBP_T_CELL_APOPTOTIC_PROCESS | 39 | 0.6014484 | 1.740141 | 0.0045793 | 0.0451068 | 0.0363962 | 4124 | IDO1/CCL5/TSC22D3/ADAM8/RIPK3/CD274/LGALS9/PRKCQ/ARG2/BCL10/IL7R/PRELID1/PIP/ST3GAL1/FAS/BAK1/FADD/BMP4/HIF1A/RAG1/TP53/RIPK1/AKT1 |
| GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | 45 | 0.5671351 | 1.689236 | 0.0045963 | 0.0451796 | 0.0364550 | 1400 | PAX6/FGF2/LIF/CDKN2B/SERPINE1/SFN/BMP6/SOX9/ACVRL1/ZBED2/TRIM16/PAX8/ATOH8 |
| GOBP_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR | 44 | 0.5685979 | 1.683640 | 0.0046377 | 0.0454909 | 0.0367061 | 3437 | ASCL1/SOX9/ERRFI1/DUSP3/MYC/COL1A1/DAB2/PTPN12/MARS1/MAPK3/GAREM1/PDE8A/ZFP36/ID1/DAB2IP/PLCG1/PTPN11/ZPR1/IQGAP1/CFLAR |
| GOBP_POSITIVE_REGULATION_OF_SECRETION | 216 | 0.3849591 | 1.453222 | 0.0047705 | 0.0466952 | 0.0376779 | 2462 | PLA2G3/ACHE/TTN/HYAL3/SYT1/ITGAM/SNCA/ACSL4/IL1B/KMO/CNR1/CD177/EDN1/AACS/ADAM8/ANKRD1/IL1A/RAB8B/S100A8/BMP6/GPR68/STXBP1/PCK2/UNC13D/BMP2/C1QTNF1/TLR2/TGFB2/PTGES/TLR4/PTAFR/LRRC8A/HLA-F/INHBA/ADAM9/GPR27/ANO1/STX4/ATP13A2/IRS2/GAB2/DAB2/C1QTNF3/SOX4/CFTR/ISL1/RAB27B/GABBR1/F2RL1/GLUD1/TRPM4/SYK/PFKFB2/STX1A/P2RX4/DOC2B/SLC12A2/FRMD4A/IL4R/RAB27A |
| GOBP_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC | 63 | 0.5014605 | 1.605747 | 0.0047858 | 0.0467466 | 0.0377194 | 1313 | NTRK1/SYT1/MAPK8IP2/UNC13A/KMO/RELN/PTGS2/CNR1/DKK1/DGKI/GRIK4/TNF/STXBP1/GRM1/MEF2C/CACNG8 |
| GOBP_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY | 14 | 0.7620532 | 1.773575 | 0.0048871 | 0.0476360 | 0.0384370 | 2242 | MICA/CEACAM1/LGALS9/SERPINB4/SERPINB9/HLA-G/KLRD1/HLA-F/HLA-E/HLA-B |
| GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT | 48 | 0.5620999 | 1.690935 | 0.0049047 | 0.0477081 | 0.0384952 | 2331 | PLA2G3/ACSL1/SNCA/IL1B/KMO/THBS1/EDN1/CLTRN/IL1A/TNF/STXBP1/PTGES/IRS2/ACE2/GABBR1/SYK/ACSL5/P2RX4/SLC12A2 |
| GOBP_NIK_NF_KAPPAB_SIGNALING | 109 | 0.4474164 | 1.553345 | 0.0049321 | 0.0477760 | 0.0385500 | 2875 | TCIM/TNFRSF10A/IL1B/CCN3/ZC3H12A/IL23A/BIRC3/EDN1/IFI35/NFKB2/RELB/TNF/RIPK3/NFKBIA/LGALS9/IKBKE/TLR2/NMI/RTKN2/IL18R1/TLR4/PTP4A3/GREM1/EIF2AK2/TNFSF14/NOD2/SPHK1/C1QTNF3/IRAK1/PTPN22/CARD10/HDAC7/ILK/TNFSF15/BCL3/TRAF2/TMSB4X/MALT1/NOD1/RBCK1/CD86/TRADD/IL18/TNFRSF10B |
| GOBP_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM | 493 | 0.3265520 | 1.328524 | 0.0049224 | 0.0477760 | 0.0385500 | 4682 | ADRA1A/TRIB3/NPC1/HSPB8/SNCA/RAB24/KDR/ADPRH/DEPP1/ZC3H12A/PLK3/UCHL1/FEZ1/MAP1LC3B2/LAMP3/S100A8/TICAM1/SREBF2/IKBKG/HDAC6/TP53INP2/TRIM21/DDIT3/ADRB2/TRIM5/GABARAPL1/DAPK3/RNF213/TRIM14/RUBCN/S100A9/MET/MTCL1/OPTN/ATP13A2/TPCN2/CHMP7/TMEM41B/WIPI1/ACER2/DRAM1/NOD2/IFI16/CAMKK2/STBD1/EEF1A2/BOK/SESN2/CHMP6/PTPN22/ARSB/EPM2A/MAPK3/RNF31/HAP1/VPS33B/VMP1/TAB3/PIP4K2A/SQSTM1/GPSM1/HMOX1/DAPK2/RIPK2/MCOLN1/TRIM22/SRC/VPS37B/NOD1/PLAA/RRAGC/AUP1/ATG2A/VIPAS39/PIP4K2C/TBC1D25/TIGAR/FOXK2/PIK3C2A/RHEB/ERN1/GABARAP/ITGB4/NEDD4/HK2/MAP1LC3B/ATP6V1E2/VPS18/RAB12/DEPDC5/FLCN/DDRGK1/MUL1/FEZ2/SH3GLB1/VCP/FZD5/EIF4G1/UBQLN4/CHMP1B/ATG13/ABL2/TRIM27/PLK2/TBC1D17/PIP4K2B/CHMP4C/WDR45/RETREG3/CTTN/TAFAZZIN/RAB43/PACS2/RMC1/VPS37D/EI24/PHF23/SMURF1/ZFYVE1/MCL1/ATP6V1B2/GSK3B/ULK3/ILRUN/RAB33B/HIF1A/VPS4A/KAT5/TRIM65/CHMP2B/ATG14/VPS37A/USP36/ATP6V0B/EXOC8/TP53/UFM1/STX12/PIKFYVE/RAB8A/ATP6V0A1/SPTLC2/RAB7A/MVB12A/AKT1/DAP/ARL8B/RAB19/EVA1A/GOLGA2/WDR81/PSEN1/SNF8/UBQLN1/TOLLIP/TECPR2/MTMR14/FNBP1L/SNX6/CPTP/ATG101/CALCOCO2/SYT11/QSOX1/ATP6V1H/ATG9A/HTT/TMEM208/GNAI3/RALB/PIK3CB/CHMP1A/ANXA7/FOXK1/ATG7/RAB5A/CHMP3/NRBP2/RPTOR/AP4M1/SBF2/PGAM5/PIK3CA/ORMDL3/TSPO |
| GOBP_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION | 132 | 0.4279049 | 1.518798 | 0.0049832 | 0.0481713 | 0.0388689 | 3060 | FGL2/TNFSF9/FOXP3/ZC3H12A/IL23A/CAMK4/IL4I1/ADAM8/CYP26B1/CD83/SOCS1/IL1RL2/LAG3/CARD11/VNN1/FANCA/LGALS9/PRDM1/HLA-G/INHBA/DUSP10/CD46/NFKBIZ/IL15RA/NFKBID/SOX4/IL7R/TOX/ZEB1/ANXA1/PTPN2/PRELID1/PNP/SYK/MMP14/RIPK2/MALT1/IL4R/CD86/IL15/IRF1/SOS2/IL18/ZBTB7B/BTN2A2/TGFBR2 |
| GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY | 48 | 0.5610552 | 1.687792 | 0.0050381 | 0.0486012 | 0.0392158 | 2242 | CXCL6/MICA/ITGAM/IL23A/CEACAM1/LAG3/RIPK3/NOS2/LGALS9/SERPINB4/SERPINB9/RAET1E/ICAM1/HLA-G/KLRD1/HLA-F/PVR/CADM1/IL7R/HLA-E/F2RL1/HLA-B |
| GOBP_CYTOSKELETON_DEPENDENT_CYTOKINESIS | 92 | -0.4281094 | -1.548039 | 0.0050912 | 0.0489604 | 0.0395057 | 1912 | DCDC1/FMN2/CIT/ROPN1B/SEPTIN5/EFHC1/RACGAP1/STMN1/SEPTIN3/KIF23/ESPL1/KIF20B/ANLN/PLK1/KIF20A/KIF4A/CEP55 |
| GOBP_NEGATIVE_REGULATION_OF_PHOSPHORYLATION | 324 | 0.3508034 | 1.382017 | 0.0050963 | 0.0489604 | 0.0395057 | 3244 | HMGCR/PAX6/MLXIPL/TRIB3/SLIT2/SLC8A1/NTRK3/PTPRH/XDH/SNCA/IL1B/ZC3H12A/CEACAM1/CDKN2B/DKK1/UCHL1/CDKN1C/SFN/SOCS1/SPRY4/OCLN/WARS1/JUN/PIK3IP1/SOCS3/FOXA2/BMP2/PMEPA1/TNFAIP3/ERRFI1/ENG/GPRC5A/PTPRO/PARP14/SH2B3/ENPP1/DUSP6/CDKN1A/PTPRJ/SPRY1/GREM1/RUBCN/CHP1/INHBA/DUSP10/GRB10/NIBAN1/ANKLE2/INCA1/CAMK2N1/IRAK3/DUSP3/CDKN2A/LYN/DBNDD1/TRIB1/IRS2/TRIB2/GADD45A/MAPK8IP1/PLPP3/MICAL1/CHMP6/PTPN22/DUSP1/DDIT4/ADAR/PTPN2/THY1/DUSP16/SPAG9/PIP4K2A/SMAD6/PRKRIP1/INPP5F/IGFBP3/YWHAG/BAK1/PIP4K2C/HYAL2/NCK1/TIGAR/PPIA/DAB2IP/PID1/STK38/LATS2/MYADM/SPRED2/SMPD1/SIRPA/SH3BP5/TWIST1/HEXIM1/CAV1/EIF4G1/TESK1 |
| GOBP_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY | 24 | -0.6455287 | -1.795745 | 0.0051069 | 0.0489612 | 0.0395063 | 2981 | RPS20/RPL11/RPL23/RPS7/RPL37/RPL5/BAG2/FBXO5/MAD2L1/CDC20B/PLK1/CDC20/UBE2C |
| GOBP_CEREBROSPINAL_FLUID_CIRCULATION | 13 | -0.7641462 | -1.819579 | 0.0051415 | 0.0491917 | 0.0396923 | 2878 | ODAD4/DNAAF11/AQP4/CFAP54/DAW1/CCDC39/SPAG16/DNAH9/CFAP45/CFAP43/CFAP221 |
| GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION | 35 | 0.6148128 | 1.752460 | 0.0051716 | 0.0493786 | 0.0398431 | 593 | FZD9/SCN3B/IFI6/KDR/HSH2D/SCN1B/HCN3/HCN2 |
| GOBP_STEROID_HORMONE_BIOSYNTHETIC_PROCESS | 27 | 0.6347207 | 1.715480 | 0.0052111 | 0.0496548 | 0.0400659 | 2708 | DHCR7/HSD17B7/HSD17B12/SRD5A3/BMP6/BMP2/HSD17B8/DAB2/EGR1/HSD17B1/WNT4 |
| GOBP_CELLULAR_LIPID_CATABOLIC_PROCESS | 182 | 0.4082613 | 1.512620 | 0.0052542 | 0.0499632 | 0.0403148 | 1887 | PNPLA3/APOC1/ACAT2/LIPC/LIPG/LPIN1/LDLR/PLA2G4C/NUDT8/SRD5A3/GPCPD1/ACOXL/CNR1/SCARB1/ALDH1L2/MFSD2A/CYP26B1/ACADL/ENPP6/NEU1/PCK2/IDH1/ECH1/BCO1/LIPH/PLPP6/LIPE/GDPD3/ADTRP/CYP1B1/IRS2/ACER2/SPHK1/CPT1C/SESN2/PLA2G15 |
GOMF
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOMF_CHEMOKINE_RECEPTOR_BINDING | 36 | 0.8302366 | 2.328789 | 0.0000000 | 0.0000002 | 0.0000001 | 842 | DEFB4A/CXCL10/CXCL11/CCL22/CCL4/NES/CXCL9/CCL20/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/DEFB1/CXCL1/PF4V1/CX3CL1/CXCL16/STAT1 |
| GOMF_CYTOKINE_ACTIVITY | 122 | 0.6410433 | 2.240342 | 0.0000000 | 0.0000002 | 0.0000001 | 1708 | CXCL10/CXCL11/IL19/CCL22/EBI3/CD70/IL36G/CCL4/CXCL9/CCL20/IL32/CXCL2/CXCL6/CXCL3/TNFSF9/CXCL8/FGF2/IL17C/LIF/CCL5/CLCF1/CXCL5/IL1B/BMP8B/CXCL1/CMTM3/IL23A/CSF3/NAMPT/EDN1/PF4V1/GDF15/INHBE/TNFSF13B/IL1RN/IL1A/CX3CL1/AREG/TNF/BMP6/CXCL16/VEGFA/BMP2/TGFB2/GREM1/IL11/INHBA/IL34/IL36A/CSF1/WNT7A/TNFSF14/SECTM1/CCL17 |
| GOMF_CYTOKINE_RECEPTOR_BINDING | 172 | 0.5867398 | 2.133656 | 0.0000000 | 0.0000002 | 0.0000001 | 3069 | NTRK1/DEFB4A/CXCL10/CXCL11/CCL22/EBI3/CD70/IL36G/CCL4/NES/CXCL9/CCL20/CXCL2/CXCL6/CXCL3/TNFSF9/CXCL8/LIF/CCL5/CLCF1/CXCL5/IL1B/DEFB1/CXCL1/IL23A/SOCS2/CSF3/PF4V1/MYD88/TNFSF13B/IL1RN/IL1A/TMBIM1/CX3CL1/TNF/CXCL16/VEGFA/STAT1/PRLR/OSMR/ENG/TGFB2/SH2B3/GREM1/IL11/IL34/IL36A/CSF1/TRAF1/ITGB3/TNFSF14/CCL17/EFNA5/BID/PXDN/SYK/ADAM17/TNFSF15/SMAD6/TRAF2/CCRL2/TGFBR1/IL13RA1/YARS1/TYK2/LRG1/IL15/S100A14/TRADD/ECM1/IL18/DAB2IP/FADD/CASP8/SPRED2/PLCG1/ITGA5/TGFBR2/JAK1/TRAF5 |
| GOMF_SIGNALING_RECEPTOR_REGULATOR_ACTIVITY | 264 | 0.5218376 | 2.010299 | 0.0000000 | 0.0000002 | 0.0000001 | 2032 | DEFB4A/PCSK9/CXCL10/CXCL11/IL19/CCL22/EBI3/CD70/IL36G/CCL4/CXCL9/CCL20/IL32/CXCL2/CXCL6/CXCL3/TNFSF9/CXCL8/FGF2/IL17C/LIF/EREG/CCL5/CLCF1/IGF2/CXCL5/IL1B/CGB7/SEMA3B/BMP8B/CXCL1/ADM2/CCN3/CMTM3/IL23A/OSGIN1/FST/CSF3/NAMPT/SEMA3D/EDN1/UTS2B/DKK1/PF4V1/GDF15/TYMP/STC2/INHBE/TNFSF13B/SEMA7A/IL1RN/IL1A/CX3CL1/FGF13/AREG/TNF/BMP6/CXCL16/VEGFA/COLEC10/HBEGF/UCN2/LYNX1/FGF1/ARTN/BMP2/MANF/MACC1/PDGFB/TGFB2/GNRH1/GREM1/IL11/INHBA/IL34/IL36A/FLRT2/EGF/CSF1/WNT7A/KL/TNFSF14/SECTM1/CCL17/FGF11/PTHLH/EFNA5/FAM3D/SCG2/MIA/PDGFC/METRNL/PXDN |
| GOMF_CHEMOKINE_ACTIVITY | 25 | 0.8547067 | 2.269778 | 0.0000000 | 0.0000013 | 0.0000012 | 804 | CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/CXCL1/PF4V1/CX3CL1/CXCL16 |
| GOMF_CXCR_CHEMOKINE_RECEPTOR_BINDING | 13 | 0.9320009 | 2.121029 | 0.0000001 | 0.0000181 | 0.0000164 | 720 | CXCL10/CXCL11/CXCL9/CXCL2/CXCL6/CXCL3/CXCL8/CXCL5/CXCL1/PF4V1/CX3CL1 |
| GOMF_ACYLTRANSFERASE_ACTIVITY | 195 | 0.4676187 | 1.734899 | 0.0000179 | 0.0024097 | 0.0021815 | 1887 | PNPLA3/ACAT2/HMGCS1/ELOVL6/ACLY/FASN/PLA2G4C/GGT7/LCAT/NAA80/ELOVL5/GGT5/ZDHHC14/ASPG/ABHD4/TGM4/ELOVL7/QPCTL/ZDHHC9/ZDHHC18/SPTSSA/GPAT3/PLAAT1/PIGW/ELOVL1/GCAT/PORCN/LPCAT1/PAFAH1B3/YKT6/SPHK1/HGSNAT/CPT1C/GPAT4/PLA2G15 |
| GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY | 262 | -0.4035046 | -1.645942 | 0.0000265 | 0.0031238 | 0.0028280 | 1250 | H3C1/PDSS1/TPM2/H3C13/P2RY1/H2AC15/H3C10/SYT10/KCNB1/H2BC11/H2AC21/CYBA/MTTP/SLC51B/AURKA/H2BC3/H4C13/NPAS1/H2BC7/H2AC16/H2AC4/AOC3/H2AC13/ABCD2/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/ADRA2A/H3C12/H2BC17/H2BC13/ABCG1/TOP2A/H3C3/H2BC14/H3C8/H3C2 |
| GOMF_DOUBLE_STRANDED_RNA_BINDING | 66 | 0.6064721 | 1.939104 | 0.0000547 | 0.0057344 | 0.0051913 | 2574 | ZBP1/OAS3/OASL/OAS1/OAS2/IFIH1/RFTN1/DDX60/EIF2AK2/MSN/SLC3A2/YRDC/DHX58/VIM/ADAR/NLRP1/PRKRIP1/TFRC |
| GOMF_ATP_DEPENDENT_ACTIVITY_ACTING_ON_DNA | 100 | -0.5216104 | -1.883473 | 0.0000638 | 0.0060204 | 0.0054502 | 1109 | DSCC1/HLTF/BRIP1/ATAD5/BLM/DNA2/RAD51/RECQL4/XRCC2/CHD1L/POLQ/RAD54B/RAD54L/ERCC6L/DMC1/TOP2A |
| GOMF_MICROTUBULE_MOTOR_ACTIVITY | 62 | -0.5821539 | -1.917317 | 0.0000780 | 0.0066894 | 0.0060558 | 1712 | KIF19/KIF1A/STARD9/KIF22/DNAH9/DYNC2H1/DNAI2/DNAH3/KIF21A/DNAH6/DNAH1/DNAH5/DYNLRB2/DNAH10/KIF11/DNAH2/DNAH12/KIF18A/KIF23/KIF14/KIF20B/KIF15/CENPE/KIF20A/KIF4A/KIF2C/KIFC1/KIF18B |
| GOMF_SULFUR_COMPOUND_BINDING | 194 | 0.4607741 | 1.709665 | 0.0001024 | 0.0080485 | 0.0072862 | 1228 | PNPLA3/CXCL10/CXCL11/FGFR4/LIPC/LIPG/FGFBP1/SLIT2/RTN4R/CXCL6/SERPINC1/CXCL8/FGF2/HSD17B12/SELL/PANK3/SMOC1/PANK1/COL13A1/NAA80/CCN3/THBS1/ADAMTS5/FST/PF4V1/CD34/LTBP2/VEGFA/ACADL/HBEGF/FBLN7/LAMC2/ADGRE2/FGF1/SAA1/LIPH/TPK1/FGFBP3/PTGES/CCN1/ENPP1 |
| GOMF_CATALYTIC_ACTIVITY_ACTING_ON_DNA | 205 | -0.4098378 | -1.621981 | 0.0001699 | 0.0123252 | 0.0111578 | 3322 | PTGES3/CRY2/FEN1/LIG1/TOP1MT/MCM4/MRE11/POLH/WRN/RAD9A/NTHL1/CHD3/LIG3/POLI/PRIMPOL/RUVBL2/NEIL1/MGMT/ENDOG/FANCM/TENT4B/ERCC1/RFC3/ZGRF1/ZRANB3/XRCC3/POLN/DSCC1/HLTF/POLD1/BRIP1/MUTYH/ATAD5/BLM/FTO/DNA2/RAD51/RECQL4/XRCC2/CHD1L/POLQ/RAD54B/EXO1/RAD54L/NEIL3/ERCC6L/POLE2/DMC1/TOP2A |
| GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING | 162 | 0.4652855 | 1.681414 | 0.0001933 | 0.0130179 | 0.0117849 | 1015 | DEFB4A/CXCL10/CXCL11/CCL22/CCL4/NES/CXCL9/CCL20/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/DEFB1/CXCL1/EDN1/UTS2B/FYN/PF4V1/UCHL1/CX3CL1/CXCL16/STAT1/UCN2/GNAZ/SAA1/HOMER3 |
| GOMF_PROTEASE_BINDING | 116 | 0.4966039 | 1.735643 | 0.0002407 | 0.0151326 | 0.0136993 | 3821 | CD70/LDLR/TTN/SERPINC1/A2ML1/SELL/TNFRSF10A/DERL3/CD177/SERPINE1/VWF/TIMP2/TNF/SERPINB4/TNFAIP3/SERPINB9/CSTB/SELENOS/ITGB3/PANX1/COL1A1/BCL10/RFFL/SERPINF2/ITGAV/NTRK2/FURIN/RIPK2/ITGA3/MALT1/F3/DERL1/IL1R1/POLG/ECM1/FAP/CSTA/UBC/FADD/FLOT1/VCP/SYVN1/OS9/CFLAR/BIN1/PRNP/STIM1/TIMP1/SERPINB13/GSK3B/RIOK3/SERPINA1 |
| GOMF_INTEGRIN_BINDING | 123 | 0.4865914 | 1.704977 | 0.0002626 | 0.0154756 | 0.0140098 | 3082 | ISG15/FGF2/ITGAM/KDR/IGF2/IL1B/ITGA9/VCAM1/CCN3/THBS1/ADAMTS5/CD177/VWF/ITGA10/SEMA7A/CX3CL1/LAMA3/FGF1/ITGB1BP2/ICAM1/CCN1/MFGE8/FERMT1/ITGB8/ADAM9/LCP1/ESM1/LYN/FRMD5/ITGB3/CD151/PLPP3/CCN4/ITGB7/PTPN2/ITGAV/THY1/SYK/ADAM17/CD9/ITGB6/TGFBI/MMP14/COL16A1/ITGA3/SRC/NRG1/PPIA/MYH9/FAP/P4HB/ITGB4/S1PR3/ITGA6/ITGA5/ITGB5 |
| GOMF_ATP_DEPENDENT_ACTIVITY | 475 | -0.3272166 | -1.419508 | 0.0002979 | 0.0165232 | 0.0149582 | 2152 | CCT6B/PEX1/ABCC6/EP400/HSP90AA1/SMC4/FANCM/RFC3/DNAH7/ZGRF1/ABCA5/TDRD9/SMC2/ABCA9/PEX6/ZRANB3/ABCC9/KIF19/XRCC3/HSPA4L/ATP8B4/KIF1A/ATP2A3/STARD9/KIF22/HSPA1L/DNAH9/ACSBG1/ABCA10/ABCB11/DYNC2H1/ATP6V1C2/DNAI2/DNAH3/KATNAL2/KIF21A/DNAH6/ABCC11/ABCA8/DNAH1/DSCC1/DNAH5/ABCA6/ABCC2/HLTF/DYNLRB2/DNAH10/CLU/BRIP1/KIF11/ORC1/DNAH2/SLC26A1/TRIP13/ATAD5/DNAH12/BLM/HELLS/DNA2/RAD51/RECQL4/KIF18A/XRCC2/KIF23/ABCD2/CHD1L/KIF14/KIF20B/KIF15/POLQ/SLC4A8/RAD54B/CENPE/RAD54L/KIF20A/KIF4A/ERCC6L/KIF2C/DMC1/KIFC1/ABCA1/ABCG1/ATP2B3/TOP2A/KIF18B |
| GOMF_MICROTUBULE_BINDING | 245 | -0.3843725 | -1.562871 | 0.0003257 | 0.0170645 | 0.0154483 | 2747 | CCDC88C/DNM3/KIF27/CEP57/CEP57L1/CEP290/KIF24/CCDC181/CCDC66/MAP6/CCDC88A/EML6/GAS2L2/KIF6/RMDN2/TOGARAM2/CCDC61/APC2/SPAG8/CDK5/CFAP157/SAXO2/SAXO1/MTUS2/CCDC170/ABRAXAS1/DCDC1/CETN3/MAP1A/KIF19/KIF1A/STARD9/HOOK1/KIF22/CETN2/REEP1/CCDC187/MAP10/KATNAL2/MDM1/KIF21A/DNAI7/RACGAP1/NDRG1/SPATA4/LZTS1/RP1/KIF11/REEP2/KIF18A/PSRC1/KIF23/CENPF/SPC24/KIF14/KIF20B/CAPN6/FAM83D/KIF15/SPAG5/PLK1/CENPE/KIF20A/KIF4A/TPX2/DLGAP5/KIF2C/SKA1/KIFC1/GTSE1/BIRC5/KIF18B |
| GOMF_CYTOSKELETAL_MOTOR_ACTIVITY | 92 | -0.4867552 | -1.745084 | 0.0003527 | 0.0175069 | 0.0158487 | 1926 | DNAI1/DNAH7/KIF19/KIF1A/STARD9/KIF22/DNAH9/DYNC2H1/DNAI2/DNAH3/KIF21A/DNAH6/DNAH1/DNAH5/DYNLRB2/DNAH10/KIF11/DNAH2/DNAH12/KIF18A/KIF23/KIF14/KIF20B/KIF15/CENPE/KIF20A/KIF4A/KIF2C/KIFC1/KIF18B |
| GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY | 107 | 0.4962078 | 1.714328 | 0.0004457 | 0.0205137 | 0.0185708 | 1359 | PLA2G3/PNPLA3/ACHE/TNFAIP6/ACOT1/LIPC/LIPG/PLA2G4C/LCAT/ASPG/ABHD4/LIPA/LIPH/PTRH1/LIPE/GDPD3/PGAP6/PLAAT1/ACOT2 |
| GOMF_GTPASE_ACTIVITY | 280 | 0.4042636 | 1.564892 | 0.0004568 | 0.0205137 | 0.0185708 | 2832 | RAB42/GEM/RGS7/RASD1/MX2/TUBB3/RGS16/MX1/RAB24/RAB32/RAB6C/ARL14/RAB40AL/RND1/TUBB2A/GBP5/GBP2/RAB8B/GTPBP2/RGS9/RHOB/RGS20/GBP1/GNAZ/RAP2B/RND3/RAB5B/TUBB6/RHOF/RRAS/GCH1/RASEF/REM1/SEPTIN11/AGAP2/GNA15/RAC3/GNA12/RAB4B/TUBA1C/EEF1A2/MRAS/GBP4/ARL8A/RAB27B/RHOG/RGS10/RAP1GAP/ARL9/RALA/RAB6A/RASD2/TUBA4A/KRAS/ATL3/RHOD/RHOC/ARF4/RAB27A/RRAGC/NRAS/RAB35/TUBB/GBP3/RHOBTB3/RAB30/RIT1/RAB9A/SEPTIN8/RHEB/ARF3 |
| GOMF_DAMAGED_DNA_BINDING | 68 | -0.5308747 | -1.789231 | 0.0004867 | 0.0208623 | 0.0188863 | 4027 | PNKP/OGG1/ERCC4/RPA3/MSH6/MSH2/POT1/CRY2/FEN1/H2AX/POLH/WRN/SMC6/HMGB1/DDB2/NTHL1/MSH3/TP63/KDM4D/POLI/NEIL1/ERCC1/BRCA1/POLD1/MUTYH/HMGB2/BLM/RECQL4/POLQ/NEIL3 |
| GOMF_TUBULIN_BINDING | 335 | -0.3513073 | -1.464856 | 0.0005097 | 0.0208984 | 0.0189190 | 2747 | CCDC88C/DNM3/TTLL9/KIF27/HSPH1/CEP57/CEP57L1/CEP290/FAM110C/BCAS3/DNAL1/KIF24/CCDC181/CCDC66/MAP6/AGBL4/CCDC88A/EML6/GAS2L2/KIF6/RMDN2/EFHC2/TOGARAM2/B9D2/CCDC61/APC2/ARL4C/SPAG8/PDE4B/CDK5/CFAP157/SAXO2/SAXO1/DIXDC1/STMND1/MTUS2/CCDC170/ABRAXAS1/DCDC1/IFT81/CETN3/MAP1A/KIF19/DLEC1/KIF1A/BRCA1/CENPJ/STARD9/HOOK1/KIF22/CETN2/EFHC1/REEP1/CCDC187/MAP10/KATNAL2/MDM1/KIF21A/DNAI7/RACGAP1/NDRG1/SPATA4/LZTS1/STMN1/RP1/KIF11/TTLL6/REEP2/PPP1R42/KIF18A/PSRC1/KIF23/CENPF/SPC24/KIF14/KIF20B/CAPN6/FAM83D/KIF15/SPAG5/PLK1/CENPE/KIF20A/KIF4A/TPX2/DLGAP5/KIF2C/SKA1/KIFC1/GTSE1/BIRC5/KIF18B |
| GOMF_GLYCOSAMINOGLYCAN_BINDING | 153 | 0.4576352 | 1.639086 | 0.0005343 | 0.0209945 | 0.0190061 | 1721 | TNFAIP6/CXCL10/CXCL11/FGFR4/LIPC/LIPG/FGFBP1/SLIT2/RTN4R/CXCL6/SERPINC1/CXCL8/FGF2/HSD17B12/SELL/SMOC1/COL13A1/CCN3/THBS1/CHODL/ADAMTS5/PGLYRP4/PF4V1/LTBP2/VEGFA/HBEGF/FBLN7/LAMC2/ADGRE2/FGF1/SAA1/LIPH/PGLYRP3/ENG/TLR2/FGFBP3/HAPLN3/CCN1/VIT/HMMR/COL5A3/FSTL1/SELP/PCOLCE2/NOD2 |
| GOMF_CCR_CHEMOKINE_RECEPTOR_BINDING | 18 | 0.7882652 | 1.941977 | 0.0006052 | 0.0228274 | 0.0206653 | 842 | DEFB4A/CCL22/CCL4/NES/CCL20/CCL5/DEFB1/CX3CL1/STAT1 |
| GOMF_PROTEIN_SELF_ASSOCIATION | 51 | 0.5928301 | 1.802567 | 0.0007328 | 0.0265786 | 0.0240613 | 2384 | ACHE/PCSK9/RSAD2/TTN/CCL5/ADAM8/MYD88/CARD11/TNFAIP3/DVL2/SPTBN5/BCL10/TMEM43/NLRP1/MALT1 |
| GOMF_OXYGEN_BINDING | 18 | -0.7419081 | -1.929381 | 0.0010335 | 0.0360945 | 0.0326759 | 1179 | ADGB/CYP4B1/MB/NGB/CYGB/HBB/CYP2F1/CYP26A1 |
| GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS | 110 | 0.4934312 | 1.710695 | 0.0011534 | 0.0388464 | 0.0351671 | 3931 | ZBP1/APOBEC3A/DPYSL2/HDAC9/HINT2/PGLYRP4/APOBEC3B/ASPG/CD101/MTHFD2/OPLAH/VNN1/HDAC6/PGLYRP3/CDA/GCH1/PDF/ARG2/ACER2/NTAQ1/ADAR/DDAH2/HDAC7/LACC1/HINT3/GDA/ACY3/SIRT7/NTAN1/DHODH/GLS/AMDHD2/APOBEC3F/APOBEC3G/TGM2/DPYSL3/PM20D2/DCTD/ADAT1/SIRT6 |
| GOMF_PLUS_END_DIRECTED_MICROTUBULE_MOTOR_ACTIVITY | 16 | -0.7595711 | -1.925207 | 0.0014941 | 0.0485848 | 0.0439832 | 1712 | KIF19/KIF1A/KIF11/KIF18A/KIF14/KIF20B/CENPE/KIF18B |
Reactome
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF | 55 | 0.8599375 | 2.670809 | 0.0000000 | 0.0000000 | 0.0000000 | 364 | MVD/HMGCS1/CYP51A1/ELOVL6/DHCR7/LSS/FDPS/HMGCR/INSIG1/IDI1/FDFT1/TM7SF2/SCD/SQLE/SC5D/FASN/MVK/HELZ2 |
| REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP | 42 | 0.8846378 | 2.593326 | 0.0000000 | 0.0000000 | 0.0000000 | 364 | MVD/HMGCS1/CYP51A1/ELOVL6/DHCR7/LSS/FDPS/HMGCR/IDI1/FDFT1/TM7SF2/SCD/SQLE/SC5D/FASN/MVK/HELZ2 |
| REACTOME_HDACS_DEACETYLATE_HISTONES | 81 | -0.7297199 | -2.531763 | 0.0000000 | 0.0000000 | 0.0000000 | 1352 | SAP30/H3C1/H3C13/H2AC15/H3C10/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_CHOLESTEROL_BIOSYNTHESIS | 24 | 0.9496592 | 2.509335 | 0.0000000 | 0.0000000 | 0.0000000 | 398 | MVD/ACAT2/HMGCS1/CYP51A1/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/IDI1/HSD17B7/FDFT1/TM7SF2/NSDHL/SQLE/SC5D/MVK/DHCR24 |
| REACTOME_METABOLISM_OF_STEROIDS | 126 | 0.7108781 | 2.477691 | 0.0000000 | 0.0000000 | 0.0000000 | 620 | MVD/ACAT2/HMGCS1/CYP51A1/ELOVL6/EBP/DHCR7/LSS/FDPS/MSMO1/HMGCR/INSIG1/IDI1/HSD17B7/FDFT1/TM7SF2/NSDHL/SCD/SQLE/STARD4/SC5D/FASN/MVK/HSD17B12/HELZ2/DHCR24/SRD5A3/CYP46A1/SLCO1B1 |
| REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES | 61 | -0.7408130 | -2.469931 | 0.0000000 | 0.0000000 | 0.0000000 | 3093 | H4C2/NCAPG2/H2AX/H2AZ2/H3C6/H2BC6/H4C6/NCAPD3/PHF8/H2BC15/H2BC9/H3-3A/H3C11/SMC4/H4C12/H2BC12/H4C4/SMC2/H3C1/H3C13/H3C10/H2BC11/H2BC3/CCNB1/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/CDK1/PLK1/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RMTS_METHYLATE_HISTONE_ARGININES | 66 | -0.7235302 | -2.431173 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/H3C13/H2AC15/H3C10/H2AC21/H4C13/H2AC14/H2AC16/H2AC4/H2AC13/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_HATS_ACETYLATE_HISTONES | 128 | -0.6533711 | -2.423903 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/H3C13/H2AC15/H3C10/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | 54 | 0.7795495 | 2.407983 | 0.0000000 | 0.0000000 | 0.0000000 | 1942 | IFIT2/MX2/ISG15/RSAD2/IFITM1/IFIT1/IFIT3/OAS3/OASL/ISG20/IFI6/OAS1/MX1/XAF1/OAS2/IFI27/BST2/IRF7/USP18/IFI35/IFITM3/GBP2/SOCS1/STAT1/IFIT5/SOCS3/HLA-G/HLA-F/HLA-C/STAT2/IRF9/HLA-E/ADAR |
| REACTOME_CELL_CYCLE_CHECKPOINTS | 281 | -0.5818605 | -2.407481 | 0.0000000 | 0.0000000 | 0.0000000 | 879 | H2BC11/BRIP1/ANAPC4/ORC1/CCNE1/MAD1L1/H2BC3/CCNB1/H4C13/CENPU/CENPP/BLM/H2BC7/CDCA8/CDC25C/CCNA2/DNA2/CDC25A/CENPK/KIF18A/ZWINT/SGO2/CENPF/CLSPN/SPC24/H2BC10/H4C1/CCNE2/MAD2L1/H4C9/KNL1/CDK1/NDC80/PLK1/CENPE/EXO1/CCNB2/H2BC17/BUB1/ERCC6L/NUF2/H2BC13/KIF2C/MCM10/SKA1/CDC20/CDC45/SGO1/GTSE1/BUB1B/UBE2C/BIRC5/H2BC14/SPC25 |
| REACTOME_DNA_REPLICATION | 176 | -0.6161768 | -2.402321 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/ORC6/H3C13/POLD1/H3C10/GINS1/H2BC11/ANAPC4/ORC1/CCNE1/H2BC3/E2F1/H4C13/H2AC14/H2BC7/CCNA2/DNA2/GINS2/H2AC4/CDT1/H2BC10/E2F2/H4C1/CCNE2/H3C7/H4C9/H3C12/H2BC17/POLE2/H2BC13/MCM10/CDC45/UBE2C/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MITOTIC_SPINDLE_CHECKPOINT | 108 | -0.6666410 | -2.401590 | 0.0000000 | 0.0000000 | 0.0000000 | 861 | ANAPC4/MAD1L1/CENPU/CENPP/CDCA8/CENPK/KIF18A/ZWINT/SGO2/CENPF/SPC24/MAD2L1/KNL1/NDC80/PLK1/CENPE/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/SGO1/BUB1B/UBE2C/BIRC5/SPC25 |
| REACTOME_DNA_REPLICATION_PRE_INITIATION | 133 | -0.6173981 | -2.279230 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/ORC6/H3C13/H3C10/H2BC11/ORC1/H2BC3/E2F1/H4C13/H2AC14/H2BC7/H2AC4/CDT1/H2BC10/E2F2/H4C1/H3C7/H4C9/H3C12/H2BC17/POLE2/H2BC13/MCM10/CDC45/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_INTERFERON_SIGNALING | 170 | 0.6192385 | 2.269829 | 0.0000000 | 0.0000000 | 0.0000000 | 3219 | IFIT2/MX2/ISG15/RSAD2/IFITM1/IFIT1/IFIT3/OAS3/OASL/ISG20/IFI6/OAS1/MX1/XAF1/OAS2/IFI27/BST2/VCAM1/IRF7/HERC5/USP18/IFI35/IFITM3/GBP5/GBP2/PML/SOCS1/TRIM31/STAT1/IFIT5/GBP1/SOCS3/UBE2L6/TRIM21/IFNGR1/TRIM5/PTAFR/ICAM1/HLA-G/TRIM14/HLA-F/MT2A/EIF2AK2/HLA-C/STAT2/SP100/IRF9/GBP4/HLA-E/ADAR/TRIM25/MAPK3/PTPN2/TRIM29/SEC13/IFITM2/HLA-B/TRIM22/FLNA/TYK2/KPNA2/EGR1/GBP3/IRF1/UBC/NEDD4/PLCG1/HLA-A/PTPN11/JAK1/EIF4A1/IFNGR2/EIF4G1 |
| REACTOME_M_PHASE | 390 | -0.5162866 | -2.197544 | 0.0000000 | 0.0000000 | 0.0000000 | 879 | H2BC11/ANAPC4/MAD1L1/H2BC3/CCNB1/H4C13/CENPU/CENPP/H2AC14/LMNB1/TUBB8B/H2BC7/CDCA8/CENPK/KIF18A/ZWINT/PTTG1/H2AC4/KIF23/SGO2/CENPF/SPC24/ESPL1/H2BC10/H4C1/H3C7/MAD2L1/H4C9/KNL1/CDK1/NDC80/PLK1/CENPE/NEK2/CCNB2/PLK4/KIF20A/CDCA5/H3C12/H2BC17/BUB1/ERCC6L/NUF2/H2BC13/KIF2C/SKA1/CDC20/NCAPH/SGO1/BUB1B/UBE2C/BIRC5/H3C3/H2BC14/NCAPG/SPC25/H3C8/H3C2 |
| REACTOME_RHO_GTPASE_EFFECTORS | 290 | -0.4936626 | -2.045378 | 0.0000000 | 0.0000000 | 0.0000000 | 879 | H2BC11/CYBA/MAD1L1/H2BC3/H4C13/CENPU/CENPP/H2AC14/WAS/TUBB8B/H2BC7/CDCA8/CDC25C/CENPK/KIF18A/ZWINT/H2AC4/SGO2/CENPF/SPC24/KIF14/H2BC10/H4C1/H3C7/MAD2L1/H4C9/KNL1/DIAPH3/NDC80/PLK1/CENPE/H3C12/H2BC17/BUB1/ERCC6L/NUF2/H2BC13/KIF2C/SKA1/CDC20/IQGAP3/SGO1/BUB1B/BIRC5/H3C3/H2BC14/SPC25/H3C8/H3C2 |
| REACTOME_HCMV_LATE_EVENTS | 103 | -0.6565035 | -2.376337 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/H3C13/H2AC15/H3C10/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION | 115 | -0.6274596 | -2.269102 | 0.0000000 | 0.0000000 | 0.0000000 | 758 | MAD1L1/CCNB1/CENPU/CENPP/TUBB8B/CDCA8/CENPK/KIF18A/ZWINT/SGO2/CENPF/SPC24/MAD2L1/KNL1/CDK1/NDC80/PLK1/CENPE/CCNB2/CDCA5/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/SGO1/BUB1B/BIRC5/SPC25 |
| REACTOME_CHROMATIN_MODIFYING_ENZYMES | 255 | -0.4983274 | -2.053000 | 0.0000000 | 0.0000000 | 0.0000000 | 3023 | H2AX/H2AZ2/RPS2/ING4/H3C6/SUPT20H/H2BC6/KMT5C/HDAC8/H4C6/CHD3/KDM4D/SMYD3/PHF8/H2BC15/H2BC9/RUVBL2/SMARCD3/SMARCE1/EP400/H3C11/H4C12/H2BC12/SMYD2/H4C4/JADE1/SAP30/H3C1/H3C13/H2AC15/H3C10/EZH2/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS | 95 | -0.6507245 | -2.318090 | 0.0000000 | 0.0000000 | 0.0000000 | 3232 | NUP54/NUP155/H4C2/H2AX/H2AZ2/POLR2I/H3C6/H2BC6/H4C6/NDC1/H2BC15/H2BC9/H3-3A/H3C11/H4C12/H2BC12/H4C4/NUP37/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING | 97 | -0.6584022 | -2.355073 | 0.0000000 | 0.0000000 | 0.0000000 | 2377 | H2BC15/H2BC9/H3-3A/H3C11/H4C12/TNRC6C/H2BC12/H4C4/ATP2A3/NOTCH1/H3C1/MIR200B/ST3GAL3/H3C13/H3C10/H2BC11/H2BC3/E2F1/ST3GAL6/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/MIR449C/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE | 223 | -0.5175649 | -2.096812 | 0.0000000 | 0.0000000 | 0.0000000 | 861 | ANAPC4/MAD1L1/CCNB1/CENPU/CENPP/LMNB1/TUBB8B/CDCA8/CENPK/KIF18A/ZWINT/PTTG1/SGO2/CENPF/SPC24/ESPL1/MAD2L1/KNL1/CDK1/NDC80/PLK1/CENPE/CCNB2/CDCA5/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/SGO1/BUB1B/UBE2C/BIRC5/SPC25 |
| REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA | 61 | -0.7252284 | -2.417970 | 0.0000000 | 0.0000000 | 0.0000000 | 2377 | H2BC15/H2BC9/H3-3A/H3C11/H4C12/H2BC12/H4C4/PHF19/H3C1/H3C13/H3C10/EZH2/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MITOTIC_PROMETAPHASE | 191 | -0.5502065 | -2.171767 | 0.0000000 | 0.0000000 | 0.0000000 | 758 | MAD1L1/CCNB1/CENPU/CENPP/TUBB8B/CDCA8/CENPK/KIF18A/ZWINT/SGO2/CENPF/SPC24/MAD2L1/KNL1/CDK1/NDC80/PLK1/CENPE/NEK2/CCNB2/PLK4/CDCA5/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/NCAPH/SGO1/BUB1B/BIRC5/NCAPG/SPC25 |
| REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE | 78 | -0.6826630 | -2.354830 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_SEPARATION_OF_SISTER_CHROMATIDS | 178 | -0.5524789 | -2.149772 | 0.0000000 | 0.0000000 | 0.0000000 | 861 | ANAPC4/MAD1L1/CENPU/CENPP/TUBB8B/CDCA8/CENPK/KIF18A/ZWINT/PTTG1/SGO2/CENPF/SPC24/ESPL1/MAD2L1/KNL1/NDC80/PLK1/CENPE/CDCA5/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/SGO1/BUB1B/UBE2C/BIRC5/SPC25 |
| REACTOME_MEIOTIC_RECOMBINATION | 70 | -0.6988848 | -2.373989 | 0.0000000 | 0.0000000 | 0.0000000 | 2377 | H2BC15/MSH5/H2BC9/H3-3A/PSMC3IP/H3C11/H4C12/H2BC12/H4C4/BRCA1/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/BLM/H2BC7/RAD51/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/DMC1/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION | 96 | -0.6442307 | -2.299286 | 0.0000000 | 0.0000000 | 0.0000000 | 1352 | SAP30/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_DNA_METHYLATION | 52 | -0.7400772 | -2.393995 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H2BC15/H2BC9/H3-3A/H3C11/H4C12/H2BC12/H4C4/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION | 64 | -0.7174191 | -2.399446 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H4C2/H2AX/H2AZ2/H3C6/H2BC6/H4C6/CHD3/H2BC15/H2BC9/H3-3A/H3C11/H4C12/H2BC12/H4C4/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION | 79 | -0.6753202 | -2.338579 | 0.0000000 | 0.0000000 | 0.0000000 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION | 98 | -0.6395745 | -2.292337 | 0.0000000 | 0.0000001 | 0.0000000 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION | 94 | -0.6468797 | -2.290400 | 0.0000000 | 0.0000001 | 0.0000000 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MEIOSIS | 95 | -0.6333176 | -2.256081 | 0.0000000 | 0.0000001 | 0.0000000 | 2433 | SYNE1/H2BC15/MSH5/H2BC9/H3-3A/PSMC3IP/H3C11/H4C12/H2BC12/H4C4/BRCA1/H3C1/SYCP2/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/LMNB1/BLM/H2BC7/RAD51/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/DMC1/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION | 57 | -0.7411435 | -2.453905 | 0.0000000 | 0.0000001 | 0.0000001 | 1250 | H3C1/ORC6/H3C13/H3C10/H2BC11/ORC1/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_GENE_SILENCING_BY_RNA | 123 | -0.5952829 | -2.190296 | 0.0000000 | 0.0000001 | 0.0000001 | 3287 | MIR23B/NUP54/NUP155/H4C2/H2AX/TDRD6/H2AZ2/PIWIL2/POLR2I/H3C6/H2BC6/H4C6/TDRD1/NDC1/H2BC15/H2BC9/H3-3A/PLD6/H3C11/HSP90AA1/MYBL1/H4C12/TNRC6C/H2BC12/H4C4/NUP37/TDRD9/H3C1/H3C13/H3C10/ANG/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH | 89 | -0.6409563 | -2.246587 | 0.0000000 | 0.0000001 | 0.0000001 | 1250 | H3C1/H3C13/H3C10/EZH2/H2BC11/H2BC3/H4C13/H2AC14/LMNB1/H2BC7/CDC25C/CDC25A/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_CELLULAR_SENESCENCE | 181 | -0.5312325 | -2.073201 | 0.0000000 | 0.0000001 | 0.0000001 | 1108 | H3C13/H3C10/EZH2/H2BC11/CBX2/ANAPC4/CCNE1/H2BC3/E2F1/H4C13/H2AC14/LMNB1/H2BC7/CCNA2/CDKN2C/H2AC4/H2BC10/MAP2K6/E2F2/H4C1/CCNE2/H3C7/H4C9/H1-5/H3C12/H2BC17/H1-1/H2BC13/UBE2C/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION | 56 | -0.7285613 | -2.405405 | 0.0000000 | 0.0000001 | 0.0000001 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX | 78 | -0.6636967 | -2.289406 | 0.0000000 | 0.0000002 | 0.0000001 | 2454 | TLE3/H2BC15/H2BC9/H3-3A/H3C11/H4C12/H2BC12/H4C4/TCF7/AXIN2/H3C1/H3C13/LEF1/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 | 53 | -0.7346422 | -2.401499 | 0.0000000 | 0.0000002 | 0.0000002 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION | 134 | -0.5698088 | -2.108058 | 0.0000000 | 0.0000002 | 0.0000002 | 1352 | SAP30/H3C1/H3C13/H3C10/EZH2/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS | 112 | -0.5962855 | -2.158983 | 0.0000000 | 0.0000003 | 0.0000002 | 1250 | H3C1/H3C13/H3C10/H2BC11/MYB/H2BC3/GATA2/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS | 74 | -0.6658665 | -2.280635 | 0.0000000 | 0.0000004 | 0.0000003 | 1250 | H3C1/H3C13/LEF1/H3C10/H2BC11/MYB/H2BC3/E2F1/GATA2/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MITOTIC_PROPHASE | 130 | -0.5643673 | -2.090293 | 0.0000000 | 0.0000006 | 0.0000005 | 3232 | NUP54/NUP155/TMPO/H4C2/NCAPG2/H2AX/H2AZ2/PRKCA/H3C6/H2BC6/H4C6/NCAPD3/PHF8/NDC1/H2BC15/H2BC9/H3-3A/H3C11/SMC4/H4C12/H2BC12/VRK1/H4C4/NUP37/SMC2/H3C1/H3C13/H3C10/H2BC11/H2BC3/CCNB1/H4C13/H2AC14/LMNB1/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/CDK1/PLK1/CCNB2/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP | 99 | -0.5951460 | -2.140480 | 0.0000000 | 0.0000008 | 0.0000007 | 1250 | H3C1/H3C13/H3C10/H2BC11/ANAPC4/H2BC3/H4C13/H2AC14/H2BC7/CCNA2/CDKN2C/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/UBE2C/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_HOMOLOGY_DIRECTED_REPAIR | 130 | -0.5567461 | -2.062066 | 0.0000000 | 0.0000012 | 0.0000009 | 3741 | NSD2/ERCC4/POLD3/RFC5/RPA3/BARD1/TIMELESS/RPS27A/H4C3/ATRIP/FEN1/ATM/RAD9B/ATR/H4C2/H2AX/MRE11/POLH/WRN/RAD52/H2BC6/RAD9A/RMI1/H4C6/LIG3/H2BC15/H2BC9/H4C12/ERCC1/RFC3/H2BC12/ABRAXAS1/H4C4/XRCC3/BRCA1/EME1/RMI2/POLD1/H2BC11/BRIP1/H2BC3/H4C13/BLM/H2BC7/CCNA2/DNA2/RAD51/XRCC2/RAD51AP1/CLSPN/H2BC10/H4C1/POLQ/H4C9/EXO1/H2BC17/POLE2/H2BC13/H2BC14 |
| REACTOME_CHROMOSOME_MAINTENANCE | 126 | -0.5714214 | -2.117202 | 0.0000001 | 0.0000014 | 0.0000011 | 3694 | POLD3/MIS18BP1/RFC5/RPA3/RUVBL1/NPM1/H4C3/POT1/SHQ1/FEN1/LIG1/H4C2/CENPW/H2AX/H2AZ2/POLR2I/WRN/H2BC6/H4C6/CENPM/H2BC15/H2BC9/RUVBL2/H3-3A/WRAP53/CENPC/H4C12/MIS18A/RFC3/CENPH/H2BC12/H4C4/DSCC1/POLD1/H2BC11/H2BC3/H4C13/CENPU/CENPP/H2AC14/BLM/H2BC7/CCNA2/DNA2/CENPK/H2AC4/H2BC10/H4C1/OIP5/H4C9/KNL1/H2BC17/H2BC13/H2BC14/HJURP |
| REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE | 111 | -0.5807097 | -2.102714 | 0.0000001 | 0.0000016 | 0.0000013 | 1250 | H3C1/H3C13/H3C10/EZH2/H2BC11/CBX2/H2BC3/E2F1/H4C13/H2AC14/H2BC7/CDKN2C/H2AC4/H2BC10/MAP2K6/E2F2/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RHO_GTPASES_ACTIVATE_PKNS | 78 | -0.6327971 | -2.182819 | 0.0000001 | 0.0000024 | 0.0000019 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/CDC25C/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION | 134 | -0.5421804 | -2.005844 | 0.0000001 | 0.0000025 | 0.0000020 | 3093 | H4C2/BCL2/H2AX/H2AZ2/POLR2I/H3C6/ERBB4/H2BC6/H4C6/TLE3/H2BC15/H2BC9/TFF3/H3-3A/H3C11/HSP90AA1/H4C12/TNRC6C/H2BC12/H4C4/NR5A2/H3C1/H3C13/H3C10/H2BC11/MYB/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION | 81 | -0.6196588 | -2.149906 | 0.0000001 | 0.0000031 | 0.0000025 | 1250 | H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | 24 | 0.8461576 | 2.235847 | 0.0000002 | 0.0000041 | 0.0000032 | 804 | CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/CCR3/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/CXCL1/CX3CL1/CXCL16 |
| REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | 63 | -0.6681976 | -2.230987 | 0.0000002 | 0.0000041 | 0.0000033 | 879 | H4C2/CENPW/H2AX/H2AZ2/H2BC6/H4C6/CENPM/H2BC15/H2BC9/CENPC/H4C12/MIS18A/CENPH/H2BC12/H4C4/H2BC11/H2BC3/H4C13/CENPU/CENPP/H2AC14/H2BC7/CENPK/H2AC4/H2BC10/H4C1/OIP5/H4C9/KNL1/H2BC17/H2BC13/H2BC14/HJURP |
| REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR | 159 | -0.5088214 | -1.945037 | 0.0000002 | 0.0000044 | 0.0000035 | 3741 | NSD2/ERCC4/POLD3/RFC5/RPA3/APBB1/BARD1/TIMELESS/RPS27A/H4C3/ATRIP/FEN1/ATM/RAD9B/ATR/H4C2/H2AX/MRE11/POLH/WRN/RAD52/H2BC6/RAD9A/RMI1/H4C6/LIG3/H2BC15/H2BC9/H4C12/ERCC1/RFC3/H2BC12/ABRAXAS1/H4C4/XRCC3/BRCA1/EME1/RMI2/POLD1/H2BC11/BRIP1/H2BC3/H4C13/BLM/H2BC7/CCNA2/DNA2/RAD51/XRCC2/RAD51AP1/CLSPN/H2BC10/H4C1/POLQ/H4C9/EXO1/H2BC17/POLE2/H2BC13/H2BC14 |
| REACTOME_HCMV_EARLY_EVENTS | 117 | -0.5653891 | -2.051817 | 0.0000002 | 0.0000046 | 0.0000037 | 1108 | H3C1/H3C13/H2AC15/H3C10/EZH2/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/TUBB8B/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_AMYLOID_FIBER_FORMATION | 85 | -0.6036647 | -2.119157 | 0.0000003 | 0.0000054 | 0.0000043 | 1250 | H2BC15/H2BC9/H3-3A/H3C11/LYZ/H4C12/H2BC12/H4C4/APOE/H3C1/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/LTF/H2AC4/CALB1/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_RHO_GTPASES_ACTIVATE_FORMINS | 129 | -0.5546380 | -2.055895 | 0.0000003 | 0.0000054 | 0.0000043 | 758 | MAD1L1/CENPU/CENPP/TUBB8B/CDCA8/CENPK/KIF18A/ZWINT/SGO2/CENPF/SPC24/MAD2L1/KNL1/DIAPH3/NDC80/PLK1/CENPE/BUB1/ERCC6L/NUF2/KIF2C/SKA1/CDC20/SGO1/BUB1B/BIRC5/SPC25 |
| REACTOME_BASE_EXCISION_REPAIR | 81 | -0.6058978 | -2.102162 | 0.0000004 | 0.0000072 | 0.0000057 | 4080 | H2BC4/H2BC5/TERF1/PNKP/OGG1/POLD3/RFC5/RPA3/H4C3/POT1/FEN1/LIG1/H4C2/H2AX/H2AZ2/H2BC6/H4C6/NTHL1/LIG3/H2BC15/H2BC9/NEIL1/H4C12/RFC3/H2BC12/H4C4/POLD1/H2BC11/MUTYH/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H4C9/H2BC17/NEIL3/POLE2/H2BC13/H2BC14 |
| REACTOME_REPRODUCTION | 108 | -0.5714519 | -2.058669 | 0.0000004 | 0.0000073 | 0.0000058 | 1250 | SYNE1/H2BC15/MSH5/H2BC9/H3-3A/PSMC3IP/H3C11/H4C12/H2BC12/H4C4/ADAM20/BRCA1/H3C1/SYCP2/H3C13/H3C10/H2BC11/H2BC3/H4C13/H2AC14/LMNB1/BLM/H2BC7/CATSPERD/RAD51/H2AC4/OVGP1/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/DMC1/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION | 147 | -0.5286360 | -1.996502 | 0.0000004 | 0.0000081 | 0.0000064 | 837 | DHFR/ORC1/CCNE1/E2F1/CCNB1/CCNA2/CDC25A/TYMS/CDKN2C/CDT1/E2F2/CCNE2/CDK1/TK1/POLE2/MCM10/RRM2/CDC45/TOP2A/MYBL2 |
| REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE | 70 | -0.6325423 | -2.148635 | 0.0000005 | 0.0000093 | 0.0000074 | 879 | H1-3/H4C3/POT1/ATM/H1-2/H4C2/H2AX/H2AZ2/MRE11/H2BC6/H4C6/H2BC15/H2BC9/EP400/H4C12/H2BC12/H4C4/H2BC11/CCNE1/H2BC3/H4C13/H2AC14/LMNB1/H2BC7/CCNA2/H2AC4/H2BC10/H4C1/CCNE2/H4C9/H1-5/H2BC17/H1-1/H2BC13/H2BC14 |
| REACTOME_HDMS_DEMETHYLATE_HISTONES | 45 | -0.7082012 | -2.199619 | 0.0000005 | 0.0000095 | 0.0000076 | 1250 | H3C1/H3C13/H3C10/H4C13/H4C1/H3C7/H4C9/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_SIGNALING_BY_NOTCH | 217 | -0.4642484 | -1.873677 | 0.0000005 | 0.0000096 | 0.0000076 | 1427 | HEY2/NBEA/NOTCH1/H3C1/MIR200B/ST3GAL3/H3C13/H3C10/H2BC11/DLL1/H2BC3/E2F1/ST3GAL6/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/TACC3/H3C7/H4C9/HEYL/H3C12/H2BC17/DLGAP5/H2BC13/MIR449C/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS | 92 | -0.5810360 | -2.045257 | 0.0000006 | 0.0000101 | 0.0000080 | 3628 | RFC5/RPA3/BARD1/TIMELESS/RPS27A/H4C3/ATRIP/ATM/RAD9B/ATR/H4C2/H2AX/MRE11/WRN/H2BC6/RAD9A/RMI1/H4C6/H2BC15/H2BC9/H4C12/RFC3/H2BC12/ABRAXAS1/H4C4/BRCA1/RMI2/H2BC11/BRIP1/H2BC3/H4C13/BLM/H2BC7/CCNA2/DNA2/CLSPN/H2BC10/H4C1/H4C9/EXO1/H2BC17/H2BC13/H2BC14 |
| REACTOME_HCMV_INFECTION | 141 | -0.5226667 | -1.953281 | 0.0000006 | 0.0000108 | 0.0000086 | 1108 | H3C13/H2AC15/H3C10/EZH2/H2BC11/H2AC21/H2BC3/H4C13/H2AC14/TUBB8B/H2BC7/H2AC16/H2AC4/H2AC13/H2BC10/H4C1/H3C7/H2AC11/H4C9/H2AC12/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | 21 | -0.8357522 | -2.245483 | 0.0000009 | 0.0000150 | 0.0000120 | 861 | ANAPC4/MAD2L1/CDC20/BUB1B/UBE2C |
| REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A | 26 | -0.8015212 | -2.233662 | 0.0000010 | 0.0000164 | 0.0000130 | 861 | ANAPC4/MAD2L1/NEK2/CDC20/BUB1B/UBE2C |
| REACTOME_INTERLEUKIN_10_SIGNALING | 33 | 0.7689498 | 2.161439 | 0.0000010 | 0.0000164 | 0.0000130 | 1443 | CXCL10/CCL22/CCL4/CCL20/CXCL2/CXCL8/LIF/IL1R2/CCL5/IL1B/CXCL1/PTGS2/CSF3/IL1RN/IL1A/TNF/TNFRSF1B/PTAFR/ICAM1/CSF1 |
| REACTOME_G2_M_CHECKPOINTS | 160 | -0.5054712 | -1.935551 | 0.0000010 | 0.0000164 | 0.0000130 | 2014 | H4C12/RFC3/H2BC12/ABRAXAS1/H4C4/BRCA1/PKMYT1/CDC7/RMI2/ORC6/H2BC11/BRIP1/ORC1/H2BC3/CCNB1/H4C13/BLM/H2BC7/CDC25C/DNA2/CDC25A/CLSPN/H2BC10/H4C1/H4C9/CDK1/EXO1/CCNB2/H2BC17/H2BC13/MCM10/CDC45/GTSE1/H2BC14 |
| REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS | 104 | -0.5712376 | -2.062994 | 0.0000010 | 0.0000166 | 0.0000132 | 1250 | H3C1/H3C13/H3C10/EZH2/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | 89 | -0.5755638 | -2.017383 | 0.0000011 | 0.0000175 | 0.0000139 | 3628 | RFC5/RPA3/BARD1/H4C3/ATRIP/ATM/RAD9B/ATR/H4C2/H2AX/MRE11/WRN/H2BC6/RAD9A/RMI1/H4C6/H2BC15/H2BC9/H4C12/RFC3/H2BC12/ABRAXAS1/H4C4/BRCA1/RMI2/H2BC11/BRIP1/H2BC3/CCNB1/H4C13/BLM/H2BC7/CDC25C/DNA2/H2BC10/H4C1/H4C9/CDK1/EXO1/H2BC17/H2BC13/H2BC14 |
| REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION | 90 | -0.5800455 | -2.032389 | 0.0000011 | 0.0000178 | 0.0000142 | 4457 | RPS11/RPS26/RPL18/RPS16/RPL18A/RPS24/RPL23A/RPL24/RPS5/RPS27/RPS12/RPL27/RPL9/RPS8/EEF1B2/RPL7A/EEF2/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/RPS29/RPL3/RPS2/RPS20/RPS13/RPS4Y1/EEF1A1/RPL29/RPS23/RPL11/RPS25/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/RPL22/RPS14/RPL7/RPL5/RPL10A/RPS3A/RPS10/RPL39L |
| REACTOME_INTERFERON_GAMMA_SIGNALING | 76 | 0.6294404 | 2.049693 | 0.0000022 | 0.0000346 | 0.0000275 | 3165 | OAS3/OASL/OAS1/OAS2/VCAM1/IRF7/GBP5/GBP2/PML/SOCS1/TRIM31/STAT1/GBP1/SOCS3/TRIM21/IFNGR1/TRIM5/PTAFR/ICAM1/HLA-G/TRIM14/HLA-F/MT2A/HLA-C/SP100/IRF9/GBP4/HLA-E/TRIM25/PTPN2/TRIM29/HLA-B/TRIM22/GBP3/IRF1/HLA-A/PTPN11/JAK1/IFNGR2 |
| REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | 228 | 0.4751126 | 1.796361 | 0.0000027 | 0.0000410 | 0.0000326 | 2336 | LUM/CAPN14/SDC3/FGF2/ITGAM/KDR/MMP25/MMP16/MMP10/MATN3/MMP17/COL13A1/ITGA9/VCAM1/CAPN12/THBS1/CEACAM1/ADAMTS14/ADAMTS5/PECAM1/COL6A3/SERPINE1/ADAM8/VWF/ITGA10/LTBP2/EMILIN2/KLK7/TIMP2/CEACAM6/LAMA3/MMP19/LAMC2/CD47/LAMB3/LOXL2/BMP2/COL6A1/PDGFB/TGFB2/MMP15/COLGALT2/ICAM1/COL9A2/MFAP2/ADAMTS9/ITGB8/PLOD3/ADAM9/MMP7/COLGALT1/ITGB3/MMP12/COL5A3/FMOD/COL1A1/COL22A1/CD151/PCOLCE2/LTBP1/HSPG2/MMP13/ITGB7/COL8A2/CTSV/PXDN/ITGAV/COL12A1/MMP24/ADAM17/FURIN/ITGB6/SERPINH1/MMP14/CAPN13/COL25A1/ADAMTS1/COL16A1/LAMC1/COL17A1/CAPN2/ITGA3 |
| REACTOME_DNA_REPAIR | 319 | -0.4048895 | -1.693911 | 0.0000032 | 0.0000481 | 0.0000383 | 4096 | RAD51B/H2BC4/H2BC5/TERF1/PNKP/CCNH/PIAS3/BRCA2/PPIE/OGG1/KDM4A/FANCL/REV3L/FANCE/NSD2/ERCC4/POLD3/RFC5/RPA3/RUVBL1/APBB1/USP45/SPRTN/MSH6/BARD1/MSH2/TIMELESS/RPS27A/H4C3/POT1/ATRIP/FEN1/ATM/LIG1/RAD9B/ATR/H4C2/H2AX/H2AZ2/UBE2T/POLR2I/MRE11/POLH/WRN/GTF2H5/RAD52/H2BC6/RAD9A/RMI1/H4C6/DDB2/NTHL1/MSH3/LIG3/POLI/H2BC15/H2BC9/NEIL1/MGMT/FANCM/H4C12/ERCC1/RFC3/H2BC12/ABRAXAS1/H4C4/XRCC3/BRCA1/POLN/CETN2/EME1/RMI2/FANCI/POLD1/PCLAF/H2BC11/BRIP1/FANCB/MUTYH/H2BC3/H4C13/H2AC14/BLM/H2BC7/FTO/CCNA2/DNA2/RAD51/XRCC2/H2AC4/RAD51AP1/CLSPN/CHD1L/H2BC10/H4C1/POLQ/H4C9/EXO1/H2BC17/NEIL3/POLE2/H2BC13/DTL/H2BC14 |
| REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | 130 | -0.5067771 | -1.876992 | 0.0000032 | 0.0000486 | 0.0000386 | 1250 | H3C1/KIF21A/RACGAP1/H3C13/H3C10/MYB/KIF11/GATA2/TUBB8B/KIF18A/KIF23/KIF20B/H3C7/KIF15/HBB/CENPE/KIF20A/KIF4A/H3C12/KIF2C/KIFC1/H3C3/H3C8/KIF18B/H3C2 |
| REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES | 65 | -0.6217848 | -2.079779 | 0.0000033 | 0.0000491 | 0.0000391 | 1250 | H3C11/H4C12/SMYD2/H4C4/H3C1/H3C13/H3C10/EZH2/H4C13/H4C1/H3C7/H4C9/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | 29 | -0.7565257 | -2.143315 | 0.0000040 | 0.0000587 | 0.0000467 | 1115 | FBXO5/DHFR/ORC1/CCNE1/E2F1/CDC25A/TYMS/CDT1/CDK1/TK1/RRM2/CDC45 |
| REACTOME_TELOMERE_MAINTENANCE | 100 | -0.5521465 | -1.981909 | 0.0000048 | 0.0000691 | 0.0000549 | 3694 | POLD3/RFC5/RPA3/RUVBL1/H4C3/POT1/SHQ1/FEN1/LIG1/H4C2/H2AX/H2AZ2/POLR2I/WRN/H2BC6/H4C6/H2BC15/H2BC9/RUVBL2/H3-3A/WRAP53/H4C12/RFC3/H2BC12/H4C4/DSCC1/POLD1/H2BC11/H2BC3/H4C13/H2AC14/BLM/H2BC7/CCNA2/DNA2/H2AC4/H2BC10/H4C1/H4C9/H2BC17/H2BC13/H2BC14 |
| REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION | 53 | -0.6523269 | -2.132416 | 0.0000061 | 0.0000880 | 0.0000700 | 3362 | H4C3/POT1/H4C2/H2AX/H2AZ2/H2BC6/H4C6/NTHL1/H2BC15/H2BC9/NEIL1/H4C12/H2BC12/H4C4/H2BC11/MUTYH/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H4C9/H2BC17/NEIL3/H2BC13/H2BC14 |
| REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS | 16 | -0.8620329 | -2.138759 | 0.0000070 | 0.0000997 | 0.0000793 | 720 | CCNB1/CDC25C/CDC25A/CENPF/FOXM1/PLK1/CCNB2/MYBL2 |
| REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE | 46 | -0.6770852 | -2.127540 | 0.0000075 | 0.0001050 | 0.0000835 | 879 | H4C3/POT1/H4C2/H2AX/H2AZ2/H2BC6/H4C6/H2BC15/H2BC9/H4C12/H2BC12/H4C4/H2BC11/MUTYH/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H4C9/H2BC17/NEIL3/H2BC13/H2BC14 |
| REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS | 85 | -0.5601243 | -1.966309 | 0.0000089 | 0.0001224 | 0.0000973 | 1115 | FBXO5/ANAPC4/AURKA/CCNB1/CCNA2/PTTG1/MAD2L1/CDK1/PLK1/NEK2/CDC20/BUB1B/UBE2C |
| REACTOME_NEUTROPHIL_DEGRANULATION | 392 | 0.4005638 | 1.597652 | 0.0000093 | 0.0001267 | 0.0001007 | 3821 | S100A7/TNFAIP6/ACLY/FGL2/PRSS3/ALDOC/S100A12/PLAUR/FCGR2A/ITGAM/RAB24/S100P/SELL/SLCO4C1/MMP25/SERPINB12/BST2/SERPINA3/HP/CXCL1/CHRNB4/PLAU/SLC2A3/CEACAM1/CD177/OLFM4/PECAM1/ADAM8/HVCN1/TMBIM1/S100A8/TIMP2/CEACAM6/TNFRSF1B/CD55/VNN1/NEU1/HSPA6/IDH1/UNC13D/CD47/RAP2B/STK10/CKAP4/TLR2/RAB5B/PTAFR/VCL/CDA/RHOF/PTPRJ/S100A9/TSPAN14/CSTB/NPC2/PDXK/CSNK2B/LRRC7/LCN2/HLA-C/LPCAT1/GLIPR1/RAB4B/HGSNAT/STBD1/OLR1/ARL8A/RHOG/ARSB/VAT1/MOSPD2/ITGAV/PTGES2/PNP/ATP11A/HLA-B/RAB6A/CAP1/STOM/MGST1/HEXB/SURF4/DSN1/COTL1/PSMD11/RAB27A/NRAS/LRG1/TMC6/GYG1/GHDC/DGAT1/TUBB/CNN2/DIAPH1/CTSC/NFKB1/PPIA/TMEM63A/C3/ACAA1/SLC15A4/MGAM/JUP/ARSA/HLA-A/PLEKHO2/SIRPA/VCP/AP1M1/ALDOA/DNAJC13/RAP2C/HMOX2/MANBA/QPCT/PGRMC1/ATAD3B/IQGAP1/TMEM30A/MAGT1/HEBP2/IMPDH1/PSMD1/CD63/APEH/FRK/ALOX5/ITGAL/PSMD7/SLC44A2/RHOA/RAC1/NBEAL2/DYNC1H1/B4GALT1/CANT1/SERPINA1 |
| REACTOME_PHOSPHORYLATION_OF_THE_APC_C | 20 | -0.8036911 | -2.134205 | 0.0000123 | 0.0001655 | 0.0001316 | 861 | ANAPC4/CCNB1/CDK1/PLK1/UBE2C |
| REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 | 207 | -0.4344358 | -1.739622 | 0.0000165 | 0.0002196 | 0.0001746 | 1108 | H3C13/H3C10/CTSK/H2BC11/MYB/CBX2/H2BC3/GATA2/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/CSF2/H3C7/H4C9/CLDN5/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT | 201 | -0.4411588 | -1.761914 | 0.0000196 | 0.0002590 | 0.0002060 | 1331 | SOX13/CBY1/ZNRF3/TLE3/H2BC15/H2BC9/SOX2/FRAT2/H3-3A/H3C11/H4C12/H2BC12/H4C4/TCF7/AXIN2/H3C1/H3C13/LEF1/H3C10/H2BC11/H2BC3/WNT3A/H4C13/CXXC4/WIF1/H2AC14/H2BC7/H2AC4/LGR6/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_G0_AND_EARLY_G1 | 27 | -0.7580607 | -2.126988 | 0.0000221 | 0.0002885 | 0.0002294 | 821 | CCNE1/E2F1/CCNA2/CDC25A/CCNE2/CDK1/TOP2A/MYBL2 |
| REACTOME_EUKARYOTIC_TRANSLATION_INITIATION | 117 | -0.5108012 | -1.853715 | 0.0000246 | 0.0003167 | 0.0002519 | 4726 | RPL12/EIF3H/RPL10/RPS11/RPS26/RPL18/RPS16/RPL18A/RPS24/RPL23A/RPL24/EIF4A2/RPS5/RPS27/RPS12/RPL27/EIF3D/RPL9/EIF3L/RPS8/RPL7A/EIF3F/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/PABPC1/RPS29/RPL3/RPS2/RPS20/RPS13/RPS4Y1/RPL29/RPS23/RPL11/RPS25/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/EIF3E/RPL22/EIF4B/RPS14/RPL7/RPL5/RPL10A/RPS3A/RPS10/RPL39L |
| REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS | 254 | -0.3971720 | -1.635569 | 0.0000379 | 0.0004837 | 0.0003846 | 2098 | H3C11/HSP90AA1/ARL4C/PIK3R1/H4C12/TNRC6C/PDK4/H2BC12/H4C4/NR1H3/NR5A2/GNGT1/APOE/PLIN1/H3C1/AKR1C3/RDH5/EEPD1/H3C13/H3C10/ADH1C/H2BC11/MYB/H2BC3/PLTP/H4C13/H2AC14/H2BC7/ALDH1A1/SREBF1/H2AC4/H2BC10/FABP5/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/ABCA1/MYLIP/ABCG1/H3C3/H2BC14/CYP26A1/H3C8/H3C2 |
| REACTOME_MEIOTIC_SYNAPSIS | 62 | -0.5818364 | -1.930450 | 0.0000487 | 0.0006144 | 0.0004885 | 3362 | H4C3/POT1/ATR/H4C2/H2AX/H2AZ2/H2BC6/H4C6/SYNE1/H2BC15/H2BC9/H4C12/H2BC12/H4C4/BRCA1/SYCP2/H2BC11/H2BC3/H4C13/H2AC14/LMNB1/H2BC7/H2AC4/H2BC10/H4C1/H4C9/H2BC17/H2BC13/H2BC14 |
| REACTOME_INHIBITION_OF_DNA_RECOMBINATION_AT_TELOMERE | 58 | -0.6117005 | -2.031656 | 0.0000562 | 0.0007021 | 0.0005583 | 3362 | H4C3/POT1/H4C2/H2AX/H2AZ2/POLR2I/H2BC6/H4C6/H2BC15/H2BC9/H3-3A/H4C12/H2BC12/H4C4/H2BC11/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H4C9/H2BC17/H2BC13/H2BC14 |
| REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B | 24 | -0.7530019 | -2.078724 | 0.0000569 | 0.0007024 | 0.0005585 | 861 | ANAPC4/CCNB1/CDK1/CDC20/UBE2C |
| REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE | 95 | -0.5111712 | -1.820956 | 0.0000652 | 0.0007974 | 0.0006340 | 4054 | AHI1/TTBK2/HAUS3/IQCB1/ALMS1/TMEM216/DYNLL1/CEP41/CEP250/HAUS4/CEP76/TCTN2/CEP135/SFI1/HAUS1/B9D1/CEP57/CEP43/TCTN1/MKS1/CEP290/KIF24/CEP162/HAUS5/CEP97/CEP164/NPHP1/TUBB4B/CNTRL/RPGRIP1L/B9D2/AKAP9/HSP90AA1/PCM1/CC2D2A/TMEM67/CCP110/CEP83/CENPJ/CEP152/CETN2/FBF1/CEP78/CDK1/PLK1/NEK2/PLK4 |
| REACTOME_SIGNALING_BY_INTERLEUKINS | 375 | 0.3980414 | 1.582370 | 0.0000745 | 0.0009010 | 0.0007164 | 3188 | CXCL10/IL19/CCL22/EBI3/IL36G/CCL4/CCL20/S100A12/IL32/CXCL2/CXCL8/FGF2/IL17C/LIF/ITGAM/IL2RG/IL1R2/CCL5/CLCF1/LBP/IL1RL1/IL1B/VCAM1/CXCL1/IL23A/PTGS2/SOCS2/IRAK2/CSF3/FYN/NFKB2/IL31RA/FOS/SERPINB2/MYD88/IL1RN/IL1A/SOCS1/IL1RL2/TNF/STX3/TNFRSF1B/VEGFA/STAT1/NFKBIA/NOS2/MAPK11/PSME4/JUN/BATF/SOCS3/IKBKG/LGALS9/SAA1/OSMR/IL18R1/MEF2C/PTAFR/ICAM1/TNIP2/DUSP6/CDKN1A/IL11/LCP1/MSN/IRAK3/PSMA6/DUSP3/MYC/IL34/IL36A/CSF1/STX4/LYN/IRS2/PIM1/LCN2/IL15RA/GAB2/IFNLR1/STAT2/NOD2/PELI1/PTPN12/IL7R/IRAK1/MAP3K8/VIM/ZEB1/MAPK3/ANXA1/PTPN2/SYK/STX1A/TALDO1/MAPK7/TAB3/SQSTM1/RALA/HMOX1/RIPK2/STAT5A/PTPN18/NOD1/IL13RA1/IL4R/PSMB9/PSMD11/TYK2/MAP2K1/DUSP4/CNN2/JUNB/CD86/IL15/PTPN9/IL1R1/MAP3K3/MAP2K3/NFKB1/NFKBIB/PPIA/SOS2/MUC1/IL18/CISH/IL10RB/UBC/CEBPD/P4HB/MAPKAPK2/NKIRAS2/PPP2R1B/PSME2/PTPN11/JAK1/MMP1/TWIST1/PSMC4/MAPKAPK3/RPS6KA3/CFL1 |
| REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE | 95 | 0.5492536 | 1.847742 | 0.0000770 | 0.0009217 | 0.0007329 | 3178 | S100A12/IRF7/BIRC3/IRAK2/NFKB2/FOS/RIPK3/TICAM1/NFKBIA/MAPK11/JUN/IKBKG/SAA1/IKBKE/LY96/MEF2C/TLR4/TNIP2/DUSP6/DUSP3/NOD2/IRAK1/MAP3K8/MAPK3/MAPK7/TAB3/RIPK2/NOD1/MAP2K1/DUSP4/MAP2K3/NFKB1/NFKBIB/UBC/MAPKAPK2/FADD/NKIRAS2/CASP8/PPP2R1B/PTPN11/MAPKAPK3/RPS6KA3 |
| REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ | 63 | -0.5756476 | -1.921980 | 0.0000901 | 0.0010677 | 0.0008490 | 3486 | BARD1/H4C3/ATM/H4C2/H2AX/MRE11/H2BC6/H4C6/H2BC15/H2BC9/H4C12/H2BC12/ABRAXAS1/H4C4/BRCA1/H2BC11/H2BC3/H4C13/H2BC7/H2BC10/H4C1/H4C9/H2BC17/H2BC13/H2BC14 |
| REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 139 | 0.4915866 | 1.738911 | 0.0000921 | 0.0010798 | 0.0008586 | 3230 | S100A12/ITGAM/LBP/IRF7/BIRC3/IRAK2/NFKB2/FOS/MYD88/SOCS1/S100A8/RIPK3/TICAM1/NFKBIA/MAPK11/JUN/IKBKG/SAA1/IKBKE/LY96/TLR2/MEF2C/TLR4/TNIP2/DUSP6/S100A9/IRAK3/DUSP3/LGMN/NOD2/PELI1/IRAK1/MAP3K8/MAPK3/CTSV/MAPK7/TAB3/RIPK2/NOD1/MAP2K1/DUSP4/MAP2K3/NFKB1/NFKBIB/UBC/MAPKAPK2/FADD/NKIRAS2/CASP8/PPP2R1B/TIRAP/PTPN11/MAPKAPK3/RPS6KA3/GSDME |
| REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA | 66 | 0.5910041 | 1.892932 | 0.0000965 | 0.0011039 | 0.0008777 | 2975 | ISG15/S100A12/NLRC5/IRF7/IFIH1/HERC5/NFKB2/CASP10/NFKBIA/IKBKG/SAA1/IKBKE/UBE2L6/TNFAIP3/DHX58/TRIM25/TRAF2/NFKB1/NFKBIB/UBC/FADD/NKIRAS2/CASP8 |
| REACTOME_SIGNALING_BY_NTRKS | 123 | 0.5066677 | 1.770212 | 0.0000970 | 0.0011039 | 0.0008777 | 3743 | ARC/NTRK1/NTRK3/ASCL1/FOSB/FYN/EGR2/FOS/MAPK11/SGK1/PTPRO/MEF2C/JUND/DUSP6/DUSP3/TRIB1/IRS2/SHC2/ID4/SRF/MAPK3/ID3/AP2B1/NTRK2/FURIN/MAPK7/RALA/KRAS/SRC/FOSL1/NRAS/MAP2K1/EGR1/F3/DUSP4/JUNB/RIT1/ID1/MAPKAPK2/PPP2R1B/PLCG1/PTPN11/MAPKAPK3/RPS6KA3/MAP2K2/MAPK13/IRS1/SHC1/CRK/HRAS/MAPK12/RHOA/RAC1/RAPGEF1 |
| REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 175 | 0.4644928 | 1.709358 | 0.0000968 | 0.0011039 | 0.0008777 | 2945 | SLC26A9/SLC18A2/SLC2A6/SLC29A2/SLC2A4/RHCG/SLC8A1/SLC39A8/SLC7A11/SLC5A1/SLCO4C1/SLC26A4/SLC5A8/SLC7A9/SLCO4A1/SLC6A11/SLC2A3/SLC26A6/SLCO1B1/SLC9A4/SLC6A14/SLC13A5/HEPH/SLC20A1/SLC15A3/SLC9A2/SLC16A3/SLC35C1/SLC10A6/SLC15A1/SLC9A3/SLC4A3/SLC3A2/SLC50A1/SLC2A12/SLC12A4/SLC7A7/SLC8B1/SLC28A1/SLC9A6/SLCO3A1/SLC11A2/SLC28A3/SLC1A4/SLC39A1/SLC5A5/SLC27A4/SLC5A12/SLC39A7/SLC7A1/SLC12A2/SLC7A5/SLC5A6/SLC9A7/SLC9A1/SLC39A4/SLC25A22/SLC31A1/SLC41A2/AHCYL2/CTNS/SLC36A1/SLC38A5/SLC15A4 |
| REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING | 126 | 0.5083084 | 1.771655 | 0.0001047 | 0.0011802 | 0.0009384 | 3817 | IL36G/S100A12/IL1R2/IL1RL1/IL1B/IRAK2/NFKB2/MYD88/IL1RN/IL1A/IL1RL2/NFKBIA/PSME4/IKBKG/SAA1/IL18R1/TNIP2/IRAK3/PSMA6/IL36A/NOD2/PELI1/PTPN12/IRAK1/MAP3K8/PTPN2/TAB3/SQSTM1/RIPK2/PTPN18/NOD1/PSMB9/PSMD11/MAP2K1/PTPN9/IL1R1/MAP3K3/NFKB1/NFKBIB/IL18/UBC/NKIRAS2/PSME2/PTPN11/PSMC4/RELA/PSMD1/PSMA1/ALOX5/IL18BP/PSMD7/PSMB8/SMAD3 |
| REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | 80 | 0.5481913 | 1.803735 | 0.0001479 | 0.0016513 | 0.0013130 | 3495 | MX2/ISG15/IFIT1/OAS3/OASL/OAS1/MX1/OAS2/HERC5/USP18/STAT1/UBE2L6/EIF2AK2/TRIM25/MAPK3/SEC13/FLNA/KPNA2/UBC/NEDD4/PLCG1/JAK1/EIF4A1/EIF4G1/NUP58/KPNA1 |
| REACTOME_DISEASES_OF_DNA_REPAIR | 34 | -0.6713804 | -1.969009 | 0.0001573 | 0.0017398 | 0.0013834 | 3490 | RAD51B/BRCA2/OGG1/MSH6/BARD1/MSH2/ATM/MRE11/WRN/RMI1/NTHL1/MSH3/NEIL1/BRCA1/RMI2/BRIP1/MUTYH/BLM/DNA2/RAD51/XRCC2/RAD51AP1/EXO1/NEIL3 |
| REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | 32 | -0.6917515 | -1.995914 | 0.0001829 | 0.0020037 | 0.0015932 | 1540 | GMNN/CDC7/ORC6/ORC1/CDT1/POLE2/MCM10/CDC45 |
| REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | 24 | -0.7247637 | -2.000770 | 0.0001856 | 0.0020139 | 0.0016013 | 720 | PKMYT1/CCNB1/CDC25C/CCNA2/CDC25A/CDK1/FOXM1/PLK1/CCNB2 |
| REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE | 90 | 0.5319528 | 1.785211 | 0.0002339 | 0.0025146 | 0.0019994 | 3178 | S100A12/IRF7/IRAK2/NFKB2/FOS/MYD88/TICAM1/NFKBIA/MAPK11/JUN/IKBKG/SAA1/LY96/MEF2C/TLR4/TNIP2/DUSP6/DUSP3/NOD2/PELI1/IRAK1/MAP3K8/MAPK3/MAPK7/TAB3/RIPK2/NOD1/MAP2K1/DUSP4/MAP2K3/NFKB1/NFKBIB/UBC/MAPKAPK2/NKIRAS2/PPP2R1B/MAPKAPK3/RPS6KA3 |
| REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES | 446 | 0.3689054 | 1.485095 | 0.0002563 | 0.0027304 | 0.0021711 | 3281 | ARC/NTRK1/FGFR4/FGFBP1/TRIB3/NTRK3/FGF2/NCF1/KDR/IL2RG/ASCL1/EREG/IGF2/FOSB/KLB/NCF2/THBS1/FYN/EGR2/COL6A3/FOS/SOCS1/AREG/VEGFA/LAMA3/STAT1/HBEGF/LAMC2/MAPK11/SGK1/ELMO1/FGF1/CD274/LAMB3/COL6A1/PRDM1/NCF4/PDGFB/PTPRO/FGFBP3/ITPR2/MEF2C/WASF1/SH2B3/JUND/DUSP6/COL9A2/PTPRJ/SPRY1/MKNK1/GRB10/DUSP3/MET/MYC/FLRT2/EGF/LYN/TRIB1/FLT1/ITGB3/COL5A3/IRS2/PTPRK/KL/SHC2/COL1A1/GAB2/ITPR3/SPHK1/RAB4B/ID4/PTPN12/AKT3/MST1R/PDGFC/SRF/TNS4/MAPK3/PTPN2/ID3/ITGAV/AP2B1/ADAM17/NTRK2/FURIN/MAPK7/RALA/LAMC1/BCAR1/ITGA3/KRAS/SRC/STAT5A/PTPN18/FOSL1/COL24A1/TGFA/SPINT1/ADAP1/NRAS/MAP2K1/EGR1/F3/NRG1/DUSP4/JUNB/ACTB/DIAPH1/NCK1/RIT1/ACTG1/POLR2G/ID1/UBC/MAPKAPK2/NEDD4/PPP2R1B/ATP6V1E2/JUP/SPRED2/PLCG1/SHB/SPARC/PTPN11/MAPKAPK3/GTF2F2/SH3KBP1/RPS6KA3/CAV1/MAP2K2/ELMO2/THBS4/GRB7 |
| REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | 110 | -0.4748945 | -1.716568 | 0.0002588 | 0.0027312 | 0.0021717 | 4457 | RPS11/RPS26/RPL18/RPS16/RPL18A/RPS24/RPL23A/SEC61A2/RPL24/RPS5/RPS27/RPS12/RPL27/RPL9/RPS8/RPL7A/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/SRP9/RPS29/RPL3/RPS2/RPS20/RPS13/RPS4Y1/RPL29/RPS23/RPL11/RPS25/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/RPL22/RPS14/RPL7/RPL5/RPL10A/RPS3A/RPS10/RPL39L |
| REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | 65 | 0.5761577 | 1.839128 | 0.0002803 | 0.0029314 | 0.0023309 | 2336 | LUM/ITGAM/KDR/COL13A1/ITGA9/VCAM1/THBS1/PECAM1/COL6A3/VWF/ITGA10/CD47/COL6A1/ICAM1/COL9A2/ITGB8/ITGB3/COL5A3/COL1A1/HSPG2/ITGB7/COL8A2/ITGAV/ITGB6/COL16A1/ITGA3 |
| REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 62 | 0.5849400 | 1.856641 | 0.0002876 | 0.0029813 | 0.0023706 | 998 | CXCL10/CXCL11/CCL22/CCL4/CXCL9/CCL20/CCR3/CXCL2/CXCL6/CXCL3/CXCL8/CCL5/CXCL5/CXCL1/C5AR2/EDN1/UTS2B/GALR2/CX3CL1/CXCL16/SAA1 |
| REACTOME_NONSENSE_MEDIATED_DECAY_NMD | 113 | -0.4890005 | -1.768846 | 0.0002976 | 0.0030577 | 0.0024313 | 4726 | RPL12/UPF2/RPL10/UPF1/RPS11/RPS26/RPL18/RPS16/RPL18A/RPS24/UPF3A/RPL23A/RPL24/RPS5/RPS27/RPS12/RPL27/RPL9/RPS8/RPL7A/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/PABPC1/RPS29/RPL3/RPS2/RPS20/RPS13/RPS4Y1/RPL29/RPS23/RPL11/RPS25/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/RPL22/RPS14/RPL7/RPL5/RPL10A/RPS3A/RPS10/RPL39L |
| REACTOME_LDL_CLEARANCE | 17 | 0.7687538 | 1.886306 | 0.0004121 | 0.0041244 | 0.0032795 | 2201 | PCSK9/LDLR/NPC1/LIPA/NPC2/AP2B1/LSR |
| REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE | 72 | -0.5386470 | -1.840062 | 0.0004090 | 0.0041244 | 0.0032795 | 3573 | APBB1/BARD1/RPS27A/H4C3/ATM/H4C2/H2AX/MRE11/H2BC6/H4C6/H2BC15/H2BC9/H4C12/H2BC12/ABRAXAS1/H4C4/BRCA1/H2BC11/H2BC3/H4C13/H2BC7/H2BC10/H4C1/H4C9/H2BC17/H2BC13/H2BC14 |
| REACTOME_SIGNALING_BY_WNT | 283 | -0.3659253 | -1.512109 | 0.0004105 | 0.0041244 | 0.0032795 | 1497 | CAMK2A/GNGT1/WNT16/TCF7/ITPR1/PDE6A/AXIN2/ROR1/H3C1/H3C13/LEF1/H3C10/H2BC11/H2BC3/WNT3A/H4C13/CXXC4/WIF1/H2AC14/H2BC7/H2AC4/LGR6/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_METALLOPROTEASE_DUBS | 30 | -0.6723336 | -1.923869 | 0.0004210 | 0.0041637 | 0.0033107 | 1933 | ABRAXAS1/STAMBPL1/BRCA1/H2AC15/H2AC21/H2AC14/H2AC16/H2AC4/H2AC13/H2AC11/H2AC12 |
| REACTOME_PROTEIN_UBIQUITINATION | 77 | -0.5174296 | -1.779797 | 0.0004232 | 0.0041637 | 0.0033107 | 1041 | HLTF/H2BC11/H2BC3/H2BC7/H2BC10/H2BC17/H2BC13/UBE2C/H2BC14 |
| REACTOME_KERATINIZATION | 70 | 0.5513193 | 1.778804 | 0.0004737 | 0.0046212 | 0.0036745 | 1364 | SPRR2E/SPRR2F/SPRR2A/SPRR1A/SPRR3/SPRR2D/KRT78/RPTN/KRT6B/KRT24/PI3/KRT23/PRSS8/KRT7/IVL/DSC2/KRT80/KRTAP2-3/KRT17/KRT40/KRT86/SPRR1B/KRT8 |
| REACTOME_ESR_MEDIATED_SIGNALING | 194 | -0.4040032 | -1.604627 | 0.0005221 | 0.0050514 | 0.0040166 | 2377 | TLE3/H2BC15/H2BC9/TFF3/H3-3A/H3C11/HSP90AA1/PIK3R1/H4C12/TNRC6C/H2BC12/H4C4/NR5A2/GNGT1/H3C1/H3C13/H3C10/H2BC11/MYB/H2BC3/H4C13/H2AC14/H2BC7/H2AC4/H2BC10/H4C1/H3C7/H4C9/H3C12/H2BC17/H2BC13/H3C3/H2BC14/H3C8/H3C2 |
| REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS | 115 | 0.4810602 | 1.670780 | 0.0005284 | 0.0050698 | 0.0040312 | 2009 | CXCL10/CXCL11/ADRA1A/CCL22/CCL4/CXCL9/CCL20/CCR3/CXCL2/CXCL6/CXCL3/CXCL8/OXER1/CCL5/LPAR5/CXCL5/CXCL1/CNR1/C5AR2/EDN1/UTS2B/GALR2/CX3CL1/CXCL16/GPR68/SAA1/GNRH1/ADRB2/PTAFR/ECE1/OPN3/NLN/LPAR2/CCL17/HCAR3/HTR4/HRH1/GPR37L1/ANXA1/F2RL1 |
| REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1 | 17 | 0.7606669 | 1.866463 | 0.0005345 | 0.0050864 | 0.0040444 | 938 | ZBP1/NFKB2/MYD88/RIPK3/TICAM1/NFKBIA/IKBKG |
| REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | 20 | -0.7358202 | -1.953974 | 0.0006230 | 0.0057861 | 0.0046007 | 1442 | CDC14A/ANAPC4/CDC20/UBE2C |
| REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA | 37 | -0.6250409 | -1.855077 | 0.0006186 | 0.0057861 | 0.0046007 | 3720 | ERCC4/RFC5/RPA3/BARD1/ATRIP/ATM/RAD9B/ATR/MRE11/WRN/RAD52/RAD9A/RMI1/ERCC1/RFC3/BRCA1/RMI2/BRIP1/BLM/DNA2/RAD51/EXO1 |
| REACTOME_S_PHASE | 160 | -0.4184783 | -1.602437 | 0.0006172 | 0.0057861 | 0.0046007 | 1211 | ORC6/POLD1/GINS1/ANAPC4/ORC1/CCNE1/E2F1/CCNA2/DNA2/CDC25A/GINS2/CDT1/CCNE2/ESCO2/CDCA5/POLE2/CDC45/UBE2C |
| REACTOME_INTERLEUKIN_7_SIGNALING | 29 | -0.6488657 | -1.838303 | 0.0006344 | 0.0058457 | 0.0046482 | 1250 | H3C1/H3C13/H3C10/IL7/TSLP/H3C7/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_CILIUM_ASSEMBLY | 184 | -0.4020773 | -1.577674 | 0.0006455 | 0.0059010 | 0.0046921 | 3904 | HAUS3/IFT22/TUBAL3/UNC119B/BBS12/ARL6/ARL13B/IQCB1/ALMS1/ARL3/TMEM216/WDR19/BBS4/DYNLL1/CEP41/BBIP1/CEP250/HAUS4/CEP76/TRAF3IP1/KIF17/TCTN2/IFT74/CEP135/DYNC2I1/SFI1/HAUS1/TCP1/BBS9/B9D1/CEP57/DYNLT5/DYNLT2B/IFT43/CEP43/TCTN1/MKS1/CEP290/BBS2/KIF24/DYNC2LI1/CEP162/IFT52/HAUS5/IFT122/IFT140/CEP97/CEP164/NPHP1/TUBB4B/IFT57/CNTRL/DYNLT2/RPGRIP1L/LZTFL1/B9D2/IFT27/AKAP9/HSP90AA1/WDR35/CLUAP1/PCM1/IFT88/CC2D2A/IFT81/TMEM67/CCP110/CEP83/IFT172/IFT80/CENPJ/CEP152/CETN2/DYNC2H1/FBF1/TTC21B/CEP78/DYNLRB2/CNGA4/TUBB8B/CDK1/PLK1/NEK2/PLK4 |
| REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS | 20 | 0.7453390 | 1.890291 | 0.0006650 | 0.0059854 | 0.0047592 | 938 | ZBP1/NFKB2/MYD88/RIPK3/TICAM1/NFKBIA/IKBKG |
| REACTOME_AURKA_ACTIVATION_BY_TPX2 | 70 | -0.5168346 | -1.755596 | 0.0006646 | 0.0059854 | 0.0047592 | 3416 | DYNLL1/CEP41/CEP250/HAUS4/CEP76/CEP135/SFI1/HAUS1/CEP57/CEP43/CEP290/HAUS5/CEP164/TUBB4B/CNTRL/AKAP9/HSP90AA1/PCM1/CCP110/CENPJ/CEP152/CETN2/CEP78/AURKA/CDK1/PLK1/NEK2/PLK4/TPX2 |
| REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE | 42 | -0.5944830 | -1.823037 | 0.0006811 | 0.0060824 | 0.0048363 | 3628 | RFC5/RPA3/BARD1/ATRIP/ATM/RAD9B/ATR/MRE11/WRN/RAD9A/RMI1/RFC3/XRCC3/BRCA1/RMI2/BRIP1/BLM/DNA2/RAD51/XRCC2/RAD51AP1/EXO1 |
| REACTOME_SYNTHESIS_OF_DNA | 118 | -0.4494650 | -1.637442 | 0.0007359 | 0.0065220 | 0.0051859 | 1211 | ORC6/POLD1/GINS1/ANAPC4/ORC1/CCNE1/CCNA2/DNA2/GINS2/CDT1/CCNE2/POLE2/CDC45/UBE2C |
| REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS | 392 | 0.3581083 | 1.428318 | 0.0007640 | 0.0067198 | 0.0053432 | 4597 | FGFR4/BCL2A1/DLL4/NR4A1/FGF2/KDR/EREG/KLB/HDAC9/CLCN6/FYN/DKK1/PPP2R5B/DUSP8/VWF/AREG/STAT1/HBEGF/PSME4/FGF1/HDAC6/EIF2AK3/PDGFB/VCL/DUSP6/RNF213/CDKN1A/DUSP10/LMNA/MSN/PSMA6/MET/MYC/LMO7/EGF/TPM4/LYN/ITGB3/IRS2/PIM1/KL/PORCN/GAB2/PTPN12/RRBP1/MRAS/AKT3/RHOG/MAPK3/ADAM17/HDAC7/DUSP16/SQSTM1/KRAS/TGFBR1/SRC/STAT5A/PSMB9/TGFA/PSMD11/NRAS/MAP2K1/NRG1/JUNB/ACTB/CD86/STRN/CEBPB/ACTG1/MYH9/POLR2G/UBC/PPP2R1B/PSME2/SPRED2/PLCG1/PPFIBP1/PTPN11/TGFBR2/PSMC4/SEC31A/GTF2F2/VCP/FZD5/SYVN1/MAP2K2/OS9/IQGAP1/FGF5/AXIN1/ZC3HAV1/IRS1/TPM3/PDGFRA/PSMD1/SHC1/PSMA1/HRAS/APH1A/PSMD7/PPP1CB/RAC1/PPP2R5A/FZD8/ZC3HC1/PSMB8/RAC2/GSK3B/SMAD3/KLC1/FOXO6/MPRIP/MDM2/AGTRAP/DERL2/BCR/ARAF/QKI/PSMB2/AKT1/YES1/PPM1B/PPP2R5D/ERBB3/PSEN1/NCOR1/VAV1/AKT1S1/ARRB1/NCSTN/PSME1/SPTBN1/MAML1/RPS6KB2/DUSP7/TFG/WDCP/PIK3CB/POLR2L/ATG7/MYO18A/CSK/PIK3R3 |
| REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | 96 | 0.5052404 | 1.702256 | 0.0008803 | 0.0076847 | 0.0061104 | 3083 | GRB14/SDC3/L1CAM/ITGAM/SLC7A11/SELL/SLC7A9/TNFRSF10A/CEACAM1/CD177/PROCR/FYN/CEACAM5/PECAM1/PF4V1/ESAM/CEACAM6/CD47/SLC16A3/SLC3A2/LYN/PSG5/ITGB3/COL1A1/SELP/SLC7A7/OLR1/ATP1B1/ITGAV/TREM1/ITGA3/KRAS/SRC/SLC7A5/NRAS/PPIA/TNFRSF10B/EPCAM/ITGA6/PLCG1/ITGA5/PTPN11/MMP1/SIRPA |
| REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION | 58 | 0.5793251 | 1.819856 | 0.0008900 | 0.0077114 | 0.0061316 | 2976 | ARC/ASCL1/FOSB/EGR2/FOS/MAPK11/SGK1/MEF2C/JUND/DUSP6/DUSP3/TRIB1/ID4/SRF/MAPK3/ID3/MAPK7/FOSL1/EGR1/F3/DUSP4/JUNB/ID1/MAPKAPK2/PPP2R1B |
| REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | 57 | 0.5792574 | 1.813660 | 0.0009482 | 0.0081541 | 0.0064837 | 3033 | NCR3LG1/IFITM1/MICA/SELL/VCAM1/SH2D1B/CD34/MICB/RAET1E/ICAM1/ULBP1/HLA-G/KLRD1/HLA-F/PVR/ULBP3/CD200/HLA-C/COL1A1/CD40/HLA-E/ITGB7/HLA-B/TREM1/COL17A1/NECTIN2/NPDC1/C3/CDH1/HLA-A |
| REACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_P107_RBL1_AND_P130_RBL2_IN_COMPLEX_WITH_HDAC1 | 16 | -0.7672494 | -1.903595 | 0.0009732 | 0.0083078 | 0.0066059 | 734 | E2F1/CCNA2/CDK1/MYBL2 |
| REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR | 65 | -0.5101115 | -1.706248 | 0.0009867 | 0.0083618 | 0.0066488 | 3694 | POLD3/RFC5/RPA3/BARD1/RPS27A/ATRIP/ATM/RAD9B/ATR/MRE11/POLH/WRN/RAD9A/RMI1/RFC3/XRCC3/BRCA1/EME1/RMI2/POLD1/BRIP1/BLM/DNA2/RAD51/XRCC2/RAD51AP1/EXO1/POLE2 |
| REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE | 69 | 0.5470121 | 1.761088 | 0.0010781 | 0.0090692 | 0.0072113 | 1364 | SPRR2E/SPRR2F/SPRR2A/SPRR1A/SPRR3/SPRR2D/KRT78/RPTN/KRT6B/KRT24/PI3/KRT23/PRSS8/KRT7/IVL/DSC2/KRT80/KRT17/KRT40/KRT86/SPRR1B/KRT8 |
| REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION | 85 | -0.4742442 | -1.664828 | 0.0010858 | 0.0090692 | 0.0072113 | 3498 | BORA/DYNLL1/RPS27A/CEP41/CEP250/HAUS4/CEP76/CEP135/SFI1/HAUS1/CEP57/CEP43/CEP290/HAUS5/CEP164/TUBB4B/CNTRL/AKAP9/HSP90AA1/PCM1/CCP110/CENPJ/CEP152/CETN2/CEP78/AURKA/CCNB1/CDK1/PLK1/NEK2/CCNB2/PLK4 |
| REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING | 34 | 0.6344609 | 1.788527 | 0.0011400 | 0.0094541 | 0.0075173 | 1070 | ISG15/NLRC5/IFIH1/HERC5/IKBKE/UBE2L6/TNFAIP3 |
| REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE | 29 | 0.6493643 | 1.767493 | 0.0011723 | 0.0096526 | 0.0076752 | 1023 | APOC1/PCSK9/LIPC/LDLR/NPC1/SCARB1/LIPA/AMN/APOBR |
| REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | 87 | 0.5123516 | 1.706344 | 0.0012104 | 0.0098513 | 0.0078332 | 3804 | FGFR4/TRIB3/FGF2/EREG/IL1RL1/KLB/FYN/PPP2R5B/MYD88/AREG/PHLPP2/IER3/HBEGF/FGF1/PDGFB/MET/EGF/IRS2/KL/GAB2/AKT3/IRAK1/RHOG/MAPK3/PIP4K2A/SRC/TGFA/NRG1/CD86/PIP4K2C/STRN/PPP2R1B/PTPN11/PIP4K2B/FGF5/IRS1/PDGFRA/RAC1/PPP2R5A/RAC2/PIP5K1A |
| REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE | 96 | 0.4990060 | 1.681251 | 0.0012134 | 0.0098513 | 0.0078332 | 3178 | S100A12/IRAK2/NFKB2/FOS/MYD88/SOCS1/S100A8/NFKBIA/MAPK11/JUN/IKBKG/SAA1/LY96/TLR2/MEF2C/TLR4/TNIP2/DUSP6/S100A9/IRAK3/DUSP3/NOD2/PELI1/IRAK1/MAP3K8/MAPK3/MAPK7/TAB3/RIPK2/NOD1/MAP2K1/DUSP4/MAP2K3/NFKB1/NFKBIB/UBC/MAPKAPK2/NKIRAS2/PPP2R1B/TIRAP/MAPKAPK3/RPS6KA3 |
| REACTOME_INTERLEUKIN_1_SIGNALING | 99 | 0.4948298 | 1.671531 | 0.0012219 | 0.0098513 | 0.0078332 | 3770 | S100A12/IL1R2/IL1B/IRAK2/NFKB2/MYD88/IL1RN/IL1A/NFKBIA/PSME4/IKBKG/SAA1/TNIP2/IRAK3/PSMA6/NOD2/PELI1/IRAK1/MAP3K8/TAB3/SQSTM1/RIPK2/NOD1/PSMB9/PSMD11/MAP2K1/IL1R1/MAP3K3/NFKB1/NFKBIB/UBC/NKIRAS2/PSME2/PSMC4/RELA/PSMD1/PSMA1/PSMD7/PSMB8 |
| REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES | 11 | -0.8103034 | -1.846479 | 0.0013056 | 0.0104541 | 0.0083125 | 720 | SMC4/SMC2/CCNB1/CDK1/CCNB2/NCAPH/NCAPG |
| REACTOME_SELENOAMINO_ACID_METABOLISM | 114 | -0.4497014 | -1.620538 | 0.0014202 | 0.0112938 | 0.0089802 | 4457 | RPS11/RPS26/AIMP2/SEPSECS/RPL18/RPS16/RPL18A/RPS24/RPL23A/RPL24/RPS5/RPS27/RPS12/RPL27/RPL9/RPS8/RPL7A/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/RPS15A/RPS28/RPS29/RPL3/RPS2/RPS20/RPS13/RPS4Y1/RPL29/RPS23/RPL11/RPS25/NNMT/RPL4/RPL30/RPL21/RPL23/RPL31/RPL13A/RPL32/RPL35A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/RPS7/RPL6/RPL37/RPS18/RPL22/RPS14/RPL7/RPL5/PSTK/RPL10A/RPS3A/RPS10/RPL39L/GNMT/MAT1A |
| REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS | 111 | 0.4670391 | 1.609455 | 0.0014504 | 0.0114555 | 0.0091087 | 1679 | QPRT/PRSS3/FASN/SLC5A8/PANK3/NT5E/PANK1/MMAB/SLC2A3/PTGS2/NAMPT/ALDH1L2/PARP9/AMN/MTHFD2/VNN1/ACACA/MTHFR/TPK1/MTHFD1L/PARP14/ENPP1/PDXK/SLC52A2/SLC52A3 |
| REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS | 132 | 0.4564303 | 1.603032 | 0.0016030 | 0.0125749 | 0.0099988 | 4863 | SGIP1/LDLR/SYT2/SYT1/EREG/AREG/HBEGF/TOR1B/RAB5B/ADRB2/SNX9/PACSIN1/DVL2/EGF/DAB2/CFTR/IL7R/AP2B1/ITSN1/TGFA/ITSN2/ARPC2/NECAP1/TFRC/ACTB/ACTG1/PIK3C2A/UBC/CLTB/SYNJ2/SH3KBP1/ARFGAP1/ARPC4/SH3GL1/WASL/CTTN/NECAP2/BIN1/PICALM/PACSIN2/SCARB2/PIP5K1C/ARPC5/TRIP10/UBQLN1/FNBP1L/ARRB1/GRK2/IGF2R/SYT11/FNBP1/AGFG1/STON2/RAB5A/FCHO2/SYNJ1/RAB5C/EPS15/CLTA/ARF6/OCRL/CBL/GRB2 |
| REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | 31 | 0.6417807 | 1.780017 | 0.0016824 | 0.0129359 | 0.0102858 | 2172 | ELOVL6/ACLY/SCD/FASN/ACSL1/HSD17B12/SLC25A1/ACSL4/ELOVL5/ELOVL7/ACACA/ELOVL1/HSD17B8/HACD2/ACSL5/ELOVL4 |
| REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS | 57 | -0.5346153 | -1.770096 | 0.0016819 | 0.0129359 | 0.0102858 | 1041 | HLTF/H2BC11/H2BC3/H2BC7/H2BC10/H2BC17/H2BC13/H2BC14 |
| REACTOME_RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY | 15 | 0.7538507 | 1.761158 | 0.0016723 | 0.0129359 | 0.0102858 | 2699 | TRIB3/CHAC1/ATF3/DDIT3/ATF5/ATF4/GRB10/CEBPG/CEBPB |
| REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS | 13 | -0.7819391 | -1.825989 | 0.0017152 | 0.0131013 | 0.0104174 | 365 | PDS5B/KIF23/PLK1/KIF20A |
| REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX | 31 | 0.6399876 | 1.775044 | 0.0018427 | 0.0138918 | 0.0110460 | 2950 | S100A12/IRAK2/NFKB2/NFKBIA/IKBKG/SAA1/NOD2/IRAK1/TAB3/RIPK2/NOD1/NFKB1/NFKBIB/UBC/NKIRAS2 |
| REACTOME_GPCR_LIGAND_BINDING | 182 | 0.4149020 | 1.534747 | 0.0018427 | 0.0138918 | 0.0110460 | 2009 | CXCL10/CXCL11/ADRA1A/CCL22/CCL4/FZD9/CXCL9/CCL20/CCR3/CXCL2/CXCL6/CXCL3/CXCL8/OXER1/CCL5/LPAR5/CXCL5/CXCL1/ADM2/CNR1/C5AR2/GNG2/EDN1/UTS2B/GALR2/CX3CL1/TAS2R3/CXCL16/CD55/GPR68/UCN2/ADGRE2/GRM1/SAA1/GNRH1/ADRB2/PTAFR/ECE1/OPN3/WNT7A/NLN/LPAR2/CCL17/HCAR3/PTHLH/HTR4/GABBR1/HRH1/GPR37L1/ANXA1/F2RL1 |
| REACTOME_TNFR2_NON_CANONICAL_NF_KB_PATHWAY | 87 | 0.5009022 | 1.668212 | 0.0018678 | 0.0139903 | 0.0111242 | 5664 | TNFRSF9/CD70/TNFSF9/BIRC3/TNFRSF12A/NFKB2/RELB/TNFSF13B/TNFRSF13C/TNF/TNFRSF1B/PSME4/PSMA6/TNFSF14/CD40/TNFSF15/TRAF2/PSMB9/PSMD11/UBC/PSME2/PSMC4/TNFRSF1A/PSMD1/PSMA1/TNFRSF25/PSMD7/PSMB8/PSMB2/PSME1/EDA2R/MAP3K14/TNFSF11/PSMF1/TNFRSF18/PSMC1/PSMB6/PSMD14/LTBR/PSMD2/PSMA2/BTRC/CHUK/PSMA3/PSMC6/PSME3/PSMA7/TRAF3/PSMC5/PSMB7/PSMD8 |
| REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | 109 | 0.4757583 | 1.641053 | 0.0020009 | 0.0148911 | 0.0118405 | 1887 | PLA2G3/PNPLA3/ACHE/LPIN1/PLA2G4C/GPCPD1/ABHD4/MFSD2A/PCYT2/SELENOI/TMEM86B/LIPH/PISD/GPAT3/PLAAT1/CSNK2B/LPCAT1/GPAT4/PLA2G15 |
| REACTOME_BASIGIN_INTERACTIONS | 20 | 0.7150459 | 1.813463 | 0.0020273 | 0.0149914 | 0.0119203 | 3181 | L1CAM/SLC7A11/SLC7A9/SLC16A3/SLC3A2/SLC7A7/ATP1B1/ITGA3/SLC7A5/PPIA/ITGA6/MMP1/CAV1 |
| REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | 62 | 0.5414841 | 1.718709 | 0.0024304 | 0.0178589 | 0.0142003 | 1311 | LY6G6C/RAET1L/LY6K/PLAUR/CEACAM7/ALPL/NTNG1/CEACAM5/NTM/VNN1/MELTF/PIGW |
| REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES | 79 | -0.4721664 | -1.635074 | 0.0025919 | 0.0189260 | 0.0150488 | 3416 | CEP70/CEP131/CEP192/ODF2/MZT1/TUBGCP5/NME7/HAUS3/ALMS1/DYNLL1/MZT2A/TUBGCP2/CEP41/TUBG2/CEP250/HAUS4/CEP76/CEP135/SFI1/HAUS1/CEP57/CEP43/CEP290/HAUS5/CEP164/TUBB4B/CNTRL/AKAP9/HSP90AA1/PCM1/CCP110/CENPJ/CEP152/CETN2/CEP78/CDK1/PLK1/NEK2/PLK4 |
| REACTOME_REGULATED_NECROSIS | 53 | 0.5496303 | 1.681327 | 0.0028460 | 0.0206512 | 0.0164206 | 4587 | TNFRSF10A/IL1B/BIRC3/IL1A/RIPK3/MLKL/CHMP7/PELI1/CHMP6/CASP5/TRAF2/FAS/BAK1/TRADD/IRF1/IL18/TNFRSF10B/UBC/FADD/CASP8/FLOT1/GSDME/CHMP4C/CFLAR/CHMP2B/TP53/SDCBP/RIPK1/CASP4/XIAP/CYCS/CHMP3 |
| REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM | 11 | 0.8024523 | 1.715110 | 0.0029532 | 0.0212961 | 0.0169334 | 1348 | FADS2/FADS1/ACSL1/ELOVL5/ELOVL1 |
| REACTOME_FATTY_ACID_METABOLISM | 145 | 0.4321925 | 1.542914 | 0.0031068 | 0.0222654 | 0.0177041 | 2196 | FADS2/ELOVL6/FADS1/ACOT1/ACLY/SCD/FASN/ALOXE3/ACSL1/TBXAS1/HSD17B12/SLC25A1/ACSL4/ACOXL/PTGS2/ELOVL5/GGT5/ELOVL7/ACADL/ACACA/CYP4A22/PTGES/ELOVL1/ACOT2/CYP1B1/ACOT9/HSD17B8/ACOT7/HACD2/PTGES2/ACSL5/ELOVL4/ACAA2 |
| REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | 25 | 0.6674605 | 1.782233 | 0.0034112 | 0.0242158 | 0.0192550 | 3960 | TAP1/TAP2/HLA-G/HLA-F/SEC23A/HLA-C/HLA-E/SEC13/TAPBP/HLA-B/HLA-A/SEC31A/ERAP1/SEC24D/ERAP2/SEC24A/PDIA3/CALR |
| REACTOME_MITOTIC_G2_G2_M_PHASES | 188 | -0.3804710 | -1.494569 | 0.0034207 | 0.0242158 | 0.0192550 | 791 | AURKA/E2F1/CCNB1/TUBB8B/CDC25C/CCNA2/CDC25A/CENPF/CDK1/FOXM1/PLK1/NEK2/CCNB2/PLK4/TPX2/GTSE1/MYBL2 |
| REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | 37 | -0.5801482 | -1.721838 | 0.0034984 | 0.0246163 | 0.0195734 | 3628 | RFC5/RPA3/ATRIP/RAD9B/ATR/MCM4/RAD9A/RFC3/CDC7/ORC6/ORC1/CDC25C/CDC25A/CLSPN/MCM10/CDC45 |
| REACTOME_SIGNALING_BY_GPCR | 378 | 0.3399555 | 1.352963 | 0.0036230 | 0.0253393 | 0.0201483 | 2597 | CXCL10/CXCL11/ADRA1A/RGS7/CCL22/CCL4/FZD9/CXCL9/CCL20/CCR3/RGS16/CXCL2/CXCL6/CXCL3/CXCL8/OXER1/CCL5/LPAR5/CXCL5/CXCL1/ADM2/PDE4C/GRK5/CNR1/C5AR2/GNG2/EDN1/UTS2B/CAMK4/DGKI/GALR2/CX3CL1/TAS2R3/RGS9/CXCL16/RHOB/CD55/RGS20/GPR68/HBEGF/UCN2/ADGRE2/GRM1/GNAZ/SAA1/FGD2/ITPR2/GNRH1/ADRB2/PTAFR/ECE1/PRKCQ/CAMKK1/ARHGEF9/TIAM2/GPR27/GNA15/ADCY4/MCF2L/OPN3/ADCY5/WNT7A/GNA12/NLN/NGEF/LPAR2/ITPR3/CCL17/CAMKK2/AKT3/HCAR3/PTHLH/ARHGEF40/HTR4/RGS10/GABBR1/HRH1/GPR37L1/MAPK3/ANXA1/F2RL1/TRIO/MAPK7/GPSM1/GABBR2/CCRL2/CCK/KRAS/SRC/ARHGEF1/ITSN1/RHOC/PRKCH/NRAS/ARHGEF37/KPNA2/PDE8A/PLCB3/ARHGEF3/P2RY2 |
| REACTOME_CLEC7A_DECTIN_1_SIGNALING | 98 | 0.4682328 | 1.575694 | 0.0037360 | 0.0259732 | 0.0206524 | 5664 | CCL22/IL1B/NFKB2/RELB/CARD11/NFKBIA/PSME4/IKBKG/ITPR2/CLEC7A/PSMA6/ITPR3/CCL17/BCL10/SYK/TAB3/SRC/MALT1/PSMB9/PSMD11/NFKB1/UBC/CASP8/PSME2/PSMC4/CDC34/RELA/PSMD1/PSMA1/PSMD7/PSMB8/PSMB2/PSME1/MAP3K14/PSMF1/PSMC1/TAB2/PSMB6/PSMD14/PSMD2/PSMA2/BTRC/CHUK/PSMA3/PSMC6/PSME3/PSMA7/PPP3R1/PSMC5/PSMB7/PSMD8 |
| REACTOME_NGF_STIMULATED_TRANSCRIPTION | 36 | 0.6029570 | 1.720609 | 0.0038125 | 0.0263469 | 0.0209494 | 2841 | ARC/ASCL1/FOSB/EGR2/FOS/SGK1/JUND/TRIB1/ID4/SRF/ID3/FOSL1/EGR1/F3/JUNB/ID1 |
| REACTOME_INTERLEUKIN_17_SIGNALING | 67 | 0.5176161 | 1.661008 | 0.0038900 | 0.0266981 | 0.0212287 | 3178 | IL17C/IRAK2/FOS/MAPK11/JUN/IKBKG/MEF2C/TNIP2/DUSP6/DUSP3/NOD2/IRAK1/MAP3K8/MAPK3/MAPK7/TAB3/RIPK2/NOD1/MAP2K1/DUSP4/MAP2K3/NFKB1/UBC/MAPKAPK2/PPP2R1B/MAPKAPK3/RPS6KA3 |
| REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | 171 | 0.4012393 | 1.471618 | 0.0039093 | 0.0266981 | 0.0212287 | 2001 | CXCL10/CXCL11/RGS7/CCL4/CXCL9/CCL20/CCR3/RGS16/CXCL2/CXCL6/CXCL3/CXCL8/OXER1/CCL5/LPAR5/CXCL5/CXCL1/PDE4C/CNR1/GNG2/CAMK4/GALR2/CX3CL1/TAS2R3/RGS9/CXCL16/RGS20/GNAZ/SAA1/ITPR2/CAMKK1/GNA15/ADCY4/OPN3/ADCY5/LPAR2/ITPR3/CAMKK2/HCAR3/RGS10/GABBR1/GPR37L1/ANXA1 |
| REACTOME_SIGNALLING_TO_ERKS | 32 | 0.6298710 | 1.754992 | 0.0040396 | 0.0272675 | 0.0216815 | 3743 | NTRK1/MAPK11/SHC2/MAPK3/RALA/KRAS/SRC/NRAS/MAP2K1/RIT1/MAPKAPK2/MAPKAPK3/MAP2K2/MAPK13/SHC1/CRK/HRAS/MAPK12/RAPGEF1 |
| REACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING | 11 | 0.7935098 | 1.695997 | 0.0040163 | 0.0272675 | 0.0216815 | 831 | GGT7/CHAC1/GGT5/OPLAH |
| REACTOME_KINESINS | 48 | -0.5422692 | -1.720909 | 0.0042037 | 0.0282109 | 0.0224316 | 1712 | KIF19/KIF1A/KIF22/KIF21A/RACGAP1/KIF11/TUBB8B/KIF18A/KIF23/KIF20B/KIF15/CENPE/KIF20A/KIF4A/KIF2C/KIFC1/KIF18B |
| REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | 186 | -0.3675168 | -1.447250 | 0.0045331 | 0.0302469 | 0.0240506 | 1001 | H2AC15/H2BC11/H2AC21/IL33/H2BC3/H2AC14/H2BC7/CCNA2/CDC25A/H2AC16/USP13/H2AC4/H2AC13/CLSPN/H2BC10/H2AC11/H2AC12/H2BC17/H2BC13/CDC20/H2BC14 |
| REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY | 42 | 0.5634768 | 1.651839 | 0.0048406 | 0.0321137 | 0.0255349 | 4174 | DUSP5/PPP2R5B/DUSP8/DUSP6/DUSP10/DUSP1/MAPK3/DUSP16/KRAS/NRAS/MAP2K1/DUSP4/UBC/PPP2R1B/MAP2K2/HRAS/MAPK12/PPP2R5A/ARAF/PPP2R5D |
| REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING | 117 | 0.4414470 | 1.533504 | 0.0049318 | 0.0325332 | 0.0258685 | 6056 | LAT2/FYN/FOS/CARD11/NFKBIA/PSME4/JUN/IKBKG/ITPR2/PRKCQ/PSMA6/LYN/GAB2/ITPR3/BCL10/MAPK3/SYK/TAB3/KRAS/MALT1/PSMB9/PSMD11/NRAS/NFKB1/UBC/PSME2/PLCG1/PSMC4/CDC34/RELA/PSMD1/SHC1/PSMA1/HRAS/PSMD7/RAC1/PSMB8/TEC/VAV2/MAP2K7/PSMB2/VAV1/PSME1/PIK3CB/PIK3CA/PSMF1/PSMC1/TAB2/GRB2/PSMB6/PSMD14/PSMD2/PSMA2/BTRC/CHUK/PSMA3/PSMC6/PSME3/PSMA7/PAK2/PPP3R1/PSMC5/PSMB7/PSMD8/FBXW11/PSMD3/PSMD13/MAPK1/RASGRP1/MAPK9/PSMA4 |
| REACTOME_INFLUENZA_INFECTION | 153 | -0.3821311 | -1.451089 | 0.0051622 | 0.0338607 | 0.0269240 | 4595 | RPL10/POLR2E/NUP85/RPS11/RPS26/RPL18/RPS16/NUP43/RPL18A/RPS24/RAE1/RPL23A/RPL24/RPS5/NUP107/RPS27/RPS12/RPL27/RPL9/RPS8/RPL7A/RPL14/RPS21/RPL13/RPS27A/RPL39/RPS19/RPL41/RPL27A/RPL37A/RPL34/NUP54/NUP155/RPS15A/RPS28/RPS29/RPL3/RPS2/RPS20/POLR2I/RPS13/RPS4Y1/RPL29/RPS23/RPL11/RPS25/RPL4/RPL30/RPL21/KPNA5/RPL23/RPL31/RPL13A/RPL32/RPL35A/HSPA1A/RPL26L1/RPS6/RPSA/RPS4X/RPL15/IPO5/RPS7/RPL6/NDC1/RPL37/RPS18/RPL22/RPS14/RPL7/RPL5/HSP90AA1/RPL10A/NUP37/RPS3A/RPS10/RPL39L |
| REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION | 23 | 0.6611885 | 1.728688 | 0.0053887 | 0.0345652 | 0.0274842 | 2950 | S100A12/IFIH1/NFKB2/NFKBIA/IKBKG/SAA1/TRIM25/TRAF2/NFKB1/NFKBIB/NKIRAS2 |
| REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS | 45 | -0.5353096 | -1.662631 | 0.0053581 | 0.0345652 | 0.0274842 | 791 | AURKA/CDCA8/TOP2A/BIRC5 |
| REACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC | 87 | -0.4402350 | -1.543039 | 0.0053099 | 0.0345652 | 0.0274842 | 1712 | KIF19/KIF1A/KIF22/KIF21A/RACGAP1/KIF11/TUBB8B/KIF18A/KIF23/KIF20B/KIF15/CENPE/KIF20A/KIF4A/KIF2C/KIFC1/KIF18B |
| REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA | 105 | 0.4438214 | 1.513496 | 0.0053688 | 0.0345652 | 0.0274842 | 2568 | HMGCS1/FADS1/HMGCR/FDFT1/TRIB3/ACSL1/ME1/HELZ2/ANGPTL4/ANKRD1/SREBF2/TIAM2/PPARGC1B/GLIPR1/PPARGC1A/ARNT2/MED8/TXNRD1/GPS2/MED31/SIN3B/AHR/GRHL1 |
| REACTOME_SIGNALLING_TO_RAS | 19 | 0.6696969 | 1.692786 | 0.0060857 | 0.0388216 | 0.0308687 | 3640 | NTRK1/MAPK11/SHC2/RALA/KRAS/SRC/NRAS/MAPKAPK2/MAPKAPK3/MAPK13/SHC1/HRAS/MAPK12 |
| REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | 104 | 0.4540274 | 1.548392 | 0.0063644 | 0.0403775 | 0.0321058 | 2327 | CAPN14/MMP25/MMP16/MMP10/MMP17/COL13A1/CAPN12/ADAMTS5/COL6A3/ADAM8/KLK7/TIMP2/LAMA3/MMP19/LAMC2/LAMB3/COL6A1/MMP15/COL9A2/ADAMTS9/ADAM9/MMP7/MMP12/COL5A3/COL1A1/HSPG2/MMP13/COL8A2/CTSV/COL12A1/MMP24/ADAM17/FURIN/MMP14/CAPN13/COL25A1/ADAMTS1/COL16A1/LAMC1/COL17A1/CAPN2 |
| REACTOME_SARS_COV_INFECTIONS | 143 | 0.4112185 | 1.460410 | 0.0065459 | 0.0413035 | 0.0328421 | 3915 | ZBP1/FXYD6/PARP9/VEGFA/IFNGR1/PARP14/FNTB/MGAT4C/SIGMAR1/CHMP7/ACE2/STAT2/CHMP6/PARP6/ATP1B1/AP2B1/FURIN/MGAT4A/ST3GAL1/TYK2/PARP10/TUBB/SRPK1/IL1R1/MGAT4B/UBC/MAP1LC3B/JAK1/PARP4/MGAT5/BRMS1/IFNGR2/VCP/EDEM2/PARP16/ST3GAL4/CHMP4C/MAGT1/IMPDH1/MAN2A1/STT3A/RPN2/GSK3B/ST3GAL2/CHMP2B |
| REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6 | 34 | -0.5670380 | -1.662996 | 0.0067218 | 0.0419573 | 0.0333620 | 4808 | PHC3/PCGF6/UXT/CBX5/CHEK1/BMI1/PHC1/EHMT2/YAF2/CBX3/TFDP1/EED/TFDP2/BRCA1/CDC7/EZH2/E2F1/RAD51/RRM2 |
| REACTOME_PHOSPHOLIPID_METABOLISM | 185 | 0.3949729 | 1.459876 | 0.0066969 | 0.0419573 | 0.0333620 | 4821 | PLA2G3/PNPLA3/ACHE/LPIN1/PLA2G4C/GPCPD1/PIP4P1/ABHD4/MFSD2A/PCYT2/SELENOI/TMEM86B/ENPP6/LIPH/PI4K2A/PISD/GDPD3/GPAT3/PLAAT1/PLEKHA6/CSNK2B/LPCAT1/PIK3C2G/GPAT4/PLA2G15/PITPNB/PIP4K2A/PIK3C2B/INPP5F/LPIN2/DGAT1/PIP4K2C/PLB1/GPD2/LPCAT4/MBOAT7/PIK3C2A/ARF3/PNPLA2/PLA2G4A/SYNJ2/PITPNM2/PIP4K2B/PTDSS1/PNPLA8/PLEKHA2/TAFAZZIN/GDE1/SLC44A2/MGLL/PTDSS2/PIP5K1A/LPIN3/ABHD3/PIKFYVE/PIP5K1C/MTMR12/INPP4A/DDHD2/PEMT/MTMR14/PCYT1B/CRLS1/PLD2/PIK3CB/AGPAT3/RAB5A/PIK3R3/SBF2/PIK3CA/SYNJ1/PLEKHA1/PNPLA6/INPP5K/CPNE1/OCRL/STARD10 |
| REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS | 125 | 0.4396459 | 1.530882 | 0.0067728 | 0.0420496 | 0.0334353 | 3655 | MUC21/CCL22/MUC3A/IL1B/FYN/NFKB2/RELB/CARD11/NFKBIA/PSME4/IKBKG/ITPR2/CLEC7A/PSMA6/LYN/ITPR3/CCL17/BCL10/SYK/TAB3/KRAS/SRC/MALT1/PSMB9/PSMD11/NRAS/NFKB1/MUC1/UBC/CASP8/PSME2/PSMC4/CDC34/RELA/PSMD1/PSMA1/HRAS/PSMD7 |
| REACTOME_PI3K_AKT_SIGNALING_IN_CANCER | 80 | 0.4690813 | 1.543437 | 0.0068191 | 0.0421117 | 0.0334847 | 4732 | FGFR4/NR4A1/FGF2/EREG/KLB/FYN/AREG/HBEGF/FGF1/PDGFB/CDKN1A/MET/EGF/IRS2/KL/GAB2/AKT3/RHOG/SRC/TGFA/NRG1/CD86/STRN/PTPN11/FGF5/IRS1/PDGFRA/RAC1/RAC2/GSK3B/FOXO6/MDM2/AKT1/ERBB3/VAV1/AKT1S1/RPS6KB2/PIK3CB/PIK3R3/PIK3CA/ESR1 |
| REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA | 26 | -0.6308442 | -1.758023 | 0.0069388 | 0.0426239 | 0.0338920 | 1693 | BARD1/ATM/MRE11/WRN/RMI1/XRCC3/BRCA1/RMI2/BRIP1/BLM/DNA2/RAD51/XRCC2/RAD51AP1/EXO1 |
| REACTOME_TRYPTOPHAN_CATABOLISM | 12 | 0.7421215 | 1.635818 | 0.0072773 | 0.0444684 | 0.0353586 | 1470 | IDO1/IDO2/KYNU/KMO/SLC3A2/HAAO |
| REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION | 11 | -0.7560449 | -1.722838 | 0.0075071 | 0.0456323 | 0.0362840 | 108 | PDS5B/ESCO2/CDCA5 |
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | 89 | 0.4646999 | 1.558249 | 0.0076459 | 0.0462335 | 0.0367621 | 3125 | CCL22/CXCL8/FGF2/LIF/ITGAM/IL2RG/LBP/IL1B/VCAM1/IL23A/PTGS2/FOS/IL1A/SOCS1/TNF/TNFRSF1B/VEGFA/STAT1/NOS2/BATF/SOCS3/SAA1/ICAM1/CDKN1A/MYC/PIM1/LCN2/VIM/ZEB1/ANXA1/HMOX1/IL13RA1/IL4R/TYK2/JUNB/MUC1/IL18/CEBPD/JAK1/MMP1/TWIST1 |
| REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING | 24 | 0.6495137 | 1.716244 | 0.0079425 | 0.0477786 | 0.0379907 | 2445 | EREG/FOS/AREG/HBEGF/EGF/AKT3/SRF/MAPK3/TGFA |
Cytokine + Pitavastatin vs Control
Volcano plots
GSEA analysis (logFc)
GOBP
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOBP_SISTER_CHROMATID_SEGREGATION | 188 | -0.5847771 | -2.333110 | 0.0000000 | 0.0000000 | 0.0000000 | 1101 | HECW2/PSRC1/FBXO5/ANAPC4/CCNB1/STAG3/TRIP13/CENPK/KIFC1/AXIN2/KIF4A/PTTG1/SPAG5/SGO2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/MAD2L1/CENPF/NCAPH/CENPE/NEK2/NUF2/PLK1/SGO1/KIF2C/BUB1/CEP55/ESCO2/CDC20/DLGAP5/KIF18B/NCAPG/UBE2C/TOP2A/BUB1B |
| GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION | 162 | -0.5888125 | -2.300641 | 0.0000000 | 0.0000000 | 0.0000000 | 1101 | HECW2/PSRC1/FBXO5/ANAPC4/CCNB1/TRIP13/CENPK/KIFC1/KIF4A/PTTG1/SPAG5/SGO2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/MAD2L1/CENPF/NCAPH/CENPE/NEK2/NUF2/PLK1/SGO1/KIF2C/BUB1/CEP55/CDC20/DLGAP5/KIF18B/NCAPG/UBE2C/BUB1B |
| GOBP_CHROMOSOME_SEGREGATION | 308 | -0.5391442 | -2.273317 | 0.0000000 | 0.0000000 | 0.0000000 | 1256 | KIF18A/ZCWPW1/M1AP/ABRAXAS1/PSMC3IP/HECW2/BRIP1/SPC24/PSRC1/FBXO5/FMN2/ANAPC4/CCNB1/STAG3/TRIP13/CENPK/KIFC1/AXIN2/KIF4A/PTTG1/SPAG5/KNL1/SKA3/SGO2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/MAD2L1/CENPF/CENPW/NCAPH/CDCA2/CENPE/NEK2/NUF2/CCNE2/PLK1/SGO1/SKA1/KIF2C/BUB1/CEP55/ESCO2/DMC1/CDC20/DLGAP5/KIF18B/OIP5/NCAPG/UBE2C/TOP2A/HJURP/BUB1B/SPC25/MKI67 |
| GOBP_NUCLEAR_CHROMOSOME_SEGREGATION | 250 | -0.5396545 | -2.230148 | 0.0000000 | 0.0000000 | 0.0000000 | 1256 | KIF18A/ZCWPW1/M1AP/ABRAXAS1/PSMC3IP/HECW2/BRIP1/SPC24/PSRC1/FBXO5/FMN2/ANAPC4/CCNB1/STAG3/TRIP13/CENPK/KIFC1/AXIN2/KIF4A/PTTG1/SPAG5/KNL1/SGO2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/MAD2L1/CENPF/NCAPH/CENPE/NEK2/NUF2/CCNE2/PLK1/SGO1/KIF2C/BUB1/CEP55/ESCO2/DMC1/CDC20/DLGAP5/KIF18B/NCAPG/UBE2C/TOP2A/BUB1B/SPC25 |
| GOBP_PROTEIN_DNA_COMPLEX_ASSEMBLY | 165 | -0.5624912 | -2.223801 | 0.0000000 | 0.0000000 | 0.0000000 | 2253 | NASP/MIS18A/H2BC9/HNF1B/NAP1L1/CENPH/H3C11/CENPS/H3C1/H2BC11/H3C13/H2BC15/H4C4/CHAF1B/H4C1/H3C10/HMGB2/H2BC7/H2BC3/HELLS/NAP1L3/H4C13/HEY2/CENPK/H4C9/CENPP/H2BC13/H1-5/CDT1/GMNN/H2BC14/H2BC10/CENPF/H3C7/CENPW/H1-1/ASF1B/H2BC17/H3C12/CENPE/DMC1/H3C3/DLGAP5/OIP5/HJURP/H3C8/H3C2 |
| GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 265 | 0.5556219 | 2.187474 | 0.0000000 | 0.0000000 | 0.0000000 | 2607 | SH2D1B/FGL2/EMILIN2/SOCS1/RASGRP1/ZBP1/SERPINB4/CD274/NCF1/TLR4/PTPN22/KLK7/ISG15/CD55/ADAM8/PPARG/OAS3/NOD2/OASL/GBP5/IL4I1/NLRC5/OAS1/PVR/RAET1G/CD36/IFIT1/EREG/IFI35/AIM2/SERPINB9/DDX60/USP18/LRP8/IRF7/TYRO3/ARRB2/APOE/UFD1/PARP9/MICA/RAET1E/NECTIN2/HCK/LY96/IFNLR1/DTX3L/TRIB1/CEACAM1/DUSP10/IL23A/ZC3H12A/AHR/CX3CL1/SYT11/ARG2/APPL2/PARP14/OPTN/CCL5/LGALS9/FYN/NLRP10/CARD9/RNF125/HERC5/SPINK5/ADAR/FADD/CXCL6/STAT1/MICB/PLSCR1/TRIM21/N4BP1/RIPK2/NPLOC4/TNFAIP3/AKIRIN2/SEC14L1/ZNFX1/IL15/BMP6/TRAFD1/HLA-F/STAT2/POLR3D/TRIM5/CGAS/SRC/PTPN11/MUL1/NOD1/BIRC3/TIGAR/PAK2 |
| GOBP_MITOTIC_NUCLEAR_DIVISION | 274 | -0.5213324 | -2.164997 | 0.0000000 | 0.0000000 | 0.0000000 | 1344 | MTBP/INSR/KIF18A/PKMYT1/ABRAXAS1/HECW2/KIF11/CCDC8/PSRC1/FBXO5/ANAPC4/CCNB1/TRIP13/CENPK/KIFC1/EPGN/KIF4A/PTTG1/CDC14A/SPAG5/KIF20B/SGO2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/FBXO43/MAD2L1/CENPF/TPX2/NCAPH/CDCA2/CENPE/NEK2/NUF2/PLK1/SGO1/ANLN/KIF15/KIF2C/BUB1/CEP55/CDC20/DLGAP5/KIF18B/NCAPG/CDC25C/UBE2C/BUB1B/MYBL2/MKI67 |
| GOBP_RESPONSE_TO_VIRUS | 312 | 0.5070443 | 2.044662 | 0.0000000 | 0.0000000 | 0.0000000 | 2898 | FGL2/ZBP1/APOBEC3A/HYAL1/PTPN22/CXCL10/CCL4/BATF3/IFIT2/MX2/RSAD2/ISG15/OAS3/CXCL9/ISG20/DUOX2/OASL/IFIT3/IFI44L/NLRC5/OAS1/VWCE/CCL22/MX1/MAP3K14/IFIT1/AIM2/BCL2/IFITM1/IFIH1/UNC13D/DDX60/IFI6/IRF7/GATA3/BST2/HYAL3/UFD1/TICAM1/PMAIP1/PARP9/MICA/IFI27/IFNLR1/DTX3L/OAS2/RIPK3/HIF1A/PML/FOSL1/IFITM3/ITGB8/IL23A/MYD88/TNF/ZC3H12A/SHFL/IFIT5/MAPK11/CCL5/LGALS9/CARD9/RNF125/HERC5/SERINC5/MST1R/ADAR/FADD/MLKL/STAT1/MICB/PLSCR1/TRIM21/EIF2AK2/ACTA2/APOBEC3B/TRIM25/NPLOC4/TNFAIP3/SEC14L1/ZNFX1/IL15/ITGB6/IFI44/ENO1/SAP30BP/RTP4/GBP1/FCN3/STAT2/POLR3D/AUP1/RELA/TRIM5/CGAS/SRC/MUL1/BIRC3/BCL3/CLPB/PDE12/CFL1/IFI16/MARCHF2/SMPD1/TRAF3IP2/NPC2/IKBKG/IL17RA/IKBKE |
| GOBP_ORGANELLE_FISSION | 425 | -0.4667736 | -2.025623 | 0.0000000 | 0.0000000 | 0.0000000 | 1395 | PEX11G/SHOC1/MTBP/INSR/KIF18A/RAD54B/ZCWPW1/HSPA2/PKMYT1/M1AP/ABRAXAS1/WNT5A/PSMC3IP/HECW2/KIF11/CCDC8/RAD54L/BRIP1/PSRC1/FBXO5/MEI1/FMN2/ANAPC4/CCNB1/PIWIL2/STAG3/HSF2BP/TRIP13/CENPK/KIFC1/EPGN/KIF4A/PTTG1/RAD51AP1/CDC14A/SPAG5/KIF20B/MYBL1/SGO2/MTFR2/TTK/DSCC1/CDT1/CDCA5/NDC80/KIF14/FBXO43/MAD2L1/CENPF/TPX2/CCNB2/NCAPH/CDCA2/CENPE/NEK2/NUF2/CCNE2/PLK1/SGO1/ANLN/CYP26B1/KIF15/KIF2C/BUB1/CEP55/DMC1/CDC20/DLGAP5/KIF18B/NCAPG/CDC25C/UBE2C/ASPM/TOP2A/CNTD1/BUB1B/MYBL2/MKI67 |
| GOBP_REGULATION_OF_DEFENSE_RESPONSE | 445 | 0.4800523 | 1.990991 | 0.0000000 | 0.0000000 | 0.0000000 | 2753 | SH2D1B/FGL2/PLA2G3/CCN4/EMILIN2/SOCS1/TNFAIP6/RASGRP1/ZBP1/SERPINB4/ALOX15/NCF1/TLR4/PTPN22/IL1RL1/CNR1/KLK7/CTSC/ISG15/ADAM8/PPARG/OAS3/NOD2/KLF4/GBP5/LDLR/DUOXA1/ACE/NLRC5/FNDC4/OAS1/PVR/RAET1G/IFIT1/EREG/IFI35/AIM2/IDO1/SERPINB9/GPS2/DUOXA2/USP18/CD47/LRP8/IRF7/GATA3/TYRO3/PLA2G7/ARRB2/APOE/UFD1/PARP9/MICA/ANXA1/MVK/RAET1E/NECTIN2/HCK/CD200R1/OSMR/IFNLR1/DTX3L/MFHAS1/NFKBIA/METRNL/CEACAM1/DUSP10/PTGS2/IL23A/ZFP36/MYD88/SEMA7A/TNF/ZC3H12A/PSMA6/SOCS3/CX3CL1/SYT11/CALCRL/SPHK1/ARG2/TNIP1/APPL2/PARP14/OPTN/CCL5/LGALS9/FYN/NLRP10/CCN3/CARD9/RNF125/HERC5/SPINK5/SNCA/ADAR/FADD/IL1RL2/CXCL6/STAT1/MICB/PLSCR1/TRIM21/N4BP1/RIPK2/IL20RB/NPLOC4/TNFAIP3/AKIRIN2/SEC14L1/ZNFX1/IL15/CELF1/TRAFD1/FURIN/SBNO2/C2CD4B/TMSB4X/HLA-F/RORA/TRPV4/SELENOS/STAT2/GPER1/POLR3D/RELA/TRIM5/CYLD/CGAS/SRC/PTPN11/MUL1/RHBDF2/NOD1/BIRC3/NEAT1/PAK2/PPARD/IL6ST/BCR/MAPK13/ALOX5/RHBDD3/SYK/IFI16/SLC15A4/ABCC1 |
| GOBP_CILIUM_ORGANIZATION | 375 | -0.4582800 | -1.984009 | 0.0000000 | 0.0000000 | 0.0000000 | 4025 | SPEF1/CFAP100/DNAAF11/CFAP157/LRGUK/TTC39C/CFAP298/RTTN/TBC1D8/TAPT1/TBC1D2B/UNC119B/ARL6/CEP41/TCTN1/IFT20/CEP250/DRC1/CEP164/ZMYND10/IQCB1/KIF3A/ARL13B/DYNLT2B/DNAI3/ARMC9/CFAP20/IFT46/TTC29/TMEM107/RAB17/ROPN1B/BBS10/CIBAR1/CEP135/SPATA6/ENO4/CCDC113/ODAD4/VDAC3/TEKT3/TOGARAM1/DNAAF2/ARL3/CEP19/WDPCP/TEKT5/RSPH4A/TBC1D15/DYNC2I1/PIBF1/DNAJB13/CFAP126/BBS9/CLUAP1/NEK1/CCDC66/CCDC39/CFAP54/TMEM216/DNAI1/BBIP1/IFT122/IFT43/TCTN2/CFAP74/SPAG17/DNAAF10/HYDIN/WDR90/BBS2/DNAL1/NOTCH1/BBOF1/WDR19/CENPJ/TBC1D32/ARMC2/CBY1/CFAP52/DCDC2/KIF24/DYNC2LI1/TMEM67/MAPK15/KIF27/B9D1/PCM1/CEP83/RPGR/FOXJ1/CEP97/CCDC96/CCP110/DNAAF3/POC1A/SPEF2/CEP120/CCDC65/TUB/CATIP/TTC21A/PKHD1/RSPH9/DNAH7/CFAP58/FAM161A/IFT57/IFT140/CEP162/TEKT2/CFAP61/CFAP69/IFT27/CFAP91/ODF2L/CC2D2A/UBXN10/LCA5/DRC7/IFT88/SPAG16/TMEM237/IFT52/FUZ/CFAP47/IFT74/TTC12/RFX2/CILK1/BBS12/DNAH1/IFT81/ODAD3/RPGRIP1L/WDR35/IQCG/CIBAR2/IFT172/NME5/RSPH1/CPLANE2/CFAP73/IFT80/TMEM138/DYNC2H1/DAW1/CFAP221/MKS1/B9D2/CFAP44/RFX3/CFAP65/CEP78/DNAI4/KIF19/DNAAF1/DNAAF4/CEP70/TEKT1/DNAI2/DZIP1L/BBS4/IQUB/MNS1/HOATZ/CFAP70/CFAP43/LCA5L/LRRC49/MPHOSPH9/CFAP206/TEKT4/CDKL1/CFAP161/CCDC13/DNAH2/TTC21B/DNAH5/CROCC/RP1/DNAAF6/DNAAF8/CFAP53/ODAD2/HYLS1/MEIG1/ABCC4/SAXO1/NEURL1/CDC14A/MCIDAS/CCNO/PLK4/GMNC |
| GOBP_CYTOKINE_MEDIATED_SIGNALING_PATHWAY | 339 | 0.4915632 | 1.986268 | 0.0000000 | 0.0000001 | 0.0000001 | 2580 | CCL26/SOCS1/ZBP1/IL1R2/IL13RA2/IL1RL1/CXCL10/CCL4/ISG15/CXCL11/CD44/PPARG/IL12RB2/OAS3/IL36G/CXCL9/DUOX2/OASL/IL17REL/NLRC5/OAS1/SLIT2/CXCL8/CCL22/MX1/IL2RG/EREG/IL31RA/AIM2/EBI3/F3/IL36A/IFITM1/IL1A/GPS2/USP18/EGR1/CLCF1/LRP8/CD70/IRF7/DUOX1/DOK1/EDN1/PARP9/IL1RN/IFI27/CCR3/HCK/OSMR/ACSL1/PXDN/IFNLR1/OAS2/IL18R1/IRAK2/NFKBIA/HIF1A/IFITM3/CEACAM1/CXCL1/MYD88/TNF/PLP2/LIFR/FAS/KRT18/IL1RAPL2/CX3CL1/YAP1/SPHK1/RPS6KA4/IL4R/APPL2/PARP14/CCL5/TNFRSF19/CXCL2/IL15RA/TNFRSF25/AXL/SH2B3/MST1R/ADAR/OXSR1/FADD/IL1RL2/CXCL6/STAT1/IRAK1/RIPK2/IL20RB/TRAF5/CDIP1/TNFAIP3/TNFRSF13C/IL15/CSNK2B/ST18/ADIPOR2/AKT1/TMSB4X/ADAM17/IRAK4/STAT2/PF4V1/GAS6/RELA/GFI1/RFFL/CYLD/SRC/PTPN11/CCL20/MUL1/IL27RA/BIRC3/WBP1L/CSF2 |
| GOBP_NUCLEOSOME_ASSEMBLY | 94 | -0.6254620 | -2.249064 | 0.0000000 | 0.0000007 | 0.0000005 | 2253 | NASP/MIS18A/H2BC9/NAP1L1/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/CHAF1B/H4C1/H3C10/HMGB2/H2BC7/H2BC3/NAP1L3/H4C13/H4C9/CENPP/H2BC13/H1-5/H2BC14/H2BC10/H3C7/CENPW/H1-1/ASF1B/H2BC17/H3C12/H3C3/OIP5/HJURP/H3C8/H3C2 |
| GOBP_DNA_PACKAGING | 206 | -0.5065113 | -2.045426 | 0.0000000 | 0.0000007 | 0.0000006 | 2332 | SMC4/HDAC5/NASP/MIS18A/H2BC9/NAP1L1/SMC2/H3C11/H3C1/H2BC11/H3C13/H2BC15/TET1/H4C4/CHAF1B/H4C1/M1AP/H3C10/HMGB2/H2BC7/H2BC3/HELLS/NAP1L3/H4C13/H4C9/ATF7IP2/CENPP/H2BC13/H1-5/CDCA5/H2BC14/H2BC10/H3C7/CENPW/H1-1/NCAPH/ASF1B/H2BC17/H3C12/PLK1/CDK1/H3C3/OIP5/NCAPG/TOP2A/HJURP/H3C8/H3C2 |
| GOBP_STEROL_BIOSYNTHETIC_PROCESS | 53 | 0.7521629 | 2.332720 | 0.0000000 | 0.0000008 | 0.0000007 | 887 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/DHCR7/MSMO1/HMGCR/INSIG1/CH25H/HSD17B7/IDI1/FDFT1/SQLE/NSDHL/ACLY/SC5D/G6PD/APOE/TM7SF2/ERG28/MVK |
| GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION | 81 | -0.6473587 | -2.282139 | 0.0000000 | 0.0000015 | 0.0000012 | 1101 | HECW2/FBXO5/ANAPC4/CCNB1/TRIP13/PTTG1/TTK/CDT1/NDC80/MAD2L1/CENPF/CDCA2/CENPE/PLK1/KIF2C/BUB1/DLGAP5/UBE2C/BUB1B/MKI67 |
| GOBP_DNA_CONFORMATION_CHANGE | 300 | -0.4545535 | -1.912151 | 0.0000000 | 0.0000018 | 0.0000015 | 2521 | H4C3/HMGB1/H4C2/RFC5/MRE11/SMC4/HDAC5/NASP/MIS18A/H2BC9/ZRANB3/CHTF8/NAP1L1/SMC2/H3C11/H3C1/DNA2/H2BC11/H3C13/H2BC15/TET1/H4C4/CHAF1B/H4C1/MCM8/RAD54B/M1AP/BLM/GINS1/GINS2/RAD54L/BRIP1/H3C10/HMGB2/H2BC7/H2BC3/HELLS/RECQL4/POLQ/NAP1L3/H4C13/H4C9/MCMDC2/CHD1L/ATF7IP2/CENPP/H2BC13/H1-5/DSCC1/CDCA5/H2BC14/H2BC10/H3C7/CENPW/H1-1/NCAPH/ASF1B/H2BC17/H3C12/PLK1/CDK1/ERCC6L/H3C3/OIP5/NCAPG/TOP2A/HJURP/H3C8/H3C2 |
| GOBP_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION | 211 | -0.4908236 | -1.988399 | 0.0000000 | 0.0000025 | 0.0000020 | 3971 | NPM1/H2BC12/PIH1D1/TSPYL4/ITGB3BP/RUVBL1/ACTL6A/H3-3A/H1-3/CENPC/H2AX/KNTC1/H3C6/MCM2/H2BC6/H4C5/ACTR6/GTF2H5/NAP1L4/SMARCE1/H2BC5/H4C12/RUVBL2/RPL23/RAD52/SMYD3/TCF4/ANP32E/H4C6/H2BC4/ESR1/H4C3/HMGB1/H4C2/NASP/MIS18A/H2BC9/HNF1B/NAP1L1/CENPH/H3C11/CENPS/H3C1/H2BC11/H3C13/H2BC15/H4C4/CHAF1B/H4C1/H3C10/HMGB2/H2BC7/SMARCD3/H2BC3/HELLS/INO80B/NAP1L3/H4C13/HEY2/CENPK/H4C9/CENPP/H2BC13/H1-5/CDT1/GMNN/H2BC14/H2BC10/CENPF/H3C7/CENPW/H1-1/ASF1B/H2BC17/H3C12/CENPE/DMC1/H3C3/DLGAP5/OIP5/HJURP/H3C8/H3C2 |
| GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS | 476 | 0.4279468 | 1.789366 | 0.0000000 | 0.0000033 | 0.0000028 | 2869 | NOS2/CISH/SOCS1/PNPLA3/ALOX15/IDO2/MVD/HMGCS1/ADCY5/FDPS/ELOVL6/SLC5A8/ACSS2/NNMT/GARS1/IDI1/FADS1/HAAO/ME1/ADCY4/CMPK2/LPIN1/MFSD2A/HRH1/ELOVL5/PLA2G4C/ACLY/ABHD4/IDO1/SOCS2/ANTKMT/ADCY7/LCAT/LIPH/FGF2/GUCY2C/G6PD/SRD5A3/PARP9/ELOVL7/PLA2G4A/MVK/P2RY1/HSD17B12/ACSL1/QPRT/PANK3/SERAC1/TKT/GPAT3/LPCAT4/FAR1/IDH1/ACOT7/SLC25A1/SOCS3/GCH1/PTAFR/NAMPT/UCKL1/TPK1/ELOVL1/PISD/TMEM150A/SGMS1/PIGW/ACSL4/SERINC5/PTPMT1/SELENOI/P2RY6/NOS1/ELOVL4/SNCA/SAMD8/ACACA/PLSCR1/ITPKA/ADCY10/KYNU/UPP1/GPAT4/PGAP4/NADK/VPS9D1/PIP4K2A/DGKQ/PARP10/DHDDS/TAFAZZIN/PDXK/ACP6/CKMT1B/CKMT1A/FLCN/CAPN2/PIP5K1A/ENO1/ATP5MC1/INPP1/MBOAT1/PIK3C2B/PDHA1/PLD2/TMSB4X/MYC/INPPL1/DGKA/GPER1/PTDSS1/CHP1/ATP5F1D/CTPS1/PITPNM2/ITPKC/PPARD/DOLK/NAPRT/PPARGC1A/MOCOS/TTC7A/AKR1A1/ABHD3/ACSL3/HACD1/FLAD1/IPPK |
| GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 235 | 0.5078902 | 1.966624 | 0.0000000 | 0.0000044 | 0.0000036 | 1872 | SH2D1B/NOS2/FGL2/PLA2G3/RASGRP1/IL13RA2/SERPINB4/NCF1/TLR4/PTPN22/KLK7/RSAD2/CD55/NOD2/IL4I1/PVR/RAET1G/CD36/SERPINB9/FZD5/UNC13D/DDX60/CLCF1/CD47/SLC7A5/GATA3/BST2/ARRB2/TNFSF13/TICAM1/CD86/MICA/ANXA1/RAET1E/NECTIN2/COLEC10/IL18R1/RIPK3/NFKBID/ARID5A/CEACAM1/DUSP10/IL23A/SEMA7A/ICAM1/TNF/ZC3H12A/AHR/GAB2/HK1/HMOX1/IL4R/PTAFR/TRPM4/APPL2/ZBTB7B/LGALS9/NR4A3/ITGAM/SPINK5/FADD/CXCL6/RIPK2/IL20RB |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS | 287 | 0.4769580 | 1.897587 | 0.0000000 | 0.0000044 | 0.0000036 | 2722 | FGL2/DPP4/SOCS1/TNFAIP6/THY1/IL13RA2/SERPINB4/ALOX15/CD274/LGALS7B/TLR4/PTPN22/PDCD1LG2/IL1RL1/CNR1/SFRP1/ISG15/CD55/PPARG/OAS3/NOD2/LDLR/IL4I1/NLRC5/OAS1/SLIT2/IL31RA/IDO1/SERPINB9/GPS2/USP18/CD47/BST2/TYRO3/ARRB2/CD86/MICA/ANXA1/HCK/CD200R1/KITLG/HLA-DOB/TRIB1/SOX9/CEACAM1/DUSP10/TNF/ZC3H12A/AHR/DUSP3/CX3CL1/SYT11/HMOX1/ARG2/IL4R/DLG1/PARP14/ZBTB7B/LGALS9/THBS1/FYN/CCN3/GREM1/AXL/SPINK5/MMP28/ADAR/FADD/TRIM21/IL20RB/TNFAIP3/CD46/FCRLB/WASL/TRAFD1/FURIN/PRNP/DLG5/SCRIB/GBP1/PAWR/AKT1/HLA-F/MYC/SELENOS/UBASH3B/STAT2/GPER1/RUNX1/SRC/MUL1/RHBDF2/IL27RA/MIA3/BCR/LGALS3/RHBDD3/SYK/IFI16 |
| GOBP_DEFENSE_RESPONSE_TO_SYMBIONT | 234 | 0.5122573 | 1.981033 | 0.0000000 | 0.0000047 | 0.0000039 | 2730 | FGL2/ZBP1/APOBEC3A/PTPN22/CXCL10/IFIT2/MX2/RSAD2/ISG15/OAS3/CXCL9/ISG20/OASL/IFIT3/IFI44L/NLRC5/OAS1/MX1/MAP3K14/IFIT1/AIM2/BCL2/IFITM1/IFIH1/UNC13D/DDX60/IFI6/IRF7/BST2/UFD1/TICAM1/PMAIP1/PARP9/MICA/IFI27/IFNLR1/DTX3L/OAS2/RIPK3/PML/IFITM3/IL23A/MYD88/ZC3H12A/SHFL/IFIT5/CARD9/RNF125/HERC5/SERINC5/ADAR/FADD/MLKL/STAT1/MICB/PLSCR1/TRIM21/EIF2AK2/APOBEC3B/TRIM25/NPLOC4/TNFAIP3/SEC14L1/ZNFX1/IL15/RTP4/GBP1/FCN3/STAT2/POLR3D/RELA/TRIM5/CGAS/MUL1/BIRC3/CLPB/PDE12/IFI16/MARCHF2 |
| GOBP_MEIOTIC_CELL_CYCLE | 198 | -0.4775727 | -1.918379 | 0.0000001 | 0.0000211 | 0.0000174 | 1416 | XRCC2/MNS1/SHOC1/INSR/KIF18A/RAD54B/ZCWPW1/HSPA2/WBP2NL/PKMYT1/M1AP/WNT5A/PSMC3IP/CDC25A/RAD54L/BRIP1/FBXO5/MEI1/FMN2/PIWIL2/STAG3/HSF2BP/TRIP13/MCMDC2/PTTG1/RAD51AP1/EXO1/MYBL1/SGO2/TTK/NDC80/FBXO43/CCNB2/NCAPH/NEK2/NUF2/CCNE2/PLK1/SGO1/CYP26B1/BUB1/DMC1/CDC20/CDC25C/ASPM/TOP2A/CNTD1/BUB1B |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 302 | 0.4693532 | 1.879433 | 0.0000001 | 0.0000211 | 0.0000174 | 2753 | CCL26/SH2D1B/PLA2G3/CCN4/EMILIN2/RASGRP1/ZBP1/TLR4/IL1RL1/CXCL10/PRKD1/CNR1/CCL4/KLK7/CTSC/ADAM8/NOD2/OASL/GBP5/LDLR/ACE/NLRC5/SLIT2/CXCL8/PVR/RAET1G/EREG/ARTN/NTRK3/IFI35/AIM2/F3/IDO1/VEGFA/DDX60/FGF2/DAPK2/CD47/IRF7/SMOC2/PLA2G7/EDN1/PARP9/MET/RAET1E/NECTIN2/HCK/LY96/OSMR/NFKBIA/STX3/S100A7/THBD/PTGS2/IL23A/KDR/TNF/CAMK1D/CX3CL1/TNIP1/OPTN/CCL5/LGALS9/THBS1/FYN/NLRP10/NDEL1/FKBP1B/CARD9/P2RX4/SNCA/OXSR1/FADD/RAC1/PLSCR1/RIPK2/SCG2/AKIRIN2/ZNFX1/IL15/BMP6/MCU/C2CD4B/TMSB4X/HLA-F/ADAM17/TRPV4/POLR3D/GAS6/TRIM5/STX4/CGAS/SRC/NOD1/NEAT1/PAK2/IL6ST/MAPK13/S100A14/SYK/IFI16/SLC15A4/ABCC1 |
| GOBP_MICROTUBULE_BASED_MOVEMENT | 330 | -0.4188094 | -1.784974 | 0.0000001 | 0.0000244 | 0.0000201 | 3518 | DRC1/HSPB1/ZMYND10/KIF2A/KIF3A/DNAL4/CFAP251/DYNLT2B/DNAI3/CFAP20/IFT46/TTC29/ROPN1B/AGBL4/SLC22A16/ENO4/ODAD4/TEKT3/DNAAF2/ARL3/TEKT5/RSPH4A/DYNLT1/DYNC2I1/AP3M2/CCDC39/CFAP54/DNAI1/IFT122/KIF7/IFT43/SPAG17/HYDIN/BBS2/KIF23/WDR19/KIF6/ARMC2/CFAP52/KIF17/KIF24/DYNC2LI1/KIF27/MAPK8IP3/KATNIP/PCM1/ZBBX/RPGR/DPCD/SPEF2/CCDC65/TUB/TTC21A/RSPH9/GAS2L2/DNAH7/CFAP58/IFT57/ROPN1L/IFT140/TEKT2/CFAP61/CFAP69/IFT27/CFAP91/MAP1A/LCA5/DRC7/IFT88/INPP5B/MAPT/SPAG16/IFT52/CFAP47/SPA17/IFT74/TTC12/DNAH9/CILK1/BBS12/DNAH1/IFT81/ODAD3/WDR35/SLC26A8/IQCG/IFT172/NME5/CLN3/CFAP73/DYNC2H1/DAW1/CFAP221/CFAP44/DYNLT2/AQP4/RFX3/CFAP65/PLTP/NEFL/DNAH3/DNAI4/KIF19/DNAAF1/DNAAF4/TEKT1/KIF22/DNAI2/DNAH6/BBS4/MNS1/HOATZ/CFAP70/TCTE1/CFAP43/DNAH10/LCA5L/CFAP45/KIF18A/CFAP206/TEKT4/KIF26B/STARD9/KIF11/DYNLRB2/DNAH2/TTC21B/TTLL6/DNAH5/FMN2/DNAAF6/CFAP53/ODAD2/CNIH2/KIFC1/NEK10/KIF21A/MEIG1/DLG2/KIF4A/NEURL1/KIF20B/KIF14/DYNLT4/CENPE/CATSPERD/KIF15/KIF2C/EPPIN/KIF20A/DLGAP5/KIF18B |
| GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS | 437 | 0.4208893 | 1.748098 | 0.0000002 | 0.0000291 | 0.0000239 | 2372 | PLA2G3/APOC1/ALOX15/CBS/CYP51A1/MVD/HMGCS1/EBP/TRIB3/TBXAS1/FADS2/PSAT1/FDPS/ELOVL6/LSS/LIPG/DHCR7/MSMO1/HMGCR/INSIG1/PCK2/NNMT/HSD17B7/IDI1/FGFR4/FADS1/STARD4/ALDH1A3/ASNS/HAAO/FDFT1/HRH1/ELOVL5/BCAT1/ALOXE3/SCD/NSDHL/PYCR1/FA2H/ACLY/PHGDH/IDO1/SC5D/ALOX15B/LIPH/SESN2/FGF2/EGR1/FASN/G6PD/MTHFD1L/SRD5A3/APOE/DPYD/TM7SF2/EDN1/FBP1/ELOVL7/PLA2G4A/GOT1/ATF4/CTH/CYP27B1/ANXA1/MVK/P2RY1/PRTFDC1/HSD17B12/SHMT2/GGT5/ERFE/CEACAM1/PTGS2/MLXIPL/TNF/AMD1/ACOT7/SLC25A1/CYP46A1/SPHK1/GCH1/PTAFR/GGT7/BMP2/LTA4H/HSD3B7/UCKL1/TPK1/ELOVL1/CYP2C9/PPTC7/SERINC5/ACADL/P2RY6/ELOVL4/SNCA/ACACA/PLOD3/NAGS/AACS/ITPKA/FAM3C/KYNU/NLN/DGKQ/ATF3/DHDDS/PDXK/ASS1/SLC39A14/PGD/BMP6/SLC35B4/ACER2/DHCR24/MID1IP1/KAT2B/GLS/SELENOS/ASAH2/CYB5R3/GPER1 |
| GOBP_IMMUNE_EFFECTOR_PROCESS | 393 | 0.4324209 | 1.770190 | 0.0000002 | 0.0000319 | 0.0000262 | 2641 | SH2D1B/NOS2/FGL2/PLA2G3/RASGRP1/IL13RA2/C8B/SERPINB4/NCF1/TLR4/PTPN22/TCIM/KLK7/CTSC/RSAD2/CD55/LAT2/NOD2/ACE/IL4I1/ULBP1/PVR/RAET1G/CD36/IFI35/SERPINB9/FZD5/UNC13D/DDX60/CLCF1/CD47/SLC7A5/CD70/IRF7/GATA3/BST2/ANXA3/ARRB2/TNFSF13/TICAM1/CD86/MICA/RELB/ANXA1/RAET1E/NECTIN2/COLEC10/ULBP2/HCK/DOCK11/HLA-DOB/IL18R1/RIPK3/NFKBID/ARID5A/CEACAM1/DUSP10/IL23A/MYD88/SEMA7A/ICAM1/TNF/CEBPG/ZC3H12A/CFB/AHR/GAB2/HK1/HMOX1/IL4R/PTAFR/TRPM4/APPL2/ZBTB7B/LGALS9/FYN/NR4A3/ITGAM/CARD9/RNF19B/TUBB/SPINK5/FADD/CXCL6/ULBP3/RIPK2/IL20RB/C1S/RNF8/CD46/SHLD2/WDR1/BATF/SBNO2/BCL10/LIMK1/HLA-DQB2/PLD2/HLA-F/ADAM17/RORA/IRAK4/FCN3/C2/CD177/PLEC/STX4/CGAS/SRC/IL27RA/BCL3/STXBP2/BCR/LGALS3 |
| GOBP_SISTER_CHROMATID_COHESION | 54 | -0.6726041 | -2.199664 | 0.0000002 | 0.0000381 | 0.0000313 | 2514 | PDS5B/HORMAD1/HASPIN/MRE11/CHTF8/ESPL1/KIF22/STAG3/AXIN2/SGO2/DSCC1/CDCA5/PLK1/SGO1/BUB1/ESCO2/CDC20/BUB1B |
| GOBP_RESPONSE_TO_INTERFERON_GAMMA | 104 | 0.6072704 | 2.122520 | 0.0000003 | 0.0000381 | 0.0000313 | 2702 | CCL26/NOS2/SOCS1/TLR4/CCL4/PPARG/GBP5/NLRC5/CCL22/UBD/CXCL16/IFITM1/CD47/BST2/EDN1/PARP9/CYP27B1/HCK/SLC26A6/IFITM3/TNF/MYO1C/CX3CL1/SHFL/GCH1/PARP14/CCL5/LGALS9/EPRS1/GSN/SNCA/RAB43/STAT1/TRIM21/KYNU/ASS1/DAPK3/GBP1/MYC/STX4/CCL20/GBP4/CLDN1/CALCOCO2/PDE12/ACTG1 |
| GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 170 | 0.5393717 | 2.001428 | 0.0000002 | 0.0000381 | 0.0000313 | 2740 | SH2D1B/SOCS1/RASGRP1/ZBP1/SERPINB4/NCF1/TLR4/PTPN22/ISG15/ADAM8/PPARG/OAS3/NOD2/GBP5/NLRC5/OAS1/PVR/RAET1G/EREG/IFI35/AIM2/SERPINB9/USP18/LRP8/IRF7/TYRO3/ARRB2/APOE/PARP9/MICA/RAET1E/NECTIN2/HCK/CEACAM1/DUSP10/APPL2/PARP14/CCL5/LGALS9/FYN/CARD9/ADAR/FADD/PLSCR1/TRIM21/N4BP1/TNFAIP3/AKIRIN2/ZNFX1/TRAFD1/HLA-F/STAT2/POLR3D/TRIM5/CGAS/SRC/PTPN11/MUL1/BIRC3/PAK2/SYK/IFI16/SLC15A4 |
| GOBP_NUCLEOSOME_ORGANIZATION | 139 | -0.5187049 | -1.984320 | 0.0000003 | 0.0000381 | 0.0000313 | 3971 | NPM1/H2BC12/TSPYL4/ITGB3BP/RUVBL1/ACTL6A/H3-3A/H1-3/H2AX/H3C6/MCM2/H2BC6/H4C5/ACTR6/NAP1L4/SMARCE1/H2BC5/H4C12/RUVBL2/SMYD3/ANP32E/H4C6/H2BC4/H4C3/H4C2/NASP/MIS18A/H2BC9/NAP1L1/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/CHAF1B/H4C1/H3C10/HMGB2/H2BC7/SMARCD3/H2BC3/INO80B/NAP1L3/H4C13/H4C9/CENPP/H2BC13/H1-5/H2BC14/H2BC10/H3C7/CENPW/H1-1/ASF1B/H2BC17/H3C12/H3C3/OIP5/HJURP/H3C8/H3C2 |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE | 286 | 0.4642742 | 1.849026 | 0.0000003 | 0.0000381 | 0.0000313 | 1639 | NTRK1/ANO1/SOCS1/CA2/PNPLA3/EDNRA/TLR4/PTPN22/TRIB3/PCSK9/INSIG1/PCK2/GJB2/PPARG/MAP1B/KL/NOD2/LPIN1/NR4A1/CPEB2/PRKCQ/CD36/MIR200A/GDF15/HDAC9/KLF11/MARS1/SOCS2/KLF2/SLC29A2/CACNB1/EDN1/FBP1/GOT1/PTPRE/GRB10/ENPP1/ERFE/RAB8B/CEACAM1/ICAM1/TNF/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/ZBTB7B/GRB14/EPRS1/BCAR1/FYN/ERRFI1/CCND3/NDEL1/NR4A3/RAB15/SLC9A1 |
| GOBP_LEUKOCYTE_DIFFERENTIATION | 404 | 0.4213027 | 1.732894 | 0.0000004 | 0.0000606 | 0.0000498 | 2403 | NTRK1/FGL2/PLA2G3/CCN4/SOCS1/TNFAIP6/RASGRP1/TLR4/PTPN22/FZD9/SLC9B2/BATF3/PRDM1/SFRP1/MT1G/RSAD2/ADAM8/PPARGC1B/PPARG/BATF2/RUNX2/BCL11B/IL4I1/KLF6/DLL4/IL31RA/UBD/HDAC9/FOS/HHEX/BCL2/VEGFA/IL1A/FZD5/TOX/GPS2/EGR1/CLCF1/FASN/LRRC8A/IRF7/GATA3/TYRO3/CD86/RELB/ANXA1/KITLG/DOCK11/TNFSF9/IL18R1/RIPK3/TRIB1/NFKBID/BAK1/IKZF1/CARD11/ROR2/CEACAM1/DUSP10/ITGB8/IL23A/TNF/NFIL3/CEBPG/ZC3H12A/GAB2/CD83/LIF/IL4R/CMTM7/EPHA2/ZBTB7B/LGALS9/TFE3/IL15RA/AXL/SPINK5/FADD/IL1RL2/PRXL2A/MYH9/RIPK2/PRELID1/FAM20C/JUNB/CD46/IL15/BATF/ITGB6/SBNO2/LTBR/PIR/AP3D1/JUN/ADAM17/RORA/MYC/UBASH3B/GAS6/JMJD6 |
| GOBP_RESPONSE_TO_WOUNDING | 433 | 0.4210333 | 1.746689 | 0.0000004 | 0.0000615 | 0.0000505 | 2729 | NTRK1/CCN4/ADRA2C/EMILIN2/C1QTNF1/VWF/SELP/EDNRA/ALOX15/SERPINB2/SPRR3/TLR4/PROCR/RTN4R/HBEGF/SLC7A11/SERPINC1/PLAUR/CD44/PHLDB2/PPARG/FAP/MAP1B/KLF4/PAX6/DUOX2/PRKCQ/CD36/EREG/NTRK3/TNC/F3/BCL2/VEGFA/IL1A/PLAU/SLC12A2/FGF2/CLASP1/GRHL3/SMOC2/DUOX1/TYRO3/APOE/EDN1/TNFRSF12A/PLA2G4A/CD9/ANXA1/P2RY1/KRT6A/EPPK1/SCARB1/NOTCH4/MSX2/THBD/HIF1A/VCL/PEAR1/OCLN/TFPI2/ANXA8/CEACAM1/ZFP36/KDR/TNF/CDH3/CLDN4/CX3CL1/SYT11/HMOX1/RIPOR1/YAP1/ID3/NREP/ST3GAL4/THBS1/SOX2/NDEL1/FKBP1B/LOX/AXL/SH2B3/RAP2B/ENTPD2/P2RX4/MYOF/RAC1/PLSCR1/ACTA2/TGFA/MYH9/DGKI/TEC/TNFAIP3/DGKQ/CHMP6/ACTB/CSRP1/TIMP1/ITGB6/ADIPOR2/CDKN1A/SCRIB/SPP1/CHMP7/GNA12/ITPK1/RHOC/JUN/TGFBR1/ADAM17/MYC/DGKA/UBASH3B/PF4V1/GAS6/TMPRSS4/CD151/PDPN/PLEC/ACTN1/SRC/CLDN1/FERMT1/PPARD/CADM4/IL6ST/MIA3/MAP2K1/ALOX5/ACTG1/SYK/DAG1/PAFAH2 |
| GOBP_WOUND_HEALING | 337 | 0.4423733 | 1.784336 | 0.0000005 | 0.0000656 | 0.0000539 | 3002 | CCN4/ADRA2C/EMILIN2/C1QTNF1/VWF/SELP/ALOX15/SERPINB2/SPRR3/TLR4/PROCR/HBEGF/SLC7A11/SERPINC1/PLAUR/CD44/PHLDB2/PPARG/FAP/DUOX2/PRKCQ/CD36/EREG/F3/VEGFA/IL1A/PLAU/SLC12A2/FGF2/CLASP1/GRHL3/SMOC2/DUOX1/TYRO3/APOE/EDN1/TNFRSF12A/PLA2G4A/CD9/ANXA1/P2RY1/KRT6A/EPPK1/SCARB1/NOTCH4/MSX2/THBD/HIF1A/VCL/PEAR1/OCLN/TFPI2/ANXA8/CEACAM1/KDR/TNF/CDH3/CLDN4/CX3CL1/SYT11/HMOX1/YAP1/ST3GAL4/THBS1/LOX/AXL/SH2B3/RAP2B/ENTPD2/MYOF/PLSCR1/ACTA2/TGFA/MYH9/DGKI/TEC/TNFAIP3/DGKQ/CHMP6/ACTB/CSRP1/TIMP1/ITGB6/ADIPOR2/CDKN1A/SCRIB/CHMP7/GNA12/ITPK1/RHOC/TGFBR1/ADAM17/DGKA/UBASH3B/PF4V1/GAS6/CD151/PDPN/PLEC/ACTN1/SRC/CLDN1/FERMT1/PPARD/CADM4/IL6ST/MIA3/ALOX5/ACTG1/SYK/DAG1/PAFAH2/VAV2/SMPD1/CAV1/DGKD/MYL12A/CRK/FERMT2/COMP/GGCX |
| GOBP_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 61 | -0.6410830 | -2.127126 | 0.0000006 | 0.0000795 | 0.0000653 | 1101 | HECW2/FBXO5/ANAPC4/CCNB1/TRIP13/TTK/CDT1/NDC80/MAD2L1/CENPF/CENPE/PLK1/BUB1/DLGAP5/UBE2C/BUB1B |
| GOBP_REGULATION_OF_CHROMOSOME_SEPARATION | 66 | -0.6289327 | -2.116362 | 0.0000007 | 0.0000825 | 0.0000678 | 1101 | HECW2/FBXO5/ANAPC4/CCNB1/TRIP13/PTTG1/TTK/CDT1/NDC80/MAD2L1/CENPF/CENPE/PLK1/BUB1/DLGAP5/UBE2C/BUB1B |
| GOBP_TAXIS | 433 | 0.4172267 | 1.730897 | 0.0000007 | 0.0000857 | 0.0000704 | 1885 | CCL26/NTRK1/DPP4/GDNF/TNFAIP6/LGR6/EDNRA/DLX5/PTPRO/DEFB4A/CXCL10/PRKD1/HBEGF/CCL4/BDNF/SEMA3B/PLAUR/CH25H/CXCL11/ADAM8/CRMP1/NOD2/CXCL9/PAX6/ARHGEF5/BCL11B/FOXD1/HRH1/NR4A1/SLIT2/CXCL8/CCL22/PRKCQ/FLT1/ST6GAL1/ARTN/NTRK3/AMOT/CXCL16/F3/VEGFA/PLAU/CMTM3/RELN/SLC12A2/FGF2/EPHB3/DAPK2/GATA3/SMOC2/PLA2G7/ARRB2/SEMA3D/TUBB3/EDN1/EGR2/MET/ANXA1/CCR3/COLEC10/ANOS1/EPHA3/STX3/S100A7/NRP2/FOSL1/PLXNA3/CXCL1/IL23A/KDR/SEMA7A/CAMK1D/PLP2/NRCAM/NIBAN2/DUSP3/CX3CL1/EPHA10/ITGA9/SEMA3A/SEMA4C/PTAFR/TRPM4/CMTM7/ECE1/EPHA2/PLEKHG5/CCL5/HSD3B7/LGALS9/SEMA6A/THBS1/BCAR1/FYN/RHOG/CXCL2/CCN3/SLIT1/GREM1/LOX/NTN1/DPYSL2/MMP28/P2RX4/IGSF9/ITGAV/OXSR1/PDE4B/CXCL6/RAC1/SLC8B1/TYMP/KIF5C/VASP |
| GOBP_REGULATION_OF_NUCLEAR_DIVISION | 116 | -0.5397231 | -2.006606 | 0.0000009 | 0.0001046 | 0.0000859 | 1344 | MTBP/INSR/PKMYT1/WNT5A/CCDC8/FBXO5/ANAPC4/CCNB1/PIWIL2/TRIP13/EPGN/RAD51AP1/KIF20B/TTK/CDT1/NDC80/FBXO43/MAD2L1/CENPF/CDCA2/NEK2/PLK1/BUB1/CDC20/DLGAP5/CDC25C/BUB1B/MKI67 |
| GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS | 108 | 0.5903293 | 2.061729 | 0.0000010 | 0.0001109 | 0.0000911 | 2650 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/DHCR7/MSMO1/HMGCR/INSIG1/PCK2/HSD17B7/IDI1/FDFT1/HRH1/NSDHL/ACLY/SC5D/FGF2/G6PD/SRD5A3/APOE/TM7SF2/GOT1/CYP27B1/MVK/P2RY1/SPHK1/GCH1/PTAFR/BMP2/P2RY6/SNCA/ITPKA/DGKQ/DHDDS/BMP6/ACER2/DHCR24/ASAH2/CYB5R3/GPER1/GFI1/ITPKC/SPTSSA/PTS |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE | 120 | 0.5749977 | 2.037943 | 0.0000010 | 0.0001109 | 0.0000911 | 2722 | FGL2/IL13RA2/SERPINB4/ALOX15/IL1RL1/ISG15/CD55/PPARG/OAS3/NOD2/IL4I1/NLRC5/OAS1/SERPINB9/USP18/TYRO3/ARRB2/MICA/ANXA1/HCK/CEACAM1/DUSP10/ZC3H12A/AHR/HMOX1/ARG2/IL4R/PARP14/ZBTB7B/LGALS9/FYN/SPINK5/ADAR/TRIM21/IL20RB/TNFAIP3/CD46/FCRLB/TRAFD1/FURIN/HLA-F/SELENOS/STAT2/SRC/MUL1/RHBDF2/IL27RA/BCR/LGALS3/SYK/IFI16 |
| GOBP_ANION_TRANSPORT | 360 | 0.4261495 | 1.728338 | 0.0000010 | 0.0001109 | 0.0000911 | 2163 | NOS2/ANO1/PLA2G3/GABRA4/SLC5A5/SLC26A4/CA2/SLC9A3/SLC26A9/SLC5A1/SLC39A8/SLC2A6/SLC24A3/SLC5A8/SLC7A11/TTYH2/ANO2/LRRC8D/SLCO4A1/CLIC2/SLCO1B1/SLC16A9/SLC25A25/ACE/MFSD2A/SLC6A14/NTRK2/ANO4/TG/CD36/SLC16A4/CLIC3/SLC3A2/IL1A/SLC7A9/SLC12A2/CD47/SLC7A5/LRRC8A/SLC7A1/EDN1/SLC16A14/PLA2G4A/SLC1A5/ATF4/CLIC4/ANXA1/ENPP1/SLC4A9/SLC36A1/TCAF2/LRRC8B/SLCO1B3/SLC26A6/SLC26A11/SLC1A4/ANO8/CEACAM1/SLC16A13/SLCO3A1/TNF/SLC27A4/SLC4A3/SFXN5/ATP8B1/SLC38A1/SLC25A1/CLDN4/LRRC8C/RGS2/SLCO4C1/PTAFR/CLCN6/SLC25A32/SLC5A12/ANO7/SLC25A3/SLC12A4/SLC38A7/SLC16A7/APOL1/SLC9A1/SERINC5/SLC6A9/SLC17A5/P2RY6/SLC9A4/SLC52A2/P2RX4/VDAC2/SNCA/SLC66A1/PRAF2/ANO9/MFSD12/PACC1/GABBR1/SLC16A3/SLC25A23/SLC39A14/SLC35D2/SLC25A22/PRNP/SLC35B4 |
| GOBP_RESPONSE_TO_PEPTIDE | 380 | 0.4231318 | 1.725881 | 0.0000010 | 0.0001109 | 0.0000911 | 2755 | NTRK1/ANO1/SOCS1/CA2/PNPLA3/EDNRA/TLR4/PTPN22/TRIB3/STC2/PCSK9/INSIG1/PCK2/GJB2/PPARG/MAP1B/KL/NOD2/LPIN1/NR4A1/CPEB2/PRKCQ/CD36/MIR200A/EREG/GDF15/HDAC9/KLF11/TRIM16/MARS1/SOCS2/KLF2/SLC29A2/SESN2/EGR1/CACNB1/EDN1/EGR2/FBP1/GOT1/PTPRE/ANXA1/GRB10/ENPP1/ZBED3/BTG1/NFKBIA/ERFE/RAB8B/CEACAM1/PTGS2/ICAM1/TNF/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/LTA4H/ZBTB7B/GRB14/EPRS1/BCAR1/FYN/ERRFI1/CCND3/NDEL1/NR4A3/RAB15/CARD9/SLC9A1/JUND/ZDHHC7/STAT1/RIPK2/PIP4K2A/TNFAIP3/SORL1/ASS1/SLC39A14/TIMP1/PRNP/AKT1/KAT2B/TRPV4/DENND4C/MYC/SELENOS/INPPL1/STAT2/GPER1/RELA/SRC/PTPN11/LPIN2/NOD1/ACVR1C/TBC1D4/GPT/DAG1/LPIN3/ABCC1/YWHAG |
| GOBP_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 14 | -0.8776155 | -2.152852 | 0.0000011 | 0.0001191 | 0.0000979 | 356 | CDT1/NDC80/CENPE/NUF2/KIF2C |
| GOBP_MEIOTIC_CELL_CYCLE_PROCESS | 154 | -0.4915931 | -1.916166 | 0.0000012 | 0.0001217 | 0.0001000 | 1256 | SHOC1/KIF18A/RAD54B/ZCWPW1/HSPA2/M1AP/WNT5A/PSMC3IP/CDC25A/RAD54L/BRIP1/FBXO5/MEI1/FMN2/PIWIL2/STAG3/HSF2BP/TRIP13/PTTG1/RAD51AP1/MYBL1/SGO2/TTK/NDC80/FBXO43/CCNB2/NCAPH/NUF2/CCNE2/PLK1/SGO1/CYP26B1/BUB1/DMC1/CDC20/CDC25C/ASPM/TOP2A/CNTD1/BUB1B |
| GOBP_REGULATION_OF_CELL_ACTIVATION | 434 | 0.4064831 | 1.687045 | 0.0000012 | 0.0001217 | 0.0001000 | 2740 | FGL2/PLA2G3/EMILIN2/DPP4/SOCS1/C1QTNF1/RASGRP1/SELP/THY1/IL13RA2/CD274/LGALS7B/TLR4/PTPN22/PDCD1LG2/IL1RL1/CNR1/CTSC/PRDM1/SFRP1/CD55/ADAM8/THEMIS2/NOD2/LDLR/IL4I1/PRKCQ/IL31RA/EBI3/IDO1/BCL2/IL1A/UNC13D/TOX/CLCF1/CD47/CD70/GATA3/SLC7A1/TYRO3/APOE/TNFSF13/TICAM1/CD86/MICA/PLA2G4A/CD9/ANXA1/CD276/NECTIN2/HLA-DOB/MFHAS1/TNFSF9/RIPK3/NFKBID/THBD/CARD11/CEACAM1/DUSP10/IL23A/MYD88/TNF/ZC3H12A/AHR/GAB2/DUSP3/CD83/CX3CL1/IRS2/SYT11/HMOX1/SPHK1/ARG2/IL4R/DLG1/PTAFR/ZBTB7B/CCL5/LGALS9/THBS1/FYN/NR4A3/ITGAM/IL15RA/AXL/SH2B3/JUND/SPINK5/SNCA/FADD/IL1RL2/PLSCR1/ACTA2/RIPK2/IL20RB/PRELID1/TEC/TNFAIP3/CD46/TNFRSF13C/MAP3K8/IL15/SHLD2/PRNP/BCL10/CDKN1A/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1/HLA-F/RORA/UBASH3B/GPER1/GAS6/CD177/RUNX1/PDPN/STX4/CGAS/SRC/PTPN11/IL27RA/IL6ST/STXBP2/BCR/LGALS3/RHBDD3/SYK/MYO18A/SLC15A4 |
| GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE | 36 | -0.7170824 | -2.152611 | 0.0000016 | 0.0001499 | 0.0001232 | 1161 | ABRAXAS1/SPC24/CCNB1/SPAG5/KNL1/CDT1/NDC80/CENPE/NEK2/NUF2/SGO1/KIF2C/SPC25 |
| GOBP_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS | 179 | 0.5064493 | 1.892106 | 0.0000015 | 0.0001499 | 0.0001232 | 2650 | ALOX15/CYP51A1/MVD/HMGCS1/EBP/PSAT1/FDPS/LSS/DHCR7/SLC7A11/MSMO1/HMGCR/INSIG1/CH25H/PCK2/HSD17B7/KL/IDI1/FGFR4/STARD4/FDFT1/HRH1/SQLE/NSDHL/ACLY/SC5D/ALOX15B/FGF2/G6PD/GATA3/SRD5A3/APOE/TM7SF2/ERG28/GOT1/CYP27B1/MVK/P2RY1/TNF/CDH3/CYP46A1/SPHK1/GCH1/PTAFR/BMP2/HSD3B7/P2RY6/SNCA/ZEB2/ITPKA/DGKQ/MFSD12/DHDDS/PDXK/BMP6/ACER2/DHCR24/ASAH2/CYB5R3/GPER1/OSBPL1A/GFI1/GIPC1/ITPKC/SPTSSA/PTS |
| GOBP_REGULATION_OF_CHROMOSOME_ORGANIZATION | 201 | -0.4476498 | -1.800467 | 0.0000015 | 0.0001499 | 0.0001232 | 1101 | HECW2/PKIB/FBXO5/INO80B/ANAPC4/CCNB1/TRIP13/AXIN2/PTTG1/ATF7IP2/TTK/CDT1/CDCA5/NDC80/MAD2L1/CENPF/NCAPH/CENPE/NEK2/PLK1/BUB1/DLGAP5/NCAPG/UBE2C/TOP2A/BUB1B |
| GOBP_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY | 193 | -0.4608469 | -1.847296 | 0.0000017 | 0.0001536 | 0.0001262 | 4152 | H2BC8/H2BC18/NDN/UBN2/SUV39H1/NPM1/H2BC12/TSPYL4/RBBP4/ITGB3BP/BEND3/H3-3A/H1-3/H2AX/H3C6/MCM2/H2BC6/H4C5/CBX3/NAP1L4/SMARCE1/H2BC5/HIRIP3/H4C12/HAT1/FAM172A/SMYD3/H4C6/H2BC4/EZH2/H4C3/H4C2/HDAC5/NASP/MIS18A/H2BC9/NAP1L1/H3C11/H3C1/H2BC11/H3C13/H2BC15/TET1/H4C4/CHAF1B/PADI2/H4C1/M1AP/H3C10/HMGB2/H2BC7/SMARCD3/H2BC3/HELLS/NAP1L3/H4C13/H4C9/ATF7IP2/CENPP/H2BC13/H1-5/H2BC14/H2BC10/H3C7/CENPW/H1-1/ASF1B/H2BC17/H3C12/H3C3/OIP5/HJURP/H3C8/H3C2 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 284 | 0.4515682 | 1.797230 | 0.0000017 | 0.0001536 | 0.0001262 | 2749 | FGL2/DPP4/C1QTNF1/TNFAIP6/SERPINB4/SERPINB2/PTPRO/RTN4R/SEMA3B/ISG15/PHLDB2/PPARG/FAP/OAS3/NOD2/KLF4/LDLR/NLRC5/FNDC4/OAS1/SLIT2/ST6GAL1/PLAU/SERPINB9/SLC12A2/GPS2/USP18/FGF2/CLASP1/GATA3/TYRO3/ARRB2/APOE/SEMA3D/UFD1/EDN1/MICA/CD9/MVK/HCK/CD200R1/MFHAS1/EPPK1/TRIB1/THBD/METRNL/CEACAM1/DUSP10/PLXNA3/ZFP36/SEMA7A/TNF/SOCS3/DUSP3/CX3CL1/SYT11/CALCRL/SEMA3A/SEMA4C/ARG2/PARP14/LGALS9/SEMA6A/THBS1/FYN/CCN3/SLIT1/GREM1/RNF125/SH2B3/SPINK5/MMP28/ADAR/MICB/TRIM21/IL20RB/NPLOC4/TNFAIP3/SEC14L1/TRAFD1/FURIN/SPP1/HLA-F/RORA/SELENOS/UBASH3B/STAT2/GPER1/DRD1/SRC/MUL1/RHBDF2/PPARD/BCR/ALOX5/SYK/IFI16/SEMA4F |
| GOBP_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION | 51 | 0.6955870 | 2.135511 | 0.0000020 | 0.0001779 | 0.0001462 | 2010 | APOBEC3A/RSAD2/ISG15/OAS3/ISG20/OASL/OAS1/MX1/IFIT1/IFITM1/IFIH1/BST2/OAS2/IFITM3/TNF/SHFL/TNIP1/IFIT5/CCL5/PLSCR1/N4BP1/EIF2AK2/APOBEC3B/PARP10/ZNFX1 |
| GOBP_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY | 35 | -0.7091001 | -2.120791 | 0.0000021 | 0.0001779 | 0.0001462 | 4334 | ODAD1/CCDC40/CFAP100/DNAAF11/DRC1/ZMYND10/DNAI3/ODAD4/DNAAF2/CCDC39/DNAI1/DNAAF10/DNAL1/DNAAF3/CCDC65/DNAH7/TEKT2/TTC12/DNAH1/ODAD3/CFAP73/DAW1/DNAI4/DNAAF1/DNAAF4/DNAI2/LRRC49/DNAH2/DNAH5/DNAAF6/DNAAF8/ODAD2 |
| GOBP_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 169 | 0.5050104 | 1.874634 | 0.0000021 | 0.0001779 | 0.0001462 | 1588 | SH2D1B/NOS2/PLA2G3/RASGRP1/IL13RA2/TLR4/PTPN22/KLK7/RSAD2/CD55/NOD2/PVR/RAET1G/CD36/FZD5/UNC13D/DDX60/CLCF1/SLC7A5/GATA3/TNFSF13/TICAM1/CD86/ANXA1/RAET1E/NECTIN2/COLEC10/IL18R1/NFKBID/ARID5A/IL23A/SEMA7A/TNF/GAB2/HK1/HMOX1/IL4R/PTAFR/APPL2/LGALS9/NR4A3/ITGAM |
| GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE | 357 | 0.4208870 | 1.707012 | 0.0000021 | 0.0001779 | 0.0001462 | 2968 | SH2D1B/PLA2G3/RASGRP1/ZBP1/THY1/C8B/CD274/TLR4/PTPN22/CNR1/KLK7/HMSD/RSAD2/CD55/ADAM8/THEMIS2/LAT2/NOD2/GBP5/NLRC5/PVR/PRKCQ/RAET1G/EREG/IFI35/AIM2/IDO1/BCL2/FZD5/CMTM3/GPS2/CLCF1/CD47/IRF7/GATA3/TNFSF13/CD86/PARP9/PLA2G4A/ANXA1/CD276/RAET1E/NECTIN2/COLEC10/HCK/IL18R1/NFKBID/ARID5A/CARD11/CEACAM1/IL23A/TNF/ZC3H12A/CFB/GAB2/DUSP3/IL4R/PTAFR/APPL2/PRKCH/CCL5/LGALS9/BCAR1/FYN/NLRP10/NR4A3/ITGAM/CARD9/PDE4B/FADD/MICB/PLSCR1/RBCK1/RIPK2/C1S/TEC/CD46/AKIRIN2/ZNFX1/IL15/RAB29/SHLD2/PRNP/BCL10/LIMK1/GBP1/PAWR/PLD2/HLA-F/FCN3/POLR3D/C2/CD177/RELA/TRIM5/STX4/CGAS/SRC/IL27RA/PAK2/IL6ST/LGALS3/SYK/IFI16/SLC15A4/VAV2/SKAP1/CSK/IKBKG/IKBKE/HEXIM1/C4BPA/EXOSC6 |
| GOBP_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA | 85 | 0.6086345 | 2.069276 | 0.0000022 | 0.0001780 | 0.0001462 | 2702 | CCL26/NOS2/SOCS1/TLR4/CCL4/PPARG/GBP5/NLRC5/CCL22/CD47/EDN1/PARP9/HCK/SLC26A6/TNF/MYO1C/CX3CL1/PARP14/CCL5/LGALS9/EPRS1/GSN/RAB43/STAT1/ASS1/DAPK3/GBP1/MYC/STX4/CCL20/GBP4/CLDN1/PDE12/ACTG1 |
| GOBP_POSITIVE_REGULATION_OF_LOCOMOTION | 456 | 0.4032557 | 1.676995 | 0.0000022 | 0.0001780 | 0.0001462 | 2712 | CCL26/CCN4/HAS2/TNFAIP6/SELP/THY1/LGR6/CD274/HYAL1/TLR4/CXCL10/PRKD1/HBEGF/CCL4/SEMA3B/CEMIP/SH3RF2/ADAM8/DUOX2/FGFBP1/SLIT2/CXCL8/FLT1/MIR200A/ARTN/NTRK3/HDAC9/CXCL16/F3/BCL2/VEGFA/IL1A/PLAU/NEDD9/RELN/DUOXA2/FGF2/CLASP1/DAPK2/CD47/GATA3/SMOC2/DUOX1/ANXA3/PLA2G7/SEMA3D/ADAM9/EDN1/MET/ANXA1/WASHC1/KITLG/TCAF2/SCARB1/STX3/S100A7/FAM110C/NRP2/HIF1A/SOX9/ROR2/PTGS2/IL23A/KDR/RHOD/SEMA7A/ICAM1/TNF/ZC3H12A/CAMK1D/DDR2/MYO1C/CLDN4/CX3CL1/IRS2/HMOX1/RIPOR1/SPHK1/SEMA3A/SEMA4C/PTAFR/NSMF/EPHA2/BMP2/CCL5/LGALS9/SEMA6A/THBS1/BCAR1/ITGA6/NR4A3/NTN1/SERPINB3/P2RY6/SPAG9/P2RX4/CPNE3/ITGAV/RUFY3/OXSR1/FADD/TJP1/SLC8A1/RAC1/FAM83H/AKT3/ACTA2/RHOB/SCG2/HDAC6/GCNT2/MCU/RHOC/DAPK3/AKT1/JUN/PODXL/LAMB1/TGFBR1/TMSB4X/ADAM17/TRPV4/MYC/GPER1/GAS6/DIAPH1/ITGA3/CD151/PDPN/DRD1/STX4/SRC/HDAC7/RRAS2/CCL20/PLAA/CLDN1/MAPRE2/FERMT1/SHTN1/MIA3/LGALS3/DDRGK1/FUT4/ACTG1/S100A14/TIAM1 |
| GOBP_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 | 81 | 0.6111244 | 2.051251 | 0.0000026 | 0.0002053 | 0.0001687 | 2546 | CCL26/HAS2/ZBP1/IL1R2/HYAL1/CCL4/SFRP1/CXCL8/CCL22/KLF2/EGR1/CD47/HYAL3/EDN1/IL1RN/IRAK2/HIF1A/SOX9/MYD88/ZC3H12A/CX3CL1/RPS6KA4/MAPK11/CCL5/IL1RL2/IRAK1/ST18/GBP1/RORA/MYC/IRAK4/NKX3-1/RELA/CCL20/UPF1 |
| GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS | 77 | 0.6335227 | 2.114456 | 0.0000026 | 0.0002055 | 0.0001688 | 2010 | APOBEC3A/CH25H/RSAD2/ISG15/OAS3/ISG20/OASL/OAS1/MX1/IFIT1/IFITM1/IFIH1/BST2/OAS2/IFITM3/ZFP36/TNF/SHFL/TNIP1/IFIT5/CCL5/TRIM14/GSN/STAT1/PLSCR1/TRIM21/N4BP1/EIF2AK2/APOBEC3B/TRIM25/PARP10/ZNFX1 |
| GOBP_CHROMOSOME_SEPARATION | 88 | -0.5688863 | -2.021222 | 0.0000027 | 0.0002069 | 0.0001700 | 1375 | SHOC1/M1AP/HECW2/FBXO5/ANAPC4/CCNB1/TRIP13/PTTG1/TTK/CDT1/NDC80/MAD2L1/CENPF/NCAPH/CENPE/PLK1/BUB1/DLGAP5/UBE2C/TOP2A/BUB1B |
| GOBP_AXONEME_ASSEMBLY | 78 | -0.5779735 | -2.012822 | 0.0000027 | 0.0002069 | 0.0001700 | 4025 | SPEF1/CFAP100/DNAAF11/CFAP157/LRGUK/DRC1/ZMYND10/DNAI3/ODAD4/TOGARAM1/DNAAF2/RSPH4A/DNAJB13/CCDC39/DNAI1/CFAP74/SPAG17/DNAAF10/HYDIN/BBS2/DNAL1/ARMC2/FOXJ1/DNAAF3/SPEF2/CCDC65/RSPH9/DNAH7/CFAP58/TEKT2/CFAP69/CFAP91/CC2D2A/DRC7/SPAG16/CFAP47/TTC12/DNAH1/ODAD3/IQCG/RSPH1/CFAP73/DAW1/CFAP44/CFAP65/DNAI4/DNAAF1/DNAAF4/DNAI2/MNS1/HOATZ/CFAP43/LRRC49/CFAP206/DNAH2/DNAH5/RP1/DNAAF6/DNAAF8/ODAD2/MEIG1/NEURL1 |
| GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE | 169 | 0.5023979 | 1.864936 | 0.0000027 | 0.0002069 | 0.0001700 | 3697 | FGL2/TNFAIP6/SERPINB4/ISG15/PPARG/OAS3/NOD2/KLF4/LDLR/NLRC5/FNDC4/OAS1/SERPINB9/GPS2/USP18/GATA3/TYRO3/ARRB2/APOE/UFD1/MICA/MVK/HCK/CD200R1/MFHAS1/METRNL/CEACAM1/DUSP10/ZFP36/SOCS3/CX3CL1/SYT11/CALCRL/ARG2/PARP14/LGALS9/FYN/CCN3/RNF125/SPINK5/ADAR/MICB/TRIM21/IL20RB/NPLOC4/TNFAIP3/SEC14L1/TRAFD1/FURIN/HLA-F/RORA/SELENOS/STAT2/GPER1/SRC/MUL1/RHBDF2/PPARD/BCR/ALOX5/SYK/IFI16/SIRT2/ISL1/CRK/DHX58/MIR149/GIT1/ILRUN/HLA-G/PLK2/CXCL17/NMI/HLA-A/SIRPA/TTLL12/HLA-B/HLA-E/LYN/MAPK7 |
| GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION | 99 | -0.5523049 | -2.018499 | 0.0000030 | 0.0002189 | 0.0001799 | 1344 | MTBP/INSR/PKMYT1/CCDC8/FBXO5/ANAPC4/CCNB1/TRIP13/EPGN/KIF20B/TTK/CDT1/NDC80/FBXO43/MAD2L1/CENPF/CDCA2/NEK2/PLK1/BUB1/DLGAP5/CDC25C/BUB1B/MKI67 |
| GOBP_LEUKOCYTE_MEDIATED_IMMUNITY | 258 | 0.4507141 | 1.768009 | 0.0000034 | 0.0002481 | 0.0002039 | 2416 | SH2D1B/NOS2/PLA2G3/RASGRP1/IL13RA2/C8B/SERPINB4/TLR4/CTSC/RSAD2/CD55/LAT2/NOD2/ACE/IL4I1/ULBP1/PVR/RAET1G/SERPINB9/FZD5/UNC13D/CLCF1/CD70/IRF7/GATA3/BST2/ANXA3/ARRB2/TNFSF13/TICAM1/MICA/RAET1E/NECTIN2/ULBP2/HLA-DOB/IL18R1/RIPK3/ARID5A/CEACAM1/IL23A/MYD88/ICAM1/TNF/CEBPG/AHR/GAB2/HMOX1/IL4R/PTAFR/TRPM4/LGALS9/NR4A3/ITGAM/CARD9/RNF19B/TUBB/FADD/CXCL6/ULBP3/IL20RB/C1S/RNF8/CD46/SHLD2/WDR1/BATF/BCL10/HLA-DQB2/HLA-F/ADAM17/IRAK4/C2/CD177 |
| GOBP_CELLULAR_RESPONSE_TO_PEPTIDE_HORMONE_STIMULUS | 226 | 0.4655340 | 1.791432 | 0.0000035 | 0.0002516 | 0.0002067 | 2887 | SOCS1/CA2/PNPLA3/EDNRA/TRIB3/PCSK9/INSIG1/PCK2/GJB2/PPARG/MAP1B/KL/LPIN1/NR4A1/CPEB2/PRKCQ/GDF15/HDAC9/MARS1/SOCS2/SLC29A2/EDN1/FBP1/GOT1/PTPRE/GRB10/ENPP1/ERFE/RAB8B/CEACAM1/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/ZBTB7B/GRB14/EPRS1/BCAR1/ERRFI1/CCND3/NDEL1/NR4A3/RAB15/SLC9A1/ZDHHC7/STAT1/PIP4K2A/SORL1/ASS1/SLC39A14/AKT1/KAT2B/DENND4C/MYC/SELENOS/GPER1/RELA/SRC/PTPN11/LPIN2/TBC1D4/GPT/LPIN3/YWHAG/CSK/CAV1/IGF2 |
| GOBP_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY | 464 | 0.3882675 | 1.620066 | 0.0000038 | 0.0002682 | 0.0002203 | 3036 | CCL26/NTRK1/ADRA1A/RASGRP1/THY1/EDNRA/FZD10/RGS7/PRKD1/RTN4R/CCL4/SFRP1/PPARGC1B/PPARG/ARHGEF5/CCL22/FLT1/NTRK3/ADPRH/AIM2/F3/VEGFA/NEDD9/BBC3/ARHGAP11B/FGF2/GRHL3/RAP1GAP/CD86/PMAIP1/RGS16/XDH/RIC1/DOCK11/RIPK3/BAK1/BIN1/GMIP/HIP1/ASAP3/PML/MAPK12/ADAP2/TNF/SNX9/FAS/SLC27A4/PPP1R15B/CLDN4/CX3CL1/CAV2/NLRP2/PTAFR/EPHA2/BMP2/ARHGAP27/CCL5/LGALS9/GNA15/CYCS/FYN/RHOG/NDEL1/ITGA6/CARD9/SOX7/SERPINB3/GSN/TBC1D22A/P2RY6/ADAP1/SNCA/FADD/SIPA1L2/RAP1GAP2/TBC1D14/RIPK2/ARHGEF10/PRELID1/AKIRIN2/EVI5L/CHN1/ST18/BCL10/FLCN/LPAR2/ACER2/PIP5K1A/SCRIB/TBC1D10A/GNA12/RHOC/S100A10/AKT1/BOK/SH3BP1/MYC/NGEF/NKX3-1/GPER1/PICALM/CCL20/MUL1/PLAA/RAPGEF4/NOD1/MAPRE2/ACVR1C/BID/BCR/DDRGK1/TBC1D4/SYK/TIAM1/IFI16/TBC1D9/RGP1/TBC1D20/TIAM2/EIF2AK3/RAP1A/DOCK7/CAV1/PRSS22/ARF4/TBC1D16/CASP2/CRK/SIPA1L1/FERMT2/DOCK6/SMCR8/LGMN/PCOLCE2 |
| GOBP_INTRACILIARY_TRANSPORT | 36 | -0.7029254 | -2.110113 | 0.0000042 | 0.0002794 | 0.0002296 | 3642 | IFT20/DYNLT2B/IFT46/ARL3/DYNC2I1/IFT122/IFT43/WDR19/DYNC2LI1/PCM1/RPGR/TUB/TTC21A/IFT57/IFT140/IFT27/LCA5/IFT88/IFT52/IFT74/CILK1/BBS12/IFT81/WDR35/IFT172/DYNC2H1/LCA5L/TTC21B |
| GOBP_MEIOSIS_I_CELL_CYCLE_PROCESS | 98 | -0.5423230 | -1.980148 | 0.0000041 | 0.0002794 | 0.0002296 | 1375 | SHOC1/RAD54B/ZCWPW1/HSPA2/M1AP/PSMC3IP/CDC25A/RAD54L/BRIP1/FBXO5/MEI1/FMN2/PIWIL2/STAG3/HSF2BP/TRIP13/PTTG1/RAD51AP1/MYBL1/SGO2/NDC80/CCNB2/CCNE2/PLK1/SGO1/DMC1/CDC25C/TOP2A/CNTD1 |
| GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 164 | 0.5139272 | 1.898501 | 0.0000042 | 0.0002794 | 0.0002296 | 1477 | SH2D1B/NOS2/PLA2G3/RASGRP1/IL13RA2/SERPINB4/TLR4/RSAD2/CD55/NOD2/IL4I1/PVR/RAET1G/SERPINB9/FZD5/UNC13D/CLCF1/GATA3/BST2/ARRB2/TNFSF13/TICAM1/MICA/RAET1E/NECTIN2/IL18R1/RIPK3/ARID5A/CEACAM1/IL23A/ICAM1/TNF/AHR/GAB2/HMOX1/IL4R/PTAFR/TRPM4/LGALS9 |
| GOBP_ADAPTIVE_IMMUNE_RESPONSE | 285 | 0.4370658 | 1.738758 | 0.0000042 | 0.0002794 | 0.0002296 | 2385 | SH2D1B/IL13RA2/C8B/ALOX15/CD274/TLR4/PDCD1LG2/IL1RL1/CTSC/PRDM1/RSAD2/CD55/LAT2/NOD2/IL4I1/PVR/PRKCQ/TAP2/BACH2/EBI3/FZD5/UNC13D/ADCY7/CLCF1/TAP1/CD70/IRF7/GATA3/RAP1GAP/ORAI1/TNFSF13/CD86/MICA/RELB/NFKB2/PLA2G4A/ANXA1/NECTIN2/HLA-DOB/IL18R1/RIPK3/NFKBID/ARID5A/LAMP3/CEACAM1/DUSP10/FCAMR/IL23A/MYD88/ICAM1/TNF/ZC3H12A/AHR/ARG2/IL4R/TRPM4/ZBTB7B/FYN/NLRP10/CARD9/RNF19B/RNF125/TFE3/FADD/CD7/MICB/RAP1GAP2/RIPK2/IL20RB/C1S/RNF8/TEC/TNFAIP3/CD46/TNFRSF13C/SHLD2/BATF/BCL10/HLA-DQB2/HLA-F/ADAM17/RORA/HLA-C/C2 |
| GOBP_RESPONSE_TO_BACTERIUM | 422 | 0.4047564 | 1.673887 | 0.0000041 | 0.0002794 | 0.0002296 | 2737 | NOS2/EMILIN2/SELP/CD274/STATH/TLR4/LPO/PTPN22/PDCD1LG2/DEFB4A/CXCL10/PRKD1/CNR1/KLK7/PCK2/ISG15/CD55/CXCL11/GJB6/GJB2/IL12RB2/OAS3/IL36G/NOD2/CXCL9/TNIP3/LRAT/GBP5/GSDMC/CMPK2/ACE/NR4A1/OAS1/CXCL8/CD36/ALPL/FOS/IDO1/MAPKAPK3/IL36A/IL1A/FZD5/PRB3/ANXA3/TICAM1/CD86/ADAM9/EDN1/MICA/HPGD/CYP27B1/HERC6/KRT6A/HCK/LY96/OAS2/PI3/TRIB1/IRAK2/ARID5A/SCARB1/NFKBIA/S100A7/THBD/C15orf48/DUSP10/PTGS2/CXCL1/IL23A/ZFP36/MYD88/TNF/ZC3H12A/ADAMTS9/CX3CL1/SYT11/RNF213/ARG2/GCH1/PTAFR/TNIP1/EPHA2/OPTN/BMP2/CCL5/LGALS9/NOCT/NLRP10/CXCL2/LYG1/CARD9/HP/AXL/SLC17A5/JUND/SPINK5/NOS1/SNCA/PDE4B/CXCL6/IRAK1/RBCK1/RIPK2/TNFAIP3/AKIRIN2/WASL/ZNFX1/RAB29/ASS1/BMP6/SBNO2/NFKBIB/BCL10/TMEM255A/CAPN2/IFI44/AKT1/ADAM17/SELENOS/PF4V1/C2/MAPKAPK2/RELA/TRIM5/GFI1/SRC/CCL20/GBP4/PLAA/CLDN1/UPF1/IL27RA/NOD1/CSF2/BCL3/CYP2E1/PPARD/BCR/S100A14/SYK/MARCHF2/FER1L6 |
| GOBP_CHROMATIN_REMODELING | 226 | -0.4323764 | -1.765266 | 0.0000046 | 0.0002954 | 0.0002427 | 3971 | NPM1/H2BC12/PIH1D1/KAT2A/TSPYL4/RBBP4/ITGB3BP/RUVBL1/RBBP7/ACTL6A/H3-3A/H1-3/HCFC2/H2AX/H3C6/MCM2/H2BC6/FOXA1/H4C5/CBX3/SMARCA2/ACTR6/NAP1L4/SMARCE1/H2BC5/H4C12/RUVBL2/SMYD3/ANP32E/H4C6/H2BC4/ESR1/H4C3/H4C2/HDAC5/NASP/MIS18A/H2BC9/NAP1L1/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/CHAF1B/H4C1/H3C10/HMGB2/H2BC7/SMARCD3/H2BC3/HELLS/INO80B/NAP1L3/H4C13/H4C9/CHD1L/CENPP/H2BC13/H1-5/H2BC14/H2BC10/H3C7/MYB/CENPW/H1-1/ASF1B/H2BC17/H3C12/H3C3/OIP5/HJURP/H3C8/H3C2 |
| GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT | 358 | 0.4207143 | 1.705542 | 0.0000053 | 0.0003416 | 0.0002806 | 2809 | NTRK1/PLA2G3/ARC/THY1/PMP22/PTPRO/PRKD1/RTN4R/SDC2/CNR1/BDNF/SEMA3B/SFRP1/CRMP1/MAP1B/KLF4/NTNG1/ALKAL1/MFSD2A/SLIT2/NTRK2/NTRK3/MAP2/PPP2R5B/VEGFA/TNIK/TOX/RELN/EPHB3/LRP8/ZNF365/GATA3/APOE/SEMA3D/TWF2/CHODL/PRAG1/EPHA3/DAB1/BRSK2/ROR2/PLXNA3/SEMA7A/CAMK1D/NRCAM/FZD1/LRRC7/CX3CL1/ISLR2/DBN1/SEMA3A/SEMA4C/RGS2/ATP8A2/NSMF/BRSK1/SEMA6A/MARK1/FYN/SLIT1/NDEL1/ITGA6/FKBP1B/NTN1/NDRG4/RUFY3/ARSB/DENND5A/EHD1/PTPRG/CSMD3/ITPKA/PTPN9/TENM3/RAB29/CHN1/ACAP3/PTK6/SPP1/PDLIM5/MBOAT1/LIMK1/AKT1/EFNA5/TRPV4/NGEF/PARP6/NEDD4/SHANK3/SCN1B/GFI1/ITGA3/MCF2/FGF13/EPHA7/PAK2/SHTN1/STK25/MAP2K1/CFL1/COBL/TIAM1/SEMA4F/TIAM2/RAP1A |
| GOBP_DNA_REPLICATION_DEPENDENT_CHROMATIN_ORGANIZATION | 29 | -0.7331369 | -2.134667 | 0.0000057 | 0.0003581 | 0.0002942 | 2521 | H3C6/H4C5/H4C12/HAT1/H4C6/H4C3/H4C2/NASP/H3C11/H3C1/H4C4/CHAF1B/H4C1/H3C10/H4C13/H4C9/H3C7/ASF1B/H3C12/H3C3/H3C8/H3C2 |
| GOBP_MEIOTIC_CHROMOSOME_SEGREGATION | 72 | -0.5754061 | -1.982625 | 0.0000058 | 0.0003642 | 0.0002992 | 2602 | MAPK15/HORMAD1/MRE11/SMC4/NDC1/SMC2/CENPS/ESPL1/SHOC1/ZCWPW1/M1AP/PSMC3IP/BRIP1/FMN2/STAG3/TRIP13/PTTG1/SGO2/TTK/NCAPH/NUF2/CCNE2/PLK1/SGO1/BUB1/DMC1/TOP2A/BUB1B |
| GOBP_CENTROMERIC_SISTER_CHROMATID_COHESION | 11 | -0.8904920 | -2.024711 | 0.0000062 | 0.0003820 | 0.0003138 | 677 | AXIN2/SGO2/SGO1/BUB1/BUB1B |
| GOBP_CILIUM_MOVEMENT | 137 | -0.4876382 | -1.866628 | 0.0000074 | 0.0004513 | 0.0003708 | 3581 | DRC1/ZMYND10/CFAP251/DNAI3/CFAP20/TTC29/ROPN1B/SLC22A16/ENO4/ODAD4/TEKT3/DNAAF2/TEKT5/RSPH4A/CCDC39/CFAP54/DNAI1/SPAG17/HYDIN/BBS2/ARMC2/CFAP52/KIF27/KATNIP/ZBBX/DPCD/SPEF2/CCDC65/TTC21A/RSPH9/GAS2L2/DNAH7/CFAP58/ROPN1L/TEKT2/CFAP61/CFAP69/CFAP91/DRC7/INPP5B/SPAG16/CFAP47/SPA17/TTC12/DNAH9/DNAH1/ODAD3/SLC26A8/IQCG/NME5/CFAP73/DAW1/CFAP221/CFAP44/AQP4/RFX3/CFAP65/PLTP/DNAI4/DNAAF1/DNAAF4/TEKT1/DNAI2/BBS4/MNS1/HOATZ/CFAP70/TCTE1/CFAP43/CFAP45/CFAP206/TEKT4/TTLL6/DNAH5/DNAAF6/CFAP53/ODAD2/NEK10/MEIG1/NEURL1/CATSPERD/EPPIN |
| GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE | 140 | 0.5220207 | 1.902048 | 0.0000081 | 0.0004801 | 0.0003944 | 2603 | CCL26/NTRK1/ADRA1A/RASGRP1/ALOX15/TLR4/PTPN22/CCL4/CD44/NOD2/FGFR4/ALKAL1/CCL22/NTRK2/CD36/NTRK3/IL1A/FGF2/ARRB2/APOE/CAVIN3/P2RY1/MFHAS1/S100A7/ROR2/KDR/SEMA7A/ICAM1/TNF/CX3CL1/BMP2/CCL5/LGALS9/CARD9/ABCA7/NDRG4/P2RY6/ACTA2/RIPK2/GAREM1/GCNT2/JUN/TRPV4/GPER1/GAS6/SRC/PTPN11/CCL20/ARHGAP8/NOD1/PRXL2C |
| GOBP_VIRAL_PROCESS | 357 | 0.4086153 | 1.657241 | 0.0000080 | 0.0004801 | 0.0003944 | 3386 | APOBEC3A/CCL4/CH25H/RSAD2/ISG15/CD55/OAS3/ISG20/OASL/LDLR/ANPEP/NPC1/OAS1/CXCL8/PVR/MX1/IFIT1/ST6GAL1/SLC3A2/BCL2/IFITM1/IFIH1/STOM/IRF7/BST2/TYRO3/APOE/CD86/PARP9/SLC1A5/IFI27/NECTIN2/OAS2/TMPRSS2/SCARB1/LAMP3/VPS37B/IFITM3/ZFP36/VPS37D/ICAM1/TNF/ZC3H12A/IGF2R/RNASEK/CAV2/SHFL/TNIP1/IFIT5/EPHA2/CCL5/ST3GAL4/LGALS9/TRIM14/SERPINB3/GSN/AXL/SLC52A2/ITGAV/TPCN2/ADAR/RAB43/STAT1/PLSCR1/TRIM21/N4BP1/MGAT4B/EIF2AK2/APOBEC3B/EDEM2/TRIM25/CLDN9/CD46/NECTIN4/CHMP6/PARP10/ITGB7/ZNFX1/RAB29/ITGB6/FURIN/CHMP7/JUN/PCBP1/FCN3/NEDD4/GAS6/SLC20A2/TMPRSS4/TRIM5/GFI1/CLDN1/TMEM41B/EPS15/CALCOCO2/PDE12/CFL1/IFI16/DAG1/LARP1/TBC1D20/CCNK/SMPD1/CAV1/HEXIM1/SRPK1/TRIM22/PKN2/VPS4A/DENR/RAD23A/VPS4B/CHMP1B/CSNK1A1/TFRC/P4HB/CD81/ATG7/SNF8/TP53 |
| GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE | 253 | 0.4503913 | 1.761187 | 0.0000083 | 0.0004864 | 0.0003996 | 2753 | PLA2G3/CCN4/TNFAIP6/ZBP1/ALOX15/NCF1/TLR4/IL1RL1/CNR1/CTSC/ADAM8/PPARG/NOD2/KLF4/LDLR/DUOXA1/ACE/FNDC4/IFI35/IDO1/GPS2/DUOXA2/USP18/CD47/GATA3/TYRO3/PLA2G7/APOE/ANXA1/MVK/HCK/CD200R1/OSMR/MFHAS1/NFKBIA/METRNL/DUSP10/PTGS2/IL23A/ZFP36/MYD88/SEMA7A/TNF/PSMA6/SOCS3/CX3CL1/SYT11/CALCRL/SPHK1/TNIP1/CCL5/FYN/NLRP10/CCN3/SNCA/IL1RL2/IL20RB/TNFAIP3/IL15/CELF1/FURIN/SBNO2/C2CD4B/TMSB4X/RORA/TRPV4/SELENOS/GPER1/RELA/CYLD/SRC/RHBDF2/BIRC3/NEAT1/PPARD/IL6ST/BCR/MAPK13/ALOX5/RHBDD3/SYK/ABCC1 |
| GOBP_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY | 221 | 0.4642299 | 1.782950 | 0.0000094 | 0.0005404 | 0.0004440 | 3004 | CCL26/NTRK1/RASGRP1/THY1/FZD10/RGS7/RTN4R/CCL4/SFRP1/ARHGEF5/CCL22/NTRK3/ADPRH/NEDD9/ARHGAP11B/GRHL3/RAP1GAP/RGS16/RIC1/DOCK11/BIN1/GMIP/ASAP3/ADAP2/SNX9/SLC27A4/CX3CL1/CAV2/EPHA2/ARHGAP27/CCL5/RHOG/NDEL1/ITGA6/TBC1D22A/ADAP1/SIPA1L2/RAP1GAP2/TBC1D14/ARHGEF10/EVI5L/CHN1/FLCN/PIP5K1A/SCRIB/TBC1D10A/S100A10/SH3BP1/NGEF/PICALM/CCL20/RAPGEF4/MAPRE2/BCR/TBC1D4/TIAM1/TBC1D9/RGP1/TBC1D20/TIAM2/RAP1A/DOCK7/TBC1D16/CRK/SIPA1L1/FERMT2/DOCK6/SMCR8 |
| GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS | 114 | 0.5501689 | 1.943323 | 0.0000101 | 0.0005668 | 0.0004656 | 1710 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/PCSK9/DHCR7/MSMO1/HMGCR/INSIG1/CH25H/HSD17B7/IDI1/LDLR/FDFT1/NPC1/SQLE/NSDHL/ACLY/SC5D/NFE2L1/LCAT/G6PD/APOE/TM7SF2/CYP27B1/MVK/SCARB1/IDH1/APOL2/CYP46A1/SREBF2/APOBR/CYP2C9/APOL1/ACADL/GBA2 |
| GOBP_POSITIVE_REGULATION_OF_CELL_DEATH | 483 | 0.3757656 | 1.573527 | 0.0000101 | 0.0005668 | 0.0004656 | 2607 | NTRK1/NOS2/IL19/EMILIN2/ZBP1/CD274/TLR4/SPDEF/FZD9/PCSK9/CNR1/CTSC/IFIT2/SFRP1/ADAM8/PPARG/FAP/ALDH1A3/ACE/GADD45G/NR4A1/SLIT2/PHLDA2/CD36/MIR200A/TNFRSF10A/UBD/FOS/KLF11/IDO1/DDIT3/BBC3/OLFM1/EGR1/PLEKHN1/TNFSF12/DAPK2/EEF1A2/ARRB2/UBE2Z/PMAIP1/HPGD/TNFRSF12A/ATF4/OSGIN1/ANXA1/BTG1/RIPK3/BAK1/BIN1/MSX2/RNF122/PML/SYCE3/FOSL1/PTGS2/TNF/ZC3H12A/CAMK1D/FAS/SLC27A4/IGF2R/PEA15/HMOX1/ASCL1/ID3/STK17B/BMP2/CCL5/LGALS9/THBS1/FYN/GADD45A/E2F3/ITGA6/ITGAM/DUSP6/HP/SLC9A1/GSN/SNCA/FADD/VDR/TNFRSF10C/RBCK1/RIPK2/ADCY10/AIFM2/MAP3K9/PRELID1/RHOB/ATF3/HDAC6/LATS2/TP53BP2/CDKN2A/CELF1/DCUN1D3/PHLDA1/PRNP/BCL10/FLCN/ACER2/SQSTM1/CDKN1A/CAPN2/SCRIB/LTBR/DAPK3/PAWR/JUN/BOK/TGFBR1/MYC/NKX3-1/GPER1/GRIK2/EIF4G1/PICALM/CYLD/SRC/PLAGL2/NOD1/TIGAR/EPHA7/ACVR1C/BID/PAK2 |
| GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE | 199 | 0.4696394 | 1.778314 | 0.0000107 | 0.0005961 | 0.0004897 | 2753 | SH2D1B/PLA2G3/CCN4/EMILIN2/RASGRP1/ZBP1/TLR4/IL1RL1/CNR1/KLK7/CTSC/ADAM8/NOD2/GBP5/LDLR/ACE/NLRC5/PVR/RAET1G/EREG/IFI35/AIM2/IDO1/CD47/IRF7/PLA2G7/PARP9/RAET1E/NECTIN2/HCK/OSMR/NFKBIA/PTGS2/IL23A/TNF/CX3CL1/TNIP1/OPTN/CCL5/FYN/NLRP10/CARD9/SNCA/FADD/PLSCR1/RIPK2/AKIRIN2/ZNFX1/IL15/C2CD4B/HLA-F/TRPV4/POLR3D/TRIM5/CGAS/SRC/NOD1/NEAT1/PAK2/IL6ST/MAPK13/SYK/IFI16/SLC15A4/ABCC1 |
| GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN | 154 | 0.5141361 | 1.878411 | 0.0000116 | 0.0006371 | 0.0005234 | 2637 | NOS2/CD274/TLR4/PTPN22/PDCD1LG2/CXCL10/CD55/CXCL11/IL36G/NOD2/CXCL9/TNIP3/CMPK2/CXCL8/CD36/IL36A/IL1A/FZD5/TICAM1/CD86/ADAM9/HCK/LY96/TRIB1/IRAK2/ARID5A/SCARB1/NFKBIA/CXCL1/ZFP36/MYD88/TNF/ZC3H12A/CX3CL1/PTAFR/TNIP1/CCL5/CXCL2/AXL/PDE4B/CXCL6/IRAK1/RIPK2/TNFAIP3/ASS1/BMP6/SBNO2/NFKBIB/BCL10/CAPN2/AKT1/SELENOS/PF4V1/RELA/TRIM5/GFI1/SRC/PLAA/UPF1/CSF2/PPARD/BCR |
| GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN | 247 | 0.4465857 | 1.743580 | 0.0000132 | 0.0007176 | 0.0005895 | 2637 | NOS2/SELP/CD274/TLR4/PTPN22/PDCD1LG2/CXCL10/CNR1/PCK2/CD55/CXCL11/GJB6/GJB2/IL12RB2/IL36G/NOD2/CXCL9/TNIP3/CMPK2/ACE/NR4A1/CXCL8/CD36/ALPL/FOS/IDO1/MAPKAPK3/IL36A/IL1A/FZD5/TICAM1/CD86/ADAM9/EDN1/HPGD/CYP27B1/HCK/LY96/TRIB1/IRAK2/ARID5A/SCARB1/NFKBIA/S100A7/THBD/DUSP10/PTGS2/CXCL1/ZFP36/MYD88/TNF/ZC3H12A/CX3CL1/GCH1/PTAFR/TNIP1/CCL5/LGALS9/NOCT/CXCL2/CARD9/AXL/JUND/NOS1/SNCA/PDE4B/CXCL6/IRAK1/RIPK2/TNFAIP3/AKIRIN2/ASS1/BMP6/SBNO2/NFKBIB/BCL10/CAPN2/AKT1/ADAM17/SELENOS/PF4V1/C2/MAPKAPK2/RELA/TRIM5/GFI1/SRC/PLAA/CLDN1/UPF1/CSF2/PPARD/BCR |
| GOBP_RESPONSE_TO_PEPTIDE_HORMONE | 304 | 0.4243774 | 1.698754 | 0.0000134 | 0.0007179 | 0.0005898 | 2755 | SOCS1/CA2/PNPLA3/EDNRA/TRIB3/STC2/PCSK9/INSIG1/PCK2/GJB2/PPARG/MAP1B/KL/LPIN1/NR4A1/CPEB2/PRKCQ/EREG/GDF15/HDAC9/TRIM16/MARS1/SOCS2/SLC29A2/SESN2/EGR1/EDN1/EGR2/FBP1/GOT1/PTPRE/ANXA1/GRB10/ENPP1/ZBED3/BTG1/ERFE/RAB8B/CEACAM1/PTGS2/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/LTA4H/ZBTB7B/GRB14/EPRS1/BCAR1/ERRFI1/CCND3/NDEL1/NR4A3/RAB15/SLC9A1/JUND/ZDHHC7/STAT1/PIP4K2A/SORL1/ASS1/SLC39A14/TIMP1/AKT1/KAT2B/TRPV4/DENND4C/MYC/SELENOS/INPPL1/STAT2/GPER1/RELA/SRC/PTPN11/LPIN2/ACVR1C/TBC1D4/GPT/DAG1/LPIN3/YWHAG |
| GOBP_SPINDLE_ORGANIZATION | 184 | -0.4427487 | -1.752716 | 0.0000143 | 0.0007592 | 0.0006237 | 2042 | EFHC2/CENPH/RACGAP1/MAP10/AUNIP/ESPL1/EFHC1/KIZ/STIL/GOLGA8M/STMN1/ABRAXAS1/WDR62/STARD9/KIF11/PSRC1/FBXO5/CCNB1/KIFC1/KIF4A/SPAG5/TTK/NDC80/TPX2/CCNB2/CENPE/NEK2/NUF2/PLK1/KIF15/GOLGA8H/CDC20/DLGAP5/ASPM/SPC25/MYBL2 |
| GOBP_VIRAL_LIFE_CYCLE | 267 | 0.4337696 | 1.711075 | 0.0000157 | 0.0008224 | 0.0006756 | 2795 | APOBEC3A/CH25H/RSAD2/ISG15/CD55/OAS3/ISG20/OASL/LDLR/ANPEP/NPC1/OAS1/CXCL8/PVR/MX1/IFIT1/SLC3A2/BCL2/IFITM1/IFIH1/STOM/BST2/TYRO3/APOE/CD86/SLC1A5/IFI27/NECTIN2/OAS2/TMPRSS2/SCARB1/LAMP3/VPS37B/IFITM3/VPS37D/ICAM1/TNF/ZC3H12A/RNASEK/CAV2/SHFL/TNIP1/IFIT5/EPHA2/CCL5/LGALS9/TRIM14/SERPINB3/GSN/AXL/SLC52A2/ITGAV/TPCN2/ADAR/RAB43/PLSCR1/TRIM21/N4BP1/EIF2AK2/APOBEC3B/TRIM25/CLDN9/CD46/NECTIN4/CHMP6/PARP10/ITGB7/ZNFX1/RAB29/ITGB6/FURIN/CHMP7/PCBP1/FCN3/NEDD4/GAS6/SLC20A2/TMPRSS4/TRIM5/CLDN1/TMEM41B/EPS15/PDE12/IFI16/DAG1/LARP1/TBC1D20/CCNK/SMPD1 |
| GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS | 180 | 0.4872539 | 1.822410 | 0.0000162 | 0.0008235 | 0.0006765 | 2805 | NOS2/CD274/TLR4/PTPN22/PDCD1LG2/CXCL10/CD55/CXCL11/IL36G/NOD2/CXCL9/TNIP3/CMPK2/CXCL8/CD36/IL36A/IL1A/DDIT3/FZD5/TICAM1/CD86/ADAM9/HCK/LY96/TRIB1/IRAK2/ARID5A/SCARB1/NFKBIA/CXCL1/ZFP36/MYD88/TNF/ZC3H12A/PPP1R15B/CX3CL1/PTAFR/TNIP1/CCL5/CXCL2/AXL/PDE4B/SLX4/CXCL6/IRAK1/RIPK2/TNFAIP3/ASS1/BMP6/SBNO2/NFKBIB/BCL10/CAPN2/AKT1/SELENOS/PF4V1/MUS81/RELA/TRIM5/GFI1/SRC/PLAA/UPF1/CSF2/TIGAR/PPARD/BCR/WFS1/SYK/SIRT2/EIF2AK3 |
| GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS | 145 | -0.4666049 | -1.795729 | 0.0000162 | 0.0008235 | 0.0006765 | 3165 | TOGARAM1/MAP9/DYNLT1/HSPA1A/CHEK2/PIBF1/GPSM2/AURKA/KIF23/TOGARAM2/CEP97/SAPCD2/PKHD1/EFHC2/CENPH/RACGAP1/MAP10/ESPL1/EFHC1/STIL/ANKFN1/STMN1/ABRAXAS1/WDR62/KIF11/PSRC1/CCNB1/GJA1/KIFC1/KIF4A/TTK/NDC80/MAD2L1/TPX2/CENPE/NEK2/NUF2/PLK1/KIF15/CDC20/DLGAP5/SPC25/MYBL2 |
| GOBP_RESPONSE_TO_INSULIN | 210 | 0.4636959 | 1.769580 | 0.0000162 | 0.0008235 | 0.0006765 | 2755 | SOCS1/PNPLA3/TRIB3/PCSK9/INSIG1/PCK2/PPARG/KL/LPIN1/CPEB2/PRKCQ/HDAC9/MARS1/SLC29A2/SESN2/EGR1/EGR2/FBP1/GOT1/PTPRE/GRB10/ENPP1/ZBED3/ERFE/RAB8B/CEACAM1/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/ZBTB7B/GRB14/EPRS1/BCAR1/ERRFI1/CCND3/NDEL1/RAB15/SLC9A1/ZDHHC7/STAT1/PIP4K2A/SORL1/SLC39A14/AKT1/KAT2B/TRPV4/DENND4C/MYC/SELENOS/INPPL1/SRC/PTPN11/LPIN2/ACVR1C/TBC1D4/GPT/LPIN3/YWHAG |
| GOBP_MITOTIC_SPINDLE_ORGANIZATION | 122 | -0.4857442 | -1.814493 | 0.0000173 | 0.0008690 | 0.0007139 | 2042 | EFHC2/CENPH/RACGAP1/MAP10/EFHC1/STIL/STMN1/ABRAXAS1/WDR62/KIF11/PSRC1/CCNB1/KIFC1/KIF4A/TTK/NDC80/TPX2/CENPE/NEK2/NUF2/PLK1/KIF15/CDC20/DLGAP5/SPC25/MYBL2 |
| GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE | 359 | 0.4052114 | 1.643886 | 0.0000184 | 0.0009143 | 0.0007511 | 1935 | CCL26/NTRK1/ADRA1A/ADRA2C/C1QTNF1/RASGRP1/ALOX15/FZD10/NCF1/TLR4/PTPN22/CCL4/SH3RF2/CD44/ADAM8/KL/NOD2/FGFR4/ARHGEF5/ALKAL1/MAPK8IP2/GADD45G/CCL22/NTRK2/FLT1/CD36/GDF15/NTRK3/VEGFA/TNIK/IL1A/EDAR/FZD5/FGF2/ARRB2/APOE/ADAM9/EDN1/CAVIN3/XDH/P2RY1/KITLG/FGD2/MFHAS1/S100A7/TMEM106A/ROR2/KDR/MYD88/SEMA7A/ICAM1/TNF/ZC3H12A/ANKRD6/CX3CL1/CAV2/LIF/SPHK1/KLB/SEMA3A/SEMA4C/DOK4/BMP2/CCL5/LGALS9/THBS1/TNFRSF19/GADD45A/SOX2/CARD9/ABCA7/NDRG4/MST1R/P2RY6/SPAG9/EIF2AK2/IRAK1/ACTA2/TGFA/RIPK2/TRAF5/GAREM1/PLCE1 |
| GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS | 230 | 0.4510083 | 1.738560 | 0.0000218 | 0.0010733 | 0.0008817 | 2787 | CISH/SOCS1/PNPLA3/ALOX15/MVD/HMGCS1/FDPS/IDI1/FADS1/LPIN1/MFSD2A/PLA2G4C/ABHD4/SOCS2/LCAT/LIPH/FGF2/SRD5A3/PLA2G4A/MVK/SERAC1/GPAT3/LPCAT4/FAR1/IDH1/SOCS3/PISD/TMEM150A/SGMS1/PIGW/SERINC5/PTPMT1/SELENOI/SAMD8/PLSCR1/ITPKA/GPAT4/PGAP4/PIP4K2A/DGKQ/DHDDS/TAFAZZIN/ACP6/CAPN2/PIP5K1A/INPP1/MBOAT1/PIK3C2B/PLD2/INPPL1/DGKA/PTDSS1/CHP1/PITPNM2/ITPKC/PPARD/DOLK/TTC7A/ABHD3/ACSL3 |
| GOBP_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION | 42 | -0.6580110 | -2.032223 | 0.0000223 | 0.0010848 | 0.0008912 | 918 | FBXO5/CCNB1/TRIP13/PTTG1/TTK/CDT1/NDC80/MAD2L1/CENPF/PLK1/BUB1/BUB1B |
| GOBP_PHOSPHOLIPID_METABOLIC_PROCESS | 328 | 0.4122127 | 1.662908 | 0.0000238 | 0.0011442 | 0.0009400 | 2795 | CISH/PLA2G3/SOCS1/PNPLA3/APOC1/ALOX15/MVD/HMGCS1/FDPS/LIPG/PCSK9/IDI1/FADS1/LDLR/FDFT1/LPIN1/MFSD2A/PLA2G4C/ABHD4/ENPP6/ALOX15B/SOCS2/PLAAT1/LCAT/LIPH/FGF2/SRD5A3/PLA2G7/PLA2G4A/GPCPD1/MVK/SCARB1/SERAC1/GPAT3/LPCAT4/FAR1/IDH1/SOCS3/PISD/PLCB3/ABCA3/TMEM150A/SGMS1/PIGW/SERINC5/PTPMT1/SELENOI/SNCA/SAMD8/PLSCR1/ITPKA/GPAT4/PGAP4/PIP4K2A/DGKQ/DHDDS/TAFAZZIN/ACP6/GDPD3/CAPN2/PIP5K1A/INPP1/MBOAT1/PIK3C2B/PLD2/MTMR12/INPPL1/DGKA/SGPP1/PTDSS1/CHP1/PIP4P1/PLAA/PITPNM2/ITPKC/PPARD/DOLK/TTC7A/ABHD3/OSBPL5/ACSL3/SMPD1 |
| GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS | 172 | 0.4911855 | 1.818663 | 0.0000245 | 0.0011654 | 0.0009574 | 2755 | SOCS1/PNPLA3/TRIB3/PCSK9/INSIG1/PCK2/PPARG/KL/LPIN1/CPEB2/PRKCQ/HDAC9/MARS1/SLC29A2/FBP1/GOT1/PTPRE/GRB10/ENPP1/ERFE/RAB8B/CEACAM1/SLC27A4/MYO1C/SOCS3/IRS2/CAV2/RAB31/NAMPT/APPL2/ZBTB7B/GRB14/EPRS1/BCAR1/ERRFI1/CCND3/NDEL1/RAB15/SLC9A1/ZDHHC7/STAT1/PIP4K2A/SORL1/SLC39A14/AKT1/KAT2B/DENND4C/MYC/SELENOS/SRC/PTPN11/LPIN2/TBC1D4/GPT/LPIN3/YWHAG |
| GOBP_CHROMOSOME_CONDENSATION | 40 | -0.6503274 | -1.994619 | 0.0000249 | 0.0011693 | 0.0009606 | 363 | H1-5/CDCA5/H1-1/NCAPH/PLK1/CDK1/NCAPG/TOP2A |
| GOBP_REGULATION_OF_HORMONE_LEVELS | 352 | 0.4029557 | 1.634388 | 0.0000250 | 0.0011693 | 0.0009606 | 2372 | NOS2/ANO1/PLA2G3/TRPV6/SLC5A5/DPP4/C1QTNF1/ADCY5/SLC9B2/STC2/PCSK6/DHCR7/CNR1/SFRP1/PCK2/ADH1C/HSD17B7/PPARG/DUOX2/SLCO4A1/LRAT/SLCO1B1/ALDH1A3/DUOXA1/ACE/FOXD1/IL4I1/CYP2S1/TG/GCNT4/DUOXA2/EGR1/SLC7A5/RDH11/LRRC8A/GATA3/DUOX1/CPT1A/SRD5A3/PLA2G7/EDN1/IL1RN/DOC2B/CYP27B1/ANXA1/RAB11FIP1/P2RY1/SDR16C5/HSD17B12/STX1A/HIF1A/DHRS7/BRSK2/RAB8B/TNF/CYP2C18/NIBAN2/CYP46A1/IRS2/LIF/RETSAT/GPR27/TRPM4/ECE1/BMP2/CCL5/CCN3/BACE2/FKBP1B/CYP2C9/ACSL4/SLC8B1/RDH13/AACS/CYP3A5/DGKQ/PCSK7/VSNL1/LTBP4/GABBR1/SLC39A14/SGPL1/BMP6/FURIN/PIM3/MCU/EIPR1/TFR2/SPP1/ATP1A1/EFNA5/RAB11FIP5/TRPV4/NKX3-1/GPER1 |
| GOBP_MONONUCLEAR_CELL_DIFFERENTIATION | 310 | 0.4158197 | 1.675708 | 0.0000253 | 0.0011718 | 0.0009626 | 2403 | NTRK1/FGL2/SOCS1/RASGRP1/PTPN22/FZD9/BATF3/PRDM1/SFRP1/MT1G/RSAD2/ADAM8/PPARG/BATF2/RUNX2/BCL11B/IL4I1/KLF6/DLL4/IL31RA/UBD/HDAC9/HHEX/BCL2/VEGFA/IL1A/FZD5/TOX/GPS2/EGR1/CLCF1/FASN/LRRC8A/IRF7/GATA3/TYRO3/CD86/RELB/ANXA1/DOCK11/TNFSF9/IL18R1/RIPK3/NFKBID/BAK1/IKZF1/CARD11/DUSP10/ITGB8/IL23A/NFIL3/CEBPG/ZC3H12A/CD83/IL4R/CMTM7/ZBTB7B/LGALS9/IL15RA/AXL/SPINK5/FADD/IL1RL2/MYH9/RIPK2/PRELID1/CD46/IL15/BATF/ITGB6/LTBR/PIR/AP3D1/JUN/ADAM17/RORA/MYC/GAS6/JMJD6 |
| GOBP_MICROTUBULE_BUNDLE_FORMATION | 106 | -0.5011331 | -1.852092 | 0.0000272 | 0.0012471 | 0.0010245 | 3199 | ODAD4/TOGARAM1/DNAAF2/RSPH4A/DNAJB13/CCDC66/CCDC39/DNAI1/CFAP74/SPAG17/DNAAF10/HYDIN/BBS2/DNAL1/ARMC2/FOXJ1/DNAAF3/SPEF2/CCDC65/RSPH9/GAS2L2/DNAH7/CFAP58/TEKT2/CFAP69/CFAP91/CC2D2A/NCKAP5/DRC7/TPPP3/SPAG16/CFAP47/TTC12/DNAH1/ODAD3/IQCG/RSPH1/CFAP73/DAW1/CFAP44/CFAP65/DNAI4/DNAAF1/DNAAF4/DNAI2/MNS1/HOATZ/CFAP43/LRRC49/CFAP206/DNAH2/PSRC1/TTLL6/DNAH5/RP1/DNAAF6/DNAAF8/CAPN6/ODAD2/MEIG1/NEURL1/PLK1/KIF20A |
| GOBP_EXTRACELLULAR_TRANSPORT | 42 | -0.6545712 | -2.021599 | 0.0000278 | 0.0012622 | 0.0010370 | 3199 | ODAD4/DNAAF2/CCDC39/CFAP54/DNAI1/SPAG17/KIF27/KATNIP/DPCD/SPEF2/ROPN1L/SPAG16/SPA17/DNAH9/DNAH1/NME5/DAW1/CFAP221/AQP4/RFX3/DNAAF1/DNAAF4/CFAP43/CFAP45/DNAH5/CFAP53/NEK10 |
| GOBP_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT | 15 | 0.8591812 | 2.035969 | 0.0000286 | 0.0012837 | 0.0010546 | 1361 | NTRK1/GDNF/EDNRA/GATA3/NRP2/ASCL1/SEMA3A |
| GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 124 | 0.5270369 | 1.884621 | 0.0000309 | 0.0013748 | 0.0011294 | 926 | SH2D1B/EMILIN2/RASGRP1/ZBP1/CD274/TLR4/KLK7/ADAM8/NOD2/OASL/GBP5/NLRC5/PVR/RAET1G/EREG/IFI35/AIM2/DDX60/IRF7/PARP9/RAET1E/NECTIN2/HCK/LY96 |
| GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 344 | 0.4009114 | 1.622603 | 0.0000339 | 0.0014801 | 0.0012159 | 2622 | NOS2/PLA2G3/RASGRP1/CD274/TLR4/PTPN22/IL1RL1/RSAD2/ISG15/CD55/ADAM8/IL12RB2/OAS3/NOD2/LUM/GBP5/OAS1/PRKCQ/RAET1G/CD36/EREG/AIM2/EBI3/F3/TRIM16/IDO1/IL36A/ALOX15B/IFIH1/IL1A/DDIT3/FZD5/EGR1/SLC7A5/IRF7/GATA3/TICAM1/CD86/LURAP1/ATF4/SERPINB7/ANXA1/CD276/LY96/OAS2/IL18R1/ARID5A/PANX2/HIF1A/CARD11/TMEM106A/PTGS2/IL23A/MYD88/SEMA7A/TNF/CEBPG/SULF1/CD83/CX3CL1/HK1/HMOX1/SPHK1/NLRP2/IL4R/PTAFR/MAPK11/ZBTB7B/LGALS9/THBS1/NLRP10/NR4A3/CARD9/PDE4B/FADD/IL1RL2/STAT1/EIF2AK2/IRAK1/RIPK2/IL20RB/CD46/AKIRIN2/SORL1/IL15/SULF2/BATF/FURIN/BCL10/SCRIB/HLA-F/ADAM17/RORA/TRPV4/POLR3D/MAPKAPK2/RELA/RUNX1/CGAS/SRC/PTPN11/IL27RA/NOD1/CSF2/BCL3/FERMT1/IL6ST |
| GOBP_DNA_REPLICATION | 266 | -0.3821122 | -1.581945 | 0.0000338 | 0.0014801 | 0.0012159 | 2429 | LRWD1/RFC5/WDHD1/MRE11/JADE1/NASP/ATAD5/ZRANB3/CHTF8/NAP1L1/CENPS/CCNA2/RRM1/CHEK1/DNA2/RPA3/POLE2/POLI/LIG1/ZGRF1/CHAF1B/CDC7/MCM8/BLM/POLN/GINS1/GINS2/POLA2/FBXO5/RECQL4/GLI2/INO80B/ORC1/POLQ/MCIDAS/PCLAF/E2F7/DSCC1/CDT1/GMNN/DACH1/CCNE2/TICRR/GMNC/CDK1/RRM2/DTL/MCM10/ESCO2/FAM111B/ADRA2A |
| GOBP_STEROID_BIOSYNTHETIC_PROCESS | 129 | 0.5114956 | 1.836594 | 0.0000360 | 0.0015568 | 0.0012790 | 1471 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/DHCR7/MSMO1/HMGCR/INSIG1/CH25H/HSD17B7/IDI1/FGFR4/STARD4/FDFT1/SQLE/NSDHL/ACLY/SC5D/IL1A/EGR1/G6PD/SRD5A3/APOE/TM7SF2/ERG28/CYP27B1/MVK/HSD17B12/TNF/CYP46A1/BMP2/HSD3B7 |
| GOBP_T_CELL_ACTIVATION | 362 | 0.3972601 | 1.610977 | 0.0000375 | 0.0016082 | 0.0013212 | 2641 | TREML2/FGL2/DPP4/SOCS1/CDH26/RASGRP1/THY1/CD274/LGALS7B/PTPN22/PDCD1LG2/PRDM1/RSAD2/CD55/CD44/ADAM8/NOD2/RUNX2/BCL11B/IL4I1/PRKCQ/DLL4/EBI3/IDO1/BCL2/IL1A/FZD5/TOX/EGR1/CD47/CD70/GATA3/SLC7A1/HSH2D/CD86/MICA/RELB/ANXA1/CD276/HLA-DOB/TNFSF9/IL18R1/RIPK3/NFKBID/CARD11/CEACAM1/DUSP10/IL23A/ICAM1/ZC3H12A/DUSP3/CD83/ARG2/IL4R/DLG1/ZBTB7B/CCL5/LGALS9/FYN/CCND3/FKBP1B/GSN/SPINK5/FADD/IL1RL2/CD7/MICB/MYH9/RIPK2/IL20RB/PRELID1/ELF4/CD46/TNFRSF13C/MAP3K8/IL15/RAB29/BATF/PRNP/BCL10/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1/MSN/ADAM17/RORA/JMJD6/RUNX1/CD151/CTPS1/CGAS/SRC/PTPN11/IL27RA/BCL3/IL6ST/LGALS3 |
| GOBP_LEUKOCYTE_CELL_CELL_ADHESION | 278 | 0.4173369 | 1.658762 | 0.0000398 | 0.0016906 | 0.0013889 | 2887 | FGL2/HAS2/DPP4/SOCS1/RASGRP1/SELP/THY1/CD274/LGALS7B/SLC39A8/PTPN22/PDCD1LG2/SELL/CD55/CD44/ADAM8/NOD2/KLF4/STK10/IL4I1/PRKCQ/CERCAM/EBI3/IDO1/IL1A/CD47/CD70/GATA3/SLC7A1/CD86/ANXA1/CD276/HLA-DOB/TNFSF9/NFKBID/CARD11/CEACAM1/DUSP10/IL23A/ICAM1/TNF/ZC3H12A/DUSP3/CD83/ARG2/IL4R/DLG1/PTAFR/TNIP1/ZBTB7B/CCL5/ST3GAL4/LGALS9/FYN/NR4A3/FADD/IL1RL2/IRAK1/RIPK2/IL20RB/CD46/TNFRSF13C/ITGB7/MAP3K8/IL15/ASS1/PRNP/BCL10/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1/MSN/CD177/RELA/RUNX1/SRC/PTPN11/IL27RA/IL6ST/MIA3/LGALS3/FUT4/ALOX5/SYK/OLR1/SKAP1/CSK/CAV1/NFAT5/IGF2 |
| GOBP_ERK1_AND_ERK2_CASCADE | 237 | 0.4341435 | 1.682148 | 0.0000420 | 0.0017657 | 0.0014506 | 2603 | CCL26/NTRK1/ADRA1A/RASGRP1/ALOX15/TLR4/PTPN22/CCL4/CD44/SPRY4/NOD2/FGFR4/ARHGEF5/ALKAL1/DUSP5/CCL22/NTRK2/CD36/NTRK3/IL1A/FGF2/ARRB2/APOE/EDN1/CAVIN3/GRB10/P2RY1/MFHAS1/S100A7/SOX9/ROR2/CEACAM1/DUSP10/KDR/SEMA7A/ICAM1/TNF/DUSP3/CX3CL1/LIF/DUSP7/DLG1/SPRED2/TNIP1/EPHA2/BMP2/CCL5/LGALS9/SEMA6A/ERRFI1/CARD9/ABCA7/DUSP6/NDRG4/P2RY6/ITGAV/ACTA2/RIPK2/GAREM1/ATF3/GCNT2/CNKSR3/FLCN/GBP1/JUN/TRPV4/MYC/GPER1/GAS6/SRC/PTPN11/CCL20/ARHGAP8/NOD1/EPHA7/PRXL2C |
| GOBP_REGULATION_OF_VIRAL_PROCESS | 134 | 0.4945707 | 1.785110 | 0.0000440 | 0.0018327 | 0.0015056 | 3085 | APOBEC3A/CH25H/RSAD2/ISG15/OAS3/ISG20/OASL/OAS1/CXCL8/MX1/IFIT1/BCL2/IFITM1/IFIH1/STOM/BST2/TYRO3/NECTIN2/OAS2/TMPRSS2/LAMP3/VPS37B/IFITM3/ZFP36/TNF/SHFL/TNIP1/IFIT5/CCL5/LGALS9/TRIM14/GSN/AXL/ADAR/STAT1/PLSCR1/TRIM21/N4BP1/EIF2AK2/APOBEC3B/TRIM25/PARP10/ZNFX1/FCN3/TMPRSS4/TRIM5/PDE12/IFI16/LARP1/TBC1D20/HEXIM1/SRPK1/TRIM22/PKN2/VPS4A/RAD23A |
| GOBP_MITOTIC_METAPHASE_PLATE_CONGRESSION | 52 | -0.6031529 | -1.954348 | 0.0000445 | 0.0018386 | 0.0015105 | 1478 | KIF22/KIF18A/PSRC1/CCNB1/KIFC1/CDT1/CDCA5/NDC80/KIF14/CENPE/NUF2/KIF2C/CEP55 |
| GOBP_MALE_GAMETE_GENERATION | 375 | -0.3573809 | -1.547192 | 0.0000463 | 0.0018946 | 0.0015565 | 3442 | SMARCA2/PRKAG1/SOX30/FIGNL1/ATM/BRCA2/TCP11/ROPN1B/MERTK/PATZ1/SLC22A16/SPATA6/PYGO1/AZIN2/SFMBT1/OAZ3/PACRG/CFAP54/MORN2/RPL39L/BBS2/SPAG8/SPDYA/SPATA6L/NOTCH1/TSNAXIP1/ARMC2/PAIP2/IMMP2L/SPATA24/SYNE1/FOXJ1/HORMAD1/DPCD/SPEF2/LRRK2/TTC21A/MYCBP/ZSCAN2/CFAP58/ROPN1L/NDC1/CFAP69/IFT27/CFAP91/PCSK4/CREB3L4/DRC7/INPP5B/SPAG16/SPINK1/CFAP47/SPA17/TTC12/NPHP1/ERCC1/RFX2/DNAH1/CETN2/IFT81/HSF2/TSPAN8/SIX5/SLC26A8/IQCG/TDRP/RACGAP1/NME5/CCDC136/RSPH1/SPATA32/TCFL5/CFAP44/SPOCD1/HOOK1/IFTAP/TDRD6/CFAP65/TESMIN/GAMT/BBS4/MNS1/HOATZ/CFAP43/ROS1/MCM8/KIF18A/TSGA10/CFAP206/ZCWPW1/HSPA2/CCDC87/PMFBP1/M1AP/SPATA9/BRIP1/HMGB2/SPAG4/PIWIL2/HROB/HSF2BP/TRIP13/GJA1/ELL3/KIT/MEIG1/PTTG1/NEURL1/YBX2/KNL1/E2F1/MGAT4D/MYBL1/OCA2/MYCBPAP/BCL2L10/H1-1/ASF1B/TSSK3/CYP26B1/AR/CATSPERD/NLRP14/DMC1/ZBTB16/CDC25C/ASPM/CNTD1 |
| GOBP_REGULATION_OF_CELL_CELL_ADHESION | 345 | 0.4082131 | 1.652196 | 0.0000469 | 0.0019045 | 0.0015646 | 2711 | FGL2/EMILIN2/HAS2/DPP4/SOCS1/C1QTNF1/RASGRP1/SELP/THY1/CD274/LGALS7B/PTPN22/PDCD1LG2/MUC21/PLAUR/CD55/CD44/ADAM8/NOD2/KLF4/IL4I1/PRKCQ/EBI3/IDO1/VEGFA/IL1A/FUT3/EPHB3/CD47/CD70/GATA3/SLC7A1/CD86/IL1RN/CD9/ANXA1/CD276/HLA-DOB/TNFSF9/NFKBID/NOTCH4/CARD11/CEACAM1/DUSP10/IL23A/TNF/ZC3H12A/PIEZO1/DUSP3/CD83/CX3CL1/ARG2/IL4R/DLG1/PTAFR/BMP2/ZBTB7B/CCL5/ST3GAL4/LGALS9/FYN/SOX2/NR4A3/SH2B3/FADD/IL1RL2/TJP1/SPINT2/PTPRG/IRAK1/RIPK2/IL20RB/CD46/TENM3/TNFRSF13C/MAP3K8/IL15/GCNT2/ASS1/BMP6/MYO10/PRNP/BCL10/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1/PODXL/EFNA5/TRPV4/UBASH3B/RELA/RUNX1/PDPN/SRC/PTPN11/IL27RA/EPHA7/IL6ST/MIA3/LGALS3/FUT4/ALOX5/SYK |
| GOBP_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT | 125 | 0.5086509 | 1.815047 | 0.0000475 | 0.0019131 | 0.0015717 | 1954 | NTRK1/PLA2G3/PRKD1/CNR1/BDNF/ALKAL1/NTRK2/NTRK3/PPP2R5B/TOX/RELN/LRP8/APOE/TWF2/EPHA3/ROR2/CAMK1D/FZD1/LRRC7/CX3CL1/DBN1/RGS2/ATP8A2/FYN/NDEL1/ITGA6/FKBP1B/NDRG4/ARSB/EHD1/ITPKA/TENM3 |
| GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS | 90 | 0.5683081 | 1.944226 | 0.0000499 | 0.0019751 | 0.0016226 | 2366 | FGL2/SERPINB4/ISG15/PPARG/OAS3/IL4I1/NLRC5/OAS1/SERPINB9/USP18/TYRO3/ARRB2/UFD1/MICA/TRIB1/CEACAM1/DUSP10/AHR/ARG2/PARP14/LGALS9/RNF125/SPINK5/ADAR/MICB/TRIM21/NPLOC4/TNFAIP3/SEC14L1/TRAFD1/HLA-F/STAT2 |
| GOBP_RESPONSE_TO_INTERLEUKIN_1 | 102 | 0.5542671 | 1.936883 | 0.0000495 | 0.0019751 | 0.0016226 | 2546 | CCL26/HAS2/ZBP1/IL1R2/HYAL1/CCL4/SFRP1/CXCL8/CCL22/KLF2/EGR1/CD47/HYAL3/EDN1/IL1RN/ANXA1/IRAK2/HIF1A/SOX9/MYD88/ZC3H12A/CX3CL1/RPS6KA4/MAPK11/CCL5/LGALS9/SNCA/IL1RL2/IRAK1/RIPK2/ST18/GBP1/RORA/MYC/IRAK4/NKX3-1/RELA/SRC/CCL20/UPF1 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | 118 | 0.5243651 | 1.853422 | 0.0000508 | 0.0019932 | 0.0016375 | 1547 | CLDN5/GDNF/FOXE3/ZBED2/PAX6/HES5/TRIM16/MAFF/VEGFA/ALOX15B/IL1A/FGF2/GATA3/SFN/XDH/CYP27B1/CDKN1C/BTG1/NOTCH4/MSX2/S1PR3/VCL/SOX9/CEACAM1/ZFP36/TNF/MAFG/ASCL1/YAP1/LIF/SPRED2/PRKCH/CDKN2B/OSR1/ERRFI1 |
| GOBP_STEROL_METABOLIC_PROCESS | 116 | 0.5249047 | 1.857296 | 0.0000548 | 0.0021341 | 0.0017533 | 1710 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/PCSK9/DHCR7/MSMO1/HMGCR/INSIG1/CH25H/HSD17B7/IDI1/LDLR/FDFT1/NPC1/SQLE/NSDHL/ACLY/SC5D/NFE2L1/LCAT/G6PD/APOE/TM7SF2/ERG28/MVK/SCARB1/APOL2/CYP46A1/SREBF2/APOBR/CYP2C9/APOL1/ACADL/GBA2 |
| GOBP_IMPORT_INTO_CELL | 164 | 0.4806486 | 1.775566 | 0.0000576 | 0.0022172 | 0.0018215 | 2338 | SLC18A2/TRPV6/GDNF/ATP12A/SLC9A3/SLC5A1/SLC39A8/SLC7A11/KCNJ16/LRRC8D/SYNGR3/SLC6A14/CD36/SLC3A2/SLC29A2/SLC12A2/SLC7A5/LRRC8A/SLC7A1/HCN2/SLC1A5/SCNN1D/SLC5A3/SLC36A1/ACSL1/SLC1A4/TRPV3/TNF/SLC27A4/SLC38A1/IRS2/LRRC8C/RGS2/DLG1/TRPM4/SLC15A3/EPRS1/THBS1/FYN/SLC12A4/ATP1B1/SLC9A1/SLC6A9/SLC9A4/NOS1/SNCA/SLC8A1/SLC39A4/ACTB/SLC39A14/PRNP/TFR2/ATP1A1/GRM1/SLC6A11/AKT1/SLC29A4/TRPV4 |
| GOBP_REGULATION_OF_GTPASE_ACTIVITY | 304 | 0.4087300 | 1.636119 | 0.0000579 | 0.0022172 | 0.0018215 | 3004 | CCL26/NTRK1/RASGRP1/THY1/FZD10/RGS7/RTN4R/CCL4/SFRP1/ARHGEF5/CPEB2/CCL22/NTRK2/NTRK3/ADPRH/AMOT/NEDD9/ARHGAP11B/EPHB3/GRHL3/RAP1GAP/ARRB2/RGS16/MET/RIC1/FGD2/DOCK11/BIN1/GMIP/EPHA3/ASAP3/PLXNA3/ADAP2/GPSM1/SNX9/SLC27A4/CX3CL1/CAV2/FGD3/EPHA2/ARHGAP27/CCL5/RHOG/NDEL1/ITGA6/TBC1D22A/FGD6/ADAP1/RASA2/SIPA1L2/RAP1GAP2/TBC1D14/ARHGEF10/STMN3/EVI5L/RASIP1/CHN1/FLCN/PIP5K1A/SCRIB/TBC1D10A/S100A10/SH3BP1/EFNA5/NGEF/PICALM/CCPG1/CCL20/RAPGEF4/MAPRE2/BCR/TBC1D4/TIAM1/TBC1D9/RGP1/VAV2/TBC1D20/TIAM2/RAP1A/DOCK7/TBC1D16/CRK/SIPA1L1/FERMT2/DOCK6/SMCR8 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS | 197 | -0.4141574 | -1.665641 | 0.0000596 | 0.0022615 | 0.0018579 | 3038 | CHEK2/SLF1/GPSM2/AURKA/RAD51B/RGCC/KIF23/SMPD3/NANOGP8/DYRK3/CENPJ/DRD2/EZH2/MAPK15/SASS6/CEP120/CCN2/ATAD5/PBX1/RACGAP1/MAP10/RRM1/ESPL1/STIL/PRKCE/CDC7/MTBP/INSR/ADAMTS1/HSPA2/WNT5A/CDC25A/STOX1/FBXO5/ANAPC4/CCNB1/PIWIL2/EPGN/RAD51AP1/CDC14A/SPAG5/KIF20B/E2F7/CIT/CDT1/CDCA5/NDC80/KIF14/MAD2L1/PLK4/CDK1/RRM2/DTL/DLGAP5/CDC25C/UBE2C |
| GOBP_CENTROMERE_COMPLEX_ASSEMBLY | 30 | -0.6961618 | -2.025210 | 0.0000624 | 0.0023479 | 0.0019289 | 2253 | NASP/MIS18A/CENPH/CENPS/HELLS/CENPK/CENPP/CENPF/CENPW/CENPE/DLGAP5/OIP5/HJURP |
| GOBP_NEGATIVE_REGULATION_OF_CELL_ACTIVATION | 139 | 0.4871617 | 1.769780 | 0.0000643 | 0.0024010 | 0.0019725 | 2372 | FGL2/SOCS1/C1QTNF1/IL13RA2/CD274/LGALS7B/PTPN22/PDCD1LG2/CNR1/SFRP1/LDLR/IL4I1/IL31RA/IDO1/TYRO3/APOE/CD86/MICA/CD9/ANXA1/THBD/CEACAM1/ZC3H12A/DUSP3/CX3CL1/SYT11/HMOX1/ARG2/IL4R/DLG1/ZBTB7B/LGALS9/AXL/SH2B3/IL20RB/TNFAIP3/PRNP/DLG5/SCRIB/PAWR/HLA-F/UBASH3B/GPER1 |
| GOBP_CHROMOSOME_LOCALIZATION | 79 | -0.5301065 | -1.855338 | 0.0000649 | 0.0024056 | 0.0019763 | 1478 | KIF22/KIF18A/PSRC1/FMN2/CCNB1/KIFC1/SPAG5/CDT1/CDCA5/NDC80/KIF14/CENPF/CENPE/NUF2/KIF2C/CEP55/DLGAP5 |
| GOBP_REGULATION_OF_PLATELET_ACTIVATION | 33 | 0.7088682 | 1.995669 | 0.0000708 | 0.0026011 | 0.0021369 | 2711 | EMILIN2/C1QTNF1/SELP/TLR4/PRKCQ/APOE/PLA2G4A/CD9/THBD/CEACAM1/SH2B3/TEC/UBASH3B/PDPN/IL6ST/SYK |
| GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY | 48 | 0.6381020 | 1.923864 | 0.0000763 | 0.0027578 | 0.0022656 | 1835 | SH2D1B/RASGRP1/SERPINB4/ULBP1/PVR/RAET1G/SERPINB9/UNC13D/ARRB2/MICA/RAET1E/NECTIN2/ULBP2/CEACAM1/CEBPG/LGALS9/RNF19B/TUBB/ULBP3 |
| GOBP_METAPHASE_PLATE_CONGRESSION | 64 | -0.5601793 | -1.887646 | 0.0000759 | 0.0027578 | 0.0022656 | 1478 | KIF22/KIF18A/PSRC1/CCNB1/KIFC1/SPAG5/CDT1/CDCA5/NDC80/KIF14/CENPF/CENPE/NUF2/KIF2C/CEP55 |
| GOBP_GLYCEROLIPID_METABOLIC_PROCESS | 322 | 0.3975650 | 1.602154 | 0.0000768 | 0.0027578 | 0.0022656 | 2787 | CISH/PLA2G3/SOCS1/PNPLA3/APOC1/ALOX15/AADAC/LIPG/PCSK9/INSIG1/PCK2/LDLR/LPIN1/MFSD2A/PLA2G4C/ABHD4/ENPP6/SOCS2/PNPLA1/PLAAT1/LCAT/LIPH/FGF2/CPT1A/PLA2G7/APOE/PLA2G4A/GPCPD1/ACSL1/SCARB1/SERAC1/GPAT3/LPCAT4/FAR1/SOCS3/PISD/PLCB3/APOBR/ABCA3/TMEM150A/PIGW/SERINC5/PTPMT1/SELENOI/PLSCR1/ITPKA/DGKI/GPAT4/PGAP4/PLCE1/PIP4K2A/DGKQ/SORL1/TAFAZZIN/ACP6/GDPD3/CAPN2/PIP5K1A/INPP1/MBOAT1/PIK3C2B/PLD2/MTMR12/INPPL1/DGKA/PTDSS1/PIP4P1/PTPN11/LPIN2/PITPNM2/ITPKC/CYP2E1/TTC7A/LPIN3/ABHD3/OSBPL5/ACSL3 |
| GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY | 258 | 0.4179685 | 1.639558 | 0.0000835 | 0.0029761 | 0.0024450 | 2655 | CST1/FETUB/APOC1/SERPINB4/FZD10/SERPINB2/SERPINB10/HMSD/SERPINC1/SERPINB13/PLAUR/SERPINB12/CD44/KLF4/LPIN1/NR4A1/CPEB2/AMOT/HDAC9/VEGFA/CSTA/SERPINB9/IFI6/BST2/ARRB2/SFN/UBE2Z/SERPINB8/SERPINB7/ANXA1/ANOS1/PI3/TIMP2/BIN1/GMIP/LAMP3/TFPI2/ANXA8/PTGS2/ITIH2/GPSM1/TNF/SERPINB6/SLC27A4/SERPINB11/CSTB/RGS2/THBS1/SERPINB1/FKBP1B/SERPINB3/SPINK5/NOS1/SERPINH1/SNCA/SPINT2/ANXA8L1/A2ML1/SORL1/MASTL/SLC39A14/TIMP1/FURIN/PRNP/DHCR24/MICAL1/AKT1/GAS6/PICALM/CHP1/USP14/RFFL/SRC/BIRC3/PAK2/LGALS3/DNAJB6 |
| GOBP_NEGATIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 39 | -0.6390428 | -1.950171 | 0.0000891 | 0.0031283 | 0.0025701 | 918 | FBXO5/CCNB1/TRIP13/TTK/CDT1/NDC80/MAD2L1/CENPF/PLK1/BUB1/BUB1B |
| GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE | 61 | 0.6111885 | 1.949366 | 0.0000887 | 0.0031283 | 0.0025701 | 1591 | NOS2/PLA2G3/IL1R2/NCF1/TLR4/NOD2/GBP5/CD36/ADCY7/TICAM1/HIF1A/DUSP10/MYD88/TNF/ZC3H12A/IL4R/APPL2/CARD9 |
| GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE | 52 | -0.5873256 | -1.903064 | 0.0000942 | 0.0032835 | 0.0026976 | 2458 | HORMAD1/MRE11/SMC4/NDC1/SMC2/ZCWPW1/PSMC3IP/BRIP1/STAG3/TRIP13/SGO2/NCAPH/CCNE2/SGO1/BUB1/DMC1/BUB1B |
| GOBP_REGULATION_OF_MEIOTIC_CELL_CYCLE | 35 | -0.6512333 | -1.947722 | 0.0000974 | 0.0033694 | 0.0027681 | 1301 | INSR/WNT5A/CDC25A/FBXO5/PIWIL2/TRIP13/RAD51AP1/TTK/FBXO43/CDC20/CDC25C/ASPM/CNTD1 |
| GOBP_HORMONE_TRANSPORT | 203 | 0.4472822 | 1.697675 | 0.0001018 | 0.0034965 | 0.0028725 | 2614 | NOS2/ANO1/PLA2G3/TRPV6/C1QTNF1/ADCY5/SLC9B2/CNR1/SFRP1/PCK2/PPARG/SLCO4A1/SLCO1B1/FOXD1/SLC7A5/LRRC8A/GATA3/CPT1A/EDN1/IL1RN/DOC2B/ANXA1/RAB11FIP1/P2RY1/STX1A/HIF1A/BRSK2/RAB8B/TNF/NIBAN2/IRS2/LIF/GPR27/TRPM4/CCL5/CCN3/FKBP1B/ACSL4/SLC8B1/AACS/VSNL1/LTBP4/GABBR1/BMP6/PIM3/MCU/EIPR1/TFR2/SPP1/EFNA5/RAB11FIP5/TRPV4/NKX3-1/GPER1/STX4/PTPN11/RAPGEF4/ACVR1C/PPARD |
| GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY | 195 | 0.4532010 | 1.706706 | 0.0001131 | 0.0038329 | 0.0031489 | 2149 | SH2D1B/RASGRP1/IL13RA2/C8B/SERPINB4/CTSC/RSAD2/CD55/NOD2/IL4I1/ULBP1/PVR/RAET1G/SERPINB9/FZD5/UNC13D/CLCF1/CD70/IRF7/GATA3/ARRB2/TNFSF13/MICA/RAET1E/NECTIN2/ULBP2/HLA-DOB/IL18R1/RIPK3/ARID5A/CEACAM1/IL23A/MYD88/ICAM1/TNF/CEBPG/AHR/IL4R/TRPM4/LGALS9/CARD9/RNF19B/TUBB/FADD/ULBP3/IL20RB/C1S/RNF8/CD46/SHLD2/BATF/BCL10 |
| GOBP_REGULATION_OF_SECRETION | 429 | 0.3676353 | 1.525335 | 0.0001133 | 0.0038329 | 0.0031489 | 2718 | NOS2/ANO1/ADRA1A/PLA2G3/ADRA2C/TRPV6/GDNF/C1QTNF1/IL13RA2/CYP51A1/TLR4/ACHE/ADCY5/SLC9B2/CNR1/SGK1/HMGCR/SFRP1/RSAD2/PCK2/ADAM8/PPARG/ACE/KCNMB4/IL1A/UNC13D/SLC12A2/CLASP1/LRRC8A/CPT1A/HYAL3/APOE/ADAM9/EDN1/TTN/PLA2G4A/DOC2B/ANXA1/RAB11FIP1/P2RY1/RIC1/SYT17/STX1A/OAS2/LLGL2/HIF1A/BRSK2/RAB8B/CEACAM1/TNF/RIMS3/KCNA2/GAB2/IRS2/SYT11/HMOX1/LIF/GPR27/IL4R/PTAFR/TRPM4/BMP2/CCL5/SYT1/LGALS9/CCN3/FKBP1B/RAB15/ITGAM/PRKCG/ACSL4/P2RX4/TPCN2/SNCA/SLC8B1/ATP13A2/AACS/RAB9A/CHMP6/VSNL1/GABBR1/BMP6/PIM3/MCU/EIPR1/TFR2/MICAL1/SPP1/STXBP5/EFNA5/HLA-F/RAB11FIP5/NKX3-1/GPER1/CD177/DRD1/PNKD/STX4/PTPN11/RAPGEF4/RHBDF2/GIPC1/ACVR1C/PPARD/STXBP2/BCR/ALOX5/RALA/RHBDD3/SYK/MYO18A |
| GOBP_DNA_REPLICATION_INDEPENDENT_CHROMATIN_ORGANIZATION | 32 | -0.6663925 | -1.954484 | 0.0001177 | 0.0039542 | 0.0032486 | 4032 | UBN2/RBBP4/ITGB3BP/H3-3A/H4C5/H4C12/HAT1/H4C6/H4C3/H4C2/NASP/MIS18A/H4C4/H4C1/H4C13/H4C9/CENPP/CENPW/ASF1B/OIP5/HJURP |
| GOBP_INTERFERON_GAMMA_PRODUCTION | 77 | 0.5705778 | 1.904370 | 0.0001308 | 0.0043616 | 0.0035833 | 1872 | RASGRP1/CD274/LGALS7B/TLR4/PTPN22/PDCD1LG2/IL1RL1/ISG15/IL12RB2/NOD2/EBI3/DDIT3/FZD5/CD47/SLC7A5/GATA3/CD276/IL18R1/RIPK3/ARID5A/IL23A/TNF/CEBPG/ZC3H12A/LGALS9/AXL/PDE4B/FADD/RIPK2/IL20RB |
| GOBP_MONOCYTE_CHEMOTAXIS | 39 | 0.6719330 | 1.965495 | 0.0001363 | 0.0045140 | 0.0037085 | 1561 | CCL26/PTPRO/CXCL10/CCL4/SLIT2/CCL22/FLT1/PLA2G7/ANXA1/S100A7/CX3CL1/CCL5/CCN3/GREM1 |
| GOBP_PYRIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS | 33 | 0.6947392 | 1.955892 | 0.0001527 | 0.0050220 | 0.0041258 | 2035 | IDO2/PSAT1/SLC5A8/NNMT/HAAO/ALPL/IDO1/PARP9/NUDT17/QPRT/NAMPT/KYNU/NADK/PARP10/PDXK |
| GOBP_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 80 | -0.5125528 | -1.799874 | 0.0001639 | 0.0053519 | 0.0043968 | 1930 | PBX1/RRM1/ESPL1/STIL/CDC7/MTBP/ADAMTS1/HSPA2/CDC25A/STOX1/FBXO5/ANAPC4/CCNB1/CDT1/CDCA5/CDK1/RRM2/DTL/DLGAP5/CDC25C/UBE2C |
| GOBP_CELL_CHEMOTAXIS | 213 | 0.4292488 | 1.638277 | 0.0001659 | 0.0053804 | 0.0044203 | 1831 | CCL26/DPP4/TNFAIP6/PTPRO/DEFB4A/CXCL10/PRKD1/HBEGF/CCL4/CH25H/CXCL11/ADAM8/NOD2/CXCL9/ARHGEF5/HRH1/NR4A1/SLIT2/CXCL8/CCL22/PRKCQ/FLT1/CXCL16/VEGFA/SLC12A2/FGF2/DAPK2/SMOC2/PLA2G7/ARRB2/EDN1/MET/ANXA1/CCR3/S100A7/CXCL1/IL23A/KDR/CAMK1D/CX3CL1/ITGA9/TRPM4/EPHA2/PLEKHG5/CCL5/HSD3B7/LGALS9/THBS1/BCAR1/RHOG/CXCL2/CCN3/GREM1/LOX/MMP28/P2RX4/OXSR1/PDE4B/CXCL6/RAC1/SLC8B1 |
| GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR | 192 | 0.4442700 | 1.673043 | 0.0001674 | 0.0053902 | 0.0044283 | 3063 | CCL26/HAS2/HYAL1/CCL4/SFRP1/PCK2/CXCL8/CCL22/UBD/AIM2/CXCL16/KLF2/GPS2/CD70/GATA3/HYAL3/ADAM9/EDN1/NFKBIA/PTGS2/ZFP36/TNF/ZC3H12A/FAS/KRT18/CX3CL1/SPHK1/GCH1/CCL5/THBS1/TNFRSF19/TNFRSF25/STAT1/TRAF5/CDIP1/TNFAIP3/TNFRSF13C/ASS1/ST18/GBP1/AKT1/YBX3/TMSB4X/ADAM17/RORA/NKX3-1/GPER1/GAS6/RELA/RFFL/CYLD/CCL20/CLDN1/MAP4K3/BIRC3/SYK/SMPD1/TRAF3IP2/ACTN4/CCDC3/PELI3/ARHGEF2/NKIRAS2 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION | 224 | 0.4311466 | 1.659480 | 0.0001696 | 0.0054229 | 0.0044552 | 2887 | EMILIN2/HAS2/DPP4/SOCS1/RASGRP1/SELP/THY1/CD274/PTPN22/PDCD1LG2/PLAUR/CD55/CD44/ADAM8/NOD2/IL4I1/PRKCQ/EBI3/IL1A/FUT3/CD47/CD70/GATA3/SLC7A1/CD86/ANXA1/CD276/HLA-DOB/TNFSF9/NFKBID/CARD11/DUSP10/IL23A/TNF/PIEZO1/CD83/CX3CL1/IL4R/PTAFR/ZBTB7B/CCL5/ST3GAL4/LGALS9/FYN/SOX2/NR4A3/FADD/IL1RL2/TJP1/IRAK1/RIPK2/CD46/TNFRSF13C/MAP3K8/IL15/GCNT2/MYO10/BCL10/AP3D1/HLA-DQB2/AKT1/PODXL/RELA/RUNX1/PDPN/SRC/PTPN11/IL27RA/IL6ST/FUT4/ALOX5/SYK/SKAP1/CSK/CAV1/NFAT5/IGF2 |
| GOBP_HYALURONAN_BIOSYNTHETIC_PROCESS | 13 | 0.8529732 | 1.947950 | 0.0001743 | 0.0055365 | 0.0045485 | 307 | HAS2/HYAL1/CEMIP/HAS3 |
| GOBP_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM | 493 | 0.3564201 | 1.493651 | 0.0002025 | 0.0063886 | 0.0052485 | 4871 | ADRA1A/PTPN22/TRIB3/PRKD1/ATP6V1C2/NOD2/ATP6V0D2/NPC1/UCHL1/ADPRH/RAB24/BCL2/PLK3/DDIT3/DEPP1/FZD5/SESN2/DAPK2/HSPB8/EEF1A2/TICAM1/MET/HK2/WASHC1/LAMP3/HIF1A/VPS37B/MAP1LC3B2/GPSM1/KDR/VPS37D/ZC3H12A/ATP6V0A2/RUBCN/VMP1/SYT11/RNF213/HMOX1/OPTN/SREBF2/TRIM14/RRAGC/RRAGD/TPCN2/SNCA/CAMKK2/ARSB/RAB43/TRIM21/TBC1D14/ATP13A2/RIPK2/CTTN/PIP4K2A/HDAC6/ATP6V1E2/CHMP6/TAFAZZIN/RASIP1/FLCN/ACER2/SQSTM1/DEPDC5/MTCL1/CHMP7/DAPK3/AKT1/BOK/ATG4D/TECPR2/AUP1/NEDD4/EIF4G1/FOXK1/TRIM5/SRC/MUL1/PLAA/CPTP/EPM2A/ATG2A/TMEM41B/MCOLN1/NOD1/TIGAR/NRBP2/CALCOCO2/DDRGK1/RGS19/IFI16/LARP1/SIRT2/STX12/HAX1/IKBKG/FOXK2/MFN2/TRIM22/EVA1A/SMCR8/PIP4K2C/ATG101/VPS4A/RPTOR/VPS4B/TSC1/HTT/CHMP1B/PACS2/ILRUN/MAP1LC3B/PLK2/ATG9A/ATG7/SNF8/TP53/PLEKHM1/RAB8A/PGAM5/VPS37A/TGFBRAP1/RNF185/TOLLIP/GABARAPL1/ATP6V1H/ITGB4/ARL8B/SPTLC2/VTI1A/ERN1/RETREG3/EXOC8/MAP1S/PHF23/SNX30/UBQLN1/CDK5R1/CDC37/MTOR/TAB3/GNAI3/SLC25A46/BCL2L11/PIK3CB/RAB7A/RMC1/SLC25A5/RNF166/TP53INP2/TSPO/TRIM65/ATG4A/TBC1D25/VCP/MVB12A/RHEB/ATG13/UFM1/DRAM1/VPS29/MAPK3/ATP6V0A1/USP36/TFEB/RAB5A/PSEN1/ATP6V0B/ATP6V1B2/ATP6V0D1/ZFYVE1/RALB/VPS26A/TAB2/SH3BP4/NUPR1/UBXN2A/CAPN1/VIPAS39/FBXL2/SMG1/TECPR1/TLK2/MCL1/TMEM208/ATG16L1/CSNK2A2/ACBD5/VPS33B/UBQLN4/GSK3A/RNF41/RAB3GAP2/DNM1L/CHMP1A/ATP6V0E1/PIKFYVE/MARK2/STAM/CHMP3/SPTLC1/GSK3B/PARL/KEAP1/GOLGA2/STUB1/DAP/SBF2/ELAPOR1/SEC16A/BAD |
| GOBP_CELLULAR_RESPONSE_TO_LIPID | 432 | 0.3558567 | 1.473720 | 0.0002041 | 0.0063959 | 0.0052545 | 2731 | NOS2/FZD10/CD274/BRINP1/TLR4/PTPN22/PDCD1LG2/ADCY5/CXCL10/SGK1/INSIG1/SFRP1/PCK2/CD55/CXCL11/GJB2/PPARGC1B/IL36G/NOD2/CXCL9/TNIP3/LBH/LDLR/CMPK2/ACE/NPC1/CXCL8/CD36/NTRK3/IL36A/IL1A/LRP8/CPT1A/GJB3/TICAM1/CD86/ADAM9/EDN1/TWF2/CYP27B1/ANXA1/HCK/LY96/KLF9/TRIB1/IRAK2/ARID5A/SCARB1/NFKBIA/EPHA3/MSX2/SOX9/CXCL1/ZFP36/MYD88/TNF/ZC3H12A/AHR/CX3CL1/YAP1/ID3/PTAFR/TNIP1/WNT6/CCL5/OSR1/CXCL2/ERRFI1/NR4A3/PIM1/AXL/PDE4B/CXCL6/IRAK1/VDR/RIPK2/TNFAIP3/HDAC6/IL15/ASS1/BMP6/SBNO2/NFKBIB/BCL10/PTK6/CAPN2/SPP1/ATP1A1/AKT1/MSN/EFNA5/RORA/MYC/SELENOS/NKX3-1/GPER1/PF4V1/NEDD4/RELA/TRIM5/GFI1/SRC/PLAA/CLDN1/UPF1/CSF2/PPARD/BCR/DDRGK1/SYK/DAG1/TEAD2 |
| GOBP_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | 169 | 0.4491309 | 1.667205 | 0.0002086 | 0.0064933 | 0.0053345 | 2655 | CST1/FETUB/SERPINB4/SERPINB2/SERPINB10/HMSD/SERPINC1/SERPINB13/PLAUR/SERPINB12/CD44/KLF4/NR4A1/VEGFA/CSTA/SERPINB9/IFI6/BST2/ARRB2/SFN/UBE2Z/SERPINB8/SERPINB7/ANOS1/PI3/TIMP2/BIN1/LAMP3/TFPI2/ANXA8/PTGS2/ITIH2/TNF/SERPINB6/SERPINB11/CSTB/THBS1/SERPINB1/SERPINB3/SPINK5/SERPINH1/SNCA/SPINT2/ANXA8L1/A2ML1/SORL1/TIMP1/FURIN/PRNP/DHCR24/MICAL1/AKT1/GAS6/PICALM/USP14/RFFL/SRC/BIRC3/PAK2/DNAJB6 |
| GOBP_TRIGLYCERIDE_METABOLIC_PROCESS | 69 | 0.5623644 | 1.841004 | 0.0002164 | 0.0066927 | 0.0054984 | 1094 | PNPLA3/APOC1/AADAC/LIPG/PCSK9/INSIG1/PCK2/LDLR/LPIN1/MFSD2A/PNPLA1/LIPH/CPT1A/APOE/ACSL1/SCARB1/GPAT3 |
| GOBP_HYALURONAN_METABOLIC_PROCESS | 23 | 0.7364559 | 1.931168 | 0.0002201 | 0.0067614 | 0.0055548 | 1159 | HAS2/TNFAIP6/HYAL1/CEMIP/CD44/HAS3/FGF2/HYAL3/ITIH2 |
| GOBP_CHLORIDE_TRANSPORT | 74 | 0.5568810 | 1.848768 | 0.0002249 | 0.0068617 | 0.0056372 | 1688 | ANO1/GABRA4/SLC26A4/CA2/SLC26A9/SLC5A1/TTYH2/ANO2/CLIC2/ANO4/CLIC3/SLC12A2/LRRC8A/CLIC4/SLC26A6/ANO8/ATP8B1/CLDN4/PTAFR/CLCN6/ANO7/SLC12A4/APOL1/P2RY6 |
| GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 69 | 0.5608528 | 1.836055 | 0.0002291 | 0.0069446 | 0.0057053 | 1949 | FGL2/IL13RA2/SERPINB4/CD55/NOD2/IL4I1/SERPINB9/CD47/BST2/ARRB2/MICA/ANXA1/CEACAM1/DUSP10/TNF/ZC3H12A/AHR/HMOX1/IL4R/ZBTB7B/LGALS9/SPINK5/IL20RB/CD46 |
| GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION | 43 | -0.5890669 | -1.827631 | 0.0002327 | 0.0069643 | 0.0057214 | 2458 | HORMAD1/MRE11/NDC1/ESPL1/ZCWPW1/PSMC3IP/BRIP1/FMN2/STAG3/TRIP13/PTTG1/SGO2/CCNE2/PLK1/SGO1/DMC1 |
| GOBP_SIGNAL_RELEASE | 321 | 0.3921017 | 1.577528 | 0.0002312 | 0.0069643 | 0.0057214 | 2629 | NOS2/ANO1/ADRA1A/PLA2G3/ADRA2C/TRPV6/GDNF/C1QTNF1/SNPH/ADCY5/SLC9B2/CNR1/SFRP1/PCK2/PPARG/FOXD1/NR4A1/UNC13A/KCNMB4/ERC2/IL1A/LRRC8A/GATA3/CPT1A/EDN1/IL1RN/PLA2G4A/DOC2B/ANXA1/RAB11FIP1/P2RY1/SYT17/STX1A/STX3/SYN2/HIF1A/BRSK2/RAB8B/PPFIA3/TNF/RIMS3/NIBAN2/KCNA2/IRS2/SYT11/LIF/GPR27/TRPM4/BRSK1/CCL5/SYT1/CCN3/FKBP1B/PRKCG/ACSL4/P2RX4/SNCA/SLC8B1/AACS/VSNL1/LTBP4/GABBR1/BMP6/PIM3/MCU/EIPR1/TFR2/SCRIB/SPP1/STXBP5/EFNA5/RAB11FIP5/TRPV4/NKX3-1/GPER1/DRD1/PNKD/STX4/PTPN11/RAPGEF4/GIPC1/ACVR1C/PPARD/STXBP2 |
| GOBP_CELLULAR_AMINO_ACID_METABOLIC_PROCESS | 238 | 0.4177512 | 1.622315 | 0.0002390 | 0.0071076 | 0.0058392 | 1183 | NOS2/IDO2/CBS/HPDL/SLC39A8/WARS1/PSAT1/SLC7A11/TAT/GARS1/KYAT1/ASNS/HAAO/ASPG/IL4I1/BCAT1/PYCR1/PHGDH/IDO1/MARS1/GPT2/ARHGAP11B/YARS1/DPYD/AARS1/TARS1/GOT1/ATF4/CTH/IARS1/SHMT2/GGT5/GFPT2/HAL/SARS1 |
| GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY | 104 | -0.4635941 | -1.702819 | 0.0002409 | 0.0071191 | 0.0058486 | 3467 | CFAP251/DNAI3/CFAP20/ROPN1B/SLC22A16/ENO4/TEKT3/DNAAF2/TEKT5/RSPH4A/CCDC39/CFAP54/DNAI1/BBS2/ARMC2/CFAP52/DPCD/SPEF2/CCDC65/TTC21A/RSPH9/GAS2L2/DNAH7/CFAP58/ROPN1L/TEKT2/CFAP69/DRC7/INPP5B/SPAG16/CFAP47/TTC12/EFHC2/DNAH1/SLC26A8/IQCG/CFAP44/EFHC1/RFX3/CFAP65/PLTP/DNAH3/TEKT1/DNAH6/BBS4/MNS1/HOATZ/TCTE1/CFAP43/CFAP45/CFAP206/TEKT4/DNAH2/TTLL6/DNAH5/DNAAF6/MEIG1/NEURL1/CATSPERD/EPPIN |
| GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY | 167 | 0.4575906 | 1.695723 | 0.0002441 | 0.0071668 | 0.0058878 | 1268 | CCL26/ALOX15/MMP1/TLR4/TRABD2A/WARS1/ISG15/CDC42EP5/MAP1B/GBP5/ARHGEF5/CD36/PPP2R5B/VEGFA/CLASP1/CDC42EP1/MET/HCK/BAK1/BIN1/BIK/CAPG/OCLN/MYD88/TNF/SNX9/PIEZO1 |
| GOBP_RESPONSE_TO_EXTRACELLULAR_STIMULUS | 367 | 0.3747291 | 1.519100 | 0.0002471 | 0.0072113 | 0.0059244 | 2822 | NTRK1/CBS/FOXA3/POSTN/CXCL10/PRKD1/STC2/LIPG/PCSK9/CNR1/SFRP1/PCK2/PPARG/MAP1B/KL/NOD2/LRAT/NUAK1/FADS1/LDLR/SGIP1/ASNS/SLC25A25/ACE/MFSD2A/ALPL/GDF15/FOS/MARS1/BCL2/IL1A/DDIT3/SESN2/G6PD/CPT1A/APOE/PMAIP1/ATF4/CYP27B1/ACSL1/KIF26A/BRSK2/FOSL1/PTGS2/MAP1LC3B2/ZFP36/TNF/ZC3H12A/FAS/SLC27A4/HMOX1/RIPOR1/ASCL1/APPL2/BRSK1/SREBF2/CDKN2B/NOCT/RRAGC/FKBP1B/PRKCG/PIM1/RRAGD/AXL/ARSB/STAT1/SLC8A1/EIF2AK2/VDR/KYNU/SLC39A4/UPP1/TRIM25/ATF3/SORL1/IL15/ASS1/BCL10/FLCN/CDKN1A/DEPDC5/NDOR1/SPP1/AKT1/TRPV4/GAS6/GAS2L1/EIF4G1/FOXK1/PLEC/SRC/ACVR1C/PPARD/GPT/IFI16/PPARGC1A/LARP1/CHSY1/KPTN/SIRT2/EIF2AK3/MTHFR |
| GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 54 | 0.6022003 | 1.867929 | 0.0002515 | 0.0072926 | 0.0059912 | 4053 | SERPINB4/ISG15/PPARG/OAS3/NLRC5/OAS1/SERPINB9/USP18/TYRO3/ARRB2/MICA/CEACAM1/DUSP10/PARP14/LGALS9/ADAR/TRIM21/TNFAIP3/TRAFD1/HLA-F/STAT2/MUL1/IFI16/CRK/DHX58/HLA-G/NMI/HLA-A/TTLL12/HLA-B/HLA-E/FAM3A/CACTIN/YTHDF3 |
| GOBP_ANION_TRANSMEMBRANE_TRANSPORT | 184 | 0.4433257 | 1.666059 | 0.0002550 | 0.0073501 | 0.0060385 | 2163 | ANO1/GABRA4/SLC5A5/SLC26A4/SLC9A3/SLC26A9/SLC5A1/SLC39A8/SLC24A3/SLC5A8/SLC7A11/ANO2/LRRC8D/CLIC2/ANO4/SLC3A2/SLC12A2/SLC7A5/LRRC8A/SLC7A1/SLC1A5/SLC4A9/TCAF2/LRRC8B/SLC26A6/SLC26A11/SLC1A4/TNF/SLC4A3/SLC25A1/LRRC8C/RGS2/PTAFR/CLCN6/SLC25A32/SLC5A12/ANO7/SLC25A3/SLC12A4/SLC38A7/SLC16A7/APOL1/SLC9A1/SLC6A9/SLC9A4/VDAC2/SLC66A1/PRAF2/ANO9/MFSD12/SLC16A3/SLC35D2/SLC25A22/PRNP/SLC35B4 |
| GOBP_KINETOCHORE_ORGANIZATION | 22 | -0.7293591 | -2.001199 | 0.0002615 | 0.0074905 | 0.0061538 | 2332 | SMC4/SMC2/CENPH/CENPS/CENPK/CDT1/NDC80/CENPF/CENPW/CENPE/NUF2/DLGAP5 |
| GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS | 476 | 0.3566468 | 1.491240 | 0.0002652 | 0.0075487 | 0.0062016 | 3443 | NOS2/IDO2/APOBEC3A/MVD/HMGCS1/SLC2A6/ADCY5/ELOVL6/SLC5A8/HKDC1/ACSS2/HMGCR/UAP1/NNMT/CRMP1/GARS1/HAAO/ME1/ADCY4/PDE9A/CMPK2/ELOVL5/PDE8B/ACLY/ALDOB/PDE10A/IDO1/ACOT1/ANTKMT/ADCY7/GUCY2C/DPYD/PARP9/FBP1/ELOVL7/HK2/GALT/XDH/MVK/PRTFDC1/ENPP1/HSD17B12/SHMT2/ACSL1/NUDT17/GFPT2/GNE/ALDOC/QPRT/PANK3/HIF1A/CARD11/FAR1/MLXIPL/PFKP/AMD1/ACOT7/SLC25A1/MAGI3/HK1/DLG1/NAMPT/EPHA2/UAP1L1/UCKL1/ELOVL1/ACSL4/DPYSL2/NOS1/ENTPD2/OGDH/ELOVL4/UXS1/SNCA/GNPNAT1/PDE4B/GMPR/ACACA/NUDT8/TYMP/APOBEC3B/ADCY10/KYNU/UPP1/GPAT4/NADK/VPS9D1/GALK1/REXO2/PARP10/TAFAZZIN/PMM2/ENTPD5/FLCN/ENO1/ATP5MC1/TJP2/PDHA1/TMSB4X/RORA/MYC/FOXK1/ATP5F1D/PTHLH/CTPS1/ACOT9/TIGAR/PRXL2C/NT5C2/AMDHD2/ENTPD6/DLST/NAPRT/PPARGC1A/ACSL3/HACD1/FLAD1/PFKFB2/FOXK2/GMDS/UGP2/NUDT16/SIRT6/DCTD/GFUS/NPR2/ADPGK/GFPT1/DCK/GPI/GIT1/GLRX/ATP5MC3/GUK1/NCOR1/PMVK/PDE4D/PANK4/SLC26A2/SLC25A16/ADSS2/CNP/ICMT |
| GOBP_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS | 139 | 0.4657185 | 1.691880 | 0.0002760 | 0.0078107 | 0.0064168 | 3063 | SOCS1/ZBP1/IL1R2/TLR4/ISG15/PPARG/OAS3/KLF4/NLRC5/OAS1/SLIT2/IFIH1/GPS2/USP18/IRF7/EDN1/PARP9/IL1RN/PXDN/IRAK2/HIF1A/SPHK1/PARP14/CCL5/AXL/SH2B3/ADAR/FADD/IRAK1/RIPK2/TNFAIP3/ADAM17/STAT2/GAS6/GFI1/RFFL/CYLD/PTPN11/MUL1/SYK/PALM3/CAV1/IKBKE/CCDC3/PELI3/NKIRAS2 |
| GOBP_EPIDERMAL_CELL_DIFFERENTIATION | 151 | 0.4675141 | 1.711478 | 0.0002779 | 0.0078176 | 0.0064225 | 1689 | SPRR2E/SPRR3/SPRR2F/SPRR2A/KRT16/TMC1/SPRR1A/ZBED2/KLF4/GRXCR2/PAX6/SPRR2D/BCL11B/EREG/FA2H/HES5/TRIM16/MAFF/ALOX15B/CSTA/IL1A/SFN/PLS1/ADAM9/CLIC4/CYP27B1/ANXA1/OVOL1/FOSL2/LCE1E/S100A7/MSX2/ZFP36/MAFG/CDH3/YAP1/EPHA2/PRKCH/ERRFI1/IRF6/SPINK5 |
| GOBP_RESPONSE_TO_CHEMOKINE | 53 | 0.6066444 | 1.881416 | 0.0002853 | 0.0079098 | 0.0064983 | 1780 | CCL26/CXCL10/CCL4/CXCL11/CXCL9/SLIT2/CXCL8/CCL22/SLC12A2/EDN1/CCR3/HIF1A/CXCL1/ZC3H12A/CX3CL1/CCL5/CXCL2/LOX/SH2B3/OXSR1/CXCL6 |
| GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION | 163 | 0.4542208 | 1.676452 | 0.0002863 | 0.0079098 | 0.0064983 | 2722 | PLA2G3/CCN4/TNFAIP6/TLR4/SLC9B2/BATF3/SFRP1/MT1G/PPARGC1B/PPARG/BATF2/IL31RA/UBD/FOS/VEGFA/FASN/IRF7/GATA3/RELB/KITLG/TRIB1/ROR2/CEACAM1/ITGB8/IL23A/TNF/GAB2/LIF/EPHA2/LGALS9/TFE3/FADD/PRXL2A/MYH9/FAM20C/JUNB/IL15/BATF/ITGB6/SBNO2/LTBR/PIR/JUN/MYC/UBASH3B/RUNX1/SRC/CSF2/SNX10/IFI16 |
| GOBP_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS | 421 | 0.3683784 | 1.525097 | 0.0002842 | 0.0079098 | 0.0064983 | 2650 | SLC5A5/EDNRA/ALOX15/CYP51A1/MVD/HMGCS1/EBP/PSAT1/FDPS/LSS/PCSK9/DHCR7/SLC7A11/MAOA/MSMO1/ACSS2/HMGCR/INSIG1/CH25H/PCK2/ADH1C/HSD17B7/KL/IDI1/FGFR4/DUOX2/LRAT/LDLR/STARD4/ALDH1A3/DUOXA1/FDFT1/NPC1/HRH1/TG/SQLE/NSDHL/ALPL/ACLY/SC5D/BCL2/ALOX15B/NFE2L1/GCNT4/LCAT/DUOXA2/TTPA/FGF2/G6PD/RDH11/GATA3/DUOX1/SRD5A3/APOE/TM7SF2/ERG28/PLA2G4A/GOT1/CYP27B1/MVK/P2RY1/SLC5A3/SDR16C5/SCARB1/HIF1A/DHRS7/IDH1/TNF/CYP2C18/CDH3/APOL2/ATP8B1/CYP46A1/SPHK1/RETSAT/GCH1/PTAFR/GPD2/BMP2/HSD3B7/TPK1/SREBF2/APOBR/CYP2C9/ITGAM/APOL1/ACADL/P2RY6/GBA2/SNCA/SGPP2/ZEB2/RDH13/ITPKA/CYP3A5/DGKQ/GALK1/MFSD12/DHDDS/LIPA/PDXK/GDPD3/BMP6/ACER2/DHCR24/INPP1/ITPK1/ASAH2/CYB5R3/GPER1/SGPP1/OSBPL1A/GFI1/DRD1/PNKD/CLN6/PIP4P1/GIPC1/TIGAR/ITPKC/CYP2E1/PPARD/SPTSSA/PTS |
| GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION | 236 | 0.4092558 | 1.584740 | 0.0003104 | 0.0084747 | 0.0069623 | 1938 | HAS2/DPP4/LOXL4/MMP1/SLC39A8/VIT/POSTN/COL13A1/KLK7/ADAMTS14/PHLDB2/HAS3/ADAM8/MMP16/FAP/FGFR4/LUM/NTNG1/NID2/MMP19/NOXO1/CLASP1/MMP25/SMOC2/NFKB2/SH3PXD2B/WASHC1/RIC1/HSD17B12/PXDN/MMP17/COLGALT2/SERAC1/CAPG/ADAMTSL3/SOX9/TNF/SULF1/DDR2/ADAMTS9/CAV2/FOXF2/SCX/BMP2/ENG/ADAMTS17/MMP11/COL22A1/GREM1/LOX/GSN/SPINK5/COL17A1/MMP28/SERPINH1/MMP10/LAMB3/PLOD3/SPINT2/COLGALT1/EGFL6/BMP1/COL14A1 |
| GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 269 | -0.3681810 | -1.529097 | 0.0003090 | 0.0084747 | 0.0069623 | 1957 | KANK2/PBX1/RRM1/CHEK1/ESPL1/GPNMB/STIL/BRCA1/CDC7/MTBP/ADAMTS1/HSPA2/ABRAXAS1/CDC25A/BLM/HECW2/STOX1/FHL1/FBXO5/ANAPC4/CCNB1/ORC1/TRIP13/CDC14A/E2F1/E2F7/CCL2/TTK/CDT1/CDCA5/NDC80/KIF14/MAD2L1/CENPF/CENPE/PLK1/TICRR/CDK1/ANLN/RRM2/DTL/BUB1/GTSE1/DLGAP5/CDC25C/UBE2C/BUB1B |
| GOBP_BEHAVIOR | 411 | 0.3625831 | 1.501929 | 0.0003135 | 0.0085096 | 0.0069910 | 1754 | NTRK1/CLDN5/SLC18A2/DPP4/GDNF/ARC/LYPD1/BRINP1/ADM2/FZD9/ADCY5/CNR1/SLC7A11/SGK1/AFF2/MME/BDNF/HTR1D/HMGCR/LDLR/ALDH1A3/SGIP1/MAPK8IP2/ACE/NPC1/MFSD2A/HRH1/NTRK2/HOMER2/UCHL1/GDF15/FOS/IDO1/BCL2/TMOD1/GCNT4/RELN/LPAR5/EGR1/FGF12/CPT1A/ARRB2/APOE/EGR2/ITPR3/P2RY1/GJB4/MMP17/DAB1/HIF1A/FOSL1/PTGS2/CIART/MAFG/KCNA2/SYT11/CSTB/ATP8A2/BRSK1/PER3/THBS1/KRAS/FYN/NR4A3/ABCA7/PRKCG/NDRG4/P2RX4/SNCA/FADD |
| GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY | 11 | -0.8190624 | -1.862302 | 0.0003198 | 0.0086031 | 0.0070678 | 337 | CDC20B/PLK1/CDC20/UBE2C |
| GOBP_CELL_JUNCTION_ASSEMBLY | 339 | 0.3791513 | 1.532043 | 0.0003206 | 0.0086031 | 0.0070678 | 2855 | NTRK1/CLDN5/THY1/PTPRO/ACHE/CDH6/CLDN22/BDNF/SFRP1/GJB6/PHLDB2/GJB2/MAP1B/GPC6/ACE/LRRTM2/NTRK2/NTRK3/BCL2/VEGFA/FZD5/CDH19/ANK2/EPHB3/CLASP1/CD9/GJA4/LRRC4/LRFN4/EPHA3/SLK/VCL/OCLN/ESAM/KDR/RHOD/PKP2/TNF/UGT8/NRCAM/FZD1/MYO1C/VSTM5/CRB3/IL1RAPL2/DUSP3/CLDN4/VMP1/PCDHB2/IGFN1/DLG1/EPHA2/PRKCH/THBS1/SLIT1/GREM1/ITGA6/LSR/NTN1/SLC9A1/COL17A1/SNCA/TJP1/RAC1/MARVELD3/CTTN/CLDN9/ACTB/RAB29/CLDN7/WDR1/FLCN/DLG5/PIP5K1A/PDLIM5/RHOC/DAPK3/S100A10/SH3BP1/EFNA5/TRPV4/PCDHB6/SHANK3/EIF4G1/PLEC/ACTN1/DRD1/SRC/HDAC7/CLDN1/FGF13/TLN2/EPHA7/STRN/PAK2/BCR/LRRN3/CAMSAP3/ACTG1/GPC4/SETD5/RAP1A/CLDN12/CAV1/TESK2 |
| GOBP_RESPONSE_TO_TYPE_I_INTERFERON | 58 | 0.5929659 | 1.871820 | 0.0003287 | 0.0087200 | 0.0071639 | 1827 | ZBP1/CH25H/ISG15/OAS3/NLRC5/OAS1/MX1/IFIT1/IFITM1/USP18/IRF7/IFI27/SHMT2/OAS2/IFITM3/MYD88/SHFL/ADAR/FADD/STAT1/IRAK1 |
| GOBP_INTERLEUKIN_1_PRODUCTION | 76 | 0.5514392 | 1.841574 | 0.0003275 | 0.0087200 | 0.0071639 | 1547 | IL1R2/TLR4/NOD2/GBP5/CD36/AIM2/TRIM16/FZD5/EGR1/ARRB2/ANXA1/PANX2/S1PR3/PML/TMEM106A/CEACAM1/MYD88/TNF/ZC3H12A/CX3CL1/HK1/SPHK1/NLRP2/ARG2/LGALS9/SERPINB1/NLRP10/ERRFI1 |
| GOBP_LYMPHOCYTE_MIGRATION | 72 | 0.5490673 | 1.814899 | 0.0003383 | 0.0089246 | 0.0073320 | 2678 | CCL26/CXCL10/CCL4/CH25H/CXCL11/ADAM8/STK10/CCL22/ARTN/CXCL16/SLC12A2/GATA3/CD200R1/RIPK3/S100A7/ICAM1/CX3CL1/CCL5/HSD3B7/OXSR1/FADD/SLC8B1/WASL/ITGB7/AKT1/MSN/ADAM17/GAS6/PLEC/CCL20/IL27RA/MIA3/FUT4 |
| GOBP_REGULATION_OF_AUTOPHAGY | 306 | 0.3933286 | 1.580679 | 0.0003472 | 0.0091077 | 0.0074824 | 4771 | ADRA1A/PTPN22/TRIB3/PRKD1/ATP6V1C2/NOD2/ATP6V0D2/NPC1/UCHL1/BCL2/PLK3/DDIT3/DEPP1/FZD5/SESN2/DAPK2/HSPB8/EEF1A2/TICAM1/MET/WASHC1/LAMP3/HIF1A/GPSM1/KDR/ZC3H12A/ATP6V0A2/RUBCN/HMOX1/OPTN/SREBF2/TRIM14/RRAGC/RRAGD/TPCN2/SNCA/CAMKK2/TRIM21/TBC1D14/ATP13A2/RIPK2/CTTN/PIP4K2A/HDAC6/ATP6V1E2/RASIP1/FLCN/ACER2/DEPDC5/MTCL1/DAPK3/AKT1/BOK/NEDD4/EIF4G1/FOXK1/TRIM5/CPTP/EPM2A/ATG2A/NOD1/TIGAR/NRBP2/CALCOCO2/IFI16/LARP1/SIRT2/HAX1/IKBKG/FOXK2/TRIM22/SMCR8/PIP4K2C/RPTOR/TSC1/HTT/PLK2/ATG7/TP53/RAB8A/ATP6V1H/SPTLC2/ERN1/EXOC8/PHF23/SNX30/UBQLN1/CDK5R1/MTOR/TAB3/GNAI3/BCL2L11/PIK3CB/RMC1/SLC25A5/TP53INP2/TSPO/TRIM65/TBC1D25/RHEB/DRAM1/VPS29/MAPK3/ATP6V0A1/USP36/TFEB/ATP6V0B/ATP6V1B2/ATP6V0D1/RALB/VPS26A/TAB2/SH3BP4/NUPR1/CAPN1/FBXL2/SMG1/TECPR1/TLK2/MCL1/ATG16L1/CSNK2A2/UBQLN4/GSK3A/RNF41/RAB3GAP2/DNM1L/ATP6V0E1/SPTLC1/GSK3B/PARL/KEAP1/GOLGA2 |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME | 88 | -0.4966993 | -1.764746 | 0.0003640 | 0.0094953 | 0.0078008 | 3499 | ZWILCH/BRCA2/RUVBL2/WRAP53/SLF1/IK/MSH2/MRNIP/ESR1/EZH2/LRWD1/HASPIN/FAM47E/MTBP/MCM8/KNL1/TTK/H1-5/CDT1/CDCA5/NDC80/PLK1/CDK1/ESCO2 |
| GOBP_FEMALE_MEIOTIC_NUCLEAR_DIVISION | 27 | -0.6787145 | -1.950297 | 0.0003742 | 0.0097072 | 0.0079749 | 918 | FBXO5/FMN2/HSF2BP/TRIP13/TTK/NDC80/CCNB2/NCAPH/PLK1/TOP2A |
| GOBP_INORGANIC_ANION_TRANSPORT | 133 | 0.4943595 | 1.784212 | 0.0003975 | 0.0102532 | 0.0084234 | 1723 | ANO1/GABRA4/SLC5A5/SLC26A4/CA2/SLC26A9/SLC5A1/SLC39A8/TTYH2/ANO2/LRRC8D/CLIC2/ANO4/TG/CLIC3/SLC12A2/LRRC8A/ATF4/CLIC4/ENPP1/SLC4A9/LRRC8B/SLC26A6/SLC26A11/SLC1A4/ANO8/SLC4A3/ATP8B1/CLDN4/LRRC8C/PTAFR/CLCN6/ANO7/SLC25A3/SLC12A4/APOL1/P2RY6/VDAC2 |
| GOBP_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION | 81 | -0.4996339 | -1.761363 | 0.0004049 | 0.0103312 | 0.0084875 | 918 | FBXO5/CCNB1/TRIP13/PTTG1/TTK/CDT1/NDC80/MAD2L1/CENPF/PLK1/BUB1/TOP2A/BUB1B |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION | 187 | 0.4342450 | 1.629216 | 0.0004037 | 0.0103312 | 0.0084875 | 2887 | HAS2/DPP4/SOCS1/RASGRP1/SELP/THY1/CD274/PTPN22/PDCD1LG2/CD55/CD44/ADAM8/NOD2/IL4I1/PRKCQ/EBI3/IL1A/CD47/CD70/GATA3/SLC7A1/CD86/ANXA1/CD276/HLA-DOB/TNFSF9/NFKBID/CARD11/DUSP10/IL23A/TNF/CD83/IL4R/PTAFR/ZBTB7B/CCL5/ST3GAL4/LGALS9/FYN/NR4A3/FADD/IL1RL2/IRAK1/RIPK2/CD46/TNFRSF13C/MAP3K8/IL15/BCL10/AP3D1/HLA-DQB2/AKT1/RELA/RUNX1/SRC/PTPN11/IL27RA/IL6ST/FUT4/ALOX5/SYK/SKAP1/CSK/CAV1/NFAT5/IGF2 |
| GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS | 262 | 0.4005874 | 1.574032 | 0.0004080 | 0.0103523 | 0.0085049 | 2887 | NOS2/PLA2G3/C1QTNF1/APOC1/TRIB3/SLC2A6/DHCR7/CNR1/SLC7A11/INSIG1/NNMT/PPARG/FGFR4/LDLR/STARD4/MFSD2A/HRH1/ELOVL5/PHLDA2/PPP1R3G/ANTKMT/SESN2/EGR1/CPT1A/APOE/PMAIP1/FBP1/CYP27B1/ANXA1/P2RY1/ENPP1/ERFE/HIF1A/SOX9/CEACAM1/PTGS2/MLXIPL/TNF/SLC27A4/IRS2/PTAFR/APPL2/BMP2/PPP1R3C/PPTC7/NR4A3/ACADL/P2RY6/NOS1/SNCA/FAM3C/NLN/DGKQ/TAFAZZIN/ENTPD5/BMP6/SLC35B4/FLCN/MID1IP1/ENO1/AKT1/KAT2B/TMSB4X/RORA/MYC/SELENOS/GPER1/FOXK1/GFI1/SRC/CLYBL/ARPP19/TIGAR/PRXL2C/PPARD/GPT/PPARGC1A/CAV1/DUSP12/MIDN/PFKFB2/IGF2 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION | 29 | -0.6605761 | -1.923393 | 0.0004280 | 0.0107134 | 0.0088015 | 2836 | RAD51B/DYRK3/ATAD5/PBX1/RRM1/CDC7/HSPA2/CDC25A/STOX1/FBXO5/CCNB1/CDK1/DTL/CDC25C |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION | 23 | -0.6919580 | -1.923140 | 0.0004264 | 0.0107134 | 0.0088015 | 1344 | KNTC1/ZWILCH/IK/HASPIN/MTBP/KNL1/TTK/CDT1/NDC80/CDK1 |
| GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY | 48 | 0.5989110 | 1.805704 | 0.0004314 | 0.0107134 | 0.0088015 | 1780 | NOS2/RASGRP1/SERPINB4/PVR/SERPINB9/ARRB2/MICA/RAET1E/NECTIN2/RIPK3/CEACAM1/IL23A/ICAM1/LGALS9/ITGAM/FADD/CXCL6 |
| GOBP_SKIN_DEVELOPMENT | 207 | 0.4147205 | 1.574163 | 0.0004297 | 0.0107134 | 0.0088015 | 1689 | SPRR2E/LGR5/SPRR3/SPRR2F/SPRR2A/KRT16/SPRR1A/ZBED2/PAX6/SPRR2D/BCL11B/ALOXE3/NSDHL/EREG/FA2H/TRIM16/BCL2/ALOX15B/CSTA/IL1A/EDAR/FOXQ1/GRHL3/GJB3/SFN/ADAM9/MET/CLIC4/CYP27B1/ANXA1/OVOL1/FOSL2/LCE1E/S100A7/MSX2/SOX9/ZFP36/TNF/SLC27A4/CDH3/CLDN4/YAP1/ATP8A2/EPHA2/PRKCH/ELOVL1/TNFRSF19/ERRFI1/ITGA6/LSR/IRF6/SPINK5 |
| GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY | 342 | 0.3705499 | 1.497377 | 0.0004380 | 0.0108202 | 0.0088893 | 4015 | CCL26/SELP/ALOX15/MMP1/TLR4/TRABD2A/WARS1/ISG15/CDC42EP5/MAP1B/GBP5/ARHGEF5/SLIT2/CD36/MAP2/PPP2R5B/VEGFA/TMOD1/LCAT/CLASP1/CDC42EP1/ARHGAP40/APOE/TICAM1/TWF2/MET/TMC8/HCK/STX1A/BAK1/BIN1/BIK/CAPG/OCLN/SOX9/ESAM/MYD88/TNF/TMSB10/SNX9/FLII/PIEZO1/DBN1/SVIL/DLG1/ABCA3/GSN/ARPC5L/SSH1/GBA2/VDAC2/SNCA/RAC1/EIF2AK2/VASP/CTTN/KANK3/NCLN/HDAC6/SEPTIN8/SORL1/RASIP1/SPTBN5/RHOC/STXBP5/MSN/TMSB4X/EIF4G1/RANGRF/SRC/PTPN11/CPTP/CSF2/FERMT1/BID/LGALS3/CAMSAP3/SYK/SIRT2/ARPC4/HAX1/TRIOBP/SKAP1/TMOD2/AIDA/IKBKE/ISL1/PFN1/H3-3B/INPP5J/FERMT2/SPTBN1/TFRC/GIT1/SPTAN1/CTNNBIP1/MYADM/WASHC2C/TP53/FBLIM1/RNF4/ARPC5/CYRIB/RAB3A/NCKAP1/SLF2/PREB/AJUBA/FNIP1/NAPA/HSPA5/ARPC1B/ANKRD27/CDK5R1/TMOD3/FNIP2/ARPC1A/ARFGEF1/HIP1R/ARF6/MTOR/NRG1/COTL1/BCL2L11/CYFIP1/TIRAP/HCLS1 |
| GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION | 51 | -0.5515787 | -1.784784 | 0.0004515 | 0.0110942 | 0.0091144 | 918 | MTBP/FBXO5/CCNB1/TRIP13/TTK/CDT1/NDC80/FBXO43/MAD2L1/CENPF/PLK1/BUB1/BUB1B |
| GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION | 364 | 0.3720742 | 1.509697 | 0.0004649 | 0.0113051 | 0.0092877 | 2627 | HAS2/DPP4/GDNF/EDNRA/HYAL1/PRSS3/KRT16/PRKD1/HBEGF/SEMA3B/PPARG/FAP/KLF4/FGFBP1/S100P/NR4A1/SLIT2/MIR200A/DLL4/PKN3/AMOT/HDAC9/VEGFA/FGF2/CLASP1/TNFSF12/GATA3/SMOC2/ANXA3/APOE/SEMA3D/ADAM9/EDN1/MET/ANXA1/KITLG/EPPK1/SCARB1/NRP2/HIF1A/PML/SOX9/CEACAM1/DUSP10/PTGS2/KDR/SEMA7A/TNF/ZC3H12A/PTP4A3/DDR2/ADAMTS9/ARID5B/HMOX1/SEMA3A/SEMA4C/EPHA2/APPL2/ENG/PLEKHG5/SEMA6A/THBS1/BCAR1/GADD45A/CCN3/GREM1/TESK1/P2RX4/ARSB/STAT1/SLC8A1/RAC1/PTPRG/ZEB2/AKT3/ACTA2/MYH9/MARVELD3/NRTN/ALX1/RHOB/SCG2/HDAC6/ITGB7/CSNK2B/SGPL1/TIMP1/PIP5K1A/GNA12/AKT1/JUN/SH3BP1/TGFBR1/TMSB4X/ADAM17/ZFAND5/ITGA3/TACSTD2/RFFL/PLEC/SRC/HDAC7/PTPN11/GIPC1/MAPRE2/FERMT1/ACVR1C/PPARD/MIA3 |
| GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS | 373 | 0.3666323 | 1.494403 | 0.0004639 | 0.0113051 | 0.0092877 | 3386 | SOCS1/THY1/APOC1/PTPN22/PTPRO/TRIB3/WARS1/PPP1R16B/HMGCR/SFRP1/PPARG/SPRY4/PAX6/LPIN1/SLIT2/PTPRQ/UCHL1/NTRK3/PTPRH/HHEX/CBLC/ARRB2/APOE/SFN/FBP1/XDH/GRB10/WASHC1/ENPP1/ZBED3/CDKN1C/MFHAS1/TRIB1/BAK1/OCLN/CEACAM1/DUSP10/TRIB2/MLXIPL/TNF/ZC3H12A/NIBAN1/PPP1R15B/RUBCN/SOCS3/DUSP3/IRS2/DBNDD1/RGS2/DUSP7/SPRED2/PARP14/BMP2/ENG/CDKN2B/GADD45A/ERRFI1/GREM1/FKBP1B/DUSP6/SERPINB3/SH2B3/TESK1/SPAG9/SNCA/ADAR/ZGPAT/SLC8A1/ANKLE2/PIP4K2A/TNFAIP3/DGKQ/LATS2/CHMP6/SORL1/MASTL/RASIP1/GPRC5A/CDKN2A/CNKSR3/PRNP/FLCN/CDKN1A/PTK6/MICAL1/AKT1/KAT2B/JUN/PPP4R2/ZFYVE28/UBASH3B/EIF4G1/CHP1/PIK3IP1/PLEC/DBNDD2/ARPP19/TIGAR/PAK2/CADM4/LGALS3/YWHAG/SIRT2/SMPD1/CSK/CAV1/MIDN/AIDA/HEXIM1/PRKAR1B/SIRT6/INPP5J/CBL/SMCR8/PIP4K2C/LRRK1/PKIA/SWAP70/HEG1/INPP5F/GIT1/SPRED1/IBTK/MYADM/NCOR1/UBE2B/PDE4D/TP53 |
| GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS | 237 | 0.4009139 | 1.553395 | 0.0004791 | 0.0115907 | 0.0095222 | 1792 | PLA2G3/APOC1/ALOX15/CBS/TRIB3/TBXAS1/FADS2/PSAT1/ELOVL6/LIPG/INSIG1/FGFR4/FADS1/STARD4/ALDH1A3/ASNS/HAAO/ELOVL5/BCAT1/ALOXE3/SCD/PYCR1/FA2H/ACLY/PHGDH/IDO1/ALOX15B/LIPH/FASN/MTHFD1L/DPYD/EDN1/ELOVL7/PLA2G4A/GOT1/CTH/ANXA1/HSD17B12/SHMT2/GGT5/CEACAM1/PTGS2/MLXIPL/ACOT7/CYP46A1/GGT7/LTA4H/HSD3B7/ELOVL1/CYP2C9/SERINC5/ACADL/ELOVL4/ACACA/PLOD3/NAGS |
| GOBP_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION | 50 | -0.5687773 | -1.829090 | 0.0004912 | 0.0117603 | 0.0096616 | 2402 | RFC5/ZRANB3/CHTF8/CDC7/BLM/GINS1/GINS2/FBXO5/MCIDAS/E2F7/DSCC1/CDT1/GMNN/DACH1/TICRR |
| GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS | 264 | 0.3967322 | 1.561448 | 0.0004909 | 0.0117603 | 0.0096616 | 2787 | CISH/PLA2G3/SOCS1/PNPLA3/APOC1/ALOX15/LDLR/LPIN1/MFSD2A/PLA2G4C/ABHD4/ENPP6/SOCS2/PLAAT1/LCAT/LIPH/FGF2/PLA2G7/PLA2G4A/GPCPD1/SCARB1/SERAC1/GPAT3/LPCAT4/FAR1/SOCS3/PISD/PLCB3/ABCA3/TMEM150A/PIGW/SERINC5/PTPMT1/SELENOI/PLSCR1/ITPKA/GPAT4/PGAP4/PIP4K2A/DGKQ/TAFAZZIN/ACP6/GDPD3/CAPN2/PIP5K1A/INPP1/MBOAT1/PIK3C2B/PLD2/MTMR12/INPPL1/DGKA/PTDSS1/PIP4P1/PITPNM2/ITPKC/TTC7A/ABHD3/OSBPL5/ACSL3 |
| GOBP_SERTOLI_CELL_DEVELOPMENT | 10 | 0.8535331 | 1.835556 | 0.0004984 | 0.0118289 | 0.0097179 | 1121 | NTRK1/IL1A/SOX9 |
| GOBP_PROTEIN_LOCALIZATION_TO_CILIUM | 66 | -0.5253333 | -1.767749 | 0.0004991 | 0.0118289 | 0.0097179 | 4227 | CDK20/BBS1/ATP6V1D/DNAAF11/ARL6/TCTN1/IFT20/ZMYND10/ARL13B/TMEM107/ROPN1B/ODAD4/ARL3/BBS9/CCDC66/CCDC39/BBIP1/IFT122/TCTN2/WDR19/TBC1D32/MAPK15/SPATA7/TUB/TTC21A/CFAP58/IFT140/CC2D2A/WDR35/IFT80/DYNC2H1/LZTFL1/EFCAB7/DZIP1L/BBS4/TTC21B/CROCC/ROM1 |
| GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE | 43 | 0.6275177 | 1.859701 | 0.0005267 | 0.0123691 | 0.0101617 | 1591 | NOS2/PLA2G3/IL1R2/TLR4/NOD2/GBP5/ADCY7/TICAM1/HIF1A/MYD88/TNF/ZC3H12A/APPL2/CARD9 |
| GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION | 444 | 0.3574460 | 1.483131 | 0.0005272 | 0.0123691 | 0.0101617 | 2837 | NTRK1/GDNF/ARC/THY1/LGR6/EDNRA/DLX5/PTPRO/RTN4R/SDC2/BDNF/SEMA3B/CRMP1/MAP1B/GRXCR2/PAX6/NTNG1/BCL11B/MAPK8IP2/FOXD1/MFSD2A/CDHR1/SLIT2/NTRK2/PRKCQ/UCHL1/ARTN/MAP2/BCL2/VEGFA/TNIK/OLFM1/RELN/EPHB3/LRP8/ZNF365/GATA3/APOE/SEMA3D/PHACTR1/PLS1/TUBB3/EDN1/EGR2/TWF2/CHODL/ANOS1/EPHA3/DAB1/NRP2/VCL/BRSK2/PLXNA3/SEMA7A/NRCAM/NIBAN2/EPHA10/ISLR2/DBN1/SEMA3A/SEMA4C/ATP8A2/NSMF/ECE1/EPHA2/BRSK1/SEMA6A/FYN/RHOG/SLIT1/NDEL1/NTN1/DPYSL2/IGSF9/RUFY3/RAC1/ITPKA/KIF5C/VASP/CTTN/HDAC6/WASL/MYOT/RAPH1/ACTB/CHN1/SCRIB/SPP1/PDLIM5/LIMK1/EFNA5/NGEF/PARP6/NEDD4/SHANK3/PICALM/SCN1B/FOXB1/MCF2/PTPN11/FGF13/EPHA7/PAK2/SHTN1/STK25/MAP2K1/CFL1/COBL/TIAM1/DAG1/TTL/SEMA4F/LAMA3/EMB/TIAM2/LAMB2/TRIOBP/DOCK7 |
| GOBP_SPINDLE_ASSEMBLY | 119 | -0.4431214 | -1.651856 | 0.0005317 | 0.0124121 | 0.0101971 | 1235 | GOLGA8M/ABRAXAS1/STARD9/KIF11/FBXO5/KIFC1/KIF4A/SPAG5/NDC80/TPX2/CCNB2/NEK2/PLK1/KIF15/GOLGA8H/CDC20/ASPM/MYBL2 |
| GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS | 209 | 0.4095788 | 1.557430 | 0.0005542 | 0.0128743 | 0.0105768 | 2385 | IL13RA2/C8B/CD274/TLR4/IL1RL1/CTSC/RSAD2/CD55/NOD2/IL4I1/PVR/PRKCQ/BACH2/EBI3/FZD5/UNC13D/CLCF1/CD70/IRF7/GATA3/TNFSF13/MICA/RELB/NFKB2/PLA2G4A/ANXA1/NECTIN2/HLA-DOB/IL18R1/RIPK3/NFKBID/ARID5A/CEACAM1/IL23A/MYD88/ICAM1/TNF/ZC3H12A/AHR/IL4R/TRPM4/ZBTB7B/NLRP10/CARD9/FADD/RIPK2/IL20RB/C1S/RNF8/TNFAIP3/CD46/SHLD2/BATF/BCL10/HLA-DQB2/HLA-F/ADAM17/RORA/C2 |
| GOBP_POSITIVE_REGULATION_OF_CELL_ACTIVATION | 270 | 0.3876367 | 1.529137 | 0.0005692 | 0.0131565 | 0.0108087 | 2565 | PLA2G3/DPP4/SOCS1/RASGRP1/SELP/THY1/CD274/TLR4/PTPN22/PDCD1LG2/IL1RL1/CTSC/CD55/ADAM8/NOD2/IL4I1/PRKCQ/EBI3/BCL2/IL1A/TOX/CLCF1/CD47/CD70/GATA3/SLC7A1/TNFSF13/TICAM1/CD86/PLA2G4A/ANXA1/CD276/NECTIN2/HLA-DOB/TNFSF9/NFKBID/CARD11/DUSP10/IL23A/MYD88/TNF/GAB2/CD83/IRS2/IL4R/PTAFR/ZBTB7B/CCL5/LGALS9/THBS1/FYN/NR4A3/ITGAM/IL15RA/AXL/JUND/FADD/IL1RL2/ACTA2/RIPK2/CD46/TNFRSF13C/MAP3K8/IL15/SHLD2/BCL10/CDKN1A/AP3D1/HLA-DQB2/AKT1/HLA-F/GAS6/CD177/RUNX1/STX4/SRC/PTPN11/IL27RA |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION | 99 | -0.4803786 | -1.755631 | 0.0006085 | 0.0139962 | 0.0114985 | 2836 | RAD51B/RGCC/NANOGP8/DYRK3/CENPJ/EZH2/MAPK15/SASS6/ATAD5/PBX1/RRM1/ESPL1/STIL/CDC7/MTBP/ADAMTS1/HSPA2/CDC25A/STOX1/FBXO5/ANAPC4/CCNB1/CDT1/CDCA5/CDK1/RRM2/DTL/DLGAP5/CDC25C/UBE2C |
| GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE | 124 | 0.4740255 | 1.695058 | 0.0006296 | 0.0144099 | 0.0118383 | 2338 | TRPV6/ATP12A/SLC9A3/SLC5A1/SLC39A8/SLC7A11/KCNJ16/LRRC8D/SLC6A14/CD36/SLC3A2/SLC12A2/SLC7A5/LRRC8A/SLC7A1/HCN2/SLC1A5/SCNN1D/SLC5A3/SLC36A1/ACSL1/SLC1A4/TRPV3/TNF/IRS2/LRRC8C/RGS2/DLG1/TRPM4/SLC15A3/THBS1/FYN/SLC12A4/ATP1B1/SLC9A1/SLC6A9/SLC9A4/SLC8A1/SLC39A4/SLC39A14/PRNP/ATP1A1/GRM1/AKT1/TRPV4 |
| GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION | 142 | -0.4188731 | -1.614639 | 0.0006524 | 0.0148361 | 0.0121885 | 3038 | CHEK2/NOP53/AURKA/RAD51B/ING4/MRNIP/USH1C/DYRK3/KDM8/MRE11/CLSPN/ATAD5/CCNA2/PBX1/RRM1/CHEK1/BRCA1/CDC7/MELK/HSPA2/PKMYT1/ABRAXAS1/CDC25A/BLM/STOX1/FHL1/FBXO5/CCNB1/ORC1/NEK10/FOXM1/FBXL22/CIT/NDC80/KIF14/CENPF/CCNB2/PLK1/TICRR/CDK1/DTL/CDC25C |
| GOBP_TISSUE_MIGRATION | 268 | 0.3855299 | 1.520229 | 0.0006578 | 0.0148361 | 0.0121885 | 2627 | HAS2/DPP4/HYAL1/PRSS3/KRT16/PRKD1/HBEGF/PPARG/FAP/KLF4/FGFBP1/S100P/NR4A1/SLIT2/MIR200A/DLL4/PKN3/AMOT/HDAC9/VEGFA/FGF2/CLASP1/TNFSF12/GATA3/SMOC2/ANXA3/APOE/ADAM9/EDN1/MET/ANXA1/EPPK1/SCARB1/NRP2/HIF1A/SOX9/CEACAM1/DUSP10/PTGS2/KDR/TNF/ZC3H12A/PTP4A3/ADAMTS9/HMOX1/SEMA3A/EPHA2/PLEKHG5/THBS1/BCAR1/GADD45A/CCN3/GREM1/TESK1/P2RX4/ARSB/STAT1/RAC1/PTPRG/ZEB2/AKT3/ACTA2/MYH9/MARVELD3/RHOB/SCG2/HDAC6/CSNK2B/AKT1/JUN/SH3BP1/TGFBR1/TMSB4X/ADAM17/ITGA3/TACSTD2/SRC/HDAC7/PTPN11/GIPC1/MAPRE2/FERMT1/PPARD/MIA3 |
| GOBP_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | 355 | 0.3648646 | 1.482570 | 0.0006566 | 0.0148361 | 0.0121885 | 2898 | NTRK1/TLR4/PRKD1/SGK1/ADAM8/PPARGC1B/PPARG/NOD2/KLF4/ARHGEF5/NLRC5/PRKCQ/CD36/AIM2/PPP2R5B/VEGFA/DDIT3/RTKN2/RELN/LPAR5/LRP8/ANXA3/ARRB2/TICAM1/EDN1/CTH/ENPP1/HCK/IL18R1/RIPK3/TRIB1/IRAK2/NFKBIA/MSX2/CARD11/FOSL1/MYD88/SLCO3A1/TNF/CEBPG/ZC3H12A/CAMK1D/PSMA6/FZD1/DDR2/CX3CL1/ARID5B/HMOX1/ID3/SPHK1/RPS6KA4/NLRP2/BMP2/PRKCH/LGALS9/TRIM14/GREM1/CARD9/PIM1/ANXA4/HES6/TRIM21/EIF2AK2/IRAK1/RBCK1/RIPK2/TRAF5/TRIM25/TNFAIP3/NFKBIE/PARP10/CDKN2A/NFKBIB/PRNP/BCL10/AKT1/TMSB4X/MDFI/BHLHE40/NKX3-1/GAS6/CHP1/RELA/TRIM5/GFI1/CYLD/GLIS2/NOD1/BCL3/WFS1/DDRGK1/SYK/PPARGC1A/CAV1/IKBKG/MAP3K13/CRTC3/IKBKE |
| GOBP_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS | 17 | -0.7554980 | -1.936549 | 0.0006702 | 0.0148383 | 0.0121903 | 1441 | ECRG4/ANAPC4/CDC20B/PLK1/CDC20/UBE2C |
| GOBP_XENOBIOTIC_METABOLIC_PROCESS | 82 | -0.4908296 | -1.723640 | 0.0006737 | 0.0148383 | 0.0121903 | 1585 | GSTM2/FMO4/GSTM1/UGT1A7/HNF4A/CYP2C8/UGT1A5/CYP2W1/SULT1B1/ACSM1/GSTA3/EPHX1/AKR1C1/CYP2B6/UGT1A8/FMO5/NAT1/CYP2F1/FMO2/CYP2A6/ALDH3A1/GSTA4/CYP26B1/ABCB11/GSTA1/GSTA2 |
| GOBP_REGULATION_OF_HORMONE_SECRETION | 159 | 0.4408851 | 1.629708 | 0.0006723 | 0.0148383 | 0.0121903 | 2614 | NOS2/ANO1/PLA2G3/C1QTNF1/ADCY5/SLC9B2/CNR1/SFRP1/PCK2/PPARG/LRRC8A/CPT1A/EDN1/DOC2B/ANXA1/RAB11FIP1/P2RY1/STX1A/HIF1A/BRSK2/RAB8B/TNF/IRS2/LIF/GPR27/TRPM4/CCL5/CCN3/FKBP1B/ACSL4/SLC8B1/AACS/VSNL1/GABBR1/BMP6/PIM3/MCU/EIPR1/TFR2/SPP1/EFNA5/RAB11FIP5/NKX3-1/GPER1/STX4/PTPN11/ACVR1C/PPARD |
| GOBP_DNA_DEPENDENT_DNA_REPLICATION | 155 | -0.4076187 | -1.590409 | 0.0006720 | 0.0148383 | 0.0121903 | 2429 | TOPBP1/MMS22L/PRIM1/POLA1/OOEP/RPA1/MCM6/SAMHD1/SETMAR/EME1/E2F8/MCM2/TIMELESS/BRCA2/MCM7/POLD1/RFC3/WRN/PRIMPOL/FANCM/LRWD1/RFC5/WDHD1/MRE11/ATAD5/ZRANB3/CHTF8/CENPS/RRM1/DNA2/POLE2/LIG1/ZGRF1/CDC7/BLM/POLN/GINS1/GINS2/POLA2/FBXO5/RECQL4/ORC1/POLQ/MCIDAS/E2F7/DSCC1/CDT1/GMNN/DACH1/CCNE2/TICRR/GMNC/MCM10 |
| GOBP_POSITIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | 222 | 0.4098825 | 1.576178 | 0.0006727 | 0.0148383 | 0.0121903 | 1909 | NTRK1/TLR4/PRKD1/ADAM8/PPARGC1B/PPARG/NOD2/ARHGEF5/PRKCQ/CD36/AIM2/PPP2R5B/VEGFA/DDIT3/RTKN2/RELN/LPAR5/LRP8/ANXA3/TICAM1/EDN1/CTH/IL18R1/RIPK3/IRAK2/CARD11/FOSL1/MYD88/SLCO3A1/TNF/CEBPG/CAMK1D/PSMA6/FZD1/DDR2/CX3CL1/ARID5B/SPHK1/RPS6KA4/BMP2/PRKCH/LGALS9/TRIM14/GREM1/CARD9/TRIM21/EIF2AK2/IRAK1/RBCK1/RIPK2/TRAF5/TRIM25 |
| GOBP_REGULATION_OF_CHEMOTAXIS | 161 | 0.4477920 | 1.654237 | 0.0006817 | 0.0149440 | 0.0122771 | 1831 | CCL26/DPP4/TNFAIP6/PTPRO/CXCL10/PRKD1/CCL4/SEMA3B/NOD2/SLIT2/CXCL8/ST6GAL1/ARTN/NTRK3/F3/VEGFA/FGF2/DAPK2/SMOC2/PLA2G7/SEMA3D/EDN1/MET/STX3/S100A7/PLXNA3/IL23A/KDR/SEMA7A/CAMK1D/DUSP3/SEMA3A/SEMA4C/CCL5/LGALS9/SEMA6A/THBS1/CCN3/SLIT1/GREM1/MMP28/P2RX4/OXSR1/RAC1/SLC8B1 |
| GOBP_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY | 118 | 0.4832675 | 1.708159 | 0.0006943 | 0.0151486 | 0.0124452 | 1477 | SH2D1B/RASGRP1/SERPINB4/RSAD2/CD55/NOD2/IL4I1/PVR/RAET1G/SERPINB9/FZD5/CLCF1/GATA3/ARRB2/TNFSF13/MICA/RAET1E/NECTIN2/IL18R1/RIPK3/ARID5A/CEACAM1/IL23A/TNF/AHR/TRPM4/LGALS9 |
| GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY | 78 | 0.5321160 | 1.789430 | 0.0006995 | 0.0151902 | 0.0124794 | 1835 | NOS2/RASGRP1/SERPINB4/CTSC/ULBP1/PVR/RAET1G/SERPINB9/UNC13D/ARRB2/MICA/RAET1E/NECTIN2/ULBP2/RIPK3/CEACAM1/IL23A/MYD88/ICAM1/CEBPG/LGALS9/ITGAM/RNF19B/TUBB/FADD/CXCL6/ULBP3 |
| GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY | 161 | 0.4465230 | 1.649549 | 0.0007148 | 0.0154076 | 0.0126580 | 3190 | NTRK1/CLDN5/THY1/BDNF/SFRP1/PHLDB2/GPC6/ACE/LRRTM2/NTRK2/NTRK3/VEGFA/FZD5/EPHB3/CLASP1/LRFN4/EPHA3/SLK/VCL/KDR/TNF/FZD1/MYO1C/VSTM5/CRB3/IL1RAPL2/DUSP3/EPHA2/PRKCH/THBS1/SLIT1/GREM1/NTN1/SLC9A1/SNCA/TJP1/RAC1/DLG5/PDLIM5/DAPK3/S100A10/EFNA5/EIF4G1/SRC/CLDN1/EPHA7/LRRN3/CAMSAP3/ACTG1/GPC4/SETD5/RAP1A/CAV1/FERMT2/SLITRK6/MMP14/SLITRK5/FLOT1/TSC1/CLSTN3 |
| GOBP_POSITIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION | 148 | 0.4391939 | 1.610830 | 0.0007161 | 0.0154076 | 0.0126580 | 2338 | CCL26/ALOX15/SFRP1/CDC42EP5/MAP1B/ARHGEF5/CLASP1/CD47/CDC42EP1/APOE/EDN1/SYNPO/MET/HCK/CFL2/BIN1/OCLN/SNX9/CX3CL1/DLG1/GSN/TESK1/RAC1/COLGALT1/VASP/CTTN/ARHGEF10/WASL/WDR1/LIMK1/RHOC/S100A10/TGFBR1/TRPV4 |
| GOBP_P38MAPK_CASCADE | 47 | 0.5867892 | 1.775143 | 0.0007240 | 0.0155058 | 0.0127387 | 2507 | RASGRP1/NCF1/PTPN22/GADD45G/VEGFA/XDH/MFHAS1/DUSP10/ZFP36/ZC3H12A/SPHK1/DLG1/MAPK11/BMP2/LGALS9/GADD45A/RELL1/RELL2/MAPKAPK2/CYLD |
| GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS | 190 | 0.4169839 | 1.565329 | 0.0007428 | 0.0157652 | 0.0129518 | 3012 | CISH/SOCS1/PNPLA3/ALOX15/LPIN1/MFSD2A/PLA2G4C/ABHD4/SOCS2/LCAT/LIPH/FGF2/PLA2G4A/GPAT3/LPCAT4/FAR1/SOCS3/PISD/TMEM150A/PIGW/PTPMT1/SELENOI/PLSCR1/ITPKA/GPAT4/PGAP4/PIP4K2A/DGKQ/TAFAZZIN/ACP6/CAPN2/PIP5K1A/INPP1/PIK3C2B/PLD2/INPPL1/DGKA/PTDSS1/PITPNM2/ITPKC/TTC7A/ABHD3/ACSL3/DGKD/INPP5J/PIP4K2C |
| GOBP_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING | 255 | 0.3982842 | 1.558393 | 0.0007404 | 0.0157652 | 0.0129518 | 3063 | EDNRA/TLR4/PRKD1/NOD2/TNIP3/MAP3K14/CD36/UBD/CARD19/IL1A/EDAR/BST2/SECTM1/TICAM1/LURAP1/EDN1/RELB/NEK6/CTH/RIPK3/IRAK2/NFKBIA/LURAP1L/CARD11/TMEM106A/CANT1/TLE1/MYD88/TNF/ZC3H12A/CX3CL1/HMOX1/TNIP1/IFIT5/OPTN/PLEKHG5/LGALS9/TNFRSF19/OTUD7A/FYN/TRIM14/CARD9/SHISA5/FADD/STAT1/NDFIP2/TRIM21/IRAK1/RBCK1/RIPK2/TRAF5/TRIM25/TNFAIP3/NFKBIB/BCL10/SQSTM1/LTBR/RHOC/AKT1/RORA/IRAK4/RELA/TRIM5/MUL1/NOD1/BIRC3/BCL3/SLC20A1/DDRGK1/TRAF3IP2/AKAP13/IKBKG/IKBKE/TRIM22/TNFRSF10B/NKIRAS2 |
| GOBP_SPECIFICATION_OF_SYMMETRY | 105 | -0.4526393 | -1.667000 | 0.0007487 | 0.0158171 | 0.0129945 | 4170 | ANKS6/CCDC40/SMO/DNAAF11/ENKUR/RTTN/IHH/ARL6/DRC1/ARL13B/TMEM107/ODAD4/DNAAF2/CCDC39/DNAI1/NOTCH1/TBC1D32/CFAP52/DYNC2LI1/FOXJ1/DPCD/IFT57/IFT140/CC2D2A/IFT52/IFT74/CITED2/ACVR2B/ODAD3/RPGRIP1L/DLL1/IFT172/DYNC2H1/DAW1/MKS1/RFX3/STIL/WNT3A/FOLR1/DNAAF1/DNAAF4/DNAI2/BBS4/CFAP45/WNT5A/BICC1/DNAH5/CFAP53/GJA1/ODAD2/SOSTDC1/ASB2/SHH/MEF2C/FOXN4 |
| GOBP_REGULATION_OF_VIRAL_GENOME_REPLICATION | 78 | 0.5305488 | 1.784160 | 0.0007588 | 0.0159175 | 0.0130769 | 2010 | APOBEC3A/RSAD2/ISG15/OAS3/ISG20/OASL/OAS1/CXCL8/MX1/IFIT1/BCL2/IFITM1/IFIH1/BST2/OAS2/IFITM3/TNF/SHFL/TNIP1/IFIT5/CCL5/ADAR/PLSCR1/N4BP1/EIF2AK2/APOBEC3B/PARP10/ZNFX1 |
| GOBP_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | 80 | 0.5152110 | 1.731209 | 0.0007602 | 0.0159175 | 0.0130769 | 3267 | IL19/GDNF/BCL2/IL1A/IFI6/TMBIM1/ICAM1/TNF/CX3CL1/PEA15/HMOX1/YAP1/THBS1/ITGA6/ITGAV/EYA4/LMNA/CTTN/SCG2/TNFAIP3/AKT1/TGFBR1/RELA/RFFL/SRC/CSF2/LGALS3/SIAH2/UNC5B/PELI3/ARHGEF2/STRADB/EYA3/EYA2/HTT/SH3RF1/ZC3HC1 |
| GOBP_O_GLYCAN_PROCESSING | 38 | 0.6400168 | 1.858307 | 0.0007950 | 0.0164242 | 0.0134932 | 1720 | B3GNT6/GCNT3/GALNT4/ST6GAL1/GALNT7/GCNT4/GALNT10/GALNT6/GALNT5/ST3GAL4/B3GNT8 |
| GOBP_INTRACILIARY_RETROGRADE_TRANSPORT | 13 | -0.7737276 | -1.847026 | 0.0007915 | 0.0164242 | 0.0134932 | 3420 | DYNLT2B/DYNC2I1/IFT122/IFT43/WDR19/DYNC2LI1/TTC21A/IFT140/CILK1/WDR35/DYNC2H1/TTC21B |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS | 113 | 0.4729121 | 1.670138 | 0.0007935 | 0.0164242 | 0.0134932 | 2638 | NTRK1/PLA2G3/GDNF/FZD9/BDNF/ADAM8/NTRK2/BCL2/FOXQ1/CLCF1/NES/TYRO3/ARRB2/APOE/AARS1/HIF1A/CX3CL1/HMOX1/KRAS/PRKCG/AXL/SNCA/HYOU1/ZPR1/JUN/BOK/GRIK2/FOXB1/IL27RA/NRBP2/IL6ST/WFS1 |
| GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION | 354 | 0.3677096 | 1.493008 | 0.0008003 | 0.0164601 | 0.0135227 | 2887 | EMILIN2/HAS2/DPP4/SOCS1/RASGRP1/SELP/THY1/ALOX15/CD274/HYAL1/VIT/PTPN22/PDCD1LG2/PLAUR/SFRP1/CD55/CD44/ADAM8/NOD2/IL4I1/PRKCQ/CD36/EBI3/RAC3/VEGFA/IL1A/UNC13D/NEDD9/FUT3/CD47/CD70/GATA3/SLC7A1/CD86/ADAM9/ANXA1/CD276/HSD17B12/HLA-DOB/TNFSF9/NFKBID/STX3/CARD11/DUSP10/IL23A/KDR/RHOD/TNF/PIEZO1/CD83/CX3CL1/LIF/IL4R/PTAFR/ZBTB7B/CCL5/ST3GAL4/LGALS9/FYN/SOX2/NR4A3/TFE3/TESK1/ITGAV/FADD/IL1RL2/TJP1/RAC1/PLEKHA2/IRAK1/EGFL6/RIPK2/CD46/TNFRSF13C/MAP3K8/IL15/GCNT2/MYO10/BCL10/FLCN/AP3D1/HLA-DQB2/RELL2/S100A10/AKT1/PODXL/RELA/ITGA3/RUNX1/PDPN/CYTH3/STX4/SRC/PTPN11/IL27RA/FERMT1/IL6ST/FUT4/ALOX5/SYK/DAG1/TRIOBP/SKAP1/CSK/CAV1/NFAT5/IGF2 |
| GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS | 421 | 0.3541876 | 1.466347 | 0.0008178 | 0.0167465 | 0.0137580 | 1940 | CCL26/NTRK1/CLDN5/THY1/ALOX15/HYAL1/MMP1/TLR4/TRABD2A/WARS1/BDNF/SFRP1/ISG15/CDC42EP5/PHLDB2/HAS3/MAP1B/GBP5/ARHGEF5/LRRTM2/TENM2/NTRK2/CD36/PPP2R5B/VEGFA/EPHB3/CLASP1/CD47/CDC42EP1/TWF2/SYNPO/MET/WASHC1/HCK/DOCK11/BAK1/BIN1/BIK/CAPG/OCLN/SOX9/KDR/MYD88/TNF/SNX9/PIEZO1/VSTM5/CRB3/CX3CL1/CDK2/DLG1/EPHA2/NDEL1/ABCA3/TESK1/SNCA/SLX4/RAC1/ATP13A2/VASP/CTTN/ARHGEF10/PLCE1/PIP4K2A |
| GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | 492 | 0.3419010 | 1.431549 | 0.0008220 | 0.0167598 | 0.0137689 | 1738 | FGL2/CCN4/SOCS1/TNFAIP6/THY1/BRINP1/TLR4/SPDEF/TRIB3/CXCL10/HOPX/RTN4R/PRTG/FOXE3/BDNF/SEMA3B/INSIG1/SFRP1/PPARG/SPRY4/PAX6/LBH/LDLR/EREG/NTRK3/HES5/CEACAM5/MAP2/VEGFA/IL1A/DDIT3/GPS2/TTPA/KLF13/G6PD/GATA3/RAP1GAP/SEMA3D/PRICKLE1/XDH/ANXA1/JDP2/ENPP1/SOX6/TRIB1/NFKBIA/NOTCH4/MSX2/DAB1/S1PR3/SOX9/CEACAM1/DUSP10/PLXNA3/TRIB2/ZFP36/SEMA7A/PKP2/TNF/ZC3H12A/ASCL1/YAP1/ID3/SEMA3A/SEMA4C/RGS2/IL4R/SPRED2/TRPM4/APPL2/BMP2/ZBTB7B/MMP11/SEMA6A/CDKN2B/MARK1/KRAS/OSR1/NOCT/SOX2/CCN3/SLIT1/GREM1/NTN1/PRDM6/SPAG9/ITGAV/RUFY3 |
| GOBP_PEPTIDYL_TYROSINE_MODIFICATION | 295 | 0.3827679 | 1.531657 | 0.0008342 | 0.0169340 | 0.0139120 | 2915 | NTRK1/ADRA1A/SOCS1/THY1/NCF1/HBEGF/SFRP1/CD44/IL12RB2/NOD2/FGFR4/ALKAL1/ACE/NTRK2/FLT1/CD36/EREG/IL31RA/DOK7/NTRK3/HES5/PPP2R5B/VEGFA/NEDD9/CBLC/RELN/DOCK3/EPHB3/CLCF1/LRP8/TYRO3/ARRB2/PARP9/TTN/MET/HCK/KITLG/EPHA3/ROR2/IL23A/KDR/TNF/DDR2/SOCS3/EPHA10/LIF/EPHA2/PARP14/CCL5/FYN/ERRFI1/GREM1/PKDCC/AXL/SH2B3/RAP2B/MST1R/TESK1/ZGPAT/CAMKK2/EIF2AK2/TGFA/RIPK2/TEC/RAP2C/DGKQ/TNK2/CHMP6/IL15/GPRC5A/BMP6/PRNP/PTK6/EFNA5/ZFYVE28/ADAM17/SCYL1/GAS6/SRC/PTPN11/CSF2/EPHA7/PAK2/CADM4/IL6ST/BCR/MAP2K1/SYK/TTL/HAX1/CSK/CAV1/TESK2/IGF2/ISL1 |
| GOBP_LEUKOCYTE_APOPTOTIC_PROCESS | 84 | 0.5102678 | 1.726906 | 0.0008527 | 0.0172339 | 0.0141584 | 2389 | CD274/SLC7A11/ADAM8/NOD2/PRKCQ/ST6GAL1/PIP/IDO1/IRF7/HSH2D/ANXA1/KITLG/RIPK3/BAK1/HIF1A/FAS/IRS2/ARG2/CCL5/LGALS9/PLEKHO2/AXL/FADD/PRELID1/CDKN2A/BCL10/AKT1/ADAM17/SELENOS/GAS6 |
| GOBP_SERTOLI_CELL_DIFFERENTIATION | 13 | 0.8200017 | 1.872652 | 0.0008724 | 0.0174036 | 0.0142978 | 1385 | NTRK1/IL1A/SOX9/SCX |
| GOBP_LYMPHOCYTE_CHEMOTAXIS | 35 | 0.6431044 | 1.826390 | 0.0008703 | 0.0174036 | 0.0142978 | 2533 | CCL26/CXCL10/CCL4/CH25H/CXCL11/ADAM8/CCL22/CXCL16/SLC12A2/S100A7/CX3CL1/CCL5/HSD3B7/OXSR1/SLC8B1/ADAM17/GAS6/PLEC/CCL20 |
| GOBP_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | 207 | 0.4016106 | 1.524402 | 0.0008797 | 0.0174036 | 0.0142978 | 2013 | FGL2/PLA2G3/SOCS1/TNFAIP6/RASGRP1/TLR4/SLC9B2/PRDM1/SFRP1/ADAM8/PPARGC1B/IL4I1/FOS/TOX/IRF7/GATA3/CD86/ANXA1/KITLG/TNFSF9/TRIB1/NFKBID/CARD11/ROR2/CEACAM1/DUSP10/IL23A/TNF/ZC3H12A/CD83/LIF/IL4R/ZBTB7B/LGALS9/TFE3/IL15RA/AXL/SPINK5/FADD/IL1RL2/PRXL2A/RIPK2/PRELID1/CD46/IL15 |
| GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY | 344 | 0.3660212 | 1.481392 | 0.0008758 | 0.0174036 | 0.0142978 | 2722 | CST1/FETUB/SERPINB4/SERPINB2/SERPINB10/HMSD/SERPINC1/SERPINB13/PLAUR/SERPINB12/CD44/PPARG/KLF4/NR4A1/AIM2/F3/VEGFA/CSTA/SERPINB9/BBC3/IFI6/BST2/ARRB2/SFN/UBE2Z/PMAIP1/SERPINB8/SERPINB7/XDH/ANOS1/PI3/BAK1/TIMP2/BIN1/HIP1/LAMP3/PML/TFPI2/ANXA8/PTGS2/ITIH2/MAPK12/TNF/SERPINB6/FAS/SERPINB11/CLDN4/CSTB/NLRP2/LGALS9/THBS1/CYCS/SERPINB1/FYN/SOX2/CARD9/SOX7/SERPINB3/GSN/SPINK5/SERPINH1/SNCA/FADD/SPINT2/ANXA8L1/ATP13A2/A2ML1/RIPK2/PRELID1/AKIRIN2/SORL1/TIMP1/ST18/FURIN/PRNP/BCL10/ACER2/DHCR24/MICAL1/TBC1D10A/AKT1/BOK/MYC/NKX3-1/GPER1/GAS6/PICALM/USP14/RFFL/SRC/MUL1/NOD1/BIRC3/EPHA7/ACVR1C/BID/PAK2/DNAJB6/DDRGK1/SYK/IFI16 |
| GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION | 381 | -0.3322029 | -1.439298 | 0.0008793 | 0.0174036 | 0.0142978 | 1369 | CDC7/MTBP/MELK/ADAMTS1/HSPA2/PKMYT1/ABRAXAS1/CDC25A/BLM/HECW2/STOX1/CAMK2A/FHL1/FBXO5/ANAPC4/CCNB1/ORC1/TRIP13/CCNP/CDC14A/CCNO/E2F1/FOXM1/FBXL22/E2F7/CCL2/TTK/CIT/CDT1/CDCA5/CDKN3/NDC80/KIF14/MAD2L1/CENPF/CCNB2/CENPE/CCNE2/PLK1/TICRR/CDK1/IQGAP3/ANLN/RRM2/DTL/BUB1/GTSE1/DLGAP5/CDC25C/UBE2C/BUB1B |
| GOBP_ALCOHOL_METABOLIC_PROCESS | 283 | 0.3835913 | 1.527957 | 0.0009042 | 0.0178137 | 0.0146347 | 2869 | CYP51A1/MVD/HMGCS1/EBP/FDPS/LSS/PCSK9/DHCR7/MSMO1/ACSS2/HMGCR/INSIG1/CH25H/PCK2/ADH1C/HSD17B7/IDI1/LRAT/LDLR/ALDH1A3/FDFT1/NPC1/HRH1/SQLE/NSDHL/ACLY/SC5D/NFE2L1/LCAT/FGF2/G6PD/RDH11/SRD5A3/APOE/TM7SF2/PLA2G4A/GOT1/CYP27B1/MVK/P2RY1/SLC5A3/SDR16C5/SCARB1/DHRS7/IDH1/CYP2C18/APOL2/CYP46A1/SPHK1/RETSAT/GCH1/PTAFR/GPD2/BMP2/TPK1/SREBF2/APOBR/CYP2C9/APOL1/ACADL/P2RY6/GBA2/SNCA/SGPP2/RDH13/ITPKA/CYP3A5/DGKQ/GALK1/DHDDS/GDPD3/BMP6/ACER2/DHCR24/INPP1/ITPK1/ASAH2/CYB5R3/GPER1/SGPP1/OSBPL1A/GFI1/CLN6/PIP4P1/ITPKC/PPARD/SPTSSA/PTS/AKR1A1/OSBPL5/SMPD1/ACER3/ALDH3B2/NPC2/IPPK |
| GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION | 11 | -0.7890329 | -1.794024 | 0.0009094 | 0.0178411 | 0.0146572 | 755 | HEY2/MEF2C/CDK1/MYOCD |
| GOBP_MEIOSIS_II_CELL_CYCLE_PROCESS | 10 | -0.8133215 | -1.804383 | 0.0009188 | 0.0178862 | 0.0146943 | 479 | HORMAD1/SGO2/SGO1/BUB1/BUB1B |
| GOBP_PROTEIN_AUTOPHOSPHORYLATION | 199 | 0.4130104 | 1.563885 | 0.0009232 | 0.0178862 | 0.0146943 | 2870 | NTRK1/THY1/GRK5/PRKD1/FGFR4/STK10/ACE/NTRK2/FLT1/MAPKAPK3/PPP2R5B/VEGFA/TNIK/EPHB3/DAPK2/TYRO3/NEK6/ENPP1/HCK/GRK7/RIPK3/SLK/MKNK1/KDR/UHMK1/DDR2/STK17B/ENG/FYN/ERRFI1/GREM1/PRKCG/PIM1/RAP2B/TESK1/OXSR1/CAMKK2/EIF2AK2/IRAK1/ATP13A2/MAP3K9/TEC/TNKS1BP1/RAP2C/MAP3K21/PIM3/PTK6/DAPK3/AAK1/AKT1/JUN/CHP1/MAPKAPK2/SRC/EPHA7/PAK2/STK25/TAOK3/SYK/EIF2AK3/CSK/CAV1/MAP3K13 |
| GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT | 218 | 0.4056390 | 1.553236 | 0.0009216 | 0.0178862 | 0.0146943 | 1944 | CLDN5/EMILIN2/HYAL1/ADM2/WARS1/CXCL10/PRKD1/PPP1R16B/SFRP1/PPARG/KLF4/YJEFN3/CXCL8/FLT1/AMOT/F3/HHEX/VEGFA/KLF2/IL1A/SLC12A2/FGF2/TNFSF12/SMOC2/ANXA3/HK2/CCR3/BTG1/HIF1A/PML/CEACAM1/ITGB8/KDR/SARS1/TNF/ZC3H12A/NIBAN2/SULF1/ADAMTS9/HMOX1/SPHK1/EPHA2/ENG/SEMA6A/THBS1/GADD45A/GREM1/STIM1/SPINK5/TJP1/STAT1/AKT3/RHOB/TNFAIP3 |
| GOBP_NEURON_PROJECTION_GUIDANCE | 176 | 0.4377189 | 1.630017 | 0.0009333 | 0.0180071 | 0.0147936 | 1885 | NTRK1/GDNF/LGR6/EDNRA/DLX5/PTPRO/BDNF/SEMA3B/CRMP1/PAX6/BCL11B/FOXD1/SLIT2/PRKCQ/ARTN/VEGFA/RELN/EPHB3/GATA3/SEMA3D/TUBB3/EDN1/EGR2/ANOS1/EPHA3/NRP2/PLXNA3/SEMA7A/NRCAM/NIBAN2/EPHA10/SEMA3A/SEMA4C/ECE1/EPHA2/SEMA6A/FYN/RHOG/SLIT1/NTN1/DPYSL2/IGSF9/RAC1/KIF5C/VASP |
| GOBP_ACTIN_FILAMENT_ORGANIZATION | 379 | 0.3609575 | 1.472185 | 0.0009421 | 0.0181023 | 0.0148719 | 2987 | CCL26/ALOX15/SFRP1/CTNNA3/CDC42EP5/PHLDB2/PPARGC1B/ARHGEF5/SLIT2/RAC3/BCL2/TMOD1/NEDD9/CLASP1/CD47/CDC42EP1/ARHGAP40/PHACTR1/PLS1/TWF2/MYO1A/SYNPO/TTN/MET/WASHC1/HCK/CFL2/ZBED3/SPATC1L/SHROOM1/BIN1/HIP1/ASAP3/CAPG/ESAM/NAA80/RHOD/TMSB10/SNX9/FLII/MYO1C/SPIRE1/CX3CL1/DBN1/SVIL/MSRB1/DLG1/TNFAIP1/RND3/BCAR1/RHOG/MYO5B/SLC9A1/GSN/ARPC5L/SSH1/TESK1/GBA2/RUFY3/TJP1/MICAL2/RAC1/PSTPIP2/MYO5C/VASP/CTTN/ARHGEF10/RHOB/KANK3/WASL/TPM3/WDR1/MCU/MYO1E/FHDC1/ERMN/SPTBN5/MICAL1/MYO19/LIMK1/RHOC/PAWR/S100A10/MYO1B/SH3BP1/TGFBR1/TMSB4X/TRPV4/INPPL1/PPP1R9A/GAS2L1/SHANK3/DIAPH1/TPM4/TACSTD2/PLEC/ACTN1/SRC/PAK2/SHTN1/ACTG1/CFL1/COBL/KPTN/ARPC4/HAX1/TRIOBP/TMOD2/PPFIA1/RND1/PFN1/ELMO2/FERMT2 |
| GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION | 73 | 0.5246851 | 1.735923 | 0.0009628 | 0.0184238 | 0.0151360 | 1477 | SOCS1/CDH26/CD274/LGALS7B/RSAD2/CD55/PRKCQ/TOX/GATA3/CD86/RELB/ANXA1/IL18R1/NFKBID/IL23A/ZC3H12A/CD83/ARG2/IL4R/ZBTB7B/LGALS9 |
| GOBP_KERATINOCYTE_DIFFERENTIATION | 101 | 0.4983136 | 1.736078 | 0.0009726 | 0.0184602 | 0.0151658 | 1629 | SPRR2E/SPRR3/SPRR2F/SPRR2A/KRT16/SPRR1A/ZBED2/PAX6/SPRR2D/BCL11B/EREG/TRIM16/ALOX15B/CSTA/IL1A/SFN/ADAM9/CLIC4/CYP27B1/ANXA1/FOSL2/LCE1E/S100A7/MSX2/ZFP36/CDH3/YAP1/EPHA2/PRKCH/ERRFI1/IRF6 |
| GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY | 299 | 0.3729508 | 1.489430 | 0.0009697 | 0.0184602 | 0.0151658 | 2857 | THY1/TLR4/PTPN22/RSAD2/THEMIS2/LAT2/OAS3/NOD2/TNIP3/OASL/OAS1/PRKCQ/CD36/IFI35/MAPKAPK3/BCL2/IFIH1/CMTM3/DDX60/GPS2/CD47/IRF7/GATA3/TYRO3/ARRB2/UFD1/TICAM1/CD276/NECTIN2/HCK/CD200R1/LY96/MFHAS1/NFKBID/IRAK2/NFKBIA/CARD11/CEACAM1/MYD88/TNF/ZC3H12A/DUSP3/TNIP1/SLC15A3/APPL2/PRKCH/LGALS9/BCAR1/FYN/NR4A3/RNF125/PDE4B/MICB/PLSCR1/IRAK1/RBCK1/RIPK2/IL20RB/TRIM25/NPLOC4/TEC/TNFAIP3/SEC14L1/RAB29/PRNP/BCL10/LIMK1/GBP1/PAWR/PLD2/IRAK4/MAPKAPK2/RELA/GFI1/CYLD/SRC/NOD1/BIRC3/PAK2/CLPB/LGALS3/S100A14/SYK/SLC15A4/VAV2/SKAP1/CSK/CAV1/IKBKG |
| GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 99 | 0.5015003 | 1.740928 | 0.0009914 | 0.0187398 | 0.0153955 | 1199 | SH2D1B/NOS2/RASGRP1/RSAD2/CD55/NOD2/PVR/RAET1G/FZD5/CLCF1/GATA3/TNFSF13/TICAM1/RAET1E/NECTIN2/IL18R1/ARID5A/IL23A/TNF |
| GOBP_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION | 31 | -0.6356850 | -1.861692 | 0.0010153 | 0.0191152 | 0.0157040 | 3458 | H4C5/SCIN/H4C12/H4C6/H4C3/H4C2/H4C4/H4C1/HMGB2/RAB7B/MTURN/FAXDC2/H4C13/H4C9/MEF2C/GATA2 |
| GOBP_REGULATION_OF_CILIUM_MOVEMENT | 25 | -0.6697014 | -1.885113 | 0.0010571 | 0.0197443 | 0.0162208 | 4151 | CCDC40/CFAP298/DRC1/CFAP20/RSPH4A/CCDC39/BBS2/CCDC65/GAS2L2/CFAP69/DNAAF1/BBS4/CFAP43/CFAP45/CFAP206/TTLL6/ODAD2/EPPIN |
| GOBP_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE | 101 | 0.4965973 | 1.730098 | 0.0010572 | 0.0197443 | 0.0162208 | 2923 | SH2D1B/RASGRP1/ZBP1/TLR4/ADAM8/NOD2/GBP5/NLRC5/PVR/RAET1G/EREG/IFI35/AIM2/IRF7/PARP9/RAET1E/NECTIN2/HCK/CCL5/FYN/CARD9/FADD/PLSCR1/AKIRIN2/ZNFX1/HLA-F/POLR3D/TRIM5/CGAS/SRC/PAK2/SYK/IFI16/SLC15A4/IKBKE/HEXIM1 |
| GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY | 54 | 0.5723169 | 1.775235 | 0.0010670 | 0.0198311 | 0.0162921 | 2740 | TLR4/PTPN22/OAS3/NOD2/OASL/IFIH1/DDX60/IRF7/UFD1/NFKBIA/SLC15A3/RNF125/RIPK2/TRIM25/NPLOC4/TNFAIP3/SEC14L1/RELA/CYLD/BIRC3/CLPB/SLC15A4 |
| GOBP_BLOOD_VESSEL_MORPHOGENESIS | 487 | 0.3378596 | 1.415666 | 0.0010703 | 0.0198311 | 0.0162921 | 1944 | CLDN5/EMILIN2/HAS2/THY1/EDNRA/HYAL1/ADM2/WARS1/THSD7A/CXCL10/PRKD1/PPP1R16B/PRDM1/SFRP1/ADAM8/PPARG/FAP/KLF4/FGFBP1/LDLR/ACE/YJEFN3/ANPEP/NR4A1/SLIT2/CXCL8/NTRK2/FLT1/EREG/DLL4/AMOT/HDAC9/F3/MMP19/HHEX/VEGFA/KLF2/IL1A/FZD5/SLC12A2/FGF2/EPHB3/TNFSF12/SMOC2/ANXA3/APOE/EDN1/HPGD/TNFRSF12A/HK2/XDH/CLIC4/ANXA1/CCR3/BTG1/BAK1/NOTCH4/S100A7/NRP2/PLCD3/HIF1A/PML/CEACAM1/PTGS2/ITGB8/KDR/SARS1/TNF/ZC3H12A/NRCAM/NIBAN2/SULF1/ADAMTS9/CX3CL1/RNF213/HMOX1/CALCRL/YAP1/SPHK1/EPHA2/ENG/SEMA6A/THBS1/COL22A1/GADD45A/CCN3/GREM1/LOX/CCM2/STIM1/SPINK5/ITGAV/TJP1/STAT1/AKT3/TGFA/TYMP/MYH9/RHOB/SCG2/JUNB/TNFAIP3 |
| GOBP_ENDOCYTIC_RECYCLING | 69 | 0.5277420 | 1.727661 | 0.0010781 | 0.0198958 | 0.0163453 | 4335 | PLA2G3/ARL4C/EHD3/WASHC1/GRIP2/NDRG4/EHD1/SORL1/EIPR1/SCRIB/RAB35/VPS26C/EPS15/GGA3/CCDC93/EHD2/MICALL1/INPP5F/LMTK2/PTPN23/WASHC2C/SNF8/RAB8A/RAB11A/GRIPAP1/VPS35L/SNX12/ANKRD27/ARF6/EHD4/RAB7A/GRIP1/RAB14/VPS29/DENND1A/VPS26A |
| GOBP_MONONUCLEAR_CELL_MIGRATION | 129 | 0.4631613 | 1.663043 | 0.0011150 | 0.0204717 | 0.0168184 | 2705 | CCL26/PTPRO/CXCL10/CCL4/CH25H/CXCL11/ADAM8/ARHGEF5/STK10/SLIT2/CCL22/FLT1/ARTN/CXCL16/SLC12A2/CD47/GATA3/PLA2G7/ANXA1/CD200R1/RIPK3/S100A7/ICAM1/TNF/CX3CL1/TRPM4/CCL5/HSD3B7/LGALS9/THBS1/CCN3/GREM1/OXSR1/FADD/SLC8B1/WASL/ITGB7/AKT1/MSN/ADAM17/TRPV4/GAS6/PLEC/CCL20/IL27RA/MIA3/LGALS3/FUT4/ALOX5/S100A14 |
| GOBP_EPITHELIAL_CELL_PROLIFERATION | 329 | 0.3647105 | 1.469407 | 0.0011225 | 0.0204717 | 0.0168184 | 1944 | CCL26/HAS2/DLX5/LGR5/HYAL1/PRKD1/FOXE3/PPP1R16B/SFRP1/PPARG/FAP/NOD2/PAX6/FGFBP1/BCL11B/NR4A1/FLT1/EREG/DLL4/HES5/F3/VEGFA/FGF2/TNFSF12/GATA3/RAP1GAP/APOE/SFN/XDH/CCR3/SDR16C5/CDKN1C/EPPK1/KLF9/SCARB1/NRP2/HIF1A/SOX9/CEACAM1/DUSP10/ZFP36/KDR/TNF/CDH3/SULF1/CAV2/HMOX1/YAP1/DLG1/EPHA2/BMP2/FUT2/CDKN2B/THBS1/OSR1/SERPINB1/SOX2/ERRFI1/CCN3/NR4A3/IRF6/STAT1/SGPP2/VDR/AKT3/TGFA/MARVELD3/EHF/SCG2/TNFAIP3 |
| GOBP_GAMETE_GENERATION | 493 | -0.3087734 | -1.358500 | 0.0011224 | 0.0204717 | 0.0168184 | 2474 | PAQR7/SYNE1/FOXJ1/HORMAD1/DPCD/SPEF2/LRRK2/TTC21A/MYCBP/ZSCAN2/CFAP58/ROPN1L/NDC1/CFAP69/IFT27/CFAP91/PCSK4/CREB3L4/DRC7/INPP5B/SPAG16/SPINK1/CFAP47/SPA17/TTC12/NPHP1/ERCC1/RFX2/DNAH1/CETN2/IFT81/HSF2/TSPAN8/SIX5/SLC26A8/IQCG/TDRP/RACGAP1/NME5/CCDC136/RSPH1/SPATA32/TCFL5/BMPR1B/CFAP44/SPOCD1/HOOK1/IFTAP/FOXL2/TDRD6/PTK2B/CFAP65/TESMIN/NANOS1/GAS2/GAMT/BBS4/MNS1/HOATZ/CFAP43/ROS1/ADAMTS1/MCM8/KIF18A/TSGA10/CFAP206/ZCWPW1/HSPA2/CCDC87/PMFBP1/M1AP/GDF9/SPATA9/BRIP1/HMGB2/PLAT/FBXO5/FMN2/SPAG4/PIWIL2/HROB/HSF2BP/TRIP13/GJA1/PTN/ELL3/KIT/MEIG1/PTTG1/NEURL1/YBX2/KNL1/BMP15/E2F1/MGAT4D/MYBL1/TTK/OCA2/NDC80/MYCBPAP/BCL2L10/H1-1/CCNB2/NCAPH/ASF1B/TSSK3/PLK1/CYP26B1/AR/CATSPERD/NLRP14/DMC1/ZBTB16/CDC25C/ASPM/TOP2A/CNTD1 |
| GOBP_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT | 32 | 0.6533819 | 1.847479 | 0.0011398 | 0.0207065 | 0.0170113 | 1361 | NTRK1/GDNF/EDNRA/GATA3/EGR2/KIF26A/NRP2/PLXNA3/ASCL1/SEMA3A |
| GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 438 | 0.3391205 | 1.407613 | 0.0011572 | 0.0209418 | 0.0172046 | 3475 | NTRK1/ADRA1A/RASGRP1/PRKD1/RTN4R/RAB42/CDC42EP5/SPRY4/USP28/ARHGAP31/ARHGEF5/SLIT2/DENND4A/ARHGAP30/AMOT/RAC3/ARHGAP11B/ARHGAP21/RELN/DOCK3/FGF2/CDC42EP1/RTKN/RAP1GAP/ARHGAP40/APOE/DOK1/FBP1/MET/KITLG/FGD2/DOCK11/PRAG1/GMIP/DAB1/TAGAP/PLEKHG6/RHOD/HMOX1/RIPOR1/CDK2/FGD3/LRRC59/TNFAIP1/RND3/PLEKHG1/ARHGAP27/PLEKHG5/KRAS/RHOG/RRAGC/RAB15/CDC42SE1/NTN1/RAP2B/RASA2/ITGAV/ARHGDIA/SIPA1L2/RAC1/RAB4B/RAP1GAP2/RAB9A/PSD4/ARHGEF10/RHOB/PLCE1/RAP2C/STMN3/TNK2/RASIP1/CDKN2A/CHN1/NRAS/ARHGAP10/FLCN/SQSTM1/CDKN1A/DHCR24/RAB35/RASSF1/LIMK1/GNA12/RHOC/DENND3/JUN/PLD2/SH3BP1/DENND4C/NGEF/CHP1/RANGRF/ITGA3/PDPN/MCF2/CYTH3/EPS8L1/SRC/RRAS2/RAPGEF4/ARHGAP8/MAPRE2/SHTN1/CADM4/BCR/RABIF/RGS19/RALA/CFL1/TIAM1/VAV2/TIAM2/RAP1A/AKAP13/DOCK7/RND1/GNB1/SIAH2/MFN2/CRK/SIPA1L1/CBL/DOCK6/GBF1/MYO9B/ARHGEF2/NKIRAS2/FLOT1/WASF1/SWAP70/RREB1/ARHGAP17/ERBIN/HEG1/GARRE1/PLEKHG3/PHACTR4/RASAL1/PLK2/SH2D3C/ABR/TP53/DOCK5/RHOT2/SPRY2/ARHGEF1/LZTR1/ARFGAP1/KALRN/CYRIB |
| GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST | 157 | 0.4282660 | 1.571134 | 0.0011673 | 0.0210431 | 0.0172878 | 3358 | CH25H/CD55/LDLR/ANPEP/NPC1/CXCL8/PVR/IFIT1/SLC3A2/IFITM1/TYRO3/CD86/SLC1A5/KRT6A/NECTIN2/TMPRSS2/SCARB1/LAMP3/VPS37B/IFITM3/ICAM1/RNASEK/CAV2/EPHA2/LGALS9/TRIM14/SERPINB3/GSN/AXL/SLC52A2/ITGAV/TPCN2/PLSCR1/TRIM21/TRIM25/CLDN9/CD46/NECTIN4/CHMP6/ITGB7/ITGB6/CHMP7/FCN3/GAS6/SLC20A2/TMPRSS4/TRIM5/SRC/CLDN1/EPS15/DAG1/SMPD1/THOC6/CAV1/TRIM22/CBL/VPS4A/VPS4B/CHMP1B/TFRC/P4HB/CD81/ATG7 |
| GOBP_OUTER_DYNEIN_ARM_ASSEMBLY | 19 | -0.7031302 | -1.841911 | 0.0011727 | 0.0210583 | 0.0173003 | 3518 | ODAD1/DNAAF11/ZMYND10/ODAD4/DNAAF2/DNAI1/DNAL1/ODAD3/DAW1/DNAAF1/DNAAF4/DNAI2/LRRC49/DNAH5/DNAAF6/DNAAF8/ODAD2 |
| GOBP_REGULATION_OF_P38MAPK_CASCADE | 37 | 0.6300980 | 1.804356 | 0.0011947 | 0.0213715 | 0.0175576 | 1525 | RASGRP1/NCF1/PTPN22/GADD45G/VEGFA/XDH/MFHAS1/DUSP10/ZC3H12A/SPHK1/DLG1/BMP2/LGALS9/GADD45A |
| GOBP_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS | 26 | 0.7103726 | 1.924691 | 0.0012028 | 0.0214343 | 0.0176092 | 2035 | IDO2/PSAT1/SLC5A8/NNMT/HAAO/IDO1/PARP9/QPRT/NAMPT/KYNU/NADK/PARP10/PDXK |
| GOBP_GLYCEROLIPID_CATABOLIC_PROCESS | 49 | 0.5881757 | 1.784613 | 0.0012401 | 0.0220150 | 0.0180863 | 1025 | PNPLA3/APOC1/AADAC/LIPG/LDLR/PLA2G4C/ENPP6/PNPLA1/LIPH/PLA2G7/PLA2G4A/GPCPD1/SCARB1 |
| GOBP_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS | 23 | 0.6949942 | 1.822445 | 0.0012518 | 0.0221381 | 0.0181874 | 1987 | IDO2/SLC5A8/NNMT/HAAO/IDO1/PARP9/QPRT/NAMPT/KYNU/NADK/PARP10 |
| GOBP_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION | 78 | 0.5169673 | 1.738487 | 0.0012696 | 0.0223681 | 0.0183763 | 1899 | CCL26/ALOX15/CDC42EP5/MAP1B/CLASP1/CDC42EP1/MET/HCK/BIN1/OCLN/SNX9/DLG1/RAC1/VASP/CTTN |
| GOBP_VIRAL_GENOME_REPLICATION | 117 | 0.4665056 | 1.653806 | 0.0013085 | 0.0229681 | 0.0188693 | 3085 | APOBEC3A/RSAD2/ISG15/OAS3/ISG20/OASL/OAS1/CXCL8/MX1/IFIT1/BCL2/IFITM1/IFIH1/STOM/BST2/IFI27/OAS2/IFITM3/TNF/ZC3H12A/SHFL/TNIP1/IFIT5/CCL5/ADAR/PLSCR1/N4BP1/EIF2AK2/APOBEC3B/PARP10/ZNFX1/RAB29/PCBP1/GAS6/TMEM41B/PDE12/IFI16/LARP1/TBC1D20/CCNK/SRPK1/PKN2/RAD23A |
| GOBP_REGULATION_OF_LYMPHOCYTE_ACTIVATION | 335 | 0.3624499 | 1.461897 | 0.0013176 | 0.0230409 | 0.0189291 | 2322 | FGL2/DPP4/SOCS1/RASGRP1/THY1/CD274/LGALS7B/TLR4/PTPN22/PDCD1LG2/PRDM1/SFRP1/CD55/ADAM8/THEMIS2/NOD2/IL4I1/PRKCQ/EBI3/IDO1/BCL2/IL1A/TOX/CLCF1/CD47/CD70/GATA3/SLC7A1/TYRO3/TNFSF13/TICAM1/CD86/MICA/ANXA1/CD276/HLA-DOB/TNFSF9/RIPK3/NFKBID/CARD11/CEACAM1/DUSP10/IL23A/MYD88/ZC3H12A/AHR/DUSP3/CD83/IRS2/ARG2/IL4R/DLG1/ZBTB7B/CCL5/LGALS9/FYN/IL15RA/AXL/SPINK5/FADD/IL1RL2/RIPK2/IL20RB/PRELID1/TNFAIP3/CD46/TNFRSF13C/MAP3K8/IL15/SHLD2/PRNP/BCL10/CDKN1A/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1/HLA-F |
| GOBP_NEGATIVE_REGULATION_OF_PROTEOLYSIS | 243 | 0.3935094 | 1.534134 | 0.0013288 | 0.0231501 | 0.0190188 | 2657 | CST1/FETUB/IL1R2/SERPINB4/SERPINB2/SERPINB10/CHAC1/HMSD/SERPINC1/SERPINB13/PLAUR/SERPINB12/CD44/KLF4/NR4A1/VEGFA/CSTA/SERPINB9/IFI6/BST2/ARRB2/SFN/UBE2Z/SERPINB8/SERPINB7/ANOS1/PI3/TIMP2/BIN1/LAMP3/PML/TFPI2/ANXA8/PTGS2/ITIH2/TNF/SERPINB6/SERPINB11/CSTB/THBS1/SERPINB1/PRKCG/SERPINB3/SPINK5/SERPINH1/SNCA/SPINT2/ANXA8L1/TRIM21/N4BP1/A2ML1/HDAC6/SORL1/TIMP1/FURIN/PRNP/DHCR24/MICAL1/AKT1/GAS6/PICALM/USP14/RFFL/F8A1/SRC/BIRC3/GIPC1/PAK2/DNAJB6/DDRGK1 |
| GOBP_FAT_CELL_DIFFERENTIATION | 189 | 0.4067439 | 1.525234 | 0.0013340 | 0.0231536 | 0.0190217 | 2791 | CCN4/SOCS1/PNPLA3/GRK5/TRIB3/INSIG1/SFRP1/PPARG/KLF4/NR4A1/ALOXE3/PTPRQ/DDIT3/GPS2/GATA3/EGR2/JDP2/ENPP1/MSX2/METRNL/DUSP10/PTGS2/TRIB2/ZFP36/TNF/ZC3H12A/WDFY2/ARID5B/YAP1/LRRC8C/RGS2/TRPM4/BMP2/ZBTB7B/MMP11/NOCT/NR4A3/PIM1/CCDC71L/TFE3/LAMB3/ARL4A/HDAC6/ZBTB7C/TMEM120A/FLCN/AKT1/RORA/TRPV4/AXIN1/GPER1/TMEM120B/KLF5/PPARD/ALOX5/ATF5/PPARGC1A/SIRT2 |
| GOBP_NERVE_GROWTH_FACTOR_SIGNALING_PATHWAY | 10 | 0.8273984 | 1.779352 | 0.0013445 | 0.0231923 | 0.0190535 | 240 | NTRK1/BDNF |
| GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE | 138 | 0.4519239 | 1.642572 | 0.0013531 | 0.0231923 | 0.0190535 | 2046 | ALOX15/CD274/IL1RL1/RSAD2/CD55/NOD2/IL4I1/PVR/PRKCQ/FZD5/ADCY7/CLCF1/IRF7/GATA3/TNFSF13/PLA2G4A/ANXA1/NECTIN2/IL18R1/RIPK3/NFKBID/ARID5A/CEACAM1/DUSP10/IL23A/TNF/ZC3H12A/AHR/IL4R/TRPM4/ZBTB7B/NLRP10/CARD9/FADD/RIPK2/IL20RB/TNFAIP3/CD46/SHLD2 |
| GOBP_LEUKOCYTE_CHEMOTAXIS | 159 | 0.4302110 | 1.590251 | 0.0013512 | 0.0231923 | 0.0190535 | 1831 | CCL26/DPP4/TNFAIP6/PTPRO/CXCL10/CCL4/CH25H/CXCL11/ADAM8/NOD2/CXCL9/ARHGEF5/HRH1/SLIT2/CXCL8/CCL22/FLT1/CXCL16/VEGFA/SLC12A2/DAPK2/PLA2G7/EDN1/ANXA1/S100A7/CXCL1/IL23A/CAMK1D/CX3CL1/ITGA9/TRPM4/CCL5/HSD3B7/LGALS9/THBS1/CXCL2/CCN3/GREM1/MMP28/OXSR1/PDE4B/CXCL6/RAC1/SLC8B1 |
| GOBP_EPITHELIAL_CELL_DEVELOPMENT | 175 | 0.4204217 | 1.561785 | 0.0013561 | 0.0231923 | 0.0190535 | 2809 | NTRK1/CLDN5/EDNRA/SPDEF/PPP1R16B/PRDM1/PAX6/BCL11B/VEGFA/TMOD1/IL1A/FASN/SFN/MET/ATF4/CLIC4/FOSL2/NOTCH4/HIF1A/S1PR3/VCL/SOX9/MYD88/ICAM1/TNF/YAP1/EPHA2/COL22A1/CCM2/RAP2B/SLC9A4/PLOD3/TJP1/SPINT2/ACTA2/VSIG1/GPAT4/RAP2C/E2F4/BMP6/MYO1E/TJP2/AKT1/PODXL/MSN/PLEC/SRC/CLDN1/KLF5/TIGAR/IL6ST/C1GALT1/TBC1D20/LAMB2/RAP1A |
| GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 205 | 0.4025435 | 1.526760 | 0.0013825 | 0.0235576 | 0.0193536 | 2581 | IL1R2/CD274/LGALS7B/TLR4/PTPN22/PDCD1LG2/IL1RL1/OAS3/NOD2/KLF4/OAS1/HOMER2/HDAC9/IDO1/KLF2/DDIT3/ADCY7/GATA3/BST2/ARRB2/UFD1/RELB/ANXA1/CD200R1/PML/CEACAM1/TRIB2/IL23A/ZFP36/SARS1/TNF/ZC3H12A/CDH3/CD83/CX3CL1/SYT11/HMOX1/RPS6KA4/ARG2/EPHA2/APPL2/LGALS9/THBS1/SERPINB1/ERRFI1/RNF125/AXL/ANXA4/RAC1/N4BP1/IL20RB/NPLOC4/TNFAIP3/HOMER3/FURIN/PRNP/GBP1/TMSB4X/HLA-F/SELENOS/GAS6/CYLD/HDAC7/MUL1/CPTP/IL27RA/BCL3 |
| GOBP_LEUKOCYTE_MIGRATION | 269 | 0.3868252 | 1.526226 | 0.0013978 | 0.0237329 | 0.0194977 | 2711 | CCL26/DPP4/TNFAIP6/SELP/THY1/PTPRO/SELL/CXCL10/CCL4/CH25H/CXCL11/ADAM8/NOD2/CXCL9/ARHGEF5/STK10/HRH1/SLIT2/CXCL8/CCL22/FLT1/ARTN/CXCL16/VEGFA/IL1A/SLC12A2/DAPK2/CD47/GATA3/PLA2G7/EDN1/CD9/ANXA1/HCK/CD200R1/KITLG/RIPK3/S100A7/ROR2/CXCL1/IL23A/MYD88/ICAM1/TNF/CAMK1D/CX3CL1/ITGA9/HMOX1/PTAFR/TRPM4/CCL5/HSD3B7/ST3GAL4/LGALS9/THBS1/FYN/RHOG/CXCL2/CCN3/GREM1/ITGA6/MMP28/P2RX4/OXSR1/PDE4B/FADD/CXCL6/RAC1/SLC8B1/MYH9/SCG2/WASL/ITGB7/SBDS/WDR1/MCU/AKT1/MSN/MTUS1/ADAM17/TRPV4/IRAK4/PF4V1/GAS6/CD177/ITGA3/PLEC/SRC/CCL20/IL27RA/MIA3/BCR/LGALS3/FUT4/ALOX5/S100A14/SYK |
| GOBP_REGULATION_OF_BODY_FLUID_LEVELS | 290 | 0.3770198 | 1.502353 | 0.0014086 | 0.0238293 | 0.0195768 | 2543 | ADRA2C/EMILIN2/HAS2/C1QTNF1/VWF/SELP/NFE2/SERPINB2/STATH/TLR4/PROCR/PTPRO/KRT16/SLC7A11/SERPINC1/PLAUR/FAP/PRKCQ/CD36/ALOXE3/FA2H/F3/VEGFA/SOCS2/SLC29A2/PLAU/GRHL3/TYRO3/APOE/SFN/EDN1/PLA2G4A/MET/CD9/HK2/XDH/P2RY1/OAS2/THBD/HIF1A/VCL/PEAR1/TFPI2/ANXA8/CEACAM1/CLDN4/ZBTB7B/ST3GAL4/ELOVL1/THBS1/MYO5B/LSR/AXL/SH2B3/RAP2B/ENTPD2/PLSCR1/VDR/MYH9/DGKI/GPAT4/TEC/DGKQ/ACTB/CSRP1/GNA12/ITPK1/TRPV4/DGKA/UBASH3B/PF4V1/GAS6/FOXB1/GRHL1/PDPN/TMPRSS11F/PLEC/ACTN1/SRC/CLDN1 |
| GOBP_CELL_KILLING | 103 | 0.4756511 | 1.663204 | 0.0014189 | 0.0238940 | 0.0196300 | 1835 | NOS2/RASGRP1/SERPINB4/DEFB4A/CTSC/CD55/ULBP1/PVR/RAET1G/SERPINB9/UNC13D/ARRB2/MICA/RAET1E/NECTIN2/ULBP2/RIPK3/CEACAM1/IL23A/MYD88/ICAM1/CEBPG/LGALS9/ITGAM/RNF19B/TUBB/FADD/CXCL6/ULBP3 |
| GOBP_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING | 113 | 0.4612259 | 1.628867 | 0.0014278 | 0.0238940 | 0.0196300 | 1199 | NTRK1/RASGRP1/SELP/NCF1/PPP1R16B/NYAP1/NTRK2/FLT1/NTRK3/RELN/FGF2/GATA3/TYRO3/EDN1/PEAR1/SOX9/ROR2/CEACAM1/KDR/TNF |
| GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE | 408 | -0.3229746 | -1.396949 | 0.0014238 | 0.0238940 | 0.0196300 | 1369 | CDC7/STK33/MTBP/INSR/ADAMTS1/HSPA2/PKMYT1/ABRAXAS1/CDC25A/BLM/HECW2/CCDC8/STOX1/FHL1/FBXO5/ANAPC4/CCNB1/ORC1/GAS1/TRIP13/EPGN/CDC14A/MCIDAS/KIF20B/E2F1/E2F7/CCL2/TTK/CDT1/CDCA5/GMNN/NDC80/KIF14/FBXO43/MAD2L1/CENPF/CDCA2/CENPE/NEK2/PLK1/TICRR/CDK1/ANLN/RRM2/DTL/BUB1/GTSE1/DLGAP5/CDC25C/UBE2C/BUB1B/MKI67 |
| GOBP_NEGATIVE_REGULATION_OF_PHOSPHORYLATION | 324 | 0.3647374 | 1.468952 | 0.0014447 | 0.0240904 | 0.0197914 | 3368 | SOCS1/THY1/PTPN22/PTPRO/TRIB3/WARS1/HMGCR/SFRP1/PPARG/SPRY4/PAX6/SLIT2/PTPRQ/UCHL1/NTRK3/PTPRH/HHEX/CBLC/ARRB2/APOE/SFN/FBP1/XDH/GRB10/WASHC1/ENPP1/ZBED3/CDKN1C/TRIB1/BAK1/OCLN/CEACAM1/DUSP10/TRIB2/MLXIPL/ZC3H12A/NIBAN1/PPP1R15B/RUBCN/SOCS3/DUSP3/IRS2/DBNDD1/RGS2/DUSP7/SPRED2/PARP14/BMP2/ENG/CDKN2B/GADD45A/ERRFI1/GREM1/DUSP6/SERPINB3/SH2B3/TESK1/SPAG9/SNCA/ADAR/ZGPAT/SLC8A1/ANKLE2/PIP4K2A/TNFAIP3/DGKQ/LATS2/CHMP6/SORL1/RASIP1/GPRC5A/CDKN2A/CNKSR3/PRNP/CDKN1A/PTK6/MICAL1/AKT1/KAT2B/JUN/PPP4R2/ZFYVE28/UBASH3B/EIF4G1/CHP1/PIK3IP1/PLEC/DBNDD2/TIGAR/PAK2/CADM4/YWHAG/SIRT2/SMPD1/CSK/CAV1/MIDN/AIDA/HEXIM1/PRKAR1B/SIRT6/INPP5J/CBL/SMCR8/PIP4K2C/LRRK1/PKIA/HEG1/INPP5F/GIT1/SPRED1/IBTK/MYADM/NCOR1/UBE2B/PDE4D |
| GOBP_CHLORIDE_TRANSMEMBRANE_TRANSPORT | 43 | 0.6026443 | 1.785986 | 0.0014784 | 0.0245248 | 0.0201482 | 1617 | ANO1/GABRA4/SLC26A4/SLC26A9/SLC5A1/ANO2/CLIC2/ANO4/SLC12A2/LRRC8A/SLC26A6/CLCN6/ANO7/SLC12A4/APOL1 |
| GOBP_PROGRAMMED_CELL_DEATH_INVOLVED_IN_CELL_DEVELOPMENT | 11 | 0.8080444 | 1.782430 | 0.0014813 | 0.0245248 | 0.0201482 | 920 | NTRK1/BCL2/IL1A/FGF2/KITLG |
| GOBP_INNER_DYNEIN_ARM_ASSEMBLY | 16 | -0.7241531 | -1.826602 | 0.0015120 | 0.0248918 | 0.0204497 | 4151 | CCDC40/CFAP100/DNAAF11/ZMYND10/DNAI3/DNAAF2/CCDC39/DNAH7/TEKT2/DNAH1/CFAP73/DNAAF1/DNAAF4/DNAH2/DNAAF6 |
| GOBP_NEGATIVE_REGULATION_OF_NEURON_DEATH | 165 | 0.4275584 | 1.575302 | 0.0015194 | 0.0248918 | 0.0204497 | 3017 | NTRK1/PLA2G3/GDNF/FZD9/SLC7A11/BDNF/ADAM8/NTRK2/BCL2/FOXQ1/CLCF1/NES/TYRO3/ARRB2/APOE/AARS1/ATF4/CD200R1/HIF1A/FZD1/CX3CL1/HMOX1/AP2B1/KRAS/NR4A3/PRKCG/AXL/SNCA/ATP13A2/HYOU1/ZPR1/SORL1/AKT1/JUN/BOK/HLA-F/GRIK2/EIF4G1/FOXB1/IL27RA/TIGAR/NRBP2/IL6ST/WFS1/PPARGC1A/IKBKG/ISL1/UNC5B/CBL/LGMN |
| GOBP_REGULATION_OF_PROTEIN_SECRETION | 191 | 0.4111079 | 1.546086 | 0.0015145 | 0.0248918 | 0.0204497 | 3032 | NOS2/ANO1/CYP51A1/TLR4/ACHE/ADCY5/SLC9B2/CNR1/HMGCR/SFRP1/RSAD2/PCK2/ADAM8/PPARG/IL1A/SLC12A2/LRRC8A/CPT1A/APOE/ADAM9/TTN/DOC2B/RAB11FIP1/STX1A/LLGL2/HIF1A/BRSK2/TNF/IRS2/GPR27/TRPM4/CCL5/CCN3/FKBP1B/ACSL4/SLC8B1/ATP13A2/AACS/VSNL1/BMP6/PIM3/MCU/EIPR1/STXBP5/EFNA5/RAB11FIP5/GPER1/STX4/PTPN11/RHBDF2/ACVR1C/PPARD/ALOX5/RHBDD3/MYO18A/MIDN/PFKFB2/DNAJC1/ISL1/RHBDF1/DISP1/ICA1 |
| GOBP_REGULATION_OF_RESPONSE_TO_WOUNDING | 124 | 0.4601912 | 1.645588 | 0.0015336 | 0.0250361 | 0.0205683 | 1658 | CCN4/C1QTNF1/SERPINB2/RTN4R/HBEGF/SERPINC1/PHLDB2/FAP/KLF4/DUOX2/CD36/F3/PLAU/SLC12A2/FGF2/CLASP1/SMOC2/DUOX1/APOE/EDN1/TNFRSF12A/CD9/ANXA1/EPPK1/THBD/OCLN/CEACAM1/TNF/CLDN4/ST3GAL4/THBS1/NDEL1/FKBP1B/SH2B3 |
| GOBP_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | 131 | 0.4531594 | 1.633660 | 0.0015445 | 0.0251267 | 0.0206427 | 3267 | IL19/GDNF/SFRP1/BCL2/IL1A/IFI6/TNFSF12/TMBIM1/PMAIP1/TNFRSF12A/TMC8/PML/ICAM1/TNF/CX3CL1/PEA15/HMOX1/YAP1/THBS1/ITGA6/ITGAV/FADD/EYA4/RBCK1/LMNA/CTTN/SCG2/TNFAIP3/BCL2L14/ATF3/BCL10/LTBR/AKT1/TGFBR1/GPER1/RELA/RFFL/CYLD/STX4/SRC/CSF2/BID/PAK2/LGALS3/CAV1/SIAH2/UNC5B/PELI3/ARHGEF2/STRADB/EYA3/EYA2/HTT/SH3RF1/ZC3HC1 |
| GOBP_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORT | 65 | 0.5399947 | 1.757336 | 0.0015704 | 0.0254598 | 0.0209163 | 1617 | ANO1/GABRA4/SLC5A5/SLC26A4/SLC26A9/SLC5A1/ANO2/CLIC2/ANO4/SLC12A2/LRRC8A/SLC26A6/SLC26A11/PTAFR/CLCN6/ANO7/SLC25A3/SLC12A4/APOL1 |
| GOBP_RECEPTOR_RECYCLING | 31 | 0.6604107 | 1.847157 | 0.0016036 | 0.0258790 | 0.0212608 | 3457 | ACHE/PCSK9/LDLR/EHD3/PHETA2/PLEKHJ1/ECE1/OPTN/SNCA/SORL1/RAB29/LAMTOR1/SCRIB/TBC1D16/INPP5F/LMTK2/ANXA2 |
| GOBP_RESPONSE_TO_NICOTINE | 34 | 0.6478476 | 1.841243 | 0.0016184 | 0.0258790 | 0.0212608 | 1329 | NTRK1/LYPD1/CNR1/SLC7A11/BCL2/EDN1/TNF/HMOX1 |
| GOBP_PROTEIN_LOCALIZATION_TO_CHROMATIN | 31 | -0.6245187 | -1.828990 | 0.0016185 | 0.0258790 | 0.0212608 | 3218 | RUVBL2/MSH2/MRNIP/ESR1/EZH2/LRWD1/FAM47E/MCM8/H1-5/CDCA5/PLK1/ESCO2 |
| GOBP_REGULATION_OF_MAP_KINASE_ACTIVITY | 157 | 0.4228067 | 1.551106 | 0.0016104 | 0.0258790 | 0.0212608 | 1840 | RASGRP1/FZD10/TLR4/PTPN22/TRIB3/HMGCR/SFRP1/ADAM8/PPARG/SPRY4/NOD2/ARHGEF5/FLT1/UCHL1/NTRK3/VEGFA/FZD5/CBLC/FGF2/APOE/ADAM9/EDN1/KITLG/FGD2/TRIB1/ROR2/DUSP10/TRIB2/TNF/RGS2/DUSP7/BMP2/THBS1/SERPINB3/SH2B3/MST1R/IRAK1/TGFA |
| GOBP_ORGANIC_ANION_TRANSPORT | 248 | 0.3893696 | 1.519383 | 0.0016594 | 0.0264421 | 0.0217234 | 2250 | NOS2/PLA2G3/SLC26A4/SLC26A9/SLC39A8/SLC2A6/SLC5A8/SLC7A11/LRRC8D/SLCO4A1/SLCO1B1/SLC16A9/SLC25A25/ACE/MFSD2A/SLC6A14/NTRK2/CD36/SLC16A4/SLC3A2/IL1A/SLC7A9/SLC12A2/CD47/SLC7A5/LRRC8A/SLC7A1/EDN1/SLC16A14/PLA2G4A/SLC1A5/ANXA1/SLC4A9/SLC36A1/SLCO1B3/SLC26A6/SLC1A4/CEACAM1/SLC16A13/SLCO3A1/TNF/SLC27A4/SLC4A3/SFXN5/ATP8B1/SLC38A1/SLC25A1/LRRC8C/RGS2/SLCO4C1/SLC25A32/SLC5A12/SLC38A7/SLC16A7/SERINC5/SLC6A9/SLC17A5/SLC52A2/P2RX4/SNCA/SLC66A1/PRAF2/MFSD12/GABBR1/SLC16A3/SLC25A23/SLC35D2/SLC25A22/SLC35B4/GRM1/SLC6A11 |
| GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY | 82 | 0.5094217 | 1.718610 | 0.0017074 | 0.0271157 | 0.0222767 | 1199 | SH2D1B/RASGRP1/RSAD2/CD55/NOD2/PVR/RAET1G/FZD5/CLCF1/GATA3/TNFSF13/RAET1E/NECTIN2/IL18R1/ARID5A/IL23A/TNF |
| GOBP_ALPHA_BETA_T_CELL_ACTIVATION | 108 | 0.4700641 | 1.641702 | 0.0017297 | 0.0273754 | 0.0224901 | 1477 | SOCS1/CDH26/CD274/LGALS7B/PTPN22/PRDM1/RSAD2/CD55/BCL11B/PRKCQ/EBI3/BCL2/TOX/GATA3/CD86/RELB/ANXA1/IL18R1/NFKBID/IL23A/ZC3H12A/CD83/ARG2/IL4R/ZBTB7B/LGALS9 |
| GOBP_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY | 29 | 0.6690798 | 1.828053 | 0.0017639 | 0.0278231 | 0.0228579 | 1477 | SH2D1B/RASGRP1/SERPINB4/PVR/RAET1G/SERPINB9/ARRB2/MICA/RAET1E/NECTIN2/CEACAM1/LGALS9 |
| GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS | 63 | 0.5548951 | 1.780369 | 0.0017804 | 0.0279896 | 0.0229947 | 2389 | CD274/SLC7A11/ADAM8/NOD2/PRKCQ/ST6GAL1/PIP/IDO1/IRF7/HSH2D/ANXA1/KITLG/RIPK3/HIF1A/IRS2/ARG2/CCL5/LGALS9/AXL/FADD/PRELID1/CDKN2A/BCL10/ADAM17/SELENOS/GAS6 |
| GOBP_REGULATION_OF_CELL_KILLING | 59 | 0.5552713 | 1.761770 | 0.0018222 | 0.0285504 | 0.0234554 | 1780 | NOS2/RASGRP1/SERPINB4/CD55/PVR/SERPINB9/ARRB2/MICA/RAET1E/NECTIN2/RIPK3/CEACAM1/IL23A/ICAM1/LGALS9/ITGAM/FADD/CXCL6 |
| GOBP_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION | 98 | -0.4530832 | -1.654312 | 0.0018316 | 0.0286015 | 0.0234974 | 2983 | NOP53/AURKA/RAD51B/ING4/MRNIP/DYRK3/MRE11/CLSPN/ATAD5/PBX1/RRM1/CHEK1/BRCA1/CDC7/HSPA2/ABRAXAS1/CDC25A/BLM/STOX1/FHL1/FBXO5/CCNB1/ORC1/NEK10/KIF14/CENPF/PLK1/TICRR/CDK1/DTL/CDC25C |
| GOBP_PLATELET_ACTIVATION | 99 | 0.4871085 | 1.690968 | 0.0018563 | 0.0288902 | 0.0237346 | 2990 | ADRA2C/EMILIN2/C1QTNF1/VWF/SELP/TLR4/SLC7A11/PRKCQ/TYRO3/APOE/PLA2G4A/CD9/P2RY1/THBD/VCL/PEAR1/CEACAM1/AXL/SH2B3/RAP2B/ENTPD2/PLSCR1/MYH9/DGKI/TEC/DGKQ/ACTB/CSRP1/DGKA/UBASH3B/PF4V1/PDPN/ACTN1/SRC/IL6ST/ACTG1/SYK/VAV2/DGKD/MYL12A/COMP |
| GOBP_NEUROTROPHIN_SIGNALING_PATHWAY | 31 | 0.6538041 | 1.828679 | 0.0018730 | 0.0290540 | 0.0238691 | 597 | NTRK1/BDNF/NTRK2/NTRK3/PPP2R5B |
| GOBP_CIRCULATORY_SYSTEM_PROCESS | 401 | 0.3423939 | 1.406798 | 0.0019014 | 0.0293963 | 0.0241504 | 1796 | NOS2/CLDN5/ADRA1A/ADRA2C/ADM5/SLC5A5/EDNRA/CASQ2/SLC5A1/PTPRO/ADM2/TBXAS1/CXCL10/HOPX/SLC24A3/HBEGF/CNR1/SGK1/HTR1D/CTNNA3/PPARG/KL/CLIC2/ACE/ANPEP/MFSD2A/HRH1/SLIT2/KCNE3/CD36/DLL4/EHD3/KCNMB4/VEGFA/KLF2/SLC29A2/SLC12A2/ANK2/SLC7A5/FGF12/SLC7A1/KLK1/APOE/EDN1/TTN/SLC1A5/P2RY1/KCNK6/SLC5A3/SVEP1/BIN1/OCLN/SLC1A4/CEACAM1/PTGS2/GRIP2/SLCO3A1/PKP2/TNF/ZC3H12A/SLC27A4/SLC4A3/PTP4A3/SLC38A1/HMOX1/YAP1/SEMA3A/RGS2/GCH1/DLG1/PTAFR/TRPM4/ECE1/PLCB3/FYN/FKBP1B/SLC16A7/ATP1B1/SLC9A1/GSN/SLC6A9/NOS1/P2RX4/PDE4B/PLOD3/MYOF/TJP1/STAT1/SLC8A1/CELF2 |
| GOBP_PYRIDINE_NUCLEOTIDE_METABOLIC_PROCESS | 27 | 0.6703270 | 1.800348 | 0.0019223 | 0.0296218 | 0.0243356 | 1987 | IDO2/SLC5A8/NNMT/HAAO/IDO1/PARP9/NUDT17/QPRT/NAMPT/KYNU/NADK/PARP10 |
| GOBP_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY | 47 | 0.5589751 | 1.691001 | 0.0019441 | 0.0298586 | 0.0245302 | 1795 | ADRA1A/RASGRP1/EDNRA/FLT1/FGF2/CD86/ANXA1/ANXA8/RGS2/PTAFR/CCL5/GNA15/P2RY6/SNCA/ANXA8L1 |
| GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | 193 | 0.4117614 | 1.552355 | 0.0019524 | 0.0298876 | 0.0245540 | 3305 | IL19/GDNF/SFRP1/BCL2A1/TNFRSF10A/BCL2/IL1A/IFI6/TNFSF12/TMBIM1/CD70/PMAIP1/TNFRSF12A/IFI27/TMC8/KITLG/BAK1/PML/ICAM1/TNF/FAS/KRT18/CX3CL1/PEA15/HMOX1/YAP1/THBS1/ITGA6/ITGAV/FADD/EYA4/TNFRSF10C/RBCK1/LMNA/CTTN/SCG2/TNFAIP3/BCL2L14/ATF3/BCL10/LTBR/AKT1/BOK/TGFBR1/GPER1/SGPP1/RELA/RFFL/CYLD/STX4/SRC/CSF2/BID/PAK2/LGALS3/CAV1/SIAH2/UNC5B/CASP2/TNFRSF10B/PELI3/ARHGEF2/STRADB/EYA3/EYA2/HTT/SH3RF1/ZC3HC1/DAXX |
| GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS | 164 | 0.4250741 | 1.570268 | 0.0019925 | 0.0304025 | 0.0249770 | 1124 | NOS2/IDO2/CBS/SLC39A8/PSAT1/SLC7A11/TAT/KYAT1/ASNS/HAAO/ASPG/IL4I1/BCAT1/PYCR1/PHGDH/IDO1/GPT2/ARHGAP11B/GOT1/ATF4/CTH/SHMT2/GFPT2/HAL |
| GOBP_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION | 42 | 0.6119453 | 1.811946 | 0.0020533 | 0.0311777 | 0.0256138 | 1899 | CCL26/ALOX15/CDC42EP5/CDC42EP1/HCK/BIN1/SNX9/DLG1/VASP/CTTN |
| GOBP_SYNAPTIC_TRANSMISSION_GABAERGIC | 32 | 0.6322793 | 1.787810 | 0.0020567 | 0.0311777 | 0.0256138 | 574 | ADRA1A/GABRA4/CA2/CNR1/PHF24/RAC3 |
| GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE | 191 | 0.4067330 | 1.529633 | 0.0020673 | 0.0312370 | 0.0256626 | 2740 | SH2D1B/FGL2/PLA2G3/RASGRP1/IL13RA2/TLR4/TCIM/LAT2/IFI35/UNC13D/CLCF1/GATA3/ANXA3/TNFSF13/TICAM1/CD86/RELB/ANXA1/DOCK11/IL18R1/NFKBID/CEACAM1/IL23A/MYD88/ICAM1/ZC3H12A/GAB2/HMOX1/IL4R/PTAFR/ZBTB7B/LGALS9/NR4A3/ITGAM/RIPK2/RNF8/CD46/SHLD2/BATF/SBNO2/HLA-F/RORA/CD177/STX4/IL27RA/BCL3/STXBP2/BCR/LGALS3/SYK/SLC15A4 |
| GOBP_REGULATION_OF_TRANSMEMBRANE_TRANSPORT | 390 | 0.3383822 | 1.387498 | 0.0021046 | 0.0316975 | 0.0260409 | 2575 | CA2/ARC/THY1/EDNRA/CASQ2/TRIB3/ITLN1/RGS7/CXCL10/PRKD1/KCNS3/TMC1/CACNB4/PCSK9/CEMIP/KCNJ16/CXCL11/KCNH8/GEM/CXCL9/STAC/CLIC2/MAPK8IP2/ACE/KCNE3/EHD3/CLIC3/BCL2/ANTKMT/STOM/RELN/ANK2/G6PD/CACNB1/FGF12/SHISA6/EDN1/KCNQ4/HK2/CLIC4/GRB10/KCNK6/ENPP1/SHISA8/TCAF2/TSPAN13/ACSL1/FXYD6/BIN1/SLC26A6/ERFE/OCLN/TNF/KCNA2/VMP1/CX3CL1/IRS2/PEA15/CATSPER3/RGS2/DLG1/PTAFR/APPL2/CTTNBP2NL/THBS1/OSR1/FYN/FKBP1B/NR4A3/PIM1/ATP1B1/SLC9A1/STIM1/SLC6A9/P2RY6/NOS1/TPCN2/SNCA/OXSR1/PDE4B/SLC8A1/CACNA2D4/ANO9/KCNK15/ACTB/WDR1/CNKSR3/PRNP/SHISA9/AKT1/TMSB4X/STIM2/MYC/SELENOS/UBASH3B/GPER1/NEDD4/SHANK3/DIAPH1/CHP1/SCN1B/COA8/HVCN1/RANGRF/DRD1/PTPN11/FGF13/ARPP19 |
| GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 205 | 0.3960726 | 1.502218 | 0.0021287 | 0.0319572 | 0.0262542 | 3656 | HAS2/HYAL1/PRKD1/HBEGF/PPARG/KLF4/FGFBP1/SLIT2/MIR200A/DLL4/HDAC9/VEGFA/FGF2/CLASP1/GATA3/SMOC2/ANXA3/APOE/ADAM9/EDN1/MET/ANXA1/EPPK1/SCARB1/NRP2/HIF1A/SOX9/CEACAM1/DUSP10/PTGS2/KDR/TNF/ZC3H12A/ADAMTS9/HMOX1/SEMA3A/EPHA2/THBS1/BCAR1/GADD45A/P2RX4/ARSB/RAC1/PTPRG/AKT3/MARVELD3/RHOB/HDAC6/CSNK2B/AKT1/JUN/SH3BP1/TMSB4X/ADAM17/ITGA3/TACSTD2/SRC/HDAC7/MAPRE2/CARD10/PFN1/RAB25/MAP2K3/ATOH8/LGMN/GFUS/RREB1/GPI/STAT5A/MIR149/SPRED1/ACVRL1/PTPN23/PRKCA/PLK2/FOXC2/MACF1/DOCK5/RAB11A/CALR/ATP2B4/MMRN2/JUP/RRAS/MAP4K4 |
| GOBP_RESPONSE_TO_INTERFERON_ALPHA | 19 | 0.7392837 | 1.855218 | 0.0021771 | 0.0325792 | 0.0267653 | 2634 | IFIT2/MX2/IFIT3/IFITM1/GATA3/BST2/LAMP3/IFITM3/AXL/ADAR/EIF2AK2/GAS6/PDE12 |
| GOBP_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY | 142 | 0.4280405 | 1.553195 | 0.0021848 | 0.0325902 | 0.0267743 | 3201 | TLR4/PTPN22/RSAD2/OAS3/NOD2/TNIP3/OASL/OAS1/CD36/IFI35/MAPKAPK3/IFIH1/DDX60/GPS2/IRF7/TYRO3/ARRB2/UFD1/TICAM1/LY96/MFHAS1/IRAK2/NFKBIA/MYD88/TNF/TNIP1/SLC15A3/APPL2/LGALS9/RNF125/IRAK1/RIPK2/TRIM25/NPLOC4/TNFAIP3/SEC14L1/BCL10/IRAK4/MAPKAPK2/RELA/GFI1/CYLD/NOD1/BIRC3/CLPB/S100A14/SLC15A4/CAV1/SCARA3/FLOT1/DHX58/ERBIN/NINJ1 |
| GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS | 330 | 0.3548423 | 1.428700 | 0.0022042 | 0.0327755 | 0.0269265 | 3438 | MVD/HMGCS1/SLC2A6/ADCY5/ELOVL6/HKDC1/ACSS2/HMGCR/ADCY4/PDE9A/ELOVL5/PDE8B/ACLY/ALDOB/PDE10A/ACOT1/ANTKMT/ADCY7/GUCY2C/G6PD/DPYD/FBP1/ELOVL7/HK2/XDH/MVK/PRTFDC1/ENPP1/HSD17B12/ACSL1/ALDOC/PANK3/TKT/HIF1A/CARD11/FAR1/MLXIPL/PFKP/ACOT7/SLC25A1/MAGI3/HK1/DLG1/EPHA2/UCKL1/ELOVL1/ACSL4/OGDH/ELOVL4/SNCA/PDE4B/ACACA/NUDT8/ADCY10/UPP1/GPAT4/VPS9D1/GALK1/TAFAZZIN/ENTPD5/FLCN/ENO1/ATP5MC1/TJP2/PDHA1/TMSB4X/RORA/MYC/FOXK1/ATP5F1D/PTHLH/CTPS1/ACOT9/TIGAR/PRXL2C/NT5C2/DLST/PPARGC1A/ACSL3/HACD1/PFKFB2/FOXK2/NUDT16/SIRT6/NPR2/ADPGK/GPI/GIT1/ATP5MC3/GUK1/NCOR1/PMVK/PDE4D/PANK4/SLC26A2/SLC25A16/ADSS2 |
| GOBP_REGULATED_EXOCYTOSIS | 172 | 0.4267388 | 1.580042 | 0.0022227 | 0.0329459 | 0.0270665 | 1598 | ADRA1A/PLA2G3/TRPV6/RASGRP1/IL13RA2/SNPH/CNR1/LAT2/SYNGR3/UNC13A/ERC2/UNC13D/ANXA3/HYAL3/SYNGR2/DOC2B/RAB11FIP1/P2RY1/HCK/SYT17/STX1A/STX3/SYN2/PPFIA3/CEACAM1/RIMS3/GAB2/SYT11/HMOX1/RAB31/IL4R/PTAFR/SYT1/LGALS9/NR4A3/RAB15/ITGAM/PRKCG |
| GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION | 41 | 0.5915369 | 1.740374 | 0.0022416 | 0.0331197 | 0.0272093 | 1448 | HAS2/DPP4/PHLDB2/FAP/FGFR4/CLASP1/RIC1/SOX9/DDR2/BMP2 |
| GOBP_REGULATION_OF_WOUND_HEALING | 98 | 0.4823201 | 1.666894 | 0.0022734 | 0.0334845 | 0.0275090 | 1495 | CCN4/C1QTNF1/SERPINB2/HBEGF/SERPINC1/PHLDB2/FAP/DUOX2/CD36/F3/PLAU/SLC12A2/FGF2/CLASP1/SMOC2/DUOX1/APOE/EDN1/TNFRSF12A/CD9/ANXA1/EPPK1/THBD/OCLN/CEACAM1/TNF/CLDN4/ST3GAL4/THBS1 |
| GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE | 19 | 0.7370762 | 1.849678 | 0.0022816 | 0.0334988 | 0.0275207 | 1591 | PLA2G3/TLR4/NOD2/GBP5/TICAM1/HIF1A/MYD88/TNF/CARD9 |
| GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION | 139 | 0.4314696 | 1.567459 | 0.0023075 | 0.0337731 | 0.0277461 | 2359 | FGL2/SOCS1/C1QTNF1/CD274/LGALS7B/PTPN22/PDCD1LG2/MUC21/KLF4/IL4I1/IDO1/VEGFA/CD86/IL1RN/CD9/ANXA1/NOTCH4/CEACAM1/ZC3H12A/DUSP3/ARG2/IL4R/DLG1/BMP2/ZBTB7B/LGALS9/SH2B3/SPINT2/IL20RB/ASS1/BMP6/PRNP/DLG5/SCRIB/PAWR/AKT1/PODXL/TRPV4/UBASH3B |
| GOBP_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY | 135 | 0.4447346 | 1.602586 | 0.0023749 | 0.0346515 | 0.0284677 | 1909 | NTRK1/TLR4/PRKD1/ADAM8/NOD2/PRKCQ/CD36/AIM2/RTKN2/TICAM1/CTH/IL18R1/RIPK3/IRAK2/CARD11/MYD88/SLCO3A1/TNF/PSMA6/CX3CL1/SPHK1/RPS6KA4/PRKCH/LGALS9/TRIM14/GREM1/CARD9/TRIM21/EIF2AK2/IRAK1/RBCK1/RIPK2/TRAF5/TRIM25 |
| GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS | 28 | 0.6598148 | 1.781532 | 0.0023893 | 0.0347524 | 0.0285506 | 2787 | APOC1/LDLR/LPIN1/MFSD2A/SCARB1/IDH1/ABCA3/TAFAZZIN/CAPN2/CHP1/ACSL3 |
| GOBP_CHROMATIN_REMODELING_AT_CENTROMERE | 11 | -0.7650642 | -1.739526 | 0.0024043 | 0.0348626 | 0.0286411 | 2253 | NASP/MIS18A/HELLS/CENPP/CENPW/OIP5/HJURP |
| GOBP_ENTRY_INTO_HOST | 121 | 0.4558259 | 1.627944 | 0.0024246 | 0.0350472 | 0.0287928 | 2992 | CH25H/CD55/LDLR/ANPEP/NPC1/CXCL8/PVR/SLC3A2/IFITM1/TYRO3/CD86/SLC1A5/KRT6A/NECTIN2/TMPRSS2/SCARB1/LAMP3/IFITM3/ICAM1/RNASEK/CAV2/EPHA2/LGALS9/TRIM14/SERPINB3/GSN/AXL/SLC52A2/ITGAV/TPCN2/PLSCR1/TRIM21/TRIM25/CLDN9/CD46/NECTIN4/ITGB7/ITGB6/FCN3/GAS6/SLC20A2/TMPRSS4/TRIM5/SRC/CLDN1/EPS15/DAG1/SMPD1/CAV1/TRIM22/CBL |
| GOBP_EXTRACELLULAR_MATRIX_DISASSEMBLY | 48 | 0.5612290 | 1.692093 | 0.0024327 | 0.0350568 | 0.0288007 | 1724 | DPP4/MMP1/KLK7/ADAM8/FAP/FGFR4/MMP19/NOXO1/CLASP1/SH3PXD2B/WASHC1/CAPG/DDR2/MMP11/GSN/MMP10 |
| GOBP_SYNAPSE_ORGANIZATION | 327 | 0.3546898 | 1.430145 | 0.0024600 | 0.0353409 | 0.0290341 | 3216 | NTRK1/GDNF/ARC/PTPRO/ACHE/FZD9/CACNB4/SLC7A11/BDNF/MAP1B/NTNG1/GPC6/PDZRN3/LRRTM2/NTRK2/ELFN1/DOK7/NTRK3/UNC13A/ERC2/INA/FZD5/RELN/EPHB3/LRP8/ZNF365/CACNB1/APOE/SHISA6/SYNPO/LRRC4/LRFN4/NRP2/PPFIA3/TNF/NRCAM/FZD1/CHCHD10/VSTM5/IL1RAPL2/CX3CL1/DBN1/PCDHB2/IGFN1/DLG1/FYN/SLIT1/ITGAM/NTN1/TUBB/IGSF9/SNCA/ITPKA/CTTN/HDAC6/WASL/MYOT/ACTB/RAB29/ABHD17C/PRNP/DLG5/PDLIM5/PPFIBP1/EFNA5/NGEF/NEDD4/PCDHB6/SHANK3/EIF4G1/ITGA3/CNKSR2/ACTN1/DRD1/FGF13/EPHA7/CBLN3/LRRN3/ACTG1/CFL1/DAG1/GPC4/SETD5/LAMB2/RAPSN/PPFIA1/ARF4/PFN1/SIPA1L1/LGMN/SLITRK6/SLITRK5/WASF1/APBB2/TSC1/CLSTN3/CDH1 |
| GOBP_ALPHA_AMINO_ACID_CATABOLIC_PROCESS | 74 | 0.5018950 | 1.666222 | 0.0024739 | 0.0354321 | 0.0291090 | 938 | NOS2/IDO2/CBS/TAT/KYAT1/HAAO/IL4I1/IDO1/GPT2/ARHGAP11B/GOT1/SHMT2 |
| GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION | 47 | 0.5530616 | 1.673111 | 0.0024851 | 0.0354824 | 0.0291503 | 3339 | SOCS1/THY1/SFRP1/CBLC/SOCS3/PARP14/ERRFI1/SH2B3/ZGPAT/CHMP6/GPRC5A/PTK6/ZFYVE28/CADM4/CAV1/CBL/LRRK1/INPP5F/IBTK |
| GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 256 | 0.3754900 | 1.472544 | 0.0025257 | 0.0358617 | 0.0294620 | 3475 | NTRK1/ADRA1A/RASGRP1/RTN4R/SPRY4/ARHGAP31/ARHGEF5/SLIT2/DENND4A/ARHGAP30/AMOT/ARHGAP11B/ARHGAP21/RELN/DOCK3/RAP1GAP/ARHGAP40/APOE/FBP1/MET/KITLG/FGD2/PRAG1/GMIP/TAGAP/PLEKHG6/RHOD/FGD3/LRRC59/TNFAIP1/PLEKHG1/ARHGAP27/PLEKHG5/KRAS/CDC42SE1/RASA2/ITGAV/ARHGDIA/SIPA1L2/RAC1/RAP1GAP2/PSD4/ARHGEF10/PLCE1/STMN3/RASIP1/CHN1/ARHGAP10/FLCN/SQSTM1/DENND3/SH3BP1/DENND4C/NGEF/ITGA3/MCF2/CYTH3/EPS8L1/SRC/ARHGAP8/MAPRE2/CADM4/BCR/TIAM1/VAV2/TIAM2/AKAP13/MFN2/CRK/SIPA1L1/CBL/GBF1/MYO9B/ARHGEF2/FLOT1/SWAP70/ARHGAP17/ERBIN/HEG1/PLEKHG3/RASAL1/ABR/SPRY2/ARHGEF1/LZTR1/ARFGAP1/KALRN/CYRIB |
| GOBP_EXOCYTOSIS | 275 | 0.3712608 | 1.472480 | 0.0025270 | 0.0358617 | 0.0294620 | 2711 | ADRA1A/PLA2G3/TRPV6/RASGRP1/IL13RA2/SNPH/CNR1/LAT2/SYNGR3/UNC13A/ERC2/UNC13D/CLASP1/ANXA3/HYAL3/SYNGR2/DOC2B/ANXA1/RAB11FIP1/P2RY1/WASHC1/HCK/SYT17/STX1A/STX3/LLGL2/SYN2/BRSK2/RAB8B/PPFIA3/CEACAM1/RIMS3/GAB2/SYT11/HMOX1/RAB31/IL4R/PTAFR/CCL5/SYT1/LGALS9/NR4A3/RAB15/ITGAM/PRKCG/SYT16/TPCN2/SNCA/ATP13A2/MYH9/YKT6/RAB9A/CHMP6/VSNL1/EXOC6/SCRIB/MICAL1/STXBP5/HLA-F/RAB11FIP5/CD177/SCRN1/DRD1/STX4/EXOC3/RAPGEF4/GIPC1/MIA3/STXBP2/BCR/RALA/SYK |
| GOBP_REGULATION_OF_LIPASE_ACTIVITY | 62 | 0.5395983 | 1.727677 | 0.0025853 | 0.0365778 | 0.0300503 | 2259 | ADRA1A/RASGRP1/EDNRA/APOC1/PCSK6/FLT1/HDAC9/FGF2/CD86/ANXA1/ANXA8/RGS2/PTAFR/CCL5/GNA15/P2RY6/SNCA/ANXA8L1/FURIN/LPAR2/RHOC |
| GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS | 218 | 0.3891820 | 1.490221 | 0.0026255 | 0.0370342 | 0.0304252 | 2342 | NOS2/IDO2/ADCY5/ELOVL6/SLC5A8/ACSS2/NNMT/GARS1/HAAO/ME1/ADCY4/CMPK2/ELOVL5/ACLY/IDO1/ANTKMT/ADCY7/GUCY2C/PARP9/ELOVL7/HSD17B12/ACSL1/QPRT/PANK3/ACOT7/SLC25A1/NAMPT/UCKL1/ELOVL1/ACSL4/NOS1/ELOVL4/SNCA/ACACA/ADCY10/KYNU/UPP1/NADK/VPS9D1/PARP10/TAFAZZIN/FLCN/ENO1/ATP5MC1/PDHA1/TMSB4X/MYC |
| GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS | 34 | 0.6303083 | 1.791395 | 0.0026397 | 0.0371224 | 0.0304977 | 1857 | ALOX15/ELOVL6/ELOVL5/ALOX15B/ELOVL7/HSD17B12/ACSL1/GGT5/FAR1/SLC25A1/GGT7/ELOVL1/ACSL4/ELOVL4/ACACA/AACS |
| GOBP_REGULATION_OF_PLATELET_AGGREGATION | 21 | 0.6953676 | 1.787658 | 0.0026597 | 0.0371799 | 0.0305449 | 2711 | EMILIN2/C1QTNF1/PRKCQ/CD9/CEACAM1/SH2B3/UBASH3B/PDPN/IL6ST/SYK |
| GOBP_NATURAL_KILLER_CELL_ACTIVATION | 53 | 0.5530473 | 1.715193 | 0.0026593 | 0.0371799 | 0.0305449 | 2389 | RASGRP1/PTPN22/PRDM1/ULBP1/UNC13D/TOX/TYRO3/TICAM1/MICA/ULBP2/IL18R1/IL23A/NFIL3/IL15RA/AXL/ULBP3/ELF4/IL15/HLA-F/GAS6 |
| GOBP_REGULATION_OF_ACTION_POTENTIAL | 42 | 0.6007352 | 1.778753 | 0.0026850 | 0.0373508 | 0.0306854 | 1639 | ADRA1A/CNR1/CTNNA3/KCNE3/CD36/ANK2/FGF12/BIN1/PKP2/TNF/DLG1/TRPM4/SLC9A1 |
| GOBP_GRANULOCYTE_CHEMOTAXIS | 89 | 0.4758298 | 1.622164 | 0.0026879 | 0.0373508 | 0.0306854 | 1788 | CCL26/DPP4/TNFAIP6/CXCL10/CCL4/CXCL11/NOD2/CXCL9/HRH1/SLIT2/CXCL8/CCL22/DAPK2/EDN1/ANXA1/S100A7/CXCL1/IL23A/CAMK1D/CX3CL1/ITGA9/CCL5/THBS1/CXCL2/PDE4B/CXCL6/RAC1 |
| GOBP_T_CELL_MIGRATION | 45 | 0.5683371 | 1.703413 | 0.0027280 | 0.0375437 | 0.0308438 | 2565 | CCL26/CXCL10/CXCL11/ADAM8/CXCL16/SLC12A2/CD200R1/RIPK3/S100A7/ICAM1/CCL5/OXSR1/FADD/ITGB7/MSN/ADAM17/PLEC/CCL20/IL27RA |
| GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS | 217 | 0.3912031 | 1.496273 | 0.0027221 | 0.0375437 | 0.0308438 | 3274 | CISH/SOCS1/PNPLA3/ALOX15/PCK2/LDLR/LPIN1/MFSD2A/PLA2G4C/ABHD4/SOCS2/LCAT/LIPH/FGF2/PLA2G4A/ACSL1/SCARB1/GPAT3/LPCAT4/FAR1/SOCS3/PISD/TMEM150A/PIGW/PTPMT1/SELENOI/PLSCR1/ITPKA/GPAT4/PGAP4/PLCE1/PIP4K2A/DGKQ/TAFAZZIN/ACP6/CAPN2/PIP5K1A/INPP1/PIK3C2B/PLD2/INPPL1/DGKA/PTDSS1/LPIN2/PITPNM2/ITPKC/TTC7A/LPIN3/ABHD3/ACSL3/DGKD/INPP5J/PIP4K2C/PLA2G15/PI4K2A/INPP5F/PNPLA2/AGPAT3 |
| GOBP_REGULATION_OF_T_CELL_ACTIVATION | 248 | 0.3817195 | 1.489531 | 0.0027340 | 0.0375437 | 0.0308438 | 2283 | FGL2/DPP4/SOCS1/RASGRP1/THY1/CD274/LGALS7B/PTPN22/PDCD1LG2/PRDM1/CD55/ADAM8/NOD2/IL4I1/PRKCQ/EBI3/IDO1/IL1A/TOX/CD47/CD70/GATA3/SLC7A1/CD86/ANXA1/CD276/HLA-DOB/TNFSF9/RIPK3/NFKBID/CARD11/CEACAM1/DUSP10/IL23A/ZC3H12A/DUSP3/CD83/ARG2/IL4R/DLG1/ZBTB7B/CCL5/LGALS9/FYN/SPINK5/FADD/IL1RL2/RIPK2/IL20RB/PRELID1/CD46/TNFRSF13C/MAP3K8/IL15/PRNP/BCL10/DLG5/SCRIB/AP3D1/HLA-DQB2/PAWR/AKT1 |
| GOBP_POSITIVE_REGULATION_OF_KINASE_ACTIVITY | 394 | 0.3373173 | 1.381908 | 0.0027189 | 0.0375437 | 0.0308438 | 3073 | NTRK1/ADRA1A/ADRA2C/SOCS1/RASGRP1/FZD10/NCF1/TLR4/PRKD1/HBEGF/TCIM/CEMIP/ADAM8/NOD2/FGFR4/ARHGEF5/ALKAL1/ACE/NTRK2/FLT1/EREG/DOK7/TNFRSF10A/NTRK3/VEGFA/FZD5/NEDD9/RELN/DOCK3/FGF2/EPHB3/EGR1/LRP8/TYRO3/EEF1A2/CD86/ADAM9/EDN1/MET/KITLG/FGD2/ACSL1/SPATC1L/RIPK3/EPHA3/DAB1/ROR2/IL23A/KDR/MOB3C/TNF/SNX9/DDR2/EPHA10/DLG1/EPHA2/BMP2/CCL5/THBS1/GREM1/CCND3/AXL/MST1R/SNCA/TXN/IRAK1/TGFA/DGKQ/CDC25B/CCNYL1/GPRC5A/PRNP/BCL10/CDKN1A/AKT1/EFNA5/ADAM17/AXIN1/GAS6/MOB2/DIPK2A/SRC/FGF13/TIGAR/EPHA7/PAK2/TAOK3/MAP2K1/SYK/CARD10/DAG1/VAV2/CCNK/RAP1A/AKAP13/CSK/DUSP12/MAP3K13/PFKFB2/IGF2/STRADA/MAP2K3/FERMT2/TNFRSF10B/PKD2/TPD52L1/STRADB/RPTOR |
| GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION | 52 | 0.5507742 | 1.694299 | 0.0027433 | 0.0375613 | 0.0308583 | 1786 | ADRA1A/CASQ2/CTNNA3/CLIC2/EHD3/ANK2/BIN1/PKP2/ZC3H12A/RGS2/DLG1/TRPM4/FKBP1B/ATP1B1/SLC9A1/NOS1/P2RX4/PDE4B/SLC8A1 |
| GOBP_PROTEIN_LOCALIZATION_TO_CONDENSED_CHROMOSOME | 18 | -0.7028049 | -1.844694 | 0.0027925 | 0.0378076 | 0.0310606 | 3683 | KNTC1/ZWILCH/IK/HASPIN/MTBP/KNL1/TTK/CDT1/NDC80/CDK1 |
| GOBP_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY | 17 | 0.7407061 | 1.823251 | 0.0028040 | 0.0378076 | 0.0310606 | 1771 | CLDN5/FZD5/TNF/MYO1C/EPHA2/PRKCH/TJP1 |
| GOBP_NON_MOTILE_CILIUM_ASSEMBLY | 59 | -0.5085636 | -1.677583 | 0.0028180 | 0.0378076 | 0.0310606 | 4627 | TTC8/TMEM17/INTU/BBS1/DISC1/CEP126/CEP250/ARL13B/TMEM107/BBS10/CEP135/TOGARAM1/PIBF1/TMEM216/IFT122/BBS2/CENPJ/TBC1D32/PCM1/IFT57/IFT140/CC2D2A/IFT88/IFT52/FUZ/IFT74/RPGRIP1L/IFT172/IFT80/DYNC2H1/MKS1/BBS4/CCDC13/RP1 |
| GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE | 150 | 0.4267812 | 1.564925 | 0.0027975 | 0.0378076 | 0.0310606 | 2865 | TNFAIP6/LYPD1/FZD9/SLC7A11/CEMIP/STAC/GPC6/STOM/BBC3/TMBIM1/SHISA6/PLS1/SLC5A3/TCAF2/EPHA3/STX3/TNF/MYO1C/AP2B1/DLG1/EPHA2/PRKCH/FYN/RHOG/ITGAM/PKDCC/GSN/AP2M1/ZDHHC7/PTPN9/ACTB/PRNP/SQSTM1/MTCL1/GBP1/AKT1/GPER1/PICALM/CHP1/RANGRF/ITGA3/STX4/LGALS3/DAG1/MIEF1/GPC4/ACSL3/RAP1A/NMT1/CSK/PPFIA1 |
| GOBP_HEMOSTASIS | 172 | 0.4221044 | 1.562883 | 0.0027996 | 0.0378076 | 0.0310606 | 3002 | ADRA2C/EMILIN2/C1QTNF1/VWF/SELP/NFE2/SERPINB2/TLR4/PROCR/SLC7A11/SERPINC1/PLAUR/FAP/PRKCQ/CD36/F3/PLAU/TYRO3/APOE/EDN1/PLA2G4A/CD9/P2RY1/THBD/VCL/PEAR1/TFPI2/ANXA8/CEACAM1/ST3GAL4/THBS1/AXL/SH2B3/RAP2B/ENTPD2/PLSCR1/MYH9/DGKI/TEC/DGKQ/ACTB/CSRP1/GNA12/ITPK1/DGKA/UBASH3B/PF4V1/GAS6/PDPN/ACTN1/SRC/IL6ST/ACTG1/SYK/PAFAH2/VAV2/CAV1/DGKD/MYL12A/COMP/GGCX |
| GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION | 106 | 0.4432182 | 1.548633 | 0.0028152 | 0.0378076 | 0.0310606 | 2687 | CCN4/TRIB3/INSIG1/SFRP1/PPARG/PTPRQ/DDIT3/GPS2/GATA3/JDP2/ENPP1/MSX2/METRNL/DUSP10/PTGS2/TRIB2/ZFP36/TNF/ZC3H12A/WDFY2/YAP1/TRPM4/BMP2/ZBTB7B/MMP11/NOCT/PIM1/CCDC71L/TFE3/HDAC6/ZBTB7C/FLCN/AKT1/RORA/TRPV4/AXIN1/GPER1/KLF5/PPARD/ALOX5 |
| GOBP_MACROAUTOPHAGY | 291 | 0.3630550 | 1.447718 | 0.0027720 | 0.0378076 | 0.0310606 | 4746 | ATP6V1C2/NOD2/ATP6V0D2/NPC1/UCHL1/ADPRH/SESN2/HSPB8/HIF1A/VPS37B/MAP1LC3B2/GPSM1/KDR/VPS37D/ATP6V0A2/RUBCN/VMP1/RNF213/HMOX1/OPTN/RAB43/TBC1D14/ATP13A2/RIPK2/PIP4K2A/HDAC6/ATP6V1E2/CHMP6/TAFAZZIN/SQSTM1/CHMP7/AKT1/ATG4D/AUP1/NEDD4/SRC/PLAA/EPM2A/ATG2A/TMEM41B/MCOLN1/NOD1/TIGAR/NRBP2/CALCOCO2/DDRGK1/LARP1/STX12/IKBKG/MFN2/SMCR8/PIP4K2C/ATG101/VPS4A/VPS4B/TSC1/HTT/CHMP1B/PACS2/ILRUN/MAP1LC3B/ATG9A/ATG7/SNF8/TP53/PLEKHM1/PGAM5/VPS37A/GABARAPL1/ATP6V1H/ARL8B/SPTLC2/VTI1A/ERN1/RETREG3/EXOC8/PHF23/SNX30/UBQLN1/CDK5R1/CDC37/MTOR/GNAI3/RAB7A/SLC25A5/TP53INP2/TBC1D25/VCP/MVB12A/RHEB/ATG13/UFM1/MAPK3/ATP6V0A1/USP36/RAB5A/PSEN1/ATP6V0B/ATP6V1B2/ATP6V0D1/ZFYVE1/RALB/VPS26A/NUPR1/UBXN2A/CAPN1/VIPAS39/SMG1/TECPR1/ATG16L1/ACBD5/VPS33B/UBQLN4/RNF41/RAB3GAP2/CHMP1A/ATP6V0E1/PIKFYVE/STAM/CHMP3/SPTLC1 |
| GOBP_CELL_PROLIFERATION_IN_FOREBRAIN | 18 | -0.7012807 | -1.840694 | 0.0028305 | 0.0378668 | 0.0311092 | 2532 | PCM1/CEP120/DIXDC1/FGFR2/GLI3/WNT3A/ARX/DCT/SIX3/KIF14 |
| GOBP_INTERLEUKIN_6_PRODUCTION | 110 | 0.4463825 | 1.567427 | 0.0029014 | 0.0384920 | 0.0316229 | 2915 | NOS2/TLR4/PTPN22/NOD2/CD36/EREG/IL36A/KLF2/IFIH1/IL1A/CD47/ARRB2/TICAM1/CD200R1/ARID5A/TMEM106A/MYD88/TNF/ZC3H12A/CX3CL1/SYT11/PTAFR/LGALS9/NLRP10/CARD9/IL1RL2/RIPK2/TNFAIP3/AKIRIN2/BCL10/CAPN2/TRPV4/SELENOS/GAS6/MAPKAPK2/PTPN11/IL27RA/NOD1/MAPK13/SYK/CSK/IL17RA/ISL1 |
| GOBP_POSITIVE_REGULATION_OF_ION_TRANSPORT | 181 | 0.4050652 | 1.518090 | 0.0028863 | 0.0384920 | 0.0316229 | 1732 | PLA2G3/GDNF/ARC/THY1/EDNRA/RGS7/CXCL10/CCL4/CEMIP/CXCL11/CXCL9/STAC/EHD3/IL1A/ANTKMT/RELN/SLC12A2/ANK2/G6PD/FGF12/ORAI1/ARRB2/EDN1/PLA2G4A/ATF4/P2RY1/BAK1/TRPV3/PKP2/PRSS8/VMP1/CX3CL1/DLG1/PTAFR/CCL5/SYT1/ATP1B1/SLC9A1/STIM1/SLC6A9/P2RY6/NOS1/P2RX4/SNCA |
| GOBP_CALCIUM_ION_TRANSPORT | 281 | 0.3668018 | 1.459080 | 0.0029019 | 0.0384920 | 0.0316229 | 1831 | ADRA1A/TRPV6/TRPM6/THY1/EDNRA/CASQ2/CXCL10/PRKD1/SLC24A3/STC2/TMC1/CACNB4/CCL4/CEMIP/CXCL11/GEM/CXCL9/STAC/CLIC2/SLC25A25/ACE/HOMER2/EHD3/SLC3A2/BCL2/DDIT3/ANK2/FGF2/G6PD/CACNB1/ORAI1/ARRB2/EDN1/ITPR3/GJA4/CYP27B1/TSPAN13/BAK1/BIN1/MCUR1/PML/EPB41/PTGS2/TRPV3/VMP1/CX3CL1/CATSPER3/CALCRL/BSPRY/SLC35G1/TRPM4/CCL5/FYN/FKBP1B/ATP1B1/SLC9A1/MCUB/STIM1/P2RY6/NOS1/P2RX4/ITGAV/TPCN2/SNCA/PDE4B/SLC8A1/CACNA2D4/VDR/SLC8B1 |
| GOBP_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING | 175 | 0.4076820 | 1.514459 | 0.0029596 | 0.0391458 | 0.0321600 | 4063 | TLR4/PRKD1/NOD2/MAP3K14/CD36/UBD/IL1A/EDAR/BST2/SECTM1/TICAM1/LURAP1/NEK6/CTH/LURAP1L/CARD11/TMEM106A/CANT1/MYD88/TNF/CX3CL1/HMOX1/IFIT5/PLEKHG5/LGALS9/TNFRSF19/FYN/TRIM14/CARD9/SHISA5/FADD/NDFIP2/TRIM21/IRAK1/RBCK1/RIPK2/TRAF5/TRIM25/BCL10/LTBR/RHOC/IRAK4/RELA/TRIM5/MUL1/NOD1/BIRC3/SLC20A1/TRAF3IP2/AKAP13/IKBKG/IKBKE/TRIM22/TNFRSF10B/TFRC/EDA2R/PLK2/DDX21/FKBP1A/TRADD/TNIP2/AJUBA/FLNA/MALT1/RIPK1/GOLT1B/TAB3/TIRAP/LITAF/ECT2/CD40 |
| GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS | 93 | 0.4900638 | 1.695529 | 0.0029769 | 0.0392625 | 0.0322559 | 2004 | PNPLA3/APOC1/AADAC/LIPG/PCSK9/INSIG1/PCK2/LDLR/LPIN1/MFSD2A/PNPLA1/LIPH/CPT1A/APOE/PLA2G4A/ACSL1/SCARB1/GPAT3/APOBR/SNCA/DGKI/GPAT4/PLCE1/DGKQ/SORL1 |
| GOBP_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE | 120 | 0.4533610 | 1.606831 | 0.0030143 | 0.0396448 | 0.0325699 | 1689 | IL13RA2/TLR4/PTPN22/KLK7/RSAD2/CD55/NOD2/RAET1G/CD36/FZD5/CLCF1/SLC7A5/GATA3/BST2/TNFSF13/TICAM1/CD86/IL18R1/ARID5A/SEMA7A/TNF/HK1/HMOX1/IL4R/TRPM4/NR4A3/SPINK5 |
| GOBP_KERATINOCYTE_PROLIFERATION | 38 | 0.5997938 | 1.741518 | 0.0030360 | 0.0398176 | 0.0327119 | 1828 | HAS2/PRKD1/BCL11B/EREG/SFN/SDR16C5/EPPK1/KLF9/ZFP36/CDH3/YAP1/IRF6/VDR |
| GOBP_MONOSACCHARIDE_METABOLIC_PROCESS | 216 | 0.3923756 | 1.499303 | 0.0030549 | 0.0399537 | 0.0328237 | 2938 | OTOGL/C1QTNF1/HKDC1/PCK2/NNMT/OAS1/PHLDA2/ALDOB/PPP1R3G/SESN2/G6PD/CPT1A/PMAIP1/FBP1/HK2/GALT/ATF4/ENPP1/ALDOC/ERFE/PFKP/TNF/PFKFB4/SLC25A1/IRS2/HK1/FUOM/FUT2/PPP1R3C/GDPGP1/UXS1/FAM3C/NLN/DGKQ/ATF3/GALK1/PMM2/SLC39A14/PGD/SLC35B4/ENO1/PDHA1/AKT1/KAT2B/RORA/MYC/SELENOS/INPPL1/FOXK1/CHST1/SRC/ARPP19/PGM5/TIGAR/PPARD/FUT4/GPT/PPARGC1A/AKR1A1/DUSP12/MIDN/PFKFB2/IGF2/FOXK2 |
| GOBP_CARBOXYLIC_ACID_TRANSPORT | 190 | 0.3951567 | 1.483391 | 0.0030657 | 0.0399824 | 0.0328473 | 2117 | NOS2/PLA2G3/SLC26A4/SLC26A9/SLC5A8/SLC7A11/LRRC8D/SLCO1B1/SLC16A9/ACE/SLC6A14/NTRK2/CD36/SLC16A4/SLC3A2/IL1A/SLC7A9/SLC12A2/SLC7A5/LRRC8A/SLC7A1/EDN1/SLC16A14/PLA2G4A/SLC1A5/ANXA1/SLC36A1/SLCO1B3/SLC26A6/SLC1A4/CEACAM1/SLC16A13/SLCO3A1/TNF/SLC27A4/SFXN5/ATP8B1/SLC38A1/SLC25A1/LRRC8C/RGS2/SLC25A32/SLC5A12/SLC38A7/SLC16A7/SERINC5/SLC6A9/SLC17A5/P2RX4/SNCA/SLC66A1/PRAF2/MFSD12/GABBR1/SLC16A3/SLC35D2/SLC25A22 |
| GOBP_MYELOID_LEUKOCYTE_ACTIVATION | 161 | 0.4159091 | 1.536455 | 0.0030878 | 0.0401584 | 0.0329919 | 2718 | PLA2G3/RASGRP1/IL13RA2/TLR4/IL1RL1/CNR1/CTSC/BATF3/MT1G/LAT2/BATF2/LDLR/CXCL8/IL31RA/UBD/IFI35/UNC13D/ANXA3/TICAM1/ADAM9/RELB/PLA2G4A/ANXA1/NECTIN2/MFHAS1/TMEM106A/ITGB8/MYD88/TNF/ZC3H12A/GAB2/CX3CL1/SYT11/HMOX1/SPHK1/IL4R/PTAFR/CCL5/LGALS9/THBS1/NR4A3/ITGAM/JUND/SNCA/CXCL6/PLSCR1/IL15/BATF/ITGB6/SBNO2/LTBR/JUN/RORA/JMJD6/CD177/STX4/CSF2/STXBP2/BCR/SYK/MYO18A |
| GOBP_REGULATION_OF_CILIUM_BEAT_FREQUENCY | 15 | -0.7121416 | -1.777940 | 0.0031352 | 0.0404373 | 0.0332211 | 3365 | CFAP20/CCDC39/BBS2/GAS2L2/DNAAF1/BBS4/CFAP43/CFAP45/CFAP206/TTLL6/ODAD2 |
| GOBP_LEUKOCYTE_DEGRANULATION | 50 | 0.5591552 | 1.701833 | 0.0031287 | 0.0404373 | 0.0332211 | 2711 | PLA2G3/RASGRP1/IL13RA2/LAT2/UNC13D/ANXA3/HCK/CEACAM1/GAB2/HMOX1/IL4R/PTAFR/LGALS9/NR4A3/ITGAM/HLA-F/CD177/STX4/STXBP2/BCR/SYK |
| GOBP_REGULATION_OF_ION_TRANSPORT | 445 | 0.3294041 | 1.366186 | 0.0031319 | 0.0404373 | 0.0332211 | 2457 | PLA2G3/GDNF/CA2/ARC/THY1/EDNRA/CASQ2/RGS7/CXCL10/PRKD1/KCNS3/STC2/TMC1/CACNB4/PCSK9/CNR1/CCL4/CEMIP/KCNJ16/CXCL11/KCNH8/GEM/CXCL9/STAC/CLIC2/MAPK8IP2/ACE/KCNE3/HOMER2/EHD3/CLIC3/BCL2/IL1A/ANTKMT/STOM/RELN/SLC12A2/ANK2/G6PD/CACNB1/FGF12/ORAI1/ARRB2/SHISA6/EDN1/KCNQ4/PLA2G4A/ATF4/CLIC4/P2RY1/KCNK6/SHISA8/TCAF2/TSPAN13/SYT17/FXYD6/BAK1/BIN1/PML/EPB41/PTGS2/TRPV3/PKP2/TNF/ATP8B1/PRSS8/KCNA2/VMP1/CX3CL1/SYT11/CATSPER3/RGS2/DLG1/PTAFR/CCL5/SYT1/OSR1/FYN/FKBP1B/ATP1B1/SLC9A1/STIM1/SLC6A9/P2RY6/NOS1/P2RX4/TPCN2/SNCA/NKAIN3/OXSR1/PDE4B/SLC8A1/CACNA2D4/SLC8B1/ANO9/KCNK15/GABBR1/WDR1/HOMER3/CNKSR3/PRNP/PACSIN3/ATP1A1/SHISA9/AKT1/TMSB4X/STIM2/UBASH3B/GPER1/NEDD4/SHANK3/DIAPH1/CHP1/SCN1B/COA8/HVCN1/RANGRF |
| GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY | 443 | 0.3385238 | 1.404971 | 0.0031771 | 0.0408642 | 0.0335718 | 1511 | CCL26/CISH/ANO1/ADRA1A/ADRA2C/ADM5/CA2/LGR6/EDNRA/FZD10/LGR5/GRK5/ADM2/FZD9/DEFB4A/RGS7/ADCY5/CXCL10/CNR1/CCL4/HTR1D/OR5P3/RASD1/CXCL11/OR5P2/PPARG/CXCL9/ATRNL1/PHF24/ADCY4/HRH1/CXCL8/CCL22/HOMER2/OR2I1P/EREG/GPR146/ALOX15B/FZD5/ADCY7/LPAR5/TYRO3/ARRB2/APOE/EDN1/RGS16/HPGD/ITPR3/MET/OR2A7/GNAZ/ANXA1/P2RY1/CCR3/GRK7/S1PR3/CXCL1/IGF2R/GPR143/FZD1/RGS20/RGS9/CX3CL1/CGB7/CALCRL/SPHK1/GPR27/RGS2/PTAFR/ECE1/CCL5/GNA15/BCAR1/PLCB3 |
| GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION | 105 | 0.4497895 | 1.570660 | 0.0032127 | 0.0411780 | 0.0338295 | 2322 | FGL2/SOCS1/CD274/LGALS7B/PTPN22/PDCD1LG2/SFRP1/IL4I1/IDO1/TYRO3/CD86/MICA/ANXA1/CEACAM1/ZC3H12A/DUSP3/ARG2/IL4R/DLG1/ZBTB7B/LGALS9/AXL/IL20RB/TNFAIP3/PRNP/DLG5/SCRIB/PAWR/HLA-F |
| GOBP_AXON_DEVELOPMENT | 382 | 0.3502834 | 1.431077 | 0.0032191 | 0.0411780 | 0.0338295 | 3093 | NTRK1/GDNF/THY1/LGR6/EDNRA/DLX5/PTPRO/RTN4R/CNR1/BDNF/SEMA3B/CRMP1/MAP1B/KLF4/PAX6/NTNG1/BCL11B/FOXD1/SLIT2/NTRK2/PRKCQ/UCHL1/ARTN/MAP2/BCL2/VEGFA/OLFM1/RELN/EPHB3/GATA3/APOE/SEMA3D/TUBB3/EDN1/EGR2/TWF2/CHODL/ANOS1/EPHA3/DAB1/NRP2/VCL/BRSK2/PLXNA3/SEMA7A/NRCAM/NIBAN2/EPHA10/ISLR2/DBN1/NREP/SEMA3A/SEMA4C/ATP8A2/ECE1/EPHA2/BRSK1/SEMA6A/FYN/RHOG/SLIT1/NDEL1/FKBP1B/NTN1/DPYSL2/IGSF9/RUFY3/RAC1/KIF5C/VASP/CTTN/ZPR1/HDAC6/MYOT/RAPH1/ACTB/CHN1/SPP1/LIMK1/JUN/EFNA5/PICALM/SCN1B/FOXB1/MCF2/PTPN11/FGF13/EPHA7/PAK2/SHTN1/STK25/MAP2K1/COBL/TIAM1/DAG1/TTL/SEMA4F/LAMA3/EMB/TIAM2/LAMB2/DOCK7/MAP3K13/ISL1/UNC5B/SIPA1L1/SLC9A6/SLITRK6/SLITRK5/DIP2B/FLOT1 |
| GOBP_DNA_REPLICATION_INITIATION | 37 | -0.5708897 | -1.727969 | 0.0032551 | 0.0415249 | 0.0341145 | 1047 | POLA2/ORC1/MCIDAS/CDT1/GMNN/CCNE2/TICRR/GMNC/MCM10 |
| GOBP_COGNITION | 222 | 0.3818983 | 1.468567 | 0.0032640 | 0.0415254 | 0.0341149 | 1745 | NTRK1/CLDN5/ARC/BRINP1/FZD9/MGAT3/CNR1/SLC7A11/SGK1/AFF2/MME/BDNF/HMGCR/LDLR/MAPK8IP2/MFSD2A/HRH1/NTRK2/CBR3/TMPRSS11E/FOS/RELN/APOE/EGR2/ITPR3/HIF1A/SLC1A4/FOSL1/PTGS2/TNF/SYT11/BRSK1/ST3GAL4/KRAS/FYN/ABCA7/PRKCG/NDRG4/DOP1B/NSUN5 |
| GOBP_NEPHRON_TUBULE_FORMATION | 15 | 0.7431246 | 1.760954 | 0.0032942 | 0.0417956 | 0.0343369 | 1561 | GDNF/HES5/GATA3/SOX9/WNT6/OSR1/GREM1 |
| GOBP_NATURAL_KILLER_CELL_DIFFERENTIATION | 19 | 0.7262543 | 1.822521 | 0.0033265 | 0.0419565 | 0.0344691 | 2389 | RASGRP1/PRDM1/TOX/TYRO3/NFIL3/IL15RA/AXL/IL15/GAS6 |
| GOBP_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION | 28 | 0.6473482 | 1.747872 | 0.0033518 | 0.0419565 | 0.0344691 | 2711 | EMILIN2/C1QTNF1/PLAUR/PRKCQ/CD9/CEACAM1/CCL5/SH2B3/UBASH3B/PDPN/IL6ST/SYK |
| GOBP_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS | 64 | 0.5262953 | 1.700099 | 0.0033424 | 0.0419565 | 0.0344691 | 2013 | FGL2/PTPN22/IFIT1/AIM2/UFD1/PARP9/IFNLR1/DTX3L/IL23A/ZC3H12A/RNF125/HERC5/STAT1/MICB/NPLOC4/TNFAIP3/SEC14L1/IL15 |
| GOBP_NEURON_DEATH | 288 | 0.3598288 | 1.429240 | 0.0033462 | 0.0419565 | 0.0344691 | 2638 | NTRK1/PLA2G3/GDNF/TLR4/FZD9/PCSK9/SLC7A11/BDNF/ADAM8/NTRK2/MIR200A/FOS/BCL2/DDIT3/FOXQ1/EGR1/CLCF1/G6PD/GATA3/NES/TYRO3/ARRB2/APOE/AARS1/ATF4/CD200R1/HIF1A/TNF/FAS/FZD1/CASP7/CX3CL1/HMOX1/ASCL1/AP2B1/NSMF/CCL5/KRAS/FYN/NR4A3/ITGAM/PRKCG/SLC9A1/AXL/TBC1D24/SNCA/FADD/ATP13A2/HYOU1/ZPR1/SORL1/RAB29/PRNP/CAPN2/DHCR24/AKT1/JUN/BOK/HLA-F/GRIK2/EIF4G1/PICALM/CHP1/FOXB1/RRAS2/IL27RA/TIGAR/EPHA7/BID/NRBP2/IL6ST/WFS1 |
| GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT | 426 | 0.3352622 | 1.390464 | 0.0033477 | 0.0419565 | 0.0344691 | 3494 | ADRA1A/PLA2G3/TRPV6/ARC/APOC1/IL13RA2/ALOX15/PRKD1/PCSK9/CNR1/NOD2/SGIP1/LRRTM2/CD36/IL2RG/VEGFA/UNC13D/CLASP1/CD47/STON2/HYAL3/ARRB2/APOE/DOC2B/ANXA1/P2RY1/COLEC10/HCK/SYT17/STX1A/SCARB1/BIN1/EPHA3/HIP1/RAB8B/CEACAM1/TNF/RIMS3/CAMK1D/RUBCN/GAB2/SYT11/HMOX1/AP2B1/SPHK1/RAB31/IL4R/SMAP1/PTAFR/APPL2/SYT1/LGALS9/ANKRD13B/GREM1/RAB15/ITGAM/PKDCC/ABCA7/PRKCG/IL15RA/AXL/NDRG4/ITGAV/TPCN2/SNCA/AP2M1/EHD1/RAC1/PLSCR1/RAB4B/ATP13A2/RAB9A/DGKQ/TNK2/CHMP6/VSNL1/WASL/SORL1/IL15/RAB29/EIPR1/PACSIN3/TFR2/PACSIN2/SCRIB/MICAL1/AAK1/STXBP5/MSN/HLA-F/STON1/FCN3/C2/GAS6/RAB5B/PICALM/CD177/CD151/DRD1/STX4/SRC/RAPGEF4/GIPC1/STXBP2/BCR/LGALS3/MAP2K1/TBC1D4/RALA/SYK/MYO18A/TBC1D20/ACSL3/SMPD1/RAP1A/CSK/CAV1/DGKD/ANKFY1/PRKAR1B/RAB25/CBL/BET1L/VPS4A/EHD2/FLOT1/VPS4B/SEPTIN1/INPP5F/GIT1/PTPN23/MAP2K2/BSN/DAB2/SNF8/RAB8A/CNN2/RAB11A/ANXA2/CALR/ARFGAP1/SIRPA/CBARP/RAB3A |
| GOBP_T_CELL_CHEMOTAXIS | 17 | 0.7352127 | 1.809729 | 0.0033962 | 0.0423980 | 0.0348318 | 1743 | CCL26/CXCL10/CXCL11/CXCL16/SLC12A2/S100A7/CCL5/OXSR1 |
| GOBP_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION | 34 | 0.6203932 | 1.763215 | 0.0034230 | 0.0425090 | 0.0349230 | 1199 | CLDN5/VEGFA/XDH/BTG1/NOTCH4/S1PR3/VCL/CEACAM1/TNF |
| GOBP_MITOTIC_SPINDLE_ASSEMBLY | 68 | -0.4723430 | -1.610960 | 0.0034324 | 0.0425090 | 0.0349230 | 3165 | TOGARAM1/MAP9/HSPA1A/CHEK2/PIBF1/KIF23/TOGARAM2/CEP97/RACGAP1/MAP10/ABRAXAS1/KIF11/KIFC1/KIF4A/TPX2/NEK2/PLK1/KIF15/CDC20/MYBL2 |
| GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT | 109 | 0.4445025 | 1.556802 | 0.0034317 | 0.0425090 | 0.0349230 | 1786 | THY1/CASQ2/CXCL10/PRKD1/TMC1/CACNB4/CEMIP/CXCL11/GEM/CXCL9/STAC/CLIC2/EHD3/ANK2/G6PD/CACNB1/TSPAN13/BIN1/VMP1/CX3CL1/FYN/FKBP1B/ATP1B1/SLC9A1/STIM1/P2RY6/NOS1/SNCA/PDE4B/SLC8A1 |
| GOBP_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE | 15 | -0.7083409 | -1.768451 | 0.0034430 | 0.0425269 | 0.0349378 | 2602 | MAPK15/ESPL1/ANAPC4/CDT1/DLGAP5 |
| GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION | 79 | 0.4814590 | 1.617792 | 0.0034699 | 0.0427470 | 0.0351186 | 2334 | CCL26/PRKD1/PPP1R16B/FGFBP1/NR4A1/F3/VEGFA/FGF2/TNFSF12/CCR3/NRP2/HIF1A/KDR/CAV2/HMOX1/BMP2/AKT3/SCG2/BMP6/NRAS/AKT1/JUN/TGFBR1/ADAM17 |
| GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS | 38 | 0.5943798 | 1.725798 | 0.0034923 | 0.0429090 | 0.0352516 | 2389 | NOD2/PRKCQ/ST6GAL1/PIP/IDO1/IRF7/HSH2D/KITLG/HIF1A/IRS2/ARG2/CCL5/AXL/FADD/BCL10/SELENOS/GAS6 |
| GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE | 267 | -0.3301359 | -1.368781 | 0.0035109 | 0.0430246 | 0.0353466 | 3038 | CHEK2/SLF1/MEIS2/GPSM2/AURKA/RAD51B/RGCC/SPDYA/KIF23/SMPD3/NANOGP8/DYRK3/CENPJ/DRD2/EZH2/MAPK15/SASS6/CEP120/CCN2/ATAD5/CITED2/CKS2/PBX1/RACGAP1/MAP10/RRM1/CHEK1/ESPL1/TGM1/FGFR2/STIL/PRKCE/CDC7/MTBP/INSR/MIR590/ADAMTS1/HSPA2/WNT5A/CDC25A/STOX1/PSRC1/FBXO5/ANAPC4/CCNB1/PIWIL2/EPGN/RAD51AP1/CDC14A/SPAG5/KIF20B/E2F7/CIT/CDT1/CDCA5/NDC80/KIF14/MAD2L1/PLK4/CDK1/RRM2/DTL/DLGAP5/CDC25C/UBE2C |
| GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS | 32 | 0.6165468 | 1.743325 | 0.0035288 | 0.0431307 | 0.0354338 | 2350 | PLA2G3/PNPLA3/LPIN1/ABHD4/LIPH/GPAT3/LPCAT4/GPAT4/DGKQ/ACP6/PLD2/DGKA |
| GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS | 116 | -0.4179216 | -1.553767 | 0.0035514 | 0.0431807 | 0.0354748 | 1339 | OXTR/INSR/CACNA1H/CFAP206/CCDC87/WNT5A/CDC25A/GDF9/PLAT/FBXO5/PIWIL2/TRIP13/GJA1/RAD51AP1/OVGP1/SHH/TTK/UMODL1/FBXO43/ARHGDIB/AR/EPPIN/CDC20/CDC25C/ASPM/CNTD1 |
| GOBP_CELL_GROWTH | 400 | 0.3345992 | 1.375011 | 0.0035492 | 0.0431807 | 0.0354748 | 2363 | CISH/ADRA1A/EDNRA/HYAL1/TMEM97/RTN4R/HBEGF/SGK1/BDNF/SEMA3B/SFRP1/MEG3/MAP1B/MFSD2A/SLIT2/PRKCQ/TNC/CXCL16/UNC13A/MAP2/BCL2/VEGFA/SOCS2/OLFM1/SESN2/G6PD/BST2/APOE/SFN/SEMA3D/EDN1/TWF2/FBP1/OSGIN1/TMC8/CYP27B1/ENPP1/SYT17/BTG1/KIF26A/NRP2/VCL/PML/SOX9/CEACAM1/PLXNA3/SEMA7A/NRCAM/ISLR2/DBN1/YAP1/SPHK1/SEMA3A/SEMA4C/RGS2/SYT1/SEMA6A/BCAR1/CCN3/SLIT1/GREM1/NDEL1/NTN1/SLC9A1/DPYSL2/SPAG9/RUFY3/CTTN/PLCE1/HDAC6/LTBP4/RAPH1/ITSN2/CDKN2A/LAMTOR1/DCUN1D3/FLCN/CDKN1A/CRLF3/ENO1/SPP1/PDLIM5/LIMK1/AKT1/PAK4/TGFBR1/EFNA5/ADAM17/OGFR |
| GOBP_PROTEIN_KINASE_B_SIGNALING | 152 | 0.4233909 | 1.544902 | 0.0035718 | 0.0433159 | 0.0355859 | 2537 | NTRK1/C1QTNF1/HBEGF/ADAM8/NTRK2/GDF15/NTRK3/F3/PLK3/DDIT3/SESN2/FGF2/GATA3/TYRO3/ARRB2/CAVIN3/MET/XDH/MFHAS1/HIP1/FAM110C/PEAR1/SOX9/KDR/TNF/CX3CL1/DLG1/EPHA2/ENG/CCL5/THBS1/LOX/AXL/SH2B3/MST1R/P2RX4/TXN/GCNT2/FLCN/AKT1/TGFBR1/NKX3-1/GPER1/GAS6/SRC/MUL1 |
| GOBP_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY | 20 | 0.6917836 | 1.769427 | 0.0035920 | 0.0433355 | 0.0356020 | 1781 | SOCS1/PPARG/NLRC5/PARP9/HCK/PARP14/STAT1 |
| GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION | 440 | 0.3321154 | 1.379884 | 0.0035831 | 0.0433355 | 0.0356020 | 2929 | NOS2/ANO1/CYP51A1/TLR4/ACHE/ADCY5/SLC9B2/PRKD1/CNR1/SLC7A11/HMGCR/INSIG1/CEMIP/SFRP1/RSAD2/PCK2/ADAM8/PPARG/ARHGEF5/CD36/PLK3/IL1A/FZD5/STOM/BBC3/SLC12A2/LRRC8A/CPT1A/APOE/SFN/ADAM9/TTN/IFI27/DOC2B/RAB11FIP1/TCAF2/STX1A/LLGL2/HIF1A/BRSK2/PTGS2/TNF/ZC3H12A/UHMK1/PTP4A3/MYO1C/IRS2/RIPOR1/GPR27/TRPM4/CCL5/SREBF2/FYN/CCN3/NDEL1/FKBP1B/ITGAM/PKDCC/ACSL4/RUFY3/NDFIP2/TXN/SLC8B1/ATP13A2/AACS/EDEM2/ZPR1/HDAC6/VSNL1/SORL1/EDEM1/RAB29/BMP6/PIM3/MCU/PRNP/EIPR1/MTCL1/STXBP5/EFNA5/RAB11FIP5/GPER1/GAS6/CHP1/STX4/SRC/PTPN11/RHBDF2/FERMT1/ACVR1C/PPARD/ALOX5/RHBDD3/MYO18A/MIEF1/ACSL3/HAX1/NMT1/CSK/MIDN/PFKFB2/BAP1/DNAJC1/ISL1/RHBDF1 |
| GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS | 18 | 0.7039596 | 1.732414 | 0.0036176 | 0.0435323 | 0.0357637 | 671 | PNPLA3/AADAC/LIPG/PNPLA1/LIPH |
| GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS | 104 | 0.4547825 | 1.589548 | 0.0036356 | 0.0436365 | 0.0358493 | 2732 | NOS2/PLA2G3/NNMT/PPARG/STARD4/HRH1/ELOVL5/PPP1R3G/CPT1A/PMAIP1/ANXA1/P2RY1/HIF1A/PTGS2/MLXIPL/TNF/IRS2/PTAFR/NR4A3/P2RY6/NOS1/SNCA/TAFAZZIN/ENTPD5/BMP6/MID1IP1/ENO1/AKT1/KAT2B/TMSB4X/MYC/GPER1/SRC/CLYBL/ARPP19/PRXL2C/PPARD/GPT/PPARGC1A |
| GOBP_EOSINOPHIL_MIGRATION | 11 | 0.7768454 | 1.713610 | 0.0037177 | 0.0445077 | 0.0365650 | 1465 | CCL26/CCL4/ADAM8/HRH1/DAPK2/CX3CL1/CCL5 |
| GOBP_NEUTROPHIL_CHEMOTAXIS | 72 | 0.4906760 | 1.621891 | 0.0037378 | 0.0445203 | 0.0365754 | 1788 | CCL26/DPP4/TNFAIP6/CXCL10/CCL4/CXCL11/NOD2/CXCL9/SLIT2/CXCL8/CCL22/DAPK2/EDN1/CXCL1/IL23A/CAMK1D/CX3CL1/ITGA9/CCL5/CXCL2/PDE4B/CXCL6/RAC1 |
| GOBP_GRANULOCYTE_MIGRATION | 106 | 0.4363803 | 1.524741 | 0.0037378 | 0.0445203 | 0.0365754 | 2711 | CCL26/DPP4/TNFAIP6/CXCL10/CCL4/CXCL11/ADAM8/NOD2/CXCL9/HRH1/SLIT2/CXCL8/CCL22/IL1A/DAPK2/EDN1/ANXA1/S100A7/CXCL1/IL23A/MYD88/CAMK1D/CX3CL1/ITGA9/CCL5/THBS1/RHOG/CXCL2/PDE4B/CXCL6/RAC1/SCG2/WDR1/MCU/TRPV4/IRAK4/PF4V1/CD177/CCL20/LGALS3/FUT4/S100A14/SYK |
| GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | 136 | 0.4258987 | 1.536707 | 0.0038045 | 0.0450849 | 0.0370392 | 3458 | HAS2/HYAL1/PRKD1/HBEGF/FGFBP1/MIR200A/HDAC9/VEGFA/FGF2/CLASP1/GATA3/SMOC2/ANXA3/ADAM9/EDN1/MET/ANXA1/SCARB1/NRP2/HIF1A/SOX9/PTGS2/KDR/ZC3H12A/HMOX1/THBS1/BCAR1/P2RX4/RAC1/AKT3/RHOB/HDAC6/AKT1/JUN/TMSB4X/ADAM17/ITGA3/SRC/HDAC7/MAPRE2/PFN1/RAB25/MAP2K3/ATOH8/LGMN/GFUS/RREB1/GPI/STAT5A/PRKCA/PLK2/FOXC2/DOCK5/RAB11A/CALR |
| GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS | 288 | 0.3578688 | 1.421455 | 0.0038010 | 0.0450849 | 0.0370392 | 3044 | EDNRA/NCF1/TLR4/PRKD1/MGAT3/SLC7A11/LRRC8D/GJB2/PPARGC1B/CPEB2/CD36/PYCR1/FOS/BCL2/KLF2/DDIT3/NFE2L1/SESN2/G6PD/EDN1/RELB/MET/ATF4/ANXA1/EFHD1/RIPK3/HIF1A/PML/PTGS2/TNF/SERPINB6/ZC3H12A/FAS/FZD1/HMOX1/SPHK1/LRRC8C/GCH1/ETV5/FYN/ERRFI1/NR4A3/AXL/TBC1D24/SNCA/OXSR1/CAMKK2/TXN/ATP13A2/AIFM2/RHOB/TNFAIP3/HDAC6/SLC25A23/FANCC/RBM11/PAWR/LETM1/AKT1/JUN/YBX3/TRPV4/MYC/SELENOS/RELA/PLEC/STX4/SRC/STK25/MAPK13/ALOX5/PPARGC1A/ABCC1/SIRT2/EIF2AK3/CAV1/BAG5/LONP1/PKD2/SLC4A11/ARHGEF2 |
| GOBP_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION | 46 | 0.5594772 | 1.682217 | 0.0038750 | 0.0455728 | 0.0374400 | 1477 | SOCS1/CD274/LGALS7B/CD55/PRKCQ/GATA3/CD86/ANXA1/NFKBID/IL23A/ZC3H12A/CD83/ARG2/IL4R/ZBTB7B/LGALS9 |
| GOBP_HOMOTYPIC_CELL_CELL_ADHESION | 74 | 0.4931852 | 1.637307 | 0.0038750 | 0.0455728 | 0.0374400 | 2711 | EMILIN2/C1QTNF1/SLC7A11/PLAUR/CTNNA3/PRKCQ/CEACAM5/TYRO3/CD9/VCL/PEAR1/CEACAM1/PKP2/CCL5/SH2B3/RAP2B/MYH9/ACTB/CSRP1/TJP2/UBASH3B/DSG2/PDPN/ACTN1/IL6ST/ACTG1/SYK |
| GOBP_REGULATION_OF_ACTIN_FILAMENT_LENGTH | 134 | 0.4167871 | 1.504357 | 0.0038719 | 0.0455728 | 0.0374400 | 4165 | CCL26/ALOX15/CDC42EP5/SLIT2/TMOD1/CDC42EP1/ARHGAP40/TWF2/HCK/CFL2/BIN1/CAPG/ESAM/NAA80/TMSB10/SNX9/FLII/DBN1/SVIL/DLG1/GSN/ARPC5L/SSH1/GBA2/VASP/CTTN/KANK3/WDR1/SPTBN5/SH3BP1/TMSB4X/ARPC4/HAX1/TRIOBP/TMOD2/PFN1/SWAP70/SPTBN1/SPTAN1/MYADM/WASHC2C/ARPC5/CYRIB/NCKAP1/ARPC1B/TMOD3/ARPC1A/ARFGEF1/HIP1R/ARF6/MTOR/COTL1/CYFIP1/HCLS1/ADD3/ARPC2/LIMA1/RHOA |
| GOBP_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 44 | 0.5685735 | 1.698484 | 0.0039185 | 0.0459690 | 0.0377656 | 1788 | NTRK1/RASGRP1/RTN4R/RELN/KITLG/PRAG1/LRRC59/KRAS/ITGAV/RAC1 |
| GOBP_CEREBROSPINAL_FLUID_CIRCULATION | 13 | -0.7265283 | -1.734353 | 0.0039925 | 0.0464866 | 0.0381908 | 3199 | DNAAF11/ODAD4/CCDC39/CFAP54/KATNIP/SPAG16/DNAH9/DAW1/CFAP221/AQP4/CFAP43/CFAP45 |
| GOBP_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT | 152 | 0.4214161 | 1.537696 | 0.0039879 | 0.0464866 | 0.0381908 | 2575 | CA2/ARC/THY1/EDNRA/ITLN1/RGS7/CXCL10/CEMIP/CXCL11/CXCL9/STAC/EHD3/ANTKMT/RELN/ANK2/G6PD/EDN1/ACSL1/SLC26A6/ERFE/OCLN/VMP1/CX3CL1/IRS2/PTAFR/NR4A3/ATP1B1/SLC9A1/STIM1/SLC6A9/P2RY6/NOS1/SNCA/CNKSR3/AKT1/TMSB4X/STIM2/GPER1/SHANK3/CHP1/COA8/DRD1/PTPN11/ARPP19 |
| GOBP_REGULATION_OF_HEMOPOIESIS | 281 | 0.3598674 | 1.431496 | 0.0039840 | 0.0464866 | 0.0381908 | 1949 | FGL2/PLA2G3/SOCS1/TNFAIP6/RASGRP1/TLR4/SLC9B2/TCIM/PRDM1/SFRP1/ISG15/ADAM8/PPARGC1B/IL4I1/FOS/TOX/KLF13/IRF7/GATA3/CD86/ANXA1/KITLG/TNFSF9/TRIB1/NFKBID/NFKBIA/HIF1A/CARD11/ROR2/CEACAM1/DUSP10/IL23A/ZFP36/TNF/ZC3H12A/CD83/LIF/IL4R/SMAP1/MAPK11/ZBTB7B/LGALS9/LOX/TFE3/IL15RA/AXL/SPINK5/FADD/IL1RL2/STAT1/PRXL2A/RIPK2/PRELID1/CD46 |
| GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY | 41 | 0.5763939 | 1.695821 | 0.0040086 | 0.0465579 | 0.0382493 | 1949 | IL13RA2/SERPINB4/CD55/NOD2/IL4I1/SERPINB9/BST2/ARRB2/MICA/CEACAM1/AHR/HMOX1/LGALS9/IL20RB/CD46 |
| GOBP_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY | 81 | 0.4803281 | 1.612230 | 0.0040572 | 0.0470057 | 0.0386172 | 2607 | ADRA1A/THY1/NCF1/HBEGF/ALKAL1/ACE/EREG/DOK7/NEDD9/CBLC/RELN/DOCK3/LRP8/CCL5/ERRFI1/GREM1/RAP2B/ZGPAT/TGFA/RAP2C/CHMP6/GPRC5A/PRNP/PTK6/ZFYVE28/ADAM17/GAS6/SRC/PAK2 |
| GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY | 14 | 0.7607943 | 1.769506 | 0.0040953 | 0.0473287 | 0.0388826 | 1266 | DPP4/FAP/FGFR4/CLASP1/DDR2 |
| GOBP_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER | 48 | 0.5432349 | 1.637841 | 0.0041266 | 0.0474559 | 0.0389871 | 2543 | CLDN5/EDNRA/PPP1R16B/VEGFA/FASN/S1PR3/VCL/MYD88/ICAM1/TNF/RAP2B/TJP1/RAP2C/TJP2/MSN/CLDN1 |
| GOBP_MYELOID_LEUKOCYTE_MIGRATION | 159 | 0.4091674 | 1.512465 | 0.0041188 | 0.0474559 | 0.0389871 | 1788 | CCL26/DPP4/TNFAIP6/PTPRO/CXCL10/CCL4/CXCL11/ADAM8/NOD2/CXCL9/ARHGEF5/HRH1/SLIT2/CXCL8/CCL22/FLT1/VEGFA/IL1A/DAPK2/CD47/PLA2G7/EDN1/CD9/ANXA1/CD200R1/S100A7/ROR2/CXCL1/IL23A/MYD88/CAMK1D/CX3CL1/ITGA9/CCL5/THBS1/RHOG/CXCL2/CCN3/GREM1/MMP28/P2RX4/PDE4B/CXCL6/RAC1 |
| GOBP_REGULATION_OF_CELLULAR_RESPIRATION | 44 | 0.5676728 | 1.695793 | 0.0041960 | 0.0481349 | 0.0395450 | 2732 | NOS2/SHMT2/IFNLR1/HIF1A/MLXIPL/TNF/SNCA/PRELID1/SLC25A23/FLCN/TRPV4/MYC/PDE12/PPARGC1A |
| GOBP_TELOMERE_ORGANIZATION | 151 | -0.3832947 | -1.486710 | 0.0042361 | 0.0484762 | 0.0398253 | 3819 | PTGES3/H3-3A/ERCC4/HSP90AA1/H3C6/H4C5/ATM/BRCA2/H4C12/NAF1/WRAP53/TENT4B/WRN/SMC6/H4C6/EZH2/MAPK15/H4C3/H4C2/MRE11/ERCC1/H3C11/H3C1/DNA2/RPA3/ZSCAN4/H4C4/H4C1/BLM/H3C10/PKIB/RECQL4/H4C13/H4C9/EXO1/H3C7/H3C12/NEK2/CCNE2/H3C3/H3C8/H3C2 |
| GOBP_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION | 199 | 0.3894190 | 1.474555 | 0.0042484 | 0.0484978 | 0.0398430 | 2622 | ADRA1A/SOCS1/THY1/NCF1/HBEGF/SFRP1/CD44/NOD2/ALKAL1/ACE/CD36/EREG/IL31RA/DOK7/HES5/PPP2R5B/VEGFA/NEDD9/CBLC/RELN/DOCK3/CLCF1/LRP8/ARRB2/PARP9/KITLG/IL23A/TNF/SOCS3/LIF/PARP14/CCL5/FYN/ERRFI1/GREM1/SH2B3/RAP2B/ZGPAT/TGFA/RIPK2/TEC/RAP2C/DGKQ/TNK2/CHMP6/IL15/GPRC5A/BMP6/PRNP/PTK6/EFNA5/ZFYVE28/ADAM17/GAS6/SRC/PTPN11/CSF2/EPHA7/PAK2/CADM4/IL6ST |
| GOBP_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY | 24 | -0.6348758 | -1.779833 | 0.0042611 | 0.0485243 | 0.0398648 | 918 | FBXO5/CDC20B/MAD2L1/PLK1/CDC20/UBE2C |
| GOBP_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY | 39 | 0.5835059 | 1.706834 | 0.0044006 | 0.0499911 | 0.0410699 | 1788 | GDNF/EDNRA/SEMA3B/SEMA3D/EDN1/MET/NRP2/PLXNA3/SEMA7A/SEMA3A/SEMA4C/ECE1/SEMA6A/ARHGDIA/RAC1 |
GOMF
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| GOMF_CYTOKINE_RECEPTOR_BINDING | 172 | 0.5143361 | 1.944547 | 0.0000014 | 0.0012845 | 0.0011657 | 2711 | CCL26/NTRK1/DEFB4A/CXCL10/CCL4/BDNF/RASL11B/CXCL11/IL36G/CXCL9/CXCL8/CCL22/EBI3/CXCL16/IL36A/VEGFA/SOCS2/IL1A/CLCF1/TNFSF12/TMBIM1/CD70/YARS1/GATA3/NES/TNFSF13/IL1RN/KITLG/OSMR/PXDN/TNFSF9/CXCL1/IL23A/MYD88/TNF/LIFR/CX3CL1/LIF/SPRED2/ENG/CCL5/CXCL2/GREM1/SH2B3/FADD/CXCL6/STAT1/TRAF5/IL15/TGFBR1/EFNA5/ADAM17/IRAK4/PF4V1/CCL20/IL27RA/CSF2/BID/CADM4/IL6ST/S100A14/SYK |
| GOMF_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 226 | 0.4740712 | 1.847686 | 0.0000061 | 0.0019037 | 0.0017277 | 2163 | SLC18A2/ANO1/GABRA4/SLC5A5/SLC26A4/SLC9A3/SLC26A9/SLC39A8/SLC2A6/SLC24A3/SLC5A8/SLC7A11/TTYH2/ANO2/LRRC8D/SLCO4A1/CLIC2/SLCO1B1/SLC25A25/MFSD2A/SLC6A14/ANO4/CD36/CLIC3/SLC3A2/SLC7A9/SLC12A2/SLC7A5/LRRC8A/SLC7A1/SLC1A5/CLIC4/SLC4A9/SLC36A1/LRRC8B/SLCO1B3/SLC26A6/SLC26A11/SLC1A4/ANO8/SLCO3A1/SLC27A4/SLC4A3/SFXN5/SLC38A1/SLC25A1/CLDN4/LRRC8C/SLCO4C1/CLCN6/SLC25A32/SLC5A12/ANO7/SLC12A4/SLC38A7/SLC16A7/APOL1/SLC9A1/SERINC5/SLC6A9/SLC9A4/SLC52A2/VDAC2/SLC66A1/ANO9/MFSD12/PACC1/SLC16A3/SLC25A23/SLC39A14/SLC35D2/SLC25A22/SLC35B4 |
| GOMF_SIGNALING_RECEPTOR_REGULATOR_ACTIVITY | 264 | 0.4481086 | 1.777212 | 0.0000050 | 0.0019037 | 0.0017277 | 1945 | CCL26/IL19/DPP4/GDNF/LYPD1/INHBE/ADM2/DEFB4A/CXCL10/STC2/HBEGF/PCSK9/CCL4/BDNF/SEMA3B/IL32/CXCL11/KL/IL36G/CXCL9/IL17C/CXCL8/CCL22/TG/EREG/ARTN/GDF15/EBI3/CXCL16/IL36A/VEGFA/IL1A/CMTM3/FGF2/CLCF1/TNFSF12/CD70/FGF12/SECTM1/GNRH1/SEMA3D/TNFSF13/EDN1/IL1RN/OSGIN1/COLEC10/KITLG/PXDN/TNFSF9/ERFE/METRNL/CXCL1/IL23A/SEMA7A/TNF/CX3CL1/CGB7/LIF/SEMA3A/SEMA4C/NAMPT/CMTM7/BMP2/WNT6/CCL5/MACC1/SEMA6A/CXCL2/CCN3/GREM1/MANF/CXCL6/LYPD6B/TGFA/TYMP/NRTN/RLN1/FAM3C/BMP1/SCG2/DGKQ |
| GOMF_CYTOKINE_ACTIVITY | 122 | 0.5295073 | 1.913038 | 0.0000335 | 0.0078961 | 0.0071658 | 2103 | CCL26/IL19/INHBE/CXCL10/CCL4/IL32/CXCL11/IL36G/CXCL9/IL17C/CXCL8/CCL22/GDF15/EBI3/CXCL16/IL36A/VEGFA/IL1A/CMTM3/FGF2/CLCF1/TNFSF12/CD70/SECTM1/TNFSF13/EDN1/IL1RN/KITLG/TNFSF9/CXCL1/IL23A/TNF/CX3CL1/LIF/NAMPT/CMTM7/BMP2/WNT6/CCL5/CXCL2/GREM1/CXCL6/FAM3C/BMP1/SCG2/IL15/BMP6/TIMP1 |
| GOMF_CHEMOKINE_RECEPTOR_BINDING | 36 | 0.6796045 | 1.978611 | 0.0003554 | 0.0290473 | 0.0263609 | 1781 | CCL26/DEFB4A/CXCL10/CCL4/CXCL11/CXCL9/CXCL8/CCL22/CXCL16/YARS1/NES/CXCL1/CX3CL1/CCL5/CXCL2/CXCL6/STAT1 |
| GOMF_ANION_CHANNEL_ACTIVITY | 59 | 0.5955140 | 1.897812 | 0.0002931 | 0.0290473 | 0.0263609 | 2009 | ANO1/GABRA4/SLC26A9/TTYH2/ANO2/LRRC8D/CLIC2/ANO4/CLIC3/LRRC8A/CLIC4/LRRC8B/SLC26A6/SLC1A4/ANO8/CLDN4/LRRC8C/CLCN6/ANO7/APOL1/VDAC2/ANO9/PACC1 |
| GOMF_MICROTUBULE_MOTOR_ACTIVITY | 62 | -0.5467905 | -1.858639 | 0.0002339 | 0.0290473 | 0.0263609 | 2903 | KIF7/KIF23/KIF6/KIF17/KIF24/KIF27/DNAH7/DNAH9/DNAH1/DYNC2H1/DNAH3/KIF19/KIF22/DNAI2/DNAH6/DNAH10/KIF18A/KIF26B/STARD9/KIF11/DYNLRB2/DNAH2/DNAH5/KIFC1/KIF21A/KIF4A/KIF20B/KIF14/CENPE/KIF15/KIF2C/KIF20A/KIF18B |
| GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 106 | 0.5134834 | 1.821095 | 0.0004662 | 0.0290473 | 0.0263609 | 1723 | SLC18A2/ANO1/GABRA4/SLC5A5/SLC26A4/SLC26A9/SLC39A8/TTYH2/ANO2/LRRC8D/CLIC2/ANO4/CLIC3/SLC12A2/LRRC8A/CLIC4/SLC4A9/LRRC8B/SLC26A6/SLC26A11/SLC1A4/ANO8/SLC4A3/CLDN4/LRRC8C/CLCN6/ANO7/SLC12A4/APOL1/VDAC2 |
| GOMF_GROWTH_FACTOR_BINDING | 110 | 0.4996999 | 1.784482 | 0.0004453 | 0.0290473 | 0.0263609 | 1575 | NTRK1/CCN4/IL1R2/PCSK6/COL6A1/KL/FGFR4/FGFBP1/NTRK2/FLT1/CD36/IL2RG/NTRK3/TRIM16/IL1RN/OSMR/PXDN/NRP2/KDR/LIFR/IGF2R/KLB/EPHA2/ENG/THBS1/CCN3/ITGA6 |
| GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY | 107 | 0.4984438 | 1.768844 | 0.0005260 | 0.0290473 | 0.0263609 | 893 | PLA2G3/CA2/TNFAIP6/PNPLA3/AADAC/ACHE/LIPG/ASPG/PLA2G4C/ABHD4/ACOT1/PNPLA1/PLAAT1/LCAT/LIPH/PLA2G7/AARS1/PLA2G4A/IARS1 |
| GOMF_PROTEASE_BINDING | 116 | 0.4900587 | 1.766773 | 0.0004256 | 0.0290473 | 0.0263609 | 2488 | DPP4/VWF/SERPINB4/SELL/SERPINC1/SERPINB13/FAP/LDLR/NTRK2/TNFRSF10A/F3/BCL2/CSTA/SERPINB9/CD70/TTN/TIMP2/BIN1/TNF/SERPINB6/CSTB/SERPINB3/STIM1/ITGAV/FADD/A2ML1/RIPK2/TNFAIP3/TIMP1/FURIN/PRNP/BCL10/SELENOS/CD177/ITGA3/RFFL/RHBDD2 |
| GOMF_GLYCOSAMINOGLYCAN_BINDING | 153 | 0.4619782 | 1.730057 | 0.0002328 | 0.0290473 | 0.0263609 | 1560 | CCN4/TNFAIP6/SELP/LGR6/VIT/SELL/POSTN/CXCL10/RTN4R/PCSK6/LIPG/HBEGF/COL13A1/SERPINC1/CEMIP/SFRP1/CXCL11/CD44/NOD2/FGFR4/FGFBP1/SLIT2/CXCL8/VEGFA/LIPH/FGF2/SMOC2/APOE/CHODL/HSD17B12/ANOS1/FBLN7/HAPLN3/NRP2/ITIH2/SULF1/HK1/ENG/SGSH/THBS1/CCN3/SLIT1 |
| GOMF_SERINE_HYDROLASE_ACTIVITY | 115 | 0.4742356 | 1.705861 | 0.0005174 | 0.0290473 | 0.0263609 | 3243 | DPP4/MMP1/AADAC/ACHE/PRSS3/PCSK6/PCSK9/KLK7/CTSC/OVCH2/ADAM8/FAP/ACE/PRSS27/TMPRSS11E/F3/MMP19/PLAU/RELN/TMPRSS11B/KLK1/KLK12/TMPRSS2/TMPRSS11A/CFB/PRSS8/PRSS36/MMP11/HP/MMP10/C1S/PRSS16/BMP1/PCSK7/FURIN/RHBDL1/KLK10/C2/TMPRSS4/RHBDD2/TMPRSS11F/RHBDF2/RHBDD1/RHBDD3/PRSS22/RHBDF1/LONP1/MMP14/SEC11C/DPP9/MASP1/ST14 |
| GOMF_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 167 | 0.4467726 | 1.682281 | 0.0003134 | 0.0290473 | 0.0263609 | 2145 | SLC18A2/SLC5A5/SLC26A4/SLC9A3/SLC26A9/SLC5A1/SLC39A8/SLC9B2/SLC24A3/SLC5A8/SLC7A11/SLC9B1/SLCO4A1/SLCO1B1/SLC16A9/MFSD2A/SLC6A14/SLC16A4/SLC3A2/SLC12A2/SLC7A5/SLC28A3/SLC16A14/SLC1A5/SLC5A3/SLC4A9/SLC36A1/SLCO1B3/SLC26A6/SLC26A11/SLC1A4/SLC16A13/SLCO3A1/SLC45A4/SLC4A3/SLC38A1/SLC25A1/SLCO4C1/CLCN6/SLC15A3/SLC5A12/SLC25A3/SLC12A4/SLC35C1/SLC16A7/SLC9A1/SLC6A9/SLC17A5/SLC9A4/SLC8A1/SLC8B1/MFSD12/SLC16A3/SLC39A14/SLC35D2/SLC25A22/MCU |
| GOMF_PHOSPHATIDYLINOSITOL_BINDING | 237 | 0.4061546 | 1.591280 | 0.0004108 | 0.0290473 | 0.0263609 | 3007 | THY1/ALOX15/NCF1/SDCBP2/NCF1C/GSDMC/PHLDA2/CEACAM5/NOXO1/TTPA/PLEKHN1/TWF2/ITPR3/PLA2G4A/SH3PXD2B/FGD2/SCARB1/HIP1/CAPG/EPB41/ANXA8/ADAP2/MREG/SNX9/FLII/RUBCN/GAB2/SNX8/SVIL/APPL2/SYT1/TOM1L2/MARK1/SLC9A1/GSN/SNX24/ADAP1/TPCN2/ATP13A2/ESYT1/VEPH1/MYO10/PHLDA1/MYO1E/ZFYVE26/RAB35/PIK3C2B/AKT1/MYO1B/PLD2/ZFYVE28/CERT1/PICALM/HS1BP3/CYTH3/ZCCHC2/CGAS/PITPNM2/ATG2A/SNX10/ITPR2/PITPNB/GGA3/OSBPL5/NCF4/FCHO2/AIDA/ANKFY1/PFN1/FERMT2/GBF1 |
| GOMF_MICROTUBULE_BINDING | 245 | -0.3862802 | -1.573639 | 0.0003238 | 0.0290473 | 0.0263609 | 2819 | SPAG8/MAP6/KIF23/TOGARAM2/KIF6/KIF17/KIF24/KIF27/RMDN2/CCDC181/LRRK2/GAS2L2/FAM161A/MAP1A/CETN3/MAPT/CETN2/DCDC1/RACGAP1/MAP10/MTUS2/HOOK1/CCDC170/CEP44/SAXO2/KIF19/GAS2/KIF22/MDM1/DNAI7/KIF18A/EML6/CCDC187/ABRAXAS1/KIF26B/STARD9/KIF11/VASH2/SPC24/PSRC1/CRYAB/S100A9/RP1/KATNAL2/SPATA4/CAPN6/KIFC1/KIF21A/S100A8/KIF4A/SAXO1/SPAG5/KIF20B/APC2/KIF14/REEP1/CENPF/TPX2/NDRG1/IRAG2/CENPE/PLK1/SKA1/BIRC5/KIF15/KIF2C/KIF20A/GTSE1/DLGAP5/KIF18B |
| GOMF_ENDOPEPTIDASE_ACTIVITY | 286 | 0.3910058 | 1.558571 | 0.0003815 | 0.0290473 | 0.0263609 | 1980 | CAPN14/USP26/DPP4/MMP1/TRABD2A/PRSS3/PCSK6/PCSK9/KLK7/CTSC/ADAMTS14/MME/OVCH2/SFRP1/ADAM8/MMP16/FAP/USP28/ACE/PRSS27/PITRM1/UCHL1/CAPN12/TMPRSS11E/PIP/F3/MMP19/PLAU/USP18/TMPRSS11B/MMP25/KLK1/ADAM23/KLK12/ADAM9/MMP17/TMPRSS2/TMPRSS11A/ADAMTSL3/PSMA6/CFB/ADAMTS9/PRSS8/CASP7/PAPPA/ECE1/PRSS36/ADAMTS17/MMP11/NRIP3/BACE2/HP/MMP28/MMP10/C1S/ADAM28/BMP1/NLN/ADAM20/PCSK7 |
| GOMF_TUBULIN_BINDING | 335 | -0.3459100 | -1.456935 | 0.0005545 | 0.0290473 | 0.0263609 | 2819 | SPAG8/MAP6/DNAL1/KIF23/TOGARAM2/CENPJ/KIF6/BCAS3/KIF17/KIF24/KIF27/RMDN2/CCDC181/LRRK2/GAS2L2/AGBL5/FAM161A/MAP1A/TPPP3/CETN3/MAPT/IFT74/EFHC2/CETN2/IFT81/DCDC1/RACGAP1/MAP10/MTUS2/B9D2/HOOK1/EFHC1/DIXDC1/CCDC170/CEP44/SAXO2/KIF19/GAS2/CEP70/BRCA1/KIF22/MDM1/BBS4/AGBL1/DNAI7/KIF18A/EML6/STMND1/STMN1/CCDC187/ABRAXAS1/KIF26B/STARD9/KIF11/VASH2/SPC24/PSRC1/PPP1R42/CRYAB/S100A9/TTLL6/RP1/KATNAL2/SPATA4/CAPN6/GJA1/KIFC1/KIF21A/S100A8/KIF4A/SAXO1/SPAG5/KIF20B/APC2/KIF14/REEP1/CENPF/TPX2/NDRG1/IRAG2/CENPE/PLK1/SKA1/BIRC5/KIF15/KIF2C/KIF20A/GTSE1/DLGAP5/KIF18B |
| GOMF_PEPTIDASE_ACTIVITY | 442 | 0.3564103 | 1.474588 | 0.0006265 | 0.0295373 | 0.0268056 | 3122 | CAPN14/FGL2/USP26/DPP4/MMP1/TRABD2A/PRSS3/PCSK6/PCSK9/KLK7/CTSC/ADAMTS14/MME/OVCH2/SFRP1/USP54/ADAM8/MMP16/FAP/USP28/ACE/ANPEP/GGH/PRSS27/PITRM1/UCHL1/CAPN12/TMPRSS11E/PIP/F3/MMP19/PLAU/RELN/USP18/TMPRSS11B/MMP25/KLK1/UFD1/ADAM23/KLK12/ADAM9/MYRF/MMP17/JOSD1/GGT5/TMPRSS2/TMPRSS11A/ADAMTSL3/ZC3H12A/PSMA6/CFB/ADAMTS9/PRSS8/CASP7/PAPPA/CPA6/FOLH1/GGT7/ECE1/PRSS36/LTA4H/ADAMTS17/MMP11/OTUD7A/NRIP3/LACTB/BACE2/NDEL1/USP44/RNPEPL1/HP/MMP28/MMP10/C1S/PRSS16/ADAM28/BMP1/NLN/NCLN/TNFAIP3/ADAM20/PCSK7/METAP1D/QPCTL/FURIN/TFR2/CAPN2/RHBDL1/ATG4D/KLK10/ADAM17/C2/DNPEP/TMPRSS4/USP35/USP14/SCRN1/RHBDD2/TMPRSS11F/CYLD/RHBDF2/USP12/DESI1/RHBDD1/CAPN15/RHBDD3/CPA4/PSMD7/RCE1/ZUP1/PRSS22/PSMB2/BAP1/RHBDF1/CASP2/NUDT16/LONP1/CPQ/LGMN/USP32/USP39/MMP14/PM20D2/SEC11C/MINDY1/HM13/DPP9 |
| GOMF_INORGANIC_MOLECULAR_ENTITY_TRANSMEMBRANE_TRANSPORTER_ACTIVITY | 488 | 0.3431104 | 1.443806 | 0.0006004 | 0.0295373 | 0.0268056 | 1862 | CALHM4/SLC18A2/ANO1/TRPV6/GABRA4/SLC5A5/SLC26A4/TRPM6/ATP12A/SLC9A3/CALHM5/SLC26A9/SLC5A1/SLC39A8/KCNK3/SLC9B2/KCNS3/SLC24A3/SLC5A8/TMC1/CACNB4/CNR1/TTYH2/KCNJ16/ANO2/KCNH8/LRRC8D/ATP6V1C2/SLC9B1/ATP6V0D2/CLIC2/HTR3B/MFSD2A/KCNE3/ANO4/CNGB3/CLIC3/SLC3A2/KCNMB4/SLC12A2/LRRC8A/CACNB1/ORAI1/TMC6/SLC28A3/HCN2/ITPR3/KCNQ4/SCNN1D/TMC8/CLIC4/KCNK6/SLC5A3/SLC4A9/SLC36A1/LRRC8B/HTR3A/HCN3/SLC30A4/NIPA1/SLC26A6/SLC26A11/SLC1A4/ANO8/TRPV3/ATP6V0A2/SLC45A4/SLC4A3/PIEZO1/SLC38A1/KCNA2/CLDN4/CATSPER3/ATP13A5/LRRC8C/CLCN6/TRPM4/SLC15A3/SLC25A28/SLC5A12/ANO7/SLC25A3/SLC12A4/SLC39A1/FKBP1B/APOL1/ATP1B1/SLC9A1/MCUB/SLC6A9/SLC17A5/SLC9A4/P2RX4/VDAC2/ITGAV/TPCN2/SLC8A1/GRIK4/CACNA2D4/SLC8B1/ATP13A2/ANO9 |
| GOMF_CXCR_CHEMOKINE_RECEPTOR_BINDING | 13 | 0.8050550 | 1.878297 | 0.0006834 | 0.0306858 | 0.0278479 | 2380 | CXCL10/CXCL11/CXCL9/CXCL8/YARS1/CXCL1/CX3CL1/CXCL2/CXCL6/PF4V1 |
| GOMF_HEPARIN_BINDING | 111 | 0.4847501 | 1.727721 | 0.0007182 | 0.0307866 | 0.0279394 | 1058 | CCN4/SELP/LGR6/SELL/POSTN/CXCL10/RTN4R/PCSK6/LIPG/HBEGF/COL13A1/SERPINC1/SFRP1/CXCL11/FGFR4/FGFBP1/SLIT2/CXCL8/VEGFA/LIPH/FGF2/SMOC2/APOE/HSD17B12/ANOS1/FBLN7/NRP2 |
| GOMF_PHOSPHOLIPID_BINDING | 384 | 0.3637289 | 1.490799 | 0.0008232 | 0.0337498 | 0.0306285 | 2933 | PNPLA3/RASGRP1/THY1/APOC1/ALOX15/NCF1/GRK5/MME/SDCBP2/NCF1C/MAP1B/SGIP1/GSDMC/PHLDA2/PLA2G4C/UNC13A/F3/CEACAM5/NOXO1/TTPA/PLEKHN1/ANXA3/PLA2G7/APOE/TWF2/ITPR3/PLA2G4A/SH3PXD2B/DOC2B/ANXA1/FGD2/SYT17/SCARB1/BIN1/HIP1/CAPG/EPB41/ANXA8/ADAP2/MREG/SNX9/FLII/ATP8B1/RUBCN/GAB2/SYT11/SNX8/SVIL/PTAFR/APPL2/SYT1/TOM1L2/THBS1/MARK1/SLC9A1/GSN/AXL/SNX24/ADAP1/CPNE3/RASA2/ANXA4/VDAC2/TPCN2/SNCA/MYOF/CPNE4/ANXA8L1/ATP13A2/PSD4/TEC/ESYT1/VEPH1/MYO10/PHLDA1/MYO1E/ZFYVE26/PACSIN3/PACSIN2/RAB35/PIK3C2B/AKT1/MYO1B/PLD2/ZFYVE28/DGKA/CERT1/GAS6/PICALM/OSBPL1A/HS1BP3/CYTH3/ZCCHC2/CLN6/CGAS/CPTP/PITPNM2/ATG2A/SNX10/ITPR2/PAFAH2/PITPNB/GGA3/OSBPL5/NCF4/FCHO2/AIDA/ANKFY1/PFN1 |
| GOMF_SULFUR_COMPOUND_BINDING | 194 | 0.4136784 | 1.587453 | 0.0010318 | 0.0405411 | 0.0367918 | 1780 | CCN4/PNPLA3/SELP/LGR6/CBS/SELL/POSTN/CXCL10/RTN4R/PCSK6/LIPG/HBEGF/COL13A1/SERPINC1/SFRP1/CXCL11/FGFR4/FGFBP1/SLIT2/CXCL8/VEGFA/LIPH/FGF2/SMOC2/APOE/ENPP1/HSD17B12/ANOS1/FBLN7/NRP2/PANK3/TKT/NAA80/ACOT7/TPK1/THBS1/CCN3/SLIT1/ACADL/OGDH/CXCL6 |
| GOMF_1_PHOSPHATIDYLINOSITOL_3_KINASE_REGULATOR_ACTIVITY | 11 | 0.8193896 | 1.807005 | 0.0011304 | 0.0409999 | 0.0372081 | 1299 | CISH/SOCS1/SOCS2/SOCS3 |
| GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY | 262 | -0.3584560 | -1.475650 | 0.0011265 | 0.0409999 | 0.0372081 | 1023 | H3C10/H2AC16/H2BC7/H2BC3/CYBB/IL12A/BDKRB2/PGLYRP4/H4C13/H2AC13/H4C9/H2AC11/H2AC21/SLC51B/NPAS1/H2BC13/MTTP/GABBR2/H2AC12/MEF2C/H2BC14/H2BC10/BCL2L10/H3C7/CENPW/EPAS1/H2BC17/H3C12/ABCG1/TPM2/KCNB1/ABCD2/H3C3/TOP2A/H3C8/ADRA2A/H3C2 |
| GOMF_NEUROTROPHIN_RECEPTOR_BINDING | 10 | 0.8441598 | 1.845210 | 0.0013698 | 0.0478427 | 0.0434181 | 240 | NTRK1/BDNF |
Reactome
| ID | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalue | rank | core_enrichment |
|---|---|---|---|---|---|---|---|---|
| REACTOME_CHOLESTEROL_BIOSYNTHESIS | 24 | 0.9100095 | 2.415338 | 0.0000000 | 0.0000000 | 0.0000000 | 887 | CYP51A1/MVD/ACAT2/HMGCS1/EBP/FDPS/LSS/DHCR7/MSMO1/HMGCR/HSD17B7/IDI1/FDFT1/SQLE/NSDHL/SC5D/TM7SF2/MVK |
| REACTOME_CELL_CYCLE_CHECKPOINTS | 281 | -0.4899724 | -2.015469 | 0.0000000 | 0.0000000 | 0.0000000 | 2032 | CENPH/CENPS/CCNA2/CENPU/CHEK1/DNA2/B9D2/CENPM/H2BC11/RPA3/H2BC15/BRCA1/H4C4/H4C1/CDC7/MCM8/KIF18A/PKMYT1/ABRAXAS1/CDC25A/BLM/BRIP1/SPC24/H2BC7/H2BC3/ANAPC4/CCNB1/ORC1/H4C13/CENPK/H4C9/CENPP/H2BC13/KNL1/EXO1/SGO2/H2BC14/NDC80/H2BC10/MAD2L1/CENPF/CCNB2/H2BC17/CENPE/NUF2/CCNE2/PLK1/SGO1/CDK1/SKA1/BIRC5/KIF2C/BUB1/MCM10/ERCC6L/CDC20/GTSE1/CDC25C/UBE2C/BUB1B/SPC25 |
| REACTOME_M_PHASE | 390 | -0.4453607 | -1.894092 | 0.0000000 | 0.0000000 | 0.0000000 | 2064 | SMC2/CENPH/H3C11/CENPS/CETN2/H3C1/CENPU/VRK1/B9D2/ESPL1/CENPM/H2BC11/H3C13/CEP78/H2BC15/CEP70/H4C4/H4C1/H2AC4/KIF18A/H3C10/SPC24/H2BC7/FBXO5/H2BC3/ANAPC4/CCNB1/H4C13/CENPK/H4C9/PTTG1/CENPP/PRKAR2B/H2BC13/KNL1/H2AC14/SGO2/CDCA5/H2BC14/NDC80/H2BC10/LMNB1/MAD2L1/CENPF/H3C7/CCNB2/NCAPH/H2BC17/H3C12/CENPE/NEK2/NUF2/PLK1/PLK4/SGO1/CDK1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/KIF20A/CDC20/H3C3/NCAPG/UBE2C/H3C8/BUB1B/SPC25/H3C2 |
| REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP | 42 | 0.7926678 | 2.421620 | 0.0000000 | 0.0000003 | 0.0000002 | 887 | CYP51A1/MVD/HMGCS1/FDPS/ELOVL6/LSS/DHCR7/HMGCR/IDI1/HELZ2/FDFT1/SQLE/SCD/SC5D/FASN/TM7SF2/MVK |
| REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES | 61 | -0.6985479 | -2.328780 | 0.0000000 | 0.0000003 | 0.0000002 | 3700 | H2AX/H3C6/H2BC6/NCAPD3/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/SMC4/H2BC9/SMC2/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/CCNB1/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/PLK1/CDK1/H3C3/H3C8/H3C2 |
| REACTOME_MITOTIC_SPINDLE_CHECKPOINT | 108 | -0.6067154 | -2.222323 | 0.0000000 | 0.0000004 | 0.0000003 | 1009 | CENPH/CENPS/CENPU/B9D2/CENPM/KIF18A/SPC24/ANAPC4/CENPK/CENPP/KNL1/SGO2/NDC80/MAD2L1/CENPF/CENPE/NUF2/PLK1/SGO1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/UBE2C/BUB1B/SPC25 |
| REACTOME_DNA_REPLICATION | 176 | -0.5163359 | -2.046794 | 0.0000000 | 0.0000010 | 0.0000009 | 2017 | H3C11/H3C1/CCNA2/DNA2/H2BC11/H3C13/RPA3/POLE2/H2BC15/LIG1/H4C4/H4C1/CDC7/H2AC4/MCM8/GINS1/GINS2/POLA2/H3C10/H2BC7/H2BC3/ANAPC4/ORC1/H4C13/H4C9/H2BC13/H2AC14/E2F1/E2F2/CDT1/GMNN/H2BC14/H2BC10/H3C7/H2BC17/H3C12/CCNE2/MCM10/H3C3/UBE2C/H3C8/H3C2 |
| REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | 63 | -0.6768095 | -2.275381 | 0.0000000 | 0.0000011 | 0.0000009 | 3971 | NPM1/H2BC12/RBBP4/ITGB3BP/RUVBL1/RBBP7/CENPC/H2AX/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/MIS18A/H2BC9/MIS18BP1/CENPH/CENPS/CENPU/CENPM/H2BC11/H2BC15/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/CENPK/H4C9/CENPP/H2BC13/KNL1/H2AC14/H2BC14/H2BC10/CENPW/H2BC17/OIP5/HJURP |
| REACTOME_HDACS_DEACETYLATE_HISTONES | 81 | -0.6372707 | -2.229347 | 0.0000000 | 0.0000011 | 0.0000009 | 2162 | H2BC9/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2AC16/H2BC7/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA | 61 | -0.6767456 | -2.256096 | 0.0000000 | 0.0000014 | 0.0000011 | 3961 | H2BC12/RBBP4/RBBP7/H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/EZH2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/PHF19/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_RMTS_METHYLATE_HISTONE_ARGININES | 66 | -0.6627525 | -2.232308 | 0.0000000 | 0.0000014 | 0.0000011 | 3831 | RBBP7/ACTL6A/H2AX/H3C6/H4C5/SMARCA2/SMARCE1/H4C12/WDR77/H2AJ/H4C6/H2AZ2/H4C3/H4C2/H2AC15/H3C11/H3C1/H3C13/H4C4/H4C1/H2AC4/H3C10/H2AC16/SMARCD3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2AC14/H2AC12/H3C7/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_MEIOSIS | 95 | -0.6002354 | -2.158029 | 0.0000000 | 0.0000014 | 0.0000011 | 3813 | H3-3A/SYCP2/H2AX/H3C6/H2BC6/H4C5/ATM/BRCA2/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/SYNE1/MRE11/H2BC9/H3C11/H3C1/H2BC11/H3C13/RPA3/H2BC15/BRCA1/H4C4/H4C1/H2AC4/HSPA2/PSMC3IP/BLM/H3C10/H2BC7/H2BC3/STAG3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/LMNB1/H3C7/H2BC17/H3C12/DMC1/H3C3/H3C8/H3C2 |
| REACTOME_CHROMOSOME_MAINTENANCE | 126 | -0.5583225 | -2.075482 | 0.0000000 | 0.0000014 | 0.0000011 | 4152 | H2BC8/PRIM1/POLA1/RPA1/NPM1/POLR2I/H2BC12/RBBP4/ITGB3BP/RUVBL1/RBBP7/H3-3A/CENPC/H2AX/H2BC6/H4C5/H2BC5/H4C12/RUVBL2/POLD1/RFC3/WRAP53/H2AJ/WRN/H4C6/H2BC4/H2AZ2/H4C3/H4C2/RFC5/MIS18A/H2BC9/CHTF8/MIS18BP1/CENPH/CENPS/CCNA2/CENPU/DNA2/CENPM/H2BC11/RPA3/H2BC15/LIG1/H4C4/H4C1/H2AC4/BLM/POLA2/H2BC7/H2BC3/H4C13/CENPK/H4C9/CENPP/H2BC13/KNL1/H2AC14/DSCC1/H2BC14/H2BC10/CENPW/H2BC17/OIP5/HJURP |
| REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION | 64 | -0.6735249 | -2.256106 | 0.0000000 | 0.0000014 | 0.0000011 | 3961 | H2BC12/RBBP4/RBBP7/H3-3A/H2AX/H3C6/H2BC6/H4C5/CBX3/H2BC5/H4C12/TTF1/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION | 56 | -0.6751004 | -2.208585 | 0.0000000 | 0.0000016 | 0.0000013 | 4003 | SUV39H1/H2BC12/H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF | 55 | 0.7512270 | 2.404642 | 0.0000000 | 0.0000016 | 0.0000013 | 887 | CYP51A1/MVD/HMGCS1/FDPS/ELOVL6/LSS/DHCR7/HMGCR/INSIG1/IDI1/HELZ2/FDFT1/SQLE/SCD/SC5D/FASN/TM7SF2/MVK |
| REACTOME_MEIOTIC_RECOMBINATION | 70 | -0.6618302 | -2.258802 | 0.0000000 | 0.0000016 | 0.0000013 | 3700 | H2AX/H3C6/H2BC6/H4C5/ATM/BRCA2/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/MRE11/H2BC9/H3C11/H3C1/H2BC11/H3C13/RPA3/H2BC15/BRCA1/H4C4/H4C1/H2AC4/PSMC3IP/BLM/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/DMC1/H3C3/H3C8/H3C2 |
| REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | 54 | 0.7385567 | 2.350001 | 0.0000000 | 0.0000017 | 0.0000014 | 1781 | SOCS1/IFIT2/MX2/RSAD2/ISG15/OAS3/ISG20/OASL/IFIT3/OAS1/MX1/IFIT1/IFI35/IFITM1/USP18/IFI6/EGR1/IRF7/BST2/IFI27/XAF1/OAS2/IFITM3/SOCS3/IFIT5/IRF6/ADAR/STAT1 |
| REACTOME_HATS_ACETYLATE_HISTONES | 128 | -0.5551664 | -2.075388 | 0.0000000 | 0.0000017 | 0.0000014 | 4152 | H2BC8/H2BC18/MSL3/MCRS1/MORF4L1/H2BC12/KAT2A/EP400/RUVBL1/RBBP7/ACTL6A/ELP6/H3C6/H2BC6/H4C5/H2BC5/H4C12/RUVBL2/HAT1/H4C6/H2BC4/ING4/H4C3/H4C2/JADE1/H2BC9/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2AC16/H2BC7/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A | 26 | -0.8200483 | -2.306116 | 0.0000000 | 0.0000019 | 0.0000016 | 871 | ANAPC4/MAD2L1/NEK2/CDC20/UBE2C/BUB1B |
| REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 | 53 | -0.6949488 | -2.285318 | 0.0000000 | 0.0000019 | 0.0000016 | 3700 | H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/AR/H3C3/H3C8/H3C2 |
| REACTOME_RHO_GTPASE_EFFECTORS | 290 | -0.4445913 | -1.840399 | 0.0000000 | 0.0000020 | 0.0000016 | 1023 | H3C10/SPC24/H2BC7/MYLK/S100A9/H2BC3/CYBB/H4C13/CENPK/H4C9/WAS/S100A8/DIAPH3/CENPP/H2BC13/KNL1/H2AC14/SGO2/CIT/NOX1/H2BC14/NDC80/KIF14/H2BC10/MAD2L1/CENPF/H3C7/H2BC17/H3C12/CENPE/NUF2/PLK1/SGO1/IQGAP3/SKA1/BIRC5/AR/KIF2C/BUB1/ERCC6L/CDC20/H3C3/CDC25C/H3C8/BUB1B/SPC25/H3C2 |
| REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION | 57 | -0.6786559 | -2.227959 | 0.0000000 | 0.0000024 | 0.0000020 | 3700 | H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/ORC1/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_DNA_METHYLATION | 52 | -0.6918105 | -2.263368 | 0.0000001 | 0.0000030 | 0.0000024 | 3813 | H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION | 98 | -0.5865076 | -2.124470 | 0.0000001 | 0.0000031 | 0.0000026 | 3961 | H2BC12/POLR1C/KAT2A/RBBP4/RBBP7/H3-3A/H2AX/H3C6/H2BC6/H4C5/CBX3/GTF2H5/H2BC5/H4C12/TTF1/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE | 78 | -0.6253839 | -2.173370 | 0.0000001 | 0.0000032 | 0.0000026 | 3961 | H2BC12/POLR1C/H3-3A/H2AX/H3C6/H2BC6/H4C5/CBX3/GTF2H5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX | 78 | -0.6238631 | -2.168085 | 0.0000001 | 0.0000036 | 0.0000030 | 3852 | RUVBL1/H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/PYGO1/H2AJ/TCF4/H4C6/H2BC4/H2AZ2/BCL9/H4C3/H4C2/H2BC9/RUNX3/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/AXIN2/H2BC13/H2AC14/TCF7/LEF1/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS | 95 | -0.5820628 | -2.092693 | 0.0000001 | 0.0000047 | 0.0000039 | 3967 | POLR2I/H2BC12/H3-3A/H2AX/H3C6/H2BC6/H4C5/H2BC5/H4C12/NUP37/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/NDC1/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | 21 | -0.8388424 | -2.252758 | 0.0000002 | 0.0000067 | 0.0000055 | 871 | ANAPC4/MAD2L1/CDC20/UBE2C/BUB1B |
| REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION | 115 | -0.5579830 | -2.062884 | 0.0000002 | 0.0000095 | 0.0000079 | 1009 | SPC24/CCNB1/CENPK/CENPP/KNL1/SGO2/CDCA5/NDC80/MAD2L1/CENPF/CCNB2/CENPE/NUF2/PLK1/SGO1/CDK1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/BUB1B/SPC25 |
| REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING | 97 | -0.5690216 | -2.050953 | 0.0000003 | 0.0000107 | 0.0000089 | 2866 | H4C6/H2BC4/NOTCH1/MAML3/H2AZ2/H4C3/H4C2/H2BC9/NOTCH3/H3C11/TFDP2/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/ATP2A3/H2BC13/H2AC14/E2F1/H2BC14/H2BC10/H3C7/H2BC17/H3C12/ST3GAL6/MIR449C/H3C3/H3C8/H3C2 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS | 74 | -0.6270305 | -2.152107 | 0.0000003 | 0.0000109 | 0.0000090 | 3700 | H2AX/RXRA/H3C6/H2BC6/H4C5/DEK/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/TFDP2/H3C1/CEBPA/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/E2F1/FLI1/LEF1/H2BC14/GATA2/H2BC10/H3C7/MYB/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION | 96 | -0.5724421 | -2.062934 | 0.0000003 | 0.0000113 | 0.0000093 | 4003 | SUV39H1/H2BC12/POLR1C/SUDS3/H3-3A/H2AX/H3C6/H2BC6/H4C5/GTF2H5/H2BC5/H4C12/TTF1/H2AJ/SAP30/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_REPRODUCTION | 108 | -0.5543982 | -2.030692 | 0.0000004 | 0.0000129 | 0.0000106 | 2521 | H4C3/H4C2/SYNE1/MRE11/H2BC9/H3C11/H3C1/H2BC11/H3C13/RPA3/H2BC15/BRCA1/H4C4/H4C1/H2AC4/HSPA2/PSMC3IP/BLM/H3C10/H2BC7/H2BC3/STAG3/H4C13/H4C9/H2BC13/H2AC14/OVGP1/H2BC14/H2BC10/LMNB1/H3C7/H2BC17/H3C12/CATSPERD/DMC1/H3C3/H3C8/H3C2 |
| REACTOME_HCMV_LATE_EVENTS | 103 | -0.5576692 | -2.037416 | 0.0000004 | 0.0000130 | 0.0000107 | 2521 | H4C3/H4C2/NDC1/H2BC9/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2AC16/H2BC7/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE | 223 | -0.4551216 | -1.839857 | 0.0000004 | 0.0000133 | 0.0000110 | 1009 | SPC24/FBXO5/ANAPC4/CCNB1/CENPK/PTTG1/CENPP/KNL1/SGO2/CDCA5/NDC80/LMNB1/MAD2L1/CENPF/CCNB2/CENPE/NUF2/PLK1/SGO1/CDK1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/UBE2C/BUB1B/SPC25 |
| REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH | 89 | -0.5836347 | -2.066148 | 0.0000004 | 0.0000138 | 0.0000114 | 4152 | H2BC8/PRIM1/POLA1/FOXO3/H2BC12/RBBP4/RBBP7/H3-3A/H2AX/H3C6/CDK5/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/EZH2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/CDC25A/POLA2/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/CAPNS2/H2AC14/H2BC14/H2BC10/LMNB1/H3C7/H2BC17/H3C12/H3C3/CDC25C/H3C8/H3C2 |
| REACTOME_MITOTIC_PROMETAPHASE | 191 | -0.4729286 | -1.881723 | 0.0000005 | 0.0000151 | 0.0000124 | 1009 | PCM1/PDS5B/CEP76/CCP110/SMC4/NME7/SMC2/CENPH/CENPS/CETN2/CENPU/B9D2/CENPM/CEP78/CEP70/KIF18A/SPC24/CCNB1/CENPK/CENPP/PRKAR2B/KNL1/SGO2/CDCA5/NDC80/MAD2L1/CENPF/CCNB2/NCAPH/CENPE/NEK2/NUF2/PLK1/PLK4/SGO1/CDK1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/NCAPG/BUB1B/SPC25 |
| REACTOME_MITOTIC_PROPHASE | 130 | -0.5153263 | -1.934169 | 0.0000006 | 0.0000164 | 0.0000135 | 2643 | H2AZ2/PRKCB/H4C3/H4C2/SMC4/NDC1/H2BC9/SMC2/H3C11/H3C1/VRK1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/CCNB1/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/LMNB1/H3C7/CCNB2/H2BC17/H3C12/PLK1/CDK1/H3C3/H3C8/H3C2 |
| REACTOME_DNA_REPLICATION_PRE_INITIATION | 133 | -0.5226252 | -1.969144 | 0.0000007 | 0.0000205 | 0.0000169 | 1665 | H2BC11/H3C13/RPA3/POLE2/H2BC15/H4C4/H4C1/CDC7/H2AC4/MCM8/POLA2/H3C10/H2BC7/H2BC3/ORC1/H4C13/H4C9/H2BC13/H2AC14/E2F1/E2F2/CDT1/GMNN/H2BC14/H2BC10/H3C7/H2BC17/H3C12/MCM10/H3C3/H3C8/H3C2 |
| REACTOME_INTERFERON_SIGNALING | 170 | 0.5154131 | 1.942624 | 0.0000007 | 0.0000205 | 0.0000169 | 2535 | SOCS1/IFIT2/MX2/RSAD2/ISG15/CD44/OAS3/ISG20/OASL/GBP5/IFIT3/OAS1/MX1/IFIT1/IFI35/IFITM1/USP18/IFI6/EGR1/IRF7/BST2/IFI27/XAF1/OAS2/PML/IFITM3/ICAM1/SOCS3/PTAFR/IFIT5/UBE2L6/TRIM14/IRF6/HERC5/ADAR/STAT1/TRIM21/EIF2AK2/TRIM25/NUP188/EIF4E3/TRIM45/SEC13/HLA-DQB2/GBP1/HLA-F/HLA-C/STAT2/NEDD4/EIF4G1/TRIM5/PTPN11/GBP4 |
| REACTOME_PHOSPHORYLATION_OF_THE_APC_C | 20 | -0.8158156 | -2.160935 | 0.0000010 | 0.0000284 | 0.0000234 | 871 | ANAPC4/CCNB1/PLK1/CDK1/UBE2C |
| REACTOME_SEPARATION_OF_SISTER_CHROMATIDS | 178 | -0.4707924 | -1.862121 | 0.0000013 | 0.0000339 | 0.0000279 | 1009 | SPC24/ANAPC4/CENPK/PTTG1/CENPP/KNL1/SGO2/CDCA5/NDC80/MAD2L1/CENPF/CENPE/NUF2/PLK1/SGO1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/UBE2C/BUB1B/SPC25 |
| REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B | 24 | -0.7811961 | -2.161560 | 0.0000016 | 0.0000412 | 0.0000340 | 871 | ANAPC4/CCNB1/CDK1/CDC20/UBE2C |
| REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION | 79 | -0.5910492 | -2.059283 | 0.0000016 | 0.0000412 | 0.0000340 | 3961 | H2BC12/POLR1C/KAT2A/H3-3A/H2AX/H3C6/H2BC6/H4C5/DEK/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION | 94 | -0.5712527 | -2.057096 | 0.0000016 | 0.0000412 | 0.0000340 | 3961 | H2BC12/POLR1C/KAT2A/RBBP4/RBBP7/H3-3A/H2AX/H3C6/H2BC6/H4C5/CBX3/DEK/H2BC5/H4C12/TTF1/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_BASE_EXCISION_REPAIR | 81 | -0.5794047 | -2.026916 | 0.0000024 | 0.0000582 | 0.0000480 | 4574 | H2AC8/H4C8/LIG3/H2AC6/XRCC1/APEX1/NEIL1/H2BC8/NEIL2/RPA1/H2BC12/UNG/H2AX/NTHL1/H2BC6/H4C5/H2BC5/H4C12/POLD1/RFC3/H2AJ/OGG1/H4C6/H2BC4/H2AZ2/H4C3/H4C2/RFC5/H2BC9/H2BC11/RPA3/POLE2/H2BC15/LIG1/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H2BC17/NEIL3 |
| REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | 89 | -0.5621227 | -1.989993 | 0.0000024 | 0.0000591 | 0.0000487 | 4260 | RAD9A/TOPBP1/H2BC8/RPA1/H2BC12/RMI1/TP53BP1/H2AX/H2BC6/H4C5/RAD9B/ATM/H2BC5/H4C12/RFC3/CHEK2/WRN/H4C6/H2BC4/BARD1/H4C3/H4C2/RFC5/MRE11/H2BC9/CHEK1/DNA2/H2BC11/RPA3/H2BC15/BRCA1/H4C4/H4C1/ABRAXAS1/BLM/BRIP1/H2BC7/H2BC3/CCNB1/H4C13/H4C9/H2BC13/EXO1/H2BC14/H2BC10/H2BC17/CDK1/CDC25C |
| REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION | 134 | -0.5008421 | -1.889252 | 0.0000036 | 0.0000846 | 0.0000697 | 4003 | SUV39H1/H2BC12/POLR1C/KAT2A/RBBP4/SUDS3/RBBP7/H3-3A/H2AX/H3C6/H2BC6/H4C5/CBX3/GTF2H5/DEK/H2BC5/H4C12/TTF1/H2AJ/SAP30/H4C6/H2BC4/H2AZ2/EZH2/H4C3/H4C2/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/TET1/H4C4/H4C1/H2AC4/PHF19/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS | 16 | -0.8401569 | -2.091342 | 0.0000043 | 0.0000987 | 0.0000813 | 1178 | PKMYT1/CDC25A/CCNB1/FOXM1/CENPF/CCNB2/PLK1/CDC25C/MYBL2 |
| REACTOME_SIGNALING_BY_INTERLEUKINS | 375 | 0.4114043 | 1.674962 | 0.0000047 | 0.0001064 | 0.0000877 | 2711 | NOS2/CISH/IL19/SOCS1/IL1R2/IL13RA2/ALOX15/SERPINB2/MMP1/IL1RL1/CXCL10/CCL4/MAOA/IL32/IL12RB2/IL36G/NOD2/IL17C/CXCL8/CCL22/CD36/IL2RG/IL31RA/EBI3/FOS/MAPKAPK3/BCL2/IL36A/VEGFA/SOCS2/IL1A/FGF2/CLCF1/GATA3/CD86/NFKB2/IL1RN/ANXA1/HCK/OSMR/IFNLR1/STX1A/IL18R1/IRAK2/NFKBIA/STX3/HIF1A/PTGS2/CXCL1/IL23A/MYD88/ICAM1/TNF/LIFR/PSMA6/GAB2/SOCS3/DUSP3/IRS2/HMOX1/LIF/IL4R/DUSP7/PTAFR/MAPK11/CCL5/LGALS9/FYN/SOX2/CXCL2/ITGAM/PIM1/DUSP6/IL15RA/IL1RL2/STAT1/IRAK1/RIPK2/IL20RB/MUC1/TEC/PTPN9/JUNB/MAP3K8/IL15/PSMC4/TIMP1/BATF/NFKBIB/SQSTM1/CDKN1A/AKT1/JUN/MSN/RORA/MYC/INPPL1/IRAK4/STAT2/MAPKAPK2/RELA/STX4/PTPN11/CCL20/IL27RA/NOD1/CSF2/PAK2/IL6ST/STXBP2/PSMD11/PTPN12/MAP2K1/ALOX5/RALA/CFL1/SYK |
| REACTOME_GENE_SILENCING_BY_RNA | 123 | -0.5110819 | -1.898076 | 0.0000056 | 0.0001240 | 0.0001022 | 3700 | H2AX/HSP90AA1/H3C6/TDRD1/H2BC6/H4C5/H2BC5/H4C12/NUP37/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/HENMT1/NDC1/H2BC9/H3C11/H3C1/TDRD6/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/MIR23B/H3C10/H2BC7/H2BC3/PIWIL2/H4C13/H4C9/H2BC13/H2AC14/MYBL1/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES | 446 | 0.3896559 | 1.613445 | 0.0000057 | 0.0001241 | 0.0001023 | 2992 | NTRK1/SOCS1/ARC/CD274/NCF1/PTPRO/TRIB3/PCSK6/COL6A1/HBEGF/SGK1/BDNF/PRDM1/ATP6V1C2/KL/FGFR4/ATP6V0D2/FGFBP1/NTRK2/FLT1/IL2RG/EREG/NTRK3/FOS/F3/MAPKAPK3/VEGFA/TNS4/FOSB/DOCK3/FGF2/EGR1/APOE/EGR2/ITPR3/MET/GRB10/KITLG/ANOS1/TRIB1/NRP2/HIF1A/MKNK1/FOSL1/MAPK12/KDR/ATP6V0A2/LAMA4/GAB2/DUSP3/IRS2/ASCL1/YAP1/ID3/AP2B1/SPHK1/KLB/DUSP7/SPRED2/MAPK11/THBS1/KRAS/BCAR1/FYN/DUSP6/AXL/SH2B3/MST1R/JUND/NCF2/ADAP1/ITGAV/AP2M1/LAMB3/SPINT2/STAT1/RAC1/RAB4B/AKT3/TGFA/TEC/JUNB/ATP6V1E2/ACTB/GTF2F2/NRAS/FURIN/PTK6/SPP1/AKT1/LAMB1/ADAM17/MYC/NEDD4/DIAPH1/MAPKAPK2/SHC2/ITGA3/SH3GL1/COL5A2/SRC/PRR5/PTPN11/EPS15/PAK2/PTPN12/MAPK13/MAP2K1/EPS15L1/RALA/ITPR2/ACTG1/TIAM1/FGFBP3/GGA3/LAMA3/VAV2/LAMB2/RAP1A/NCF4/DOCK7/CSK/CAV1/IGF2/ESRP2/AP2A2/PTPN3/ELMO2/SPINT1/CRK/CBL |
| REACTOME_SIGNALING_BY_NTRKS | 123 | 0.5508215 | 1.989794 | 0.0000074 | 0.0001584 | 0.0001306 | 2974 | NTRK1/ARC/PTPRO/PCSK6/SGK1/BDNF/NTRK2/NTRK3/FOS/F3/MAPKAPK3/FOSB/DOCK3/EGR1/EGR2/TRIB1/FOSL1/MAPK12/DUSP3/IRS2/ASCL1/ID3/AP2B1/DUSP7/MAPK11/KRAS/FYN/DUSP6/JUND/AP2M1/RAC1/JUNB/NRAS/FURIN/MAPKAPK2/SHC2/SRC/PTPN11/MAPK13/MAP2K1/RALA/TIAM1/RAP1A/AP2A2/CRK |
| REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS | 104 | -0.5287602 | -1.933478 | 0.0000084 | 0.0001753 | 0.0001445 | 3967 | POLR2I/H2BC12/RBBP4/RBBP7/H3-3A/H2AX/RXRA/H3C6/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/HOXA1/H2BC4/H2AZ2/EZH2/H4C3/H4C2/H2BC9/H3C11/H3C1/HOXB4/PBX1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP | 99 | -0.5262306 | -1.912968 | 0.0000085 | 0.0001753 | 0.0001445 | 2162 | H2BC9/CDKN2C/H3C11/H3C1/CCNA2/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/ANAPC4/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/UBE2C/H3C8/H3C2 |
| REACTOME_RHO_GTPASES_ACTIVATE_PKNS | 78 | -0.5646956 | -1.962463 | 0.0000099 | 0.0002024 | 0.0001668 | 2162 | H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/AR/H3C3/CDC25C/H3C8/H3C2 |
| REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE | 46 | -0.6384464 | -2.023870 | 0.0000105 | 0.0002103 | 0.0001734 | 3700 | H2AX/H2BC6/H4C5/H2BC5/H4C12/H2AJ/OGG1/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H2BC11/H2BC15/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H2BC17/NEIL3 |
| REACTOME_HOMOLOGY_DIRECTED_REPAIR | 130 | -0.4820605 | -1.809312 | 0.0000139 | 0.0002732 | 0.0002252 | 4572 | H4C8/RAD50/ATR/LIG3/XRCC1/RAD9A/TOPBP1/H2BC8/RPA1/H2BC12/RMI1/TP53BP1/ERCC4/H2AX/EME1/H2BC6/TIMELESS/H4C5/RAD9B/ATM/BRCA2/H2BC5/H4C12/POLD1/RFC3/WRN/RAD52/H4C6/RAD51B/H2BC4/BARD1/H4C3/H4C2/RFC5/MRE11/CLSPN/H2BC9/ERCC1/CCNA2/CHEK1/DNA2/H2BC11/RPA3/POLE2/H2BC15/BRCA1/H4C4/XRCC2/H4C1/ABRAXAS1/BLM/BRIP1/H2BC7/H2BC3/POLQ/H4C13/H4C9/RAD51AP1/H2BC13/EXO1/H2BC14/H2BC10/H2BC17 |
| REACTOME_RHO_GTPASES_ACTIVATE_FORMINS | 129 | -0.4800147 | -1.793853 | 0.0000144 | 0.0002780 | 0.0002291 | 735 | CENPK/DIAPH3/CENPP/KNL1/SGO2/NDC80/MAD2L1/CENPF/CENPE/NUF2/PLK1/SGO1/SKA1/BIRC5/KIF2C/BUB1/ERCC6L/CDC20/BUB1B/SPC25 |
| REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS | 112 | -0.5019533 | -1.847652 | 0.0000159 | 0.0003033 | 0.0002499 | 1665 | H2BC9/H3C11/H3C1/H2BC11/H3C13/LMO2/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/GATA2/H2BC10/H3C7/MYB/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION | 53 | -0.6185152 | -2.033968 | 0.0000177 | 0.0003313 | 0.0002731 | 4574 | H2AC8/H4C8/H2AC6/NEIL1/H2BC8/NEIL2/H2BC12/UNG/H2AX/NTHL1/H2BC6/H4C5/H2BC5/H4C12/H2AJ/OGG1/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H2BC11/H2BC15/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H2BC17/NEIL3 |
| REACTOME_TELOMERE_MAINTENANCE | 100 | -0.5141976 | -1.871398 | 0.0000195 | 0.0003590 | 0.0002959 | 4152 | H2BC8/PRIM1/POLA1/RPA1/POLR2I/H2BC12/RUVBL1/H3-3A/H2AX/H2BC6/H4C5/H2BC5/H4C12/RUVBL2/POLD1/RFC3/WRAP53/H2AJ/WRN/H4C6/H2BC4/H2AZ2/H4C3/H4C2/RFC5/H2BC9/CHTF8/CCNA2/DNA2/H2BC11/RPA3/H2BC15/LIG1/H4C4/H4C1/H2AC4/BLM/POLA2/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/DSCC1/H2BC14/H2BC10/H2BC17 |
| REACTOME_AMYLOID_FIBER_FORMATION | 85 | -0.5397976 | -1.894173 | 0.0000227 | 0.0004123 | 0.0003398 | 2162 | H2BC9/H3C11/H3C1/H2BC11/H3C13/CALB1/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/LTF/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | 20 | -0.7733783 | -2.048526 | 0.0000237 | 0.0004226 | 0.0003483 | 871 | ANAPC4/CDC14A/CDC20/UBE2C |
| REACTOME_METABOLISM_OF_STEROIDS | 126 | 0.5279357 | 1.918570 | 0.0000317 | 0.0005580 | 0.0004598 | 1035 | CYP51A1/MVD/ACAT2/HMGCS1/EBP/FDPS/ELOVL6/LSS/DHCR7/MSMO1/HMGCR/INSIG1/CH25H/HSD17B7/IDI1/SLCO1B1/STARD4/HELZ2/FDFT1/SQLE/SCD/NSDHL/SC5D/STARD5/FASN/SRD5A3/TM7SF2/CYP27B1/MVK/HSD17B12/SLCO1B3 |
| REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING | 89 | 0.5704236 | 1.983418 | 0.0000351 | 0.0006089 | 0.0005018 | 2342 | NOS2/SOCS1/IL13RA2/ALOX15/MMP1/MAOA/CXCL8/CCL22/CD36/IL2RG/FOS/BCL2/VEGFA/IL1A/FGF2/GATA3/ANXA1/HIF1A/PTGS2/IL23A/ICAM1/TNF/SOCS3/HMOX1/LIF/IL4R/SOX2/ITGAM/PIM1/STAT1/MUC1/JUNB/TIMP1/BATF/CDKN1A/AKT1/RORA/MYC |
| REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS | 85 | -0.5342726 | -1.874786 | 0.0000366 | 0.0006250 | 0.0005151 | 918 | FBXO5/ANAPC4/CCNB1/PTTG1/CDC14A/MAD2L1/NEK2/PLK1/CDK1/CDC20/UBE2C/BUB1B |
| REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS | 92 | -0.5235500 | -1.865411 | 0.0000494 | 0.0008315 | 0.0006852 | 4260 | RAD9A/TOPBP1/H2BC8/RPA1/H2BC12/RMI1/TP53BP1/H2AX/H2BC6/TIMELESS/H4C5/RAD9B/ATM/H2BC5/H4C12/RFC3/WRN/H4C6/H2BC4/BARD1/H4C3/H4C2/RFC5/MRE11/CLSPN/H2BC9/CCNA2/CHEK1/DNA2/H2BC11/RPA3/H2BC15/BRCA1/H4C4/H4C1/ABRAXAS1/BLM/BRIP1/H2BC7/H2BC3/H4C13/H4C9/H2BC13/EXO1/H2BC14/H2BC10/H2BC17 |
| REACTOME_CELLULAR_SENESCENCE | 181 | -0.4193726 | -1.668964 | 0.0000704 | 0.0011673 | 0.0009621 | 2162 | H2BC9/CDKN2C/H3C11/TFDP2/H3C1/CCNA2/H2BC11/H3C13/MAP2K6/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/ANAPC4/H4C13/H4C9/H2BC13/H2AC14/E2F1/E2F2/H1-5/H2BC14/H2BC10/LMNB1/H3C7/H1-1/H2BC17/H3C12/CCNE2/H3C3/UBE2C/H3C8/H3C2 |
| REACTOME_MEIOTIC_SYNAPSIS | 62 | -0.5705567 | -1.904949 | 0.0001058 | 0.0017307 | 0.0014264 | 4574 | H2AC8/H4C8/ATR/H2AC6/H2BC8/STAG2/H2BC12/SYCP2/H2AX/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/SYNE1/H2BC9/H2BC11/H2BC15/BRCA1/H4C4/H4C1/H2AC4/HSPA2/H2BC7/H2BC3/STAG3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/LMNB1/H2BC17 |
| REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES | 65 | -0.5501950 | -1.849551 | 0.0001132 | 0.0018250 | 0.0015041 | 3239 | SUV39H1/RBBP4/RBBP7/H3C6/H4C5/H4C12/KMT5C/SMYD3/H4C6/EZH2/H4C3/H4C2/DPY30/SMYD2/H3C11/H3C1/H3C13/H4C4/H4C1/H3C10/H4C13/H4C9/H3C7/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_HDMS_DEMETHYLATE_HISTONES | 45 | -0.6149784 | -1.942451 | 0.0001160 | 0.0018445 | 0.0015202 | 2521 | H4C3/H4C2/H3C11/H3C1/H3C13/H4C4/H4C1/H3C10/H4C13/H4C9/H3C7/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_SIGNALING_BY_NOTCH | 217 | -0.3967567 | -1.603549 | 0.0001349 | 0.0021169 | 0.0017447 | 2019 | NOTCH3/H3C11/TFDP2/DLL1/H3C1/PBX1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/HEY1/H3C10/NBEA/H2BC7/H2BC3/H4C13/HEY2/H4C9/PLXND1/ATP2A3/NEURL1/H2BC13/H2AC14/E2F1/H2BC14/H2BC10/H3C7/H2BC17/H3C12/ST3GAL6/MIR449C/HEYL/H3C3/DLGAP5/H3C8/H3C2 |
| REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION | 134 | -0.4540423 | -1.712717 | 0.0001427 | 0.0022086 | 0.0018202 | 2866 | H4C6/ERBB4/H2BC4/ESR1/H2AZ2/TFF3/H4C3/H4C2/H2BC9/H3C11/H3C1/CXXC5/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/MYB/H2BC17/H3C12/NR5A2/H3C3/H3C8/H3C2 |
| REACTOME_INHIBITION_OF_DNA_RECOMBINATION_AT_TELOMERE | 58 | -0.5750387 | -1.902840 | 0.0001538 | 0.0023491 | 0.0019361 | 3967 | H2AC8/H4C8/H2AC6/H2BC8/POLR2I/H2BC12/H3-3A/H2AX/H2BC6/H4C5/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/H2BC9/H2BC11/H2BC15/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H2BC17 |
| REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE | 111 | -0.4762203 | -1.749237 | 0.0001636 | 0.0024346 | 0.0020065 | 3030 | H2AJ/MAPK10/H4C6/H2BC4/H2AZ2/EZH2/H4C3/H4C2/H2BC9/CDKN2C/H3C11/TFDP2/H3C1/H2BC11/H3C13/MAP2K6/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/E2F1/E2F2/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_G2_M_CHECKPOINTS | 160 | -0.4274524 | -1.656697 | 0.0001622 | 0.0024346 | 0.0020065 | 3582 | MCM2/H2BC6/H4C5/RAD9B/ATM/H2BC5/MCM7/H4C12/RFC3/CHEK2/WRN/H4C6/H2BC4/BARD1/H4C3/H4C2/RFC5/MRE11/CLSPN/H2BC9/CHEK1/DNA2/H2BC11/RPA3/H2BC15/BRCA1/H4C4/H4C1/CDC7/MCM8/PKMYT1/ABRAXAS1/CDC25A/BLM/BRIP1/H2BC7/H2BC3/CCNB1/ORC1/H4C13/H4C9/H2BC13/EXO1/H2BC14/H2BC10/CCNB2/H2BC17/CDK1/MCM10/GTSE1/CDC25C |
| REACTOME_CHROMATIN_MODIFYING_ENZYMES | 255 | -0.3805885 | -1.552443 | 0.0001719 | 0.0025262 | 0.0020820 | 4713 | RPS2/ENY2/ARID4A/HDAC2/SETD6/NSD3/H2AC8/H4C8/KDM3B/KDM4D/H2AC6/CHD4/EED/PRMT7/H2BC8/H2BC18/MSL3/MCRS1/KDM3A/MORF4L1/SUV39H1/H2BC12/KAT2A/RBBP4/SUDS3/EP400/RUVBL1/RBBP7/ACTL6A/ELP6/H2AX/H3C6/H2BC6/H4C5/SMARCA2/SMARCE1/H2BC5/H4C12/RUVBL2/HAT1/KMT5C/WDR77/H2AJ/SMYD3/SAP30/H4C6/H2BC4/ING4/H2AZ2/EZH2/H4C3/H4C2/JADE1/DPY30/H2BC9/SMYD2/PADI1/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/PADI2/H4C1/H2AC4/H3C10/H2AC16/H2BC7/SMARCD3/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ | 63 | -0.5518790 | -1.855374 | 0.0001890 | 0.0027423 | 0.0022601 | 3762 | TDP1/XRCC4/XRCC5/H4C8/RAD50/H2BC8/H2BC12/TP53BP1/H2AX/H2BC6/H4C5/ATM/H2BC5/H4C12/H4C6/H2BC4/BARD1/H4C3/H4C2/MRE11/H2BC9/H2BC11/H2BC15/BRCA1/H4C4/H4C1/ABRAXAS1/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2BC14/H2BC10/H2BC17 |
| REACTOME_HCMV_EARLY_EVENTS | 117 | -0.4641200 | -1.724741 | 0.0002180 | 0.0031243 | 0.0025749 | 2260 | NDC1/H2BC9/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2AC16/H2BC7/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | 24 | -0.6913693 | -1.913010 | 0.0002440 | 0.0034549 | 0.0028473 | 1178 | CCNA2/PKMYT1/CDC25A/CCNB1/FOXM1/CCNB2/PLK1/CDK1/CDC25C |
| REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION | 90 | -0.5004047 | -1.787646 | 0.0002726 | 0.0038135 | 0.0031429 | 5794 | RPLP0/RPL26L1/RPL17/RPS11/RPL19/RPS16/RPL12/RPL10/RPS28/RPS27A/RPS9/RPS10/RPL27/EEF2/RPL39/RPS19/RPS3/RPSA/RPL41/RPL9/RPL7A/RPL37A/RPS27/RPS2/RPS29/RPS24/EEF1A1/EEF1B2/RPS5/RPS8/RPS15A/RPL36A/RPS21/RPS20/RPL34/RPL13/RPL24/RPS13/RPS12/RPL23A/RPS7/RPS23/RPL27A/RPL3/RPL32/RPL30/RPL29/RPL21/RPL31/RPL14/RPL13A/RPS6/RPL6/RPS14/RPL11/RPL37/RPS25/RPL35A/RPL22/RPL7/RPS18/RPL23/RPL4/RPS4X/RPL10A/RPS4Y1/RPL39L/RPL26/RPL15/RPL5/RPS3A |
| REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION | 81 | -0.5133707 | -1.795911 | 0.0002831 | 0.0039127 | 0.0032247 | 2866 | H4C6/H2BC4/H2AZ2/H4C3/H4C2/DPY30/H2BC9/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR | 159 | -0.4190631 | -1.624098 | 0.0003693 | 0.0050441 | 0.0041571 | 4815 | TDP1/RAD51/XRCC4/XRCC5/H4C8/RAD50/ATR/LIG3/XRCC1/RAD9A/TOPBP1/H2BC8/RPA1/H2BC12/RMI1/TP53BP1/ERCC4/H2AX/EME1/H2BC6/TIMELESS/H4C5/RAD9B/ATM/BRCA2/H2BC5/H4C12/POLD1/RFC3/CHEK2/WRN/RAD52/H4C6/RAD51B/H2BC4/BARD1/H4C3/H4C2/RFC5/MRE11/CLSPN/H2BC9/ERCC1/CCNA2/CHEK1/DNA2/H2BC11/RPA3/POLE2/H2BC15/BRCA1/H4C4/XRCC2/H4C1/ABRAXAS1/BLM/BRIP1/H2BC7/H2BC3/POLQ/H4C13/H4C9/RAD51AP1/H2BC13/EXO1/H2BC14/H2BC10/H2BC17 |
| REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE | 70 | -0.5354568 | -1.827494 | 0.0004090 | 0.0055214 | 0.0045504 | 3961 | H2AC8/H4C8/RAD50/CDKN1B/H2AC6/H2BC8/H2BC12/EP400/H1-3/H2AX/H2BC6/H4C5/ATM/H2BC5/H4C12/H2AJ/H4C6/H2BC4/H2AZ2/H4C3/H4C2/MRE11/H2BC9/CCNA2/H2BC11/H2BC15/H4C4/H4C1/H2AC4/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2AC14/H1-5/H2BC14/H2BC10/LMNB1/H1-1/H2BC17/CCNE2 |
| REACTOME_ION_CHANNEL_TRANSPORT | 137 | 0.4580825 | 1.674726 | 0.0004391 | 0.0058597 | 0.0048293 | 1982 | ANO1/TRPV6/TRPM6/ATP12A/CASQ2/SLC9B2/SGK1/TTYH2/ANO2/ATP6V1C2/SLC9B1/ATP6V0D2/CLIC2/ANO4/STOM/SCNN1D/FXYD6/RIPK3/ATP11A/ANO8/TRPV3/ATP6V0A2/ATP8B1/ATP13A5/ATP8A2/CLCN6/TRPM4/ANO7/FKBP1B/ATP1B1/TPCN2/MLKL/ATP13A2/ANO9/RYR3/ATP6V1E2 |
| REACTOME_INTERLEUKIN_1_SIGNALING | 99 | 0.4995373 | 1.738477 | 0.0005533 | 0.0072690 | 0.0059908 | 5127 | IL1R2/NOD2/IL1A/NFKB2/IL1RN/IRAK2/NFKBIA/MYD88/PSMA6/IRAK1/RIPK2/MAP3K8/PSMC4/NFKBIB/SQSTM1/IRAK4/RELA/NOD1/PSMD11/MAP2K1/PSMD7/IKBKG/PSMB2/PSMD3/PELI3/NKIRAS2/PSMB8/PSMD14/PSMC1/TOLLIP/PSMA2/TNIP2/PSMB9/PSMD1/PSMB6/TAB3/PSMD8/PSME3/TAB2/PSME2/PSMF1/PSMA7/PSMC5/PSMD12/NFKB1/PSMD9/CHUK/PELI1/PSMD13/SEM1/PSMB7/PSMD2/SAA1/PSME4/PSMA3 |
| REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING | 117 | 0.4800937 | 1.719816 | 0.0005572 | 0.0072690 | 0.0059908 | 5127 | RASGRP1/LAT2/PRKCQ/FOS/ITPR3/NFKBIA/CARD11/PSMA6/GAB2/KRAS/FYN/RAC1/TEC/PSMC4/NRAS/BCL10/JUN/RELA/PAK2/PSMD11/ITPR2/SYK/VAV2/PSMD7/IKBKG/PSMB2/PSMD3/PSMB8/PSMD14/PSMC1/PSMA2/PSMB9/LYN/MALT1/PSMD1/PLCG1/CDC34/PSMB6/TAB3/PSMD8/PIK3CB/MAPK1/PSME3/MAPK3/TAB2/SHC1/PSME2/GRB2/PSMF1/PSMA7/HRAS/PSMC5/MAPK9/PSMD12/NFKB1/PSMD9/PAK1/CHUK/PSMD13/SEM1/PSMB7/PSMD2/PSME4/PSMA3 |
| REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | 25 | 0.6937737 | 1.863579 | 0.0006125 | 0.0079018 | 0.0065123 | 4292 | TAP2/TAP1/SEC23A/SEC13/HLA-F/HLA-C/SEC31A/TAPBP/SEC24D/HLA-G/HLA-A/CALR/SEC24A/HLA-B/SEC24C/HLA-E/HSPA5/ERAP1/PDIA3/ERAP2 |
| REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING | 10 | 0.8484964 | 1.858584 | 0.0008057 | 0.0102112 | 0.0084156 | 1080 | CD274/PRDM1/IL2RG/HIF1A |
| REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 175 | 0.4333897 | 1.637975 | 0.0008092 | 0.0102112 | 0.0084156 | 2497 | SLC18A2/SLC5A5/SLC26A4/SLC9A3/SLC26A9/SLC5A1/SLC39A8/SLC2A6/SLC24A3/SLC5A8/SLC7A11/SLCO4A1/SLCO1B1/SLC6A14/SLC3A2/SLC29A2/SLC7A9/SLC12A2/SLC7A5/SLC7A1/SLC28A3/SLC1A5/SLC5A3/SLC4A9/SLC36A1/SLCO1B3/SLC26A6/SLC26A11/SLC1A4/SLCO3A1/SLC27A4/SLC4A3/SLC38A1/SLCO4C1/AHCYL2/SLC15A3/SLC5A12/SLC12A4/SLC35C1/SLC39A1/SLC16A7/SLC9A1/SLC6A9/SLC17A5/SLC9A4/SLC8A1/SLC8B1/SLC39A4/SLC16A3/SLC39A14/SLC35D2/SLC25A22/SLC35B4/SLC39A7/SLC6A11/SLC29A4/SLC20A2/SLC50A1/RUNX1/SLC9A7 |
| REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | 24 | 0.6969385 | 1.849807 | 0.0008416 | 0.0105070 | 0.0086594 | 1486 | WARS1/GARS1/MARS1/YARS1/AARS1/TARS1/IARS1/SARS1/EPRS1 |
| REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE | 72 | -0.5048914 | -1.732447 | 0.0008664 | 0.0105883 | 0.0087264 | 3762 | TP53BP1/H2AX/H2BC6/H4C5/ATM/H2BC5/H4C12/CHEK2/H4C6/H2BC4/BARD1/H4C3/H4C2/MRE11/H2BC9/H2BC11/H2BC15/BRCA1/H4C4/H4C1/ABRAXAS1/H2BC7/H2BC3/H4C13/H4C9/H2BC13/H2BC14/H2BC10/H2BC17 |
| REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | 109 | 0.4797223 | 1.712708 | 0.0008574 | 0.0105883 | 0.0087264 | 3274 | PHOSPHO1/PLA2G3/PNPLA3/ACHE/LPIN1/MFSD2A/PLA2G4C/ABHD4/PLAAT1/LIPH/PLA2G4A/GPCPD1/GPAT3/LPCAT4/GPD2/PISD/PTPMT1/SELENOI/CPNE3/GPAT4/TAFAZZIN/CSNK2B/ACP6/MBOAT1/PLD2/PTDSS1/LPIN2/PITPNM2/PITPNB/LPIN3/ABHD3/OSBPL5/MIGA2/PLA2G15/MGLL/PNPLA2/AGPAT3 |
| REACTOME_CILIUM_ASSEMBLY | 184 | -0.3809081 | -1.512139 | 0.0008827 | 0.0106752 | 0.0087980 | 3775 | CEP57/UNC119B/HAUS1/ARL6/CEP41/TCTN1/HSP90AA1/IFT20/CEP250/TUBA4B/CEP164/CEP43/IQCB1/KIF3A/ARL13B/DYNLT2B/IFT46/BBS10/CEP135/IFT22/ARL3/DYNC2I1/BBS9/CLUAP1/TMEM216/BBIP1/IFT122/IFT43/TCTN2/BBS2/CNTRL/WDR19/CENPJ/KIF17/KIF24/DYNC2LI1/TMEM67/B9D1/PCM1/CEP83/CEP76/CEP97/CCP110/IFT57/IFT140/CEP162/IFT27/CC2D2A/IFT88/IFT52/IFT74/NPHP1/BBS12/CNGA4/CETN2/IFT81/RPGRIP1L/WDR35/IFT172/IFT80/DYNC2H1/MKS1/B9D2/DYNLT2/LZTFL1/CEP78/CEP70/BBS4/DYNLRB2/TTC21B/PRKAR2B/NEK2/PLK1/PLK4/CDK1 |
| REACTOME_SYNTHESIS_OF_PC | 25 | 0.6739735 | 1.810392 | 0.0010740 | 0.0128545 | 0.0105941 | 439 | PHOSPHO1/ACHE/LPIN1/MFSD2A |
| REACTOME_TRYPTOPHAN_CATABOLISM | 12 | 0.8131124 | 1.859454 | 0.0011985 | 0.0141985 | 0.0117017 | 709 | IDO2/KYAT1/HAAO/IDO1/SLC3A2/SLC7A5 |
| REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | 49 | 0.5925193 | 1.851894 | 0.0013214 | 0.0154969 | 0.0127718 | 1907 | B3GNT6/GCNT3/MUC21/GALNT4/MUC3A/ST6GAL1/GALNT7/GCNT4/GALNT10/GALNT6/GALNT5/ST3GAL4/B3GNT8/MUC1/MUC4 |
| REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION | 74 | 0.5224813 | 1.763508 | 0.0013488 | 0.0156591 | 0.0129055 | 6112 | RASGRP1/PRKCQ/NFKBIA/CARD11/PSMA6/PSMC4/BCL10/RELA/PSMD11/PSMD7/IKBKG/PSMB2/PSMD3/PSMB8/PSMD14/PSMC1/PSMA2/PSMB9/LYN/MALT1/PSMD1/CDC34/PSMB6/TAB3/PSMD8/PSME3/TAB2/PSME2/PSMF1/PSMA7/PSMC5/PSMD12/NFKB1/PSMD9/CHUK/PSMD13/SEM1/PSMB7/PSMD2/PSME4/PSMA3/PSMA1/UBC/UBE2D2/BTRC/TAB1/PSMC3/TRAF6/IKBKB/UBE2V1/PDPK1 |
| REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS | 73 | -0.4827062 | -1.657787 | 0.0015438 | 0.0177459 | 0.0146254 | 1585 | GSTM2/SULT1E1/GSTM1/UGT1A7/UGT1A5/UGT3A2/SULT1B1/SLC26A1/ACSM1/GSTA3/UGT1A8/NAT1/GSTA4/UGT2A1/GSTA1/GSTA2 |
| REACTOME_INTERLEUKIN_10_SIGNALING | 33 | 0.6524401 | 1.890235 | 0.0017235 | 0.0196176 | 0.0161679 | 1546 | IL1R2/CXCL10/CCL4/CXCL8/CCL22/IL1A/CD86/IL1RN/PTGS2/CXCL1/ICAM1/TNF/LIF/PTAFR/CCL5/CXCL2 |
| REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | 78 | 0.5137581 | 1.752965 | 0.0017550 | 0.0197823 | 0.0163036 | 1831 | SLC5A5/SLC26A4/SLC9A3/SLC26A9/SLC24A3/SLC5A8/SLC7A11/SLC6A14/SLC3A2/SLC7A9/SLC12A2/SLC7A5/SLC7A1/SLC1A5/SLC4A9/SLC36A1/SLC26A6/SLC26A11/SLC1A4/SLC4A3/SLC38A1/AHCYL2/SLC15A3/SLC5A12/SLC12A4/SLC9A1/SLC17A5/SLC9A4/SLC8A1/SLC8B1 |
| REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | 130 | -0.4092749 | -1.536127 | 0.0018198 | 0.0203156 | 0.0167432 | 1642 | H3C13/KIF19/KIF22/KIF18A/PRKACB/KIF26B/KIF11/H3C10/KIFC1/KIF21A/KIF4A/PRKAR2B/KIF20B/GATA2/H3C7/MYB/H3C12/CENPE/KIF15/KIF2C/KIF20A/H3C3/HBB/KIF18B/H3C8/H3C2 |
| REACTOME_DISEASES_OF_DNA_REPAIR | 34 | -0.6007858 | -1.786260 | 0.0018579 | 0.0204501 | 0.0168540 | 3602 | MUTYH/RAD51/RAD50/NEIL1/RMI1/MSH6/NTHL1/ATM/BRCA2/WRN/OGG1/MSH2/RAD51B/BARD1/MSH3/MRE11/DNA2/BRCA1/XRCC2/BLM/BRIP1/RAD51AP1/EXO1/NEIL3 |
| REACTOME_STIMULI_SENSING_CHANNELS | 79 | 0.5027272 | 1.720954 | 0.0018671 | 0.0204501 | 0.0168540 | 1936 | ANO1/TRPV6/TRPM6/CASQ2/SLC9B2/SGK1/TTYH2/ANO2/SLC9B1/CLIC2/ANO4/STOM/SCNN1D/RIPK3/ANO8/TRPV3/CLCN6/TRPM4/ANO7/FKBP1B/TPCN2/MLKL/ANO9/RYR3 |
| REACTOME_TRNA_AMINOACYLATION | 41 | 0.5901755 | 1.795637 | 0.0019425 | 0.0208816 | 0.0172096 | 1486 | WARS1/GARS1/MARS1/YARS1/AARS1/TARS1/IARS1/SARS1/EPRS1 |
| REACTOME_HCMV_INFECTION | 141 | -0.4072971 | -1.552144 | 0.0019337 | 0.0208816 | 0.0172096 | 2260 | NDC1/H2BC9/H2AC15/H3C11/H3C1/H2BC11/H3C13/H2BC15/H4C4/H4C1/H2AC4/H3C10/H2AC16/H2BC7/H2BC3/H4C13/H2AC13/H4C9/H2AC11/H2AC21/H2BC13/H2AC14/H2AC12/H2BC14/H2BC10/H3C7/H2BC17/H3C12/H3C3/H3C8/H3C2 |
| REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE | 42 | -0.5554177 | -1.727075 | 0.0020411 | 0.0217401 | 0.0179172 | 4547 | RAD50/ATR/RAD9A/TOPBP1/RPA1/RMI1/RAD9B/ATM/BRCA2/RFC3/WRN/RAD51B/BARD1/RFC5/MRE11/CHEK1/DNA2/RPA3/BRCA1/XRCC2/BLM/BRIP1/RAD51AP1/EXO1 |
| REACTOME_SIGNALLING_TO_RAS | 19 | 0.7315494 | 1.847913 | 0.0021248 | 0.0224261 | 0.0184826 | 2689 | NTRK1/MAPKAPK3/MAPK12/MAPK11/KRAS/NRAS/MAPKAPK2/SHC2/SRC/MAPK13/RALA |
| REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | 110 | -0.4337667 | -1.589391 | 0.0021643 | 0.0226379 | 0.0186571 | 5794 | RPLP0/RPL26L1/RPL17/RPS11/RPL19/RPS16/RPL12/RPL10/RPS28/RPS27A/RPS9/RPS10/RPL27/SRP14/RPL39/RPS19/RPS3/RPSA/RPL41/RPL9/RPL7A/RPL37A/RPS27/RPS2/RPS29/RPS24/RPS5/RPS8/RPS15A/RPL36A/RPS21/RPS20/RPL34/RPL13/RPL24/RPS13/RPS12/RPL23A/RPS7/RPS23/RPL27A/RPL3/RPL32/RPL30/RPL29/RPL21/RPL31/RPL14/RPL13A/RPS6/RPL6/RPS14/RPL11/RPL37/RPS25/RPL35A/RPL22/SRP9/RPL7/RPS18/RPL23/RPL4/RPS4X/RPL10A/RPS4Y1/RPL39L/SRPRB/RPL26/RPL15/RPL5/RPS3A |
| REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA | 37 | -0.5773343 | -1.764814 | 0.0022149 | 0.0227569 | 0.0187552 | 4801 | RAD51/RAD50/ATR/RAD9A/TOPBP1/RPA1/RMI1/ERCC4/RAD9B/ATM/RFC3/WRN/RAD52/BARD1/RFC5/MRE11/ERCC1/DNA2/RPA3/BRCA1/BLM/BRIP1/EXO1 |
| REACTOME_DNA_REPAIR | 319 | -0.3327307 | -1.390761 | 0.0022071 | 0.0227569 | 0.0187552 | 4094 | NEIL2/RPA1/MCRS1/ERCC5/POLR2I/H2BC12/RMI1/UNG/RUVBL1/ACTL6A/TP53BP1/ERCC4/H2AX/EME1/MSH6/NTHL1/H2BC6/TIMELESS/MGMT/H4C5/FANCL/GTF2H5/RAD9B/ATM/BRCA2/H2BC5/H4C12/POLD1/RFC3/ALKBH2/CHEK2/H2AJ/WRN/RAD52/OGG1/MSH2/H4C6/RAD51B/FANCM/H2BC4/BARD1/H2AZ2/MSH3/H4C3/H4C2/RFC5/MRE11/CLSPN/H2BC9/ERCC1/CENPS/CETN2/CCNA2/CHEK1/DNA2/FANCI/H2BC11/RPA3/POLE2/POLI/H2BC15/LIG1/BRCA1/H4C4/XRCC2/UBE2T/H4C1/H2AC4/FANCB/ABRAXAS1/BLM/POLN/BRIP1/H2BC7/H2BC3/INO80B/POLQ/H4C13/FTO/H4C9/CHD1L/RAD51AP1/H2BC13/EXO1/H2AC14/PCLAF/H2BC14/H2BC10/H2BC17/DTL/NEIL3 |
| REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | 228 | 0.3775087 | 1.475147 | 0.0022916 | 0.0233385 | 0.0192345 | 2514 | CAPN14/EMILIN2/VWF/LOXL4/MMP1/ITGA10/COL6A1/COL13A1/SDC2/KLK7/ADAMTS14/CD44/ADAM8/MMP16/LUM/NID2/CAPN12/TNC/MMP19/SDC3/FGF2/CD47/MMP25/MATN3/ADAM9/PXDN/MMP17/COLGALT2/TIMP2/CEACAM1/ITGB8/KDR/ICAM1/LAMA4/DDR2/ADAMTS9/ITGA9/BMP2/MMP11/THBS1/COL22A1/ITGA6/ITGAM/LOX/COL17A1/SERPINH1/MMP10/ITGAV/LAMB3/PLOD3/COLGALT1/BMP1/COL14A1/LTBP4/ITGB7/TIMP1/ITGB6/FURIN/CAPN2/SPP1/LAMB1/ADAM17/P4HA2/ITGA3/CD151/PLEC/COL5A2/ACTN1 |
| REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | 13 | 0.7712075 | 1.801150 | 0.0025030 | 0.0250520 | 0.0206467 | 2 | NTRK1 |
| REACTOME_G0_AND_EARLY_G1 | 27 | -0.6303936 | -1.788322 | 0.0024834 | 0.0250520 | 0.0206467 | 2188 | LIN9/TFDP2/CCNA2/CDC25A/E2F1/CCNE2/CDK1/TOP2A/MYBL2 |
| REACTOME_SIGNALLING_TO_ERKS | 32 | 0.6490895 | 1.873176 | 0.0026349 | 0.0261467 | 0.0215489 | 4622 | NTRK1/MAPKAPK3/MAPK12/MAPK11/KRAS/NRAS/MAPKAPK2/SHC2/SRC/MAPK13/MAP2K1/RALA/RAP1A/CRK/MAP2K2/KIDINS220/MAPK1/RIT1/MAPK3/RALB/SHC1/GRB2/HRAS |
| REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | 62 | 0.5277129 | 1.720474 | 0.0031192 | 0.0306895 | 0.0252929 | 914 | LY6G6C/THY1/RAET1L/LYPD1/PLAUR/NTNG1/RAET1G/ALPL/CEACAM5/LY6K/ULBP2 |
| REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING | 126 | 0.4418600 | 1.605762 | 0.0032467 | 0.0316762 | 0.0261061 | 5127 | IL1R2/IL1RL1/IL36G/NOD2/IL36A/IL1A/NFKB2/IL1RN/IL18R1/IRAK2/NFKBIA/MYD88/PSMA6/IL1RL2/IRAK1/RIPK2/PTPN9/MAP3K8/PSMC4/NFKBIB/SQSTM1/IRAK4/RELA/PTPN11/NOD1/PSMD11/PTPN12/MAP2K1/ALOX5/PSMD7/IKBKG/PSMB2/PSMD3/PELI3/NKIRAS2/PTPN23/PSMB8/PSMD14/PSMC1/IL18BP/TOLLIP/PSMA2/TNIP2/PSMB9/PTPN18/PSMD1/PSMB6/TAB3/PSMD8/PSME3/TAB2/PSME2/PSMF1/PSMA7/PSMC5/PSMD12/NFKB1/PSMD9/CHUK/PELI1/PSMD13/SEM1/PSMB7/PSMD2/SAA1/PSME4/PSMA3 |
| REACTOME_NICOTINAMIDE_SALVAGING | 16 | 0.7399894 | 1.788946 | 0.0033290 | 0.0322083 | 0.0265445 | 3132 | SLC5A8/NNMT/PARP9/PTGS2/NAMPT/PARP14/PARP10/PARP6/NAPRT/PARP4 |
| REACTOME_SUPPRESSION_OF_PHAGOSOMAL_MATURATION | 13 | 0.7585417 | 1.771569 | 0.0034616 | 0.0329423 | 0.0271495 | 9 | NOS2 |
| REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS | 53 | 0.5411698 | 1.710513 | 0.0034433 | 0.0329423 | 0.0271495 | 2943 | NOD2/AIM2/BCL2/NFKB2/IRAK2/MAPK12/HMOX1/MAPK11/CARD9/TXN/IRAK1/RIPK2/TNFAIP3/RELA/CYLD/NOD1/BIRC3/MAPK13/IKBKG/CASP2 |
| REACTOME_HYALURONAN_METABOLISM | 14 | 0.7566294 | 1.781890 | 0.0036892 | 0.0348227 | 0.0286992 | 757 | HAS2/HYAL1/CEMIP/CD44/HAS3/HYAL3 |
| REACTOME_RAB_REGULATION_OF_TRAFFICKING | 115 | 0.4459277 | 1.597028 | 0.0039039 | 0.0365520 | 0.0301245 | 5503 | DENND4A/RIC1/RAB32/RAB8B/RAB31/OPTN/RINL/TBC1D24/DENND5A/AKT3/TBC1D14/RAB9A/RAB35/TBC1D10A/DENND3/AKT1/DENND4C/RAB6A/HPS1/RAB5B/GGA3/RGP1/TBC1D20/TBC1D16/MON1A/RAB3IP/TRAPPC10/CCZ1/TSC1/MAP1LC3B/TRAPPC6A/TBC1D10B/RAB8A/RAB11A/RAB3A/MON1B/RAB21/RABGAP1/ANKRD27/ARF6/RAB5C/RAB7A/TBC1D7/SBF1/CCZ1B/DENND2C/SYTL1/RAB10/TBC1D25/DENND5B/RAB14/RAB18/RAB5A/DENND4B/GGA2/DENND1A/RAB3GAP2/TRAPPC12/SBF2/RAB27A/RAB12/GDI1/RAB1A/RABEP1/TBC1D13/TRAPPC2/ULK1/TRAPPC1/RAB33B/MADD/TRAPPC9 |
| REACTOME_GOLGI_CISTERNAE_PERICENTRIOLAR_STACK_REORGANIZATION | 14 | -0.7221659 | -1.732056 | 0.0040090 | 0.0368576 | 0.0303763 | 867 | CCNB1/CCNB2/PLK1/CDK1 |
| REACTOME_REGULATION_OF_RUNX2_EXPRESSION_AND_ACTIVITY | 69 | 0.5042976 | 1.681852 | 0.0040318 | 0.0368576 | 0.0303763 | 5850 | DLX5/PPARGC1B/RUNX2/MSX2/PSMA6/BMP2/STAT1/PSMC4/PSMD11/HIVEP3/PPARGC1A/PSMD7/PSMB2/PSMD3/PSMB8/PSMD14/PSMC1/PSMA2/PSMB9/PSMD1/PSMB6/PSMD8/PSME3/PSME2/PSMF1/PSMA7/PSMC5/PSMD12/GSK3B/PSMD9/STUB1/PSMD13/SEM1/PSMB7/PSMD2/PSME4/PSMA3/PSMA1/CBFB/UBC/WWP1/TWIST1/ESRRA/PSMC3 |
| REACTOME_BIOLOGICAL_OXIDATIONS | 158 | -0.3846918 | -1.489908 | 0.0040049 | 0.0368576 | 0.0303763 | 1934 | UGT1A4/CYP4B1/CYP27A1/PTGS1/GSTM2/SULT1E1/GSTM1/ALDH2/ADH7/ALDH1A1/UGT1A7/CYP2C8/UGT1A5/UGT3A2/CYP2W1/FMO3/SULT1B1/CYP4F3/CYP39A1/MTARC1/SLC26A1/ACSM1/ACSS1/GSTA3/POMC/EPHX1/CYP24A1/DPEP2/CYP2B6/UGT1A8/NAT1/CYP2F1/ADH6/CYP4A22/FMO2/CYP2A6/ALDH3A1/GSTA4/CYP26B1/UGT2A1/GSTA1/GSTA2 |
| REACTOME_METALLOPROTEASE_DUBS | 30 | -0.5918390 | -1.718189 | 0.0041518 | 0.0376580 | 0.0310360 | 2089 | STAMBPL1/BARD1/H2AC15/BRCA1/H2AC4/ABRAXAS1/H2AC16/H2AC13/H2AC11/H2AC21/H2AC14/H2AC12 |
| REACTOME_BASIGIN_INTERACTIONS | 20 | 0.6926358 | 1.770445 | 0.0042623 | 0.0380153 | 0.0313304 | 2847 | MMP1/SLC7A11/SLC3A2/SLC7A9/SLC7A5/ITGA6/ATP1B1/SLC16A3/ITGA3/CAV1 |
| REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | 80 | 0.4940431 | 1.699162 | 0.0042894 | 0.0380153 | 0.0313304 | 2634 | MX2/ISG15/OAS3/OASL/OAS1/MX1/IFIT1/USP18/OAS2/UBE2L6/HERC5/STAT1/EIF2AK2/TRIM25/NUP188/EIF4E3/SEC13/NEDD4/EIF4G1/PDE12 |
| REACTOME_PHOSPHOLIPID_METABOLISM | 185 | 0.3974143 | 1.510926 | 0.0042298 | 0.0380153 | 0.0313304 | 4865 | PHOSPHO1/PLA2G3/PNPLA3/ACHE/LPIN1/MFSD2A/PLA2G4C/ABHD4/ENPP6/PLAAT1/LIPH/PLA2G4A/GPCPD1/GPAT3/LPCAT4/GPD2/PISD/PLEKHA6/PTPMT1/SELENOI/CPNE3/PLEKHA2/GPAT4/PIP4K2A/TAFAZZIN/CSNK2B/ACP6/GDPD3/PIP5K1A/MBOAT1/PIK3C2B/PLD2/MTMR12/INPPL1/PTDSS1/PIP4P1/LPIN2/PITPNM2/PITPNB/LPIN3/ABHD3/OSBPL5/INPP5J/MIGA2/PIP4K2C/PLA2G15/PI4K2A/MGLL/ARF3/INPP5F/PLEKHA5/PNPLA2/AGPAT3/INPP5D/CPNE1/PIP5K1C/SYNJ1/HADHA/PIK3CB/SBF1/LPCAT1/DGAT1/PLAAT3/RAB14/MBOAT7/SYNJ2/OCRL/PCYT2/GDE1/RAB5A/OSBPL8/PLEKHA1/PCYT1A/CSNK2A2/DDHD2/STARD10/ARF1/PIKFYVE/INPP5K/PNPLA6/AGPAT2/PNPLA8/CSNK2A1/SBF2/PI4KB |
| REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE | 69 | 0.4996181 | 1.666245 | 0.0043886 | 0.0385996 | 0.0318120 | 1281 | SPRR2E/RPTN/SPRR3/SPRR2F/SPRR2A/KRT16/PCSK6/SPRR1A/KRT23/KRT24/SPRR2D/KRT40/CSTA/KLK12/KRT6A/KRT78/PI3/LCE1E/KRT8/PKP2/KRT18/PRSS8 |
| REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION | 147 | -0.3890603 | -1.490909 | 0.0044521 | 0.0388641 | 0.0320300 | 2188 | LIN9/CDKN2C/TFDP2/CCNA2/TK1/DHFR/RPA3/POLE2/CDC7/MCM8/TYMS/CDC25A/POLA2/FBXO5/CCNB1/ORC1/E2F1/E2F2/CDT1/GMNN/CCNE2/CDK1/RRM2/MCM10/TOP2A/MYBL2 |
| REACTOME_O_LINKED_GLYCOSYLATION | 85 | 0.4765247 | 1.658298 | 0.0045608 | 0.0395158 | 0.0325671 | 1907 | B3GNT6/GCNT3/THSD7A/MUC21/ADAMTS14/GALNT4/MUC3A/ST6GAL1/GALNT7/GCNT4/GALNT10/GALNT6/GALNT5/ADAMTSL3/ADAMTS9/ADAMTS17/ST3GAL4/THBS1/B3GNT8/MUC1/MUC4 |
| REACTOME_RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY | 15 | 0.7556324 | 1.795113 | 0.0046385 | 0.0396281 | 0.0326596 | 2725 | TRIB3/CHAC1/ASNS/DDIT3/ATF4/GRB10/CEBPG/ATF3/EIF2S2/ATF5 |
| REACTOME_PEPTIDE_HORMONE_METABOLISM | 53 | 0.5316861 | 1.680537 | 0.0046762 | 0.0396281 | 0.0326596 | 949 | DPP4/INHBE/ACHE/MME/KLF4/PAX6/ACE/ANPEP/PLA2G7/STX1A |
| REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR | 79 | 0.4790959 | 1.640059 | 0.0046645 | 0.0396281 | 0.0326596 | 5127 | RASGRP1/NFKBIA/CARD11/PSMA6/KRAS/NFKBIE/PSMC4/NRAS/NFKBIB/BCL10/RELA/PSMD11/PSMD7/IKBKG/PSMB2/PSMD3/PSMB8/PSMD14/PSMC1/PSMA2/FKBP1A/PPIA/PSMB9/MALT1/PSMD1/PSMB6/PSMD8/PSME3/RASGRP3/PSME2/PSMF1/PSMA7/HRAS/PSMC5/PSMD12/NFKB1/PSMD9/CHUK/PSMD13/SEM1/PSMB7/PSMD2/PSME4/PSMA3 |
| REACTOME_NGF_STIMULATED_TRANSCRIPTION | 36 | 0.6105726 | 1.808003 | 0.0048102 | 0.0404688 | 0.0333525 | 1941 | ARC/SGK1/FOS/F3/FOSB/EGR1/EGR2/TRIB1/FOSL1/ASCL1/ID3/JUND/JUNB |
| REACTOME_SIGNALING_BY_VEGF | 99 | 0.4545217 | 1.581815 | 0.0050038 | 0.0417942 | 0.0344448 | 4007 | NCF1/TRIB3/FLT1/MAPKAPK3/VEGFA/ITPR3/NRP2/MAPK12/KDR/SPHK1/MAPK11/KRAS/BCAR1/FYN/AXL/NCF2/ITGAV/RAC1/AKT3/ACTB/NRAS/AKT1/MAPKAPK2/SHC2/SRC/PRR5/PAK2/MAPK13/ITPR2/ACTG1/VAV2/NCF4/CAV1/ELMO2/CRK/WASF1/VEGFD/PRKCA/NCKAP1/JUP/PLCG1/ABI1/MTOR/PIK3CB/CYFIP1/CTNNA1 |
| REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | 14 | 0.7439570 | 1.752046 | 0.0051219 | 0.0424751 | 0.0350060 | 1466 | SLC18A2/MAOA/STX1A/PPFIA3/SYT1 |
| REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLUCAGON_LIKE_PEPTIDE_1_GLP_1 | 10 | 0.7907963 | 1.732195 | 0.0052550 | 0.0432699 | 0.0356610 | 351 | DPP4/PAX6 |
| REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES | 11 | -0.7473337 | -1.671638 | 0.0056947 | 0.0465606 | 0.0383731 | 2332 | SMC4/SMC2/CCNB1/CCNB2/NCAPH/CDK1/NCAPG |
| REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | 29 | -0.5668830 | -1.623894 | 0.0060854 | 0.0494068 | 0.0407188 | 2188 | LIN9/TFDP2/TK1/DHFR/TYMS/CDC25A/FBXO5/ORC1/E2F1/CDT1/CDK1/RRM2 |
All volcano plots
What is in common and what is specific to each conditions?
Venn diagram
Now let’s look at the 1025 + 356 (1381) genes that are common to cytokines and cyto+statin treatments. The hope is to find some that are up in cytokine and down in statin+cyto vs ctrl. There are 43 such genes.
| ensembl | log2FoldChange | protID | gene | description | padj |
|---|---|---|---|---|---|
| ENSG00000287059 | 6.9993206 | novel transcript | 0.0000000 | ||
| ENSG00000268628 | 2.5854525 | novel transcript | 0.0000000 | ||
| ENSG00000246250 | 1.9979103 | novel transcript | 0.0000000 | ||
| ENSG00000234147 | 4.7675509 | novel transcript | 0.0000000 | ||
| ENSG00000251615 | 0.9528324 | novel transcript | 0.0000001 | ||
| ENSG00000287778 | 0.8707822 | novel transcript, antisense to HS3ST1 | 0.0000006 | ||
| ENSG00000127324 | 0.7722139 | P19075 | TSPAN8 | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] | 0.0000034 |
| ENSG00000284428 | 1.0604299 | novel transcript | 0.0000039 | ||
| ENSG00000251152 | 0.6091748 | novel transcript | 0.0000083 | ||
| ENSG00000280219 | 2.1180367 | TEC | 0.0000111 | ||
| ENSG00000253671 | 0.5031609 | novel transcript | 0.0000175 | ||
| ENSG00000288018 | 1.7573141 | novel transcript | 0.0000187 | ||
| ENSG00000279806 | 0.7856891 | TEC | 0.0000485 | ||
| ENSG00000285108 | 1.5781545 | novel transcript | 0.0000544 | ||
| ENSG00000233569 | 2.1671764 | novel transcript | 0.0001470 | ||
| ENSG00000284644 | 2.4543742 | novel transcript, antisense to OR2A1 and ARHGEF5 | 0.0002324 | ||
| ENSG00000277749 | 0.5605533 | novel transcript, antisense to CCDC33 | 0.0002620 | ||
| ENSG00000237167 | 2.3959842 | novel transcript | 0.0003454 | ||
| ENSG00000283633 | 0.6714995 | novel transcript | 0.0006179 | ||
| ENSG00000287941 | 3.3810662 | novel transcript | 0.0017181 | ||
| ENSG00000280010 | 0.8654297 | TEC | 0.0017225 | ||
| ENSG00000249631 | 0.5620504 | novel transcript | 0.0025548 | ||
| ENSG00000275552 | 2.0560632 | novel transcript, antisense ABHD4 | 0.0032807 | ||
| ENSG00000289003 | 0.8687899 | novel transcript | 0.0043041 | ||
| ENSG00000285763 | 1.7240657 | novel transcript, antisense to C6orf52 | 0.0043482 | ||
| ENSG00000287906 | 0.6028958 | novel transcript | 0.0059952 | ||
| ENSG00000260196 | 0.9917662 | antisense to KCNJ11 and overlapping to a novel gene | 0.0062620 | ||
| ENSG00000254951 | 1.6005535 | novel transcript, sense overlapping OR5P2, OR5P3 and OR5P1P | 0.0066262 | ||
| ENSG00000206567 | 0.5501848 | novel transcript | 0.0101431 | ||
| ENSG00000233292 | 1.1908276 | novel zinc finger pseudogene | 0.0120839 | ||
| ENSG00000259924 | 1.6238642 | DnaJ (Hsp40) homolog, subfamily B, member 14 pseudogene | 0.0133283 | ||
| ENSG00000270127 | 1.2133600 | novel transcript | 0.0141312 | ||
| ENSG00000251194 | 1.4751694 | novel transcript | 0.0147500 | ||
| ENSG00000284968 | 0.6022887 | Novel transcript, antisense to AFF1 | 0.0198355 | ||
| ENSG00000289268 | 0.7987102 | novel transcript | 0.0259115 | ||
| ENSG00000228477 | 1.3957378 | ribosomal protein S2 (RPS2) pseudogene | 0.0266035 | ||
| ENSG00000270571 | 0.7396350 | novel transcript, antisense to TACR1 | 0.0359253 | ||
| ENSG00000260855 | 0.9748493 | novel transcript | 0.0370781 | ||
| ENSG00000272574 | 1.4570189 | novel transcript, sense intronic to UAP1 | 0.0384997 | ||
| ENSG00000287642 | 1.1546612 | novel transcript, antisense to FHDC1 | 0.0393861 | ||
| ENSG00000286811 | 1.8104343 | novel transcript | 0.0417857 |
- ENSG00000268628: lncRNA : mutations involved in cancer https://ngdc.cncb.ac.cn/lncbook/gene?geneid=HSALNG0129015#transcript_information and GWAS with high density lipoprotein cholesterol measurements.
- ENSG00000280219: TEC means To be Experimentally Confirmed
Highlight on volcano plot
Heatmap
Enrichment analysis (Over-representation analysis)
GOBP
GOMF
## R version 4.3.1 (2023-06-16 ucrt)
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## [61] glue_1.7.0 nlme_3.1-162 GOSemSim_2.26.1
## [64] shadowtext_0.1.2 reshape2_1.4.4 snow_0.4-4
## [67] fgsea_1.26.0 generics_0.1.3 gtable_0.3.4
## [70] tzdb_0.4.0 data.table_1.15.4 hms_1.1.3
## [73] tidygraph_1.2.3 xml2_1.3.5 utf8_1.2.4
## [76] XVector_0.40.0 pillar_1.9.0 yulab.utils_0.1.0
## [79] babelgene_22.9 rJava_1.0-6 splines_4.3.1
## [82] tweenr_2.0.2 treeio_1.24.3 BiocFileCache_2.8.0
## [85] lattice_0.21-8 bit_4.0.5 tidyselect_1.2.1
## [88] GO.db_3.17.0 locfit_1.5-9.8 Biostrings_2.68.1
## [91] knitr_1.44 gridExtra_2.3 svglite_2.1.2
## [94] xfun_0.40 graphlayouts_1.0.1 stringi_1.8.3
## [97] lazyeval_0.2.2 ggfun_0.1.3 yaml_2.3.7
## [100] evaluate_0.23 codetools_0.2-19 xlsxjars_0.6.1
## [103] ggraph_2.1.0 qvalue_2.32.0 ggplotify_0.1.2
## [106] cli_3.6.1 systemfonts_1.0.4 munsell_0.5.1
## [109] jquerylib_0.1.4 Rcpp_1.0.11 dbplyr_2.3.3
## [112] png_0.1-8 XML_3.99-0.14 parallel_4.3.1
## [115] blob_1.2.4 prettyunits_1.2.0 DOSE_3.26.2
## [118] bitops_1.0-7 tidytree_0.4.5 viridisLite_0.4.2
## [121] scales_1.3.0 crayon_1.5.2 rlang_1.1.1
## [124] fastmatch_1.1-4 KEGGREST_1.40.0